We're Shockingly Close To A Cure For Aging | Answers With Joe

[@zibbitybibbitybop]

I've seen what dementia does to people, it robbed my grandmother, grandfather, and great-aunt of their minds in their old age. It's an utterly horrible fate for everyone involved, so if anti-aging tech can prevent or even reverse it, it would be the single biggest boon for human dignity in the history of mankind. No one deserves to be reduced to a shell of their former self like that.

[@trackman2300]

True it Robb my grandma and great grandma

[@lindaseel9986]

So true. A cousin, aunt, uncle and a dear family friend all were taken by this horrible disease.💔

[@__Shellspace__]

it would be nice

[@PiujuqInuitArt]

Maybe she just had menopause. Here in Ontario Canada many middle aged women with menopause and other hormonal déficiences are being wrongly diagnosed with dementia and are being placed in nursing homes. The Ontario government is ultimately responsible.

[@drpoundsign]

Most of my ancestors died in a Genocide, so I never knew them. A Lot of my female relatives got Fatal Cancers. One First Degree relative DID make it to Ninety, but slowed down, mentally and physically, the last three years.

[@PhotoTrekr]

I've always said that they'll find a cure for aging about the time I'm 80 and I'll have to live forever as an 80 year old man.

[@dstinnettmusic]

God…imagine being the elderly when they first discover aging. Depending on my personal condition, I might just decide to go. Finish my bucket list and then go.

[@MrRezRising]

Or you could be a twelve year old Highlander. Which is worse?

[@Fernando-ek8jp]

Look at east Asians, particularly the Chinese and Japanese. They are quite able and self reliant even at 80, and it's just for one simple reason: activity. You can be a healthy, mobile 80 year old if you work to be healthy and mobile now. Go on regular walks, take up dancing, don't let sedentarism take over. You're right, it's not the same being a healthy 30 something and a healthy 80 something, one is clearly objectively lesser. But that doesn't mean it needs to be terrible.

[@dstinnettmusic]

@@troywilliams9688 was she 10? I thought she was like 4.

[@dstinnettmusic]

@@Fernando-ek8jp can you point me to the academic study that shows that East Asians are shown to be active in their 80s in a statistically relevant way as compared to other nationalities?

[@sharonwhite6126]

I'm 48 at 46 I was diagnosed with stage 4a cancer. Physically I feel about 90 and mentally about 12. Can't help the cancer but the way I live with it. I'm not dying from it I'm living with it. Only way to go. #hereforagoodtimenotalongtime

[@leadgindairy3709]

Amen!

[@asdfghjkl2468ist]

❤️

[@fleshanthos]

Since it's pretty ubiquitous in my family I've got a slim chance of NOT getting it. How does it affect your mind?? Do the chemo drugs take away your learning??

[@joycekisamo4896]

Wishing you well dear; the power of a positive mind is unbelievably helpful. Try whatever possible to not feel physically 90 at age 48; fight this horrible disease with all your mighty mind and determination. May the grace of Our Almighty in every Form and Way help you 🙏🏽

[@michaelwinter742]

Hell yeah! This is a person who wants to talk about their car warranty! What do you say?

[@mstr293]

You hit the nail on the end with your closing speech. I'm getting tired of those selfish people not worrying about the future because of "not living long enough to see it". It kinda shows you that these people literally screwed future generations and would rather Kamikaze themselves than face the consequences of what they did.

[@mstr293]

17:38

[@royzlatanestevez9843]

But how dare they be YOUNG while we are OLD. I think it's fair. They laugh at us being frail and having lose skin... so let them stew in our waste in return.

[@mikeximenez5285]

They say respect your elders and then don’t do anything worth respecting lmao

[@mikeximenez5285]

@@royzlatanestevez9843 admitting you’re stupid and selfish should be embarrassing not a brag 😂

[@royzlatanestevez9843]

@@mikeximenez5285 You are too young to understand. Soon you will be old and understand that aging and death are necessary parts of the circle of life that produce justice.

[@Lesminster]

I think what Sinclair's lab is doing is, hands down, one of the most fascinating stuff out there. The fact they managed to rejuvenate an old mouse to become a "teenager" is just astonishing. As I remember exactly, they had two mice of the same age. Then they olden one mouse(gray falling out hair, no energy, losing vision) measured it's results on a treadmill, and then rejuvenated it back to being young and measured again. I remember Sinclair said this "new young" mouse ran so long on a treadmill that their testing program stopped measuring because they didn't expect any mouse to run that long :) They also managed to tumorize an eye of a mouse(I think) and then cure it back to full health. Yeah, next 20 or 30 years looks quite promising, if we manage not to kill ourselves in nuclear war that looms on the horizon..

[@danieloliver20]

Rejuvenate/ rebuild an eye, I'm all for that! Maybe an "antibiotic" to combat the set of "stupid emotion" genes that have us constantly dancing with nuclear war... Vladimir, take your 💊!

[@gustavodutra3633]

We managed not to kill everyone in the first wars, it's not going to happen now, probably...

[@Oozaru85]

That nuclear war can't come fast enough. And we already are killing ourselves, albeit slowly. Nuclear bombs would just speed it up.

[@bedhead4728]

Is this the same guy who made a super soldier mouse? Mouse was like equivalent to 70 year old and ran on a treadmill like...forever. I can't find video. Think it was on vertasium. I think down side was the caloric intake needed was insane and woukd die rapid.

[@Lesminster]

@@bedhead4728 y, that's the one.

[@Ishykai]

I remember being a kid, looking at my great grandma in pain, getting cancer, breaking bones easily, and thinking that aging is to blame. That it's the disease we all have. It's super exciting thats being explored and worked against.

[@LordHarv]

I remember my great grandmother, and how she lived to 96. All the while saying she has lived long enough and is ready for it to be over. Quite frankly I dont blame her

[@Ishykai]

@@LordHarv if you're in pain all the time and prone to illness for sure, but I believe I'd be willing to live 1000s of years or more if I could stay "young".

[@gotworc]

@@Ishykai exactly. I think there might be a point though where I'd be like "yeah I've had enough" then just die lol

[@jandersen6802]

@@gotworc I think the world is expanding so fast and developing in so many interesting ways that you will never get bored. Even boredom will probably be cured in the next 1000 years.

[@beastness501]

@gotworc the real question is, which will come first, us becoming cyborgs due to the ai becoming smarter and smarter, or us fixing aging. Or, we have both, what then? If you already don’t age will you still want a mechanical hand just because you’ll be able to carry more? Idk but I personally don’t think these will happen within my lifetime, and I’m only 22. People used to think we’d have flying cars by now 100’s of years ago. Who knows though, maybe aging will be fixed by the time I die, but than the problem with cost comes in, will only rich people be able to live forever?

[@AskZch]

I think when it comes to anti-aging research you should always credit Dr. Aubrey De Grey who basically pushed for this research and pioneered it for two decades before anyone like Dr. Sinclair (big props to him) could've touch the subject and leave his career intact. These days, everything that De Grey Advocated for decades is actually happening. Surely he deserves at least a shout out.

[@salmongod9115]

As much as Eric K Drexler is I guess treated as kind of a joke these days, he was the one who first sparked my imagination to begin pondering the possibility and implications of anti-aging and transhumanist technology when I was in my late teens (in the late 90's). And I'm no scientist so that maybe doesn't matter much, but that was what led me on the path to knowing about figures like De Grey, and spreading awareness about that side of science and seeding enthusiasm to others.

[@AskZch]

@@salmongod9115 Great observation, you are absolutely right. It totally slipped my mind. Drexler wrote and spoke about this ages ago. He's not called Father of Nanotech for no reason.

[@RateOfChange]

Yes! A million times yes! He's always been in the frontline and many people just say he's crazy. He'll be remembered someday

[@ChrisBear1989]

Sure credit him to. Thanks De Grey. Its very possible(And close)

[@misterwyrd8132]

De Grey is basically the Tesla of anti-aging research and as you said should be remembered as such. I stumbled on the guy like 15 years ago when I got deep into researching the plausibility of science fiction concepts and the fact that his then "bleeding edge of research" is now a not too distant horizon is astounding.

[@bjornnuel]

Mortality has been a subject that has put me in great sadness many times. The idea that "experiencing" will end someday, and just the realization that the fact that we "experience" in the first place is so complex and so unexplicable... It makes me feel very fragile if that makes sense.

[@filipvasilevski8115]

Reverse aging and immortality any relations?

[@SeanMendicino-n3d]

I think mortality is a good thing. You don't want to live with your regrets for ever. I'm glad that I won't have to last longer than 80.

[@christopherfranklin2337]

Just remember what good ol mark twain says "I do not fear death. I had been dead for billions and billions of years before I was born, and had not suffered the slightest inconvenience from it." Always makes me feel better 😂

[@timpoint0]

If we weren’t mortal we wouldn’t cherish the “experiencing”.

[@andrewhobbs5268]

dosent have to be that way we will cure ageing i just hope it hapens in time for me to do what i need to do

[@salinagrrrl69]

Aging means two things to me: 1- INJURIES from long ago come back to remind me they happened. 2- GRAVITY really starts to be an obstacle.

[@ras573]

3- UV radiation from the sun (and other things)destroying your genes. 4- Chemicals destroying your tissue (like oxygen). 5- Indigestible trash piling up in the cells, and around them.

[@iniquity123]

The elderly (me-getting there 😞) aught to be sent to the Moon in the future to aid their health whilst doing important medical research 👍🏼.

[@alphagt62]

3- the floor gets very far away.

[@jameselliott9055]

@@iniquity123 and be extremely overpaid for no apparent reason at all. I am all for it!

[@the_algorithm]

F-K Gravity

[@TalentedTeensOf1998]

I think it's interesting how people see this and other type of scientific discoveries as unnatural when, technically, there's no such thing. One of my favorite quotes is from Sapiens: "Whatever is possible is by definition so natural. A truly unnatural behaviour, one that goes against the laws of nature, simply cannot exist, so it would need no prohibition.”

[@monhi64]

Unnatural/natural is the stupidest construct that people put an insane amount of value in

[@PyrusFlameborn]

A more useful distinction is manmade vs naturally occuring. And in that framework things like clothes, houses, cabbages and dogs are manmade and not naturally occuring.

[@thek2despot426]

@@PyrusFlameborn Yeah, but man-made constructs, and indeed man, are naturally occurring as they... occur in nature. _That's the whole point._ Maybe intelligently designed vs. not intelligently designed might be closer to the more proper distinction, but then again most people who confuse "natural" for "good" usually think "natural" is part of some divine plan, so maybe that isn't ideal either.

[@eleonarcrimson858]

i feel like that is a stupid quote, no offense. What do you say to the experiments done on people by nazi scientist? Do you call em natural? nothing is black and white. So grouping everything we do as natural is unnatural.

[@TalentedTeensOf1998]

@@eleonarcrimson858 Don't worry, I'm not offended. I guess what I was trying to say with this quote is that "natural" and "unnatural" are human constructs. The definition of natural is "caused by nature, not humankind" but humans are a part of nature, just like monkeys, pigs, mushrooms, etc. People usually think "natural" means good and "unnatural" as bad, when in reality they mean neither. Because of this people usually defend things by saying it's "natural" and when calling something "unnatural" it's usually in opposition of something. I'm kind of bad at explaining things, but what I mean to say is that everything is a part of nature therefore everything is natural. But that doesn't mean everything is "good" or "meant to be", it just is.

[@WentzCraft]

The death of a toddler carries more weight than that of a 90 year old for a singular reason "they had so much more life to live". Increasing lifespan actually increases the value of each individual life.

[@heww3960]

No it carries more weight because people are hypocrites, they preach about equality, but in reality they are the opposite of it. No one has more life to live after it is dead.

[@mrlarrybobjr]

Your two sentences contradict each other. In my brain.

[@Thelango99]

@@mrlarrybobjr Not at all. If value of a life is decided by its potential future length, every life increases in value.

[@jabrokneetoeknee6448]

If technology allows human beings to consistently live well beyond 90 years old, I think we as a species will be confronted with some pretty uncomfortable decisions. The Earth can simply not sustain current birth rates AND increased life expectancy. So do we demand 100+ years of life for every human being around the world, as a matter of right? Or do we consciously limit access to this technology, so as to prevent ecological collapse? Perhaps new methods of population control would be implemented. It’s an interesting thought: for the first time in history the population of the younger generations would be curbed so as to sustain the extended life of existing generations.

[@mrlarrybobjr]

@@Thelango99 I see your angle, but when grandpa dies we get his actual value to put in the bank. When a baby dies you only get funeral expenses. Grand dad was worth way more. But also it’s harder when a baby or small child dies because it’s out of the natural order, your children are not supposed to die before you, so it’s hard on the brain. Witch Carrie’s more weight. I don’t know anything though , just some quick thoughts here…

[@JetScreamer_YT]

It's taken me 50 years to shed the fears installed by my parents, and the world. I feel I'm just starting life after decades of mental illness.

[@Necro2Juggalo]

Then I hope you make the best of what you have left here and truly enjoy what you can

[@djzip9231]

That’s the journey it doesn’t mean we should live an extra 200 years just because we see ourselves as unfortunate

[@JetScreamer_YT]

@@djzip9231 If it were a real thing... My body my choice. How long did Moses live?

[@JetScreamer_YT]

@@Necro2Juggalo Thanks! You are very kind.

[@crukih7527]

Longevity would be a great equaliser. I’m putting myself through medical school right now in the hope of branching the gap between the science and the medical community. Your not alone. So many get a bum start in life and take decades to work out the mess their parents did to them. I’m the same, a few years older than my fellow students. I want to give everyone enough time to reach their full potential, regardless of their start in life. People who are against that don’t know how difficult and unfair things can truly be. I hope you continue to enjoy your life moving forward and I hope you can see this technology come about. We can’t get the past but we can strive for a better future.

[@fartsimpson8610]

Extreme longevity runs in my father's family. For well over 150 years, if they survived infancy, no one died under 100, including a great uncle who literally drank a bottle of whisky and smoked two packs of cigarettes a day. One of the things I've noticed is that, where eating is a social highlight for most people, none of the people on the long-living side of the family cares one bit about food. They all will often forget to eat if they get too busy with something. Perhaps it ties into the longevity benefits of fasting.

[@thebigpicture2032]

There are a lot of people who don’t get enough food. Doesn’t help them live to 100. Likely it’s genetics. Few can drink and smoke and make it to 100.

[@thtiger1]

Sounds like they were prime candidates for the Howard Foundation. Invented by Robert Heinlein the foundation was started by a billionaire who died of old age in his fifties? His foundation approaches people who had all four grandparents living and offered them a trust fund if they married someone from a list of people with all four grandparents alive. The intent to breed longevity into the human race.

[@SuperManning11]

@@thebigpicture2032 I think he meant ‘intermittent’ fasting. When they were hungry, these people ate. Being constantly malnourished is a whole other thing that certainly does not lead to a long life.

[@darcy5823]

I watched a doc on aging where it said that there is a genetic marker that is common in families with many centurions. There were many examples showing bad life style choices didn't affect their longevity!

[@aguspuig6615]

@@thebigpicture2032 not necesarily eating less, but maybe not forcing yourself on a strict schedule makes things easier on the body, i know that if i dont force myself i rarely sleep and eat at the normal hours, but i do still sleep and eat in the same amounts and it tends to feel better

[@thejohnroxbury]

I've been exercising several times a week for 20 years and started intermittent fasting 3 years ago. I am going to do everything in my power to catch the reverse aging train.

[@KentoCommenT]

Same with trying to catch that train!

[@maidende8280]

I’ve been doing extreme IF (36/12) with CRON for 15yrs. It works wonders!

[@vbgvbg1133]

i call it skipping breakfast

[@imrangul6750]

​@@vbgvbg1133 Well yeah, but you won't make as much money by saying that lol.

[@Benzknees]

Basically you've gone back to the life of a peasant in the Middle Ages. With a life expectancy 35yrs old you should certainly beat that aging problem.

[@RR-VanityInKnickers]

Something cool: 4 years ago, at the age of 55, I noticed that my hair was actually growing out black instead of gray, along with being full and silky. I found this odd since I have been a brunette most my life, and my siblings were all getting white hair including my sister who is a year younger than me. Even now, at 59, 99% is still growing in black with barely any white hairs (my younger sister is now completely white). Everyone pegs me at 10 years younger than my actual age. My body, however is a completely different story... 😆 Talking with my doctor, we came to the conclusion that it was possibly due to the steroid shot that I have been getting in my right eye, four times a year, for the last 18 years to stave off blindness due to retinal disease (I'm already blind in my left eye). So my hair, technically, doesn't seem to be aging at all. So yes, I'd like a drug that would do the same thing to the rest of my body. 😄😄

[@Darenz-cg9zg]

"You're still slowly dying, but good news, you hair will live forever!

[@fleshanthos]

I'd like that drug too!!!

[@NASkeywest]

There is testosterone injection

[@draggy6544]

Start working out seriously also maybe even talk to your doctor about testosterone replacement therapy. I knew a guy coming to my gym the man is 59 and was in crazy good shape started exercising in his early 50 and weighed like 235 with abs being only 5’7”

[@fleshanthos]

@@draggy6544 But the testosterone will make any cancer accelerate from what my dr told me...

[@willcooper7651]

Thanks! Great video. Just watching it added several years to my life. I feel it!

[@Omaw77]

Joe! I loved this video, this is the sort of thing that got me to sub in the first place, neat science stuff with a dash of clever and charisma. Much better than the disaster stuff that (unfortunately) gets you more views. I know you gotta play the game homie, but this is the kind of video I love your content for.

[@gillifish]

I’m in my early 20s, I just had a brain MRI done and apparently my brain is that of a 70-90 year old physically speaking. I definitely feel that way lol, and my body is falling apart due to genetics… but this is fascinating! If they couldn’t fix my health issues I wouldn’t live any longer than I have to 🥲 life is hell for us chronic pain/illness people, but I definitely don’t want to miss out on life (I already am). So if they can make my quality of life better and delay aging so I can enjoy myself, it would be amazing!

[@fenyx2558]

lol

[@SamanthaVimes]

Doctors treat women like old men-- if the problem isn't obvious, we are expected to live with it.

[@syyneater]

As someone else who’s been on the chronic pain track, I completely understand this. Things have gotten a little bit better with some donated stem cell treatments, but every day is a slog to get through.

[@i_love_rescue_animals]

I'm so sorry to hear this! This isn't right. Do you have issues with your memory?

[@bethanysmith2919]

I also have genetic neurological disease and connective tissue disorder. It is a hellish life, we must make people aware of these problems :)

[@Tom_Bombadil3000]

35 yr old man: "Age reversal is unnatural!" 75 yr old man: "How's that age reversal thing going?"

[@MarkGast]

300 yr old man: "Get off my asteroid!"

[@rodrigosaavedra4791]

500 yr old post human cyborg: beep bop boop

[@hernerwerzog1278]

700 yr old man: De do do do de da da da.

[@PyrusFlameborn]

Cabages are unnatural as well! They are a pure Human invention! The original plant that the cabbage descends from is nothing like the modern cabbage. It's only due to Human intervention that it exists

[@iamcyber]

900 year old man: *incoherent babble*

[@JesseDriftwood]

I wonder how much of the pushback against this type of research comes directly out of religiosity. It seems that religion has long existed as a way to answer questions about our own mortality. I can’t imagine how hard it would be to see the benefits of anti-aging science when you view aging as some long/painful/necessary road towards your mansion in the sky (obviously this isn’t how everyone views the afterlife, but that isn’t the point).

[@Lachesisms]

Do you really think that if people lived forever that they would fix things such as earthquakes, famine, racism, hate, war... how about fear, can we just take a pill to stop fearing or phobias? God doesn't let us just live forever - he fixes everything.

[@JesseDriftwood]

@@Lachesisms I have no idea what would happen to earthquakes, famines, or war. What I do know is that scientific progress has made far more progress on those fronts in the last hundred years than any other practices we’ve observed in human history. I think that believing there is a god who will one day make all things right is a very powerful message that is extremely helpful for a lot of people. What I don’t think, is that such a claim could possibly be substantiated. Believing a thing will happen one day doesn’t make it so, and every single generation as far back as we can see thought that that day was upon them, in their lifetime. Can I ask you honestly, how many thousands of years would have to pass with no signs of a returning deity, before we should start looking elsewhere for answers? Because we’re over 2000 years in now and not much has happened. I’m not trying to provoke you or be argumentative, I just genuinely don’t think humanity can afford to hold onto false hopes with no evidence for much longer.

[@Ohhelmno]

@@Lachesisms ​ I actually think it would, to an extent. The longer we live, and the healthier we are while we do it, the more exposure we get to other people… including different races and sexualities and all of the above. Studies show more exposure leads to less racism, so that would help… plus we’d be a bit less stressed about getting older which would lead to better moods, less anxiety and depression. Plus we would be able to accrue much more information and retain that information over a longer lifespan with more health in typically elder years. Obviously things like earthquakes and famine could still be issues just due to that they’re natural processes… tectonic activity for earthquakes and drought or flooding for famine, but because we’d be living longer and better able to obtain and pass on information we could mitigate them easier. Now, I’m not saying it’d be some miraculous change in intelligence or whatever, but it seems to follow that having more time to learn and pass on information would benefit us in virtually every way, even if it’s just a few percentage points.

[@deepmind5318]

@@Lachesisms some of us want to live longer because we don't feel that we have accomplished enough. It won't stop evil, but it also won't stop good. There is more good than evil even if it's just over 50% good. Also, scientists are figuring out how to stop earthquakes and famine by using innovation via artificial intelligence, or super intelligence computers.

[@mamacito1795]

You're probably right, some idea this isn't God's plan or men stepping into gods role but ironically abrahamic religions should believe this is exactly God's original plan any way.

[@spicydeath82]

i remember reading a popular science magazine back in 2008 on this very subject. they cited three factors for aging. 1) DNA degradation(ie damaged DNA), 2) debris building up in cells due to leftovers from cell division, 3) free radicals. the article covered research into cell debris. basically every time a cell splits, there's left over material that just sit inside the cells afterwards. the cells have the ability to expel these debris, but don't for some reason. overtime the debris builds up to the point that cells can no longer function properly, halting cell division, so no new cells are formed, or if they are they are defective. they found a chemical treatment that would cause the cells to expel the debris, freeing up the space for cell growth and division once more. they tested it on mice. mice have a life span of roughly 2 years. mice treated with this drug regularly, lived to be about 6 years, tripling their life span. they were also healthier for much longer and took much longer to show aging. the left over aging was due to there DNA still getting damaged over time. they tested older mice that were graying and saw surprising results. over time the gray hair went away and they started acting like younger mice. the treatment actually reversed the aging that had already happened. the mice have a relative known as the naked mole rat. unlike most other members of the rodent family, they live about 30 years. so they have 15 times the life span of mice or rats. this is due to them having a special protective coating on special DNA that cells use for error checking when making DNA copies for new cells. over time most animals special DNA gets damaged, errors start compounding, leading to aging and eventually death. since naked mole rats have this coating on their DNA they suffer far less aging effects, they almost never get cancer as a bonus. their DNA is extremely stable. if treated with the previously mentioned drug, they'd likely live longer than your average human. if you could modify human genes to have this coating like the naked mole rat DNA does, and if treated with this drug, you could see human life spans increased to a thousand years or more. it's weird im only hearing about this stuff again after 14 years.

[@kalidwapur]

As a biologist I can tell you if you haven't heard of it for so long either it was way oversold or they were unexpected issues. Unfortunately aging is a holistic issue so it's very hard to foresee what's going to happend with any treatment in a species or across species. Do you remember the name of the compound by any chance?

[@danklegosi6084]

What if it was legal for scientists to experiment on criminals on death row? I mean they're already going to die so like why not test this stuff out?

[@kalidwapur]

@@danklegosi6084 Most biologists are against the death penalty to begin with so no. It is absolutely inhumane.

[@danklegosi6084]

@@kalidwapur but the criminals themselves have done inhumane things to get there in the first place. Why not do something to benefit humanity when there bodies will basically go to the equivalent of a human dump? Why not recycle?

[@kevinchavis2755]

Want to help your cells now? Do Sun Chlorella. It penetrates the cell walls to detox them

[@MrSimonlos]

I am heading to the front of aging research. I want to create a world where everyone can decide for themselves how long they want to live. It is really sad to see most of my friends and family not understanding the implications of the fact that the top killers are only symptoms of aging and that a cure can be created within their livetimes. Often they even think it is a bad thing and should not be done. But I hope they will understand and i am proud to be participating in fighting the biggest source of suffering.

[@Global_Enlightenment_Now_2060]

Are you a scientist for this type of research 🤔......

[@stdesy]

I don’t understand the mindset of those people. Seriously wanting to die? It would be like WANTING someone to barge into your house and bludgeon you to death slowly. Obviously we should do everything in our effort to prevent that from happening

[@flash7210]

For some people, LIVING is suffering

[@mr.boomguy]

I wish you the best of luck! I'm routing for you and your fellow researchers! I think it's sad too, that people think of aging as something we'll have to deal with.

[@johannesjoseph823]

I fear my own death but I don't think it's the biggest source of suffering, not even close

[@Twisted_Code]

CGP gray had a really good video on the psychological barrier you referred to as "aging Stockholm syndrome". People that say aging gives life meaning have a perverse definition for the meaning of life. No one would say to the Grim Reaper "Hey could you cripple my son so the time he spent before being crippled is more meaningful"? Yet that's basically what people seem to think with regard to aging

[@ro4eva]

The most compelling argument for anti-aging to me is as follows: Imagine if we could have some of history's brightest minds contributing to science for ~500 years each instead of ~50 each.

[@supercal333]

Conversely, imagine history's worst tyrants living that long.

[@xanderguldie]

One of the most compelling arguments are, the brain doesn't stay malleable and it's highly likely brilliant peoples cant keep making advancements. Also, I'm pretty sure people who life hundreds of years would eventually get depressed or go insane.

[@1925683]

No, just no. This assumes that people want to live that long and be contributing to society for all those years. It also assumes that we won't have similar geniuses appear after them, and ignores the circumstances that led to their apparent genius. Everyone likes to remember the people who won the Nobel prize, but ignore the enormous body of literature and community which contributed to that genius.

[@RandomGamer-qy6ys]

We’d be a type 9 civilisation if they were all still here today

[@matheussanthiago9685]

but think about how human societal structures aren't perfect including science so many times, for science to advanced people had to literally sit down and wait to older generations to die out, because they were too stubborn to even consider anything else imagine the stagnation we'd reach with the ''owners of what's right'' never dying

[@FerrowTheFox]

I've been an anti aging advocate for most of my adult life. I became fascinated with it during high school and took a course in anti aging realted biochemistry and cytology when I studied biology in university. Not only is there the benefit of having people live healthy for longer times, wich in itself is great, but for me the biggest draw would be that a person can benefit society for far longer. Just think about it, we spent so much time learning until we're proficient in our work or even just hobbies. For my field, you study til your mid 20s to get a M.sc., at leat three more years for a PhD. That's about the same time you then got to contribute to the field AND train the next generation already. And when you retire, or eventually die, your expertise is lost forever and someone else needs to step up. It's highly inefficient. Imagine all the brightest minds in a field, be it scientists, artisans, or even contemporary witnesses, who together with their knowledge, we lose every day. If we could extend the time we could dedicate to the problems in science and society, we might get a lot better results. Just doubling the time we have would be a huge win already.

[@kvidal88]

that, and perspective is really important. imagine if we had 300 year old people alive today, who look 30-50, maybe we could avoid fighting a lot of wars & making the same stupid mistakes over & over if we have more perspective. then again, there might also be echo chamber communities of pepople who are mentally very stubborn & stuck in the past, who just get more & more ignorant as time goes on.

[@TwitchyTopHat1]

@@kvidal88 on the other hand, you could have immortal dictators calling themselves god kings.

[@samchoate1719]

That all sounds great, but the whole “contributing longer to society” sounds like it would be exploited in ways we can’t yet imagine.

[@kvidal88]

@@samchoate1719 maybe workers will have to actually stand up for themselves & stop accepting unsustainably bad wages/conditions

[@kvidal88]

@@TwitchyTopHat1 that's going to happen if this is possible at all. you can't stop rich people & large states from doing their own r&d. may as well let some decent people do it too.

[@DaveSomething]

"learn to live with your pain" is what I usually hear. I just turned 51... I look about 55 and feel about 80.

[@SeanClarke]

I'm about to turn 55, and I feel like I'm 35. My 36 year old GF actually thought I was the same age as her when we met (and she's slim and hot).

[@omnirath]

@@SeanClarke good for you 😆

[@Sara3346]

I suspect my liver will kill me or I'll overdose on painkillers by accident someday, better than living with the pain.

[@rambi1072]

@@SeanClarke Interesting, I'm actually 80 and feel about 30. When I met my 25 year old GF she thought I was 20

[@rainbowhyena1354]

@@rambi1072 do you have problems with sunlight?

[@nanzymyap]

I’m in my teen years and this is the best news of my short life. Imagine the technological advancements in 70 years or so!

[@jandersen6802]

They talked about fusion energy 70 years ago and it is still not here. Stopping biological aging is probably even harder, so don't get your hopes up too much. The best you can do is to work in the anti-aging industry in any sort of role. At least then you help increase the chances. You have to work someplace, so why not in the anti-aging industry.

[@qwerty0458]

Study biology and become a part of the war effort against aging

[@CatSingerB]

Humbling, as always. Whenever you start going into biology (I'm a grad student of immunogenetics), I start out cringing, expecting all the unavoidable inaccuracies of a complex subject broken down into a 20 min video - only to get a few new ideas for the next semesters TA job I'll be doing. Thanks, man, you rule.

[@AndrewBlucher]

Buying the book?

[@CatSingerB]

@Andrew Blucher Which book? The parts I'm most inspired by are Joes "word mess explained" moments. Oh, and the zombie thing. Great way to wake a class right up.

[@AndrewBlucher]

@@CatSingerB _Lifespan: Why We Age - and Why We Don't Have To_ by David Sinclair Be careful of his site, my antivirus software didn't like it.

[@CatSingerB]

@Andrew Blucher Oh, no. I rely on scientific papers in my work; they tend to be a much more reliable and much less biased source of information. Or at least much easier to screen for reliability and biases.

[@robinsmith8846]

That is great praise for Joe and the work he puts into the vids...while still having fun along the way.

[@danielleohallisey4218]

Several years ago, I read about a study in Norway for a drug that targeted and destroyed senescent cells. It had worked in rats and appeared to make them I’ll for a short time as the cells died off, then the vital cells grew back to fill in the blanks. Human trials were supposed to be starting when I read about it but I’ve never heard anything else. Might be a great subject for a video!

[@Strideo1]

I would imagine your body having to support all those senescent cells that aren't doing anything anymore is just like supporting deadweight (or maybe live weight 😛) that doesn't really benefit you.

[@TodayInHistoryNO]

I don't have any litterature to share off the top of my head, but this study failed or at least did not produce any promising results. The last thing I heard was that it ended. (Norwegian healthcare worker)

[@o-wolf]

Everyone up vote this so Joe can see it!!

[@o-wolf]

Its really eerie how I'd been writing a sci-fi script for a while where anti-hero character invents DNA editing software that essentially "peels back" all the junk DNA &removes the perfections etc &in the story the side effect was you'd be deathly ill akin to a a heavy flu as the DNA bots did their work.. then once it's done &you've lost alot of bodyweight &your teeth &hair have all fallen out.. you'd slowly start developing your "new &improved" physique/phenotype etc.. differences in bone strength/structure your teeth regrowing perfectly uniform (or to your specifications) from scratch etc Science isn't really my background but I just figured from casual knowledge that this would be a unique way to visualise that process instead of the typical "drinks vial with blue liquid &hulks out" Then it turns out my thoughts were closer to reality than I... Uh.. thought

[@TheReaverOfDarkness]

@@Strideo1 Those cells are still functional, just less functional. If they were completely non-functional, they would typically get shut down.

[@DraconaiMac]

I love it that you addressed quiality of life, not just years. This is happening. Cant wait to find out how the fundamentalists handle it.

[@MattGM97]

The people who are against radical life extension will just use it and pretend they were never against it. If given the option, no one chooses to die tomorrow. Most will change their mind when death starts getting really close

[@Suprm_Lord_E]

Oh they'll love to hang around a bit longer to keep making others peoples lives miserable. It's their sport And they'll even credit the longer life to jesus

[@kdub3890]

@@Suprm_Lord_E There's a different breed of zealot these days. The heretic-burning mobs aren't spilling out of churches anymore. They're praying to an image of a white dove on a blue background.

[@sendmorerum8241]

Well, they cannot whine about it, the Bible says people will "live as long as trees" in the future so it's on God if we discover how to live for centuries.

[@wolf1066]

I'm sure that their ultra-rich pastors are already doing everything they can to extend their lifespans so that they can continue living in the lap of luxury. Can't be dying and letting anyone else have the mansion, cars and Learjet, can we?

[@pubwvj]

I feel approximately the same as I did at twenty-five. I did get COVID which had a long recovery but none of the complaints that are normally associated with aging. Good genetics - long lived ancestors. Good diet - a choice. Good environment - a choice post childhood. Good mental & physical exercise - a choice and lifestyle. I hope to benefit from the good science that is coming too us in a not too distant future. (Added: I am 60 years old.)

[@royzlatanestevez9843]

This doesn't matter if you might be YOUNG. How old are you, it's not clear. You might be 26... no wonder you feel 25.

[@dissident112]

The hardest part in implementing new habits is those first few days to weeks of torture where the body's cravings fight you the entire way. It's much easier for people once they get married to simply let themselves go, gain weight, get the dad bod, stop exercising, and the body is a "use it or lose it" mechanism. If you want to maintain function of say your bladder capacity or ability to read text close up, you need to exercise these skills. Same goes for maintaining muscle mass through basic compound movements... bench presses, trap bar squats/deadlifts, and pull ups. These and a good diet keep a person in good shape, but they are uncomfortable to do, at least until the habit is formed.

[@Whelknarge]

I read "Ageless" by Andrew Steele recently which covers most of the same ground as this video, and I have to say it was the first time I ever really concidered quitting my job, going back to college and studying biology so I could get into gerontology.

[@Lutefisk445]

Do it

[@marciemoo]

Go for it!! As they say…”Life is short”, so go make everyone’s longer!🙋🏻‍♀️

[@heyegro3158]

Do it 😊

[@zenithzelious1448]

Do It!!!

[@ChrisPrimeCoaching]

Great video Joe. I've been watching you for years. Love the humour you sprinkle the information. Thanks!

[@JA-vz1nl]

"Mortality Stockholm Syndrome" that's a very good way to put it, and yes it's crazy there's so much pushback on living longer

[@autohmae]

I only have a problem with it for one reason: population growth and the limited resources of the earth/environment.

[@Fredjoe5]

@@autohmae Population isn't growing - it's now coasting. We're in for a crash in the coming century. This also will have positive effects on the Earth/environment angle. It's amazing how most people don't even know this. Population increase is caused by *births*, not length of life. And birth rates are tumbling everywhere now, even in traditionally high-birth rate nations. Population crash is fare more likely to be our concern, and longevity science will be a crucial part of dealing with that.

[@autohmae]

@@Fredjoe5 it's still growing, but in Africa, we'll get to just shy of 10 Billion. If you want to see how it will go, check out the video: "Hans Rosling: Global population growth, box by box" or more recent: video "Population Growth. Is it out of control?" by Just Have a Think

[@Fredjoe5]

@@autohmae Even Africa's replacement rate is falling into the toilet, and that's only going to increase even more as attitudes related to women and families continue to change there. Hans Rosling has done excellent work in highlighting this. If you've got the Ehrlich's criticizing you (as he has) then you're probably correct! LOL

[@bariumselenided5152]

It was a really good description of it. For hundreds of thousands of years we’ve had to put up with the pants-shitting terror of knowing we’ll die. We’ve tried to pretend we’re ok with it and at peace, calling it natural as if that makes it ok. We’ve even invented religions to try to ease the pain. There’s a big wall around that part of our lives, and I don’t think most people are willing to open that part of themselves up. Cuz if the therapy doesn’t pan out, then they’re right back in pants-shitting terror territory, and they’ll think it’s better to just die in relatively stable peace. Also that one bloke was right, population growth will be a huuuuuge problem. People are entirely too invested in making their kids their legacy instead of making their works their legacy, and that’s gonna bite us all in the ass unless we seriously switch our thinking.

[@michaellesser8043]

This is actually precisely what I'm working on! Already have some human data to show a decrease in the age of individuals DNA with a specific protocol!! Sinclair has definitely done some great research

[@abcrasshadow9341]

Got any of that cool research you can share?

Good luck on your expansion!!

[@garethbaus5471]

@@abcrasshadow9341 I too would like to read any relavent papers.

[@crukih7527]

As someone hoping to transition into this field soon, I will happily read anything and everything you produce!

[@bobgrattons4122]

I've had health problems in the past, which left me to lose what most would called "hunger." If I go too long without eating, I'll obviously become weak, but I don't feel the need to eat at set intervals, which has led me to intermittent fastening, before I even knew what it was. I can attest that it helps burn more fat, I basically have an index of around 5 to 10% body fat, which is problematic in the winter since I lack insulation, but clothes were invented for that. It's awesome in the summer, as it takes alot for me to actually get really hot. I can also confirm the help benefits. My mother keeps hassling me that I don't eat enough and that I'll get sick, but I rarely do, and when I catch something, it's usually gone in a matter of days. Great that I now know about it, so I can educate my mother and stop her nagging. Thanks Joe!

[@jay-d8g3v]

Same here. I only eat when I feel my body needs the energy, don't feel hunger and when I do it's usually hours after eating fatty foods.

[@andremattsson]

it doesn't burn more fat. Whether you loose fat or gain fat is only dependent on if you're in a calorie surplus or deficit.

[@staunch2207]

Go do some actual hard labour in the heat and you will soon overheat , I guarantee!

[@yourlocaltoad5102]

I also have no appetite and often forget to eat until I get a stomachache or see someone eating close to me. Luckily my cats remind me at least 3 times per day that it’s time to eat something. In my experience it’s harder to gain fat, but also significantly harder to gain muscle mass. And I also rarely get sick and usually it’s gone within two or three days, but not eating enough also causes circulatory issues (like seeing stars when I get up too fast) which kinda suck, but they also kept me from having to do military service in my country, so that’s kinda nice. Since I started taking adhd meds, the circulatory issues are gone and weirdly enough I sometimes have an appetite when I take the meds even tough most people experience a loss of appetite when taking stimulant medications. What triggered the loss of appetite for you? I just one day noticed that I don’t really have an appetite like other people do and wonder if maybe one of the problems I had in the past could have triggered that.

[@davidmacphee8348]

For some reason, I have also lost my sense of hunger. Eating is also difficult but we have to eat.

[@jones7299]

I did hospice care for both my grandparents. It was an experience I never want to repeat. Nor do I ever want someone to go through that for me.

[@BK-dy8jk]

I know what you mean! It’s not only excruciating to watch but also for the person in hospice care. Can be just horrible at the end. It is hell on earth and we can make this so much better

[@andrewhobbs5268]

i get it i want this for family pets and elderly relitives i dont want to lose them and we wont have lose the people or pets we love and care for not when we can cure ageing

[@PaymentsExec]

Thanks!

[@kennedy9464]

It's amazing how things come full circle. I'm 62 and I still remember a BBC documentary I saw when I was young claiming that the main cause of ageing is food. I remembered it into adulthood and decided to only eat when I'm hungry. That turned out to be between 11 am and 8 pm. Still do.

[@AwesomeSauce7176]

How do you feel at 62?

[@darcy5823]

I've been going down this rabbit hole for a few years now and still learned a lot from this video! I'm so glad you covered this. I hope it gets more views because I love your story videos (like that dead Australian beach guy) and deep dives over the doom and gloom!

[@zachweber2616]

Suspended animation, life extension, and a growing population that needs to go somewhere. Getting major long-term space travel vibes and i'm here for it

[@alphagt62]

Seeing the Earth is suffering an overpopulation problem, if everyone doubled their life span, then the population would also double. Causing starvation and poverty. So, if we create people who can live much, much longer, they need to go somewhere else! Space travel could greatly benefit from these longer living beings.

[@ptonpc]

@@alphagt62 If people life longer, you'd probably find less kids being born. The thing is, there are enough resources for everyone at the moment. It's just not distributed well.

[@mikez2779]

population might be growing but for sure not everywhere its quite common to see declining birthrate in well developped countries more and more of such keep saying the only way to keep their population productive is immigration well, what if there would be another way?

[@krashd]

@@alphagt62 The Earth is suffering a climate problem, not an overpopulation problem. The Earth could easily handle at least 12 billion people with current tech, it'll just struggle to handle 3 billion if we don't get a grip on carbon production.

[@Maia_Cyclist]

@@alphagt62 global population is in estagnation few more decades will go down until it stables

[@syberghost1890]

I recall reading an article once by Dr. Tom Rainbow about how we were on the verge of eliminating aging, and that he might be a member of the first generation for whom lifespan was not bounded by aging, as we were "at most 20 years" from eliminating it. The year was 1984. Dr. Rainbow died later that year from cancer.

[@andrewhobbs5268]

we can and will cure ageing its only a matter of time i just hope it happen for me to do what i need to do

[@dylanduerre6402]

As a graduate student pursuing aging research as a career, I love to see the excitement from the general public about aging research. But oh boy, there’s a lot of things in covered that are either misleading or just plain wrong. The basic biology behind this stuff is probably too complicated to explain in 20 minutes, but I would expect joe to do enough research to know that mTOR doesn’t repair DNA. It doesn’t have any interactions with DNA. It is a kinase that controls growth. The effects of intermittent fasting on health are almost completely attributed to the caloric restriction it induces. And let’s not get started about NAD precursors and resveratrol. I know the Sinclair book was exciting, I read it too and it got me more interested in aging research as a career path. But honestly, it’s very clear that the knowledge protrayed in this video is almost completely from the book. If you see this joe, please consider doing a follow up on this video after spending more time listening to the space beyond that book. Peter attia, brand stanfield, Matt kaeberlein, layne Norton and others will point you in the right direction without hyping up snake oil and over interpreting animal studies and saying it’ll all work in humans.

[@robinsmith8846]

Do we really want to live to 90 or 100 no matter what? Being very sick after say 87? But living through strokes...loss of sight... falls ..strokes? Seems science/meds already extend life...but worsen quality of life. No thanks I will pass.

[@kidkarate420]

everything interacts with DNA. however, RNA has long been recognized as having more immediate effects on living organisms. you'd know that if you were studying as you claimed.

[@nigelwest5776]

What degree did you get?? I'm very interested into going into this field and any advice you have

[@kidkarate420]

@@nigelwest5776 in high school (age 14-18) we learn about DNA and RNA. You may want to study there first.

[@dylanduerre6402]

@@kidkarate420 lol what. Saying “everything interacts with DNA” means literally nothing. Want to clarify what you mean? mTOR is a kinase, which adds phosphate groups to target proteins. It does not bind to, or modify DNA. It forms a complex with other proteins (forming mTORC1 or mTORC2) which in response to nutrients, activates/inactivates other target proteins. It does not interact with the genome. It doesn’t form complexes in the nucleus. Therefore it doesn’t interact with DNA. If you studied what you pretend to be knowledgeable in, you would know that.

[@qbumf]

Joe, thank you. I've been having a ton of exams this week and I come back home at the end of the day to watch your videos. I feel informed and entertained. Thank you Joe

[@trem0lo]

I’ve been following Dr. Sinclair’s work for some time now, and started taking NMN (an NAD+ booster) 3 years ago when I was 38. It’s a fantastic supplement. I feel less creaky, lighter on my feet, have more energy and my sex drive is higher than ever. I’m about 10-15 pounds lighter and currently chasing my high school 5k time. I can workout longer and harder in the gym. I take 500-1000mg per day. I also take resveratrol, but would attribute most of the positive effects to NMN.

[@GreenIsTheWayForward]

That sounds really interesting! Any source you can particularly recommend to get into this topic? The book maybe?

[@Pony341]

So what happens what you stop taking it lol

[@trem0lo]

@@Pony341 I guess I age normally lol! I’ve stopped using it for a week or so at a time, and I definitely notice a difference in energy level and motivation.

[@_Chessa_]

Nice Add

[@berniekitts1786]

I just began taking NMN so i hope it is effective. As WC Fields quipped while reading the Bible in the hospital, "Lookin' for loopholes...."

[@jon7052]

I've worked in nursing homes for 7 years and I often has gotten me thinking about aging. Yes, those I take care of tend to live a fairly long life, but their lives are usually lived in poor health towards the end. It seems like it is just suffering

[@KiltedShepherd]

"What if we had to live with our decision?" Well considering I've been getting worse health for the last 10 years and I keep telling myself I'll work out eventually, I think I know that people won't change things until they face their consequences and then they will wish they did something sooner but never actually do something than prevent it from getting worse, repeating the cycle.

[@derpatwerknsubbers1680]

It’s weird, but due to the pandemic and staying in I’m in the best shape I’ve been in in a really long time. 20 minute video between Firas Zahabi and Joe Rogan about “how to workout smarter” made me change the way I was working out. I don’t believe in being sore at all during the workout process anymore, lol. Then I started following another KZbin channel called ACHV peak that had these pre built month long workouts that are awesome, and I just keep re-using those. Best wishes! Getting started is the hardest part.

[@KiltedShepherd]

@@derpatwerknsubbers1680 hell yeah, I'm happy for you. I know I need to do something but I'll use excuses like due to a traumatic childhood I developed "learned helplessness" but my main problem like in the video by Breadsword "Gurren Lagann and Getting It" you have to get angry at your situation to change it. But I've rarely ever gotten angry about any ever in my life enough to do anything, I just lay in bed and practice escapism through KZbin videos.

[@davestagner]

That was me. 57, and in lousy shape (although better than many of my age-peers). But various health problems I’ve had for 15 years (blood pressure and low potassium, mostly) were diagnosed as a hormonal issue. Surgery (one of my adrenal glands was removed) completely cured just about everything wrong with me that wasn’t being 57 and out of shape, and I feel a million times better. This has prompted me to work hard on improving my overall health, changing my diet and exercising daily. In five months since I started (and four since I got serious), I’ve lost 20 pounds, improved my cardio health and strength, and most importantly, created sustainable habits. I’m looking at a 50-70 pound weight loss on top of strength, flexibility, and endurance improvements. Life is getting a LOT better.

[@derpatwerknsubbers1680]

Monster-Girl Lover We’re entering the age of A.I... after a pandemic shut down most of the world for the better part of a two years. From what I’ve seen? Everyone is (for the most part) doing the same thing: stay in, watch videos and reflecting. As far as learned helplessness? Been there, it’s rough... keep asking yourself “Why” and then “How” long enough and often enough and trust me: you’ll start finding reasons to get mad.

[@Eyedunno]

"Aging research is still in its infancy" is kind of a full-sentence oxymoron, am I wrong? Anyway, the Stockholm Syndrome thing reminded me of a Greg Egan story called "Border Guards" where one character who's lived for untold eons by the time of the story goes on a huge rant about how people used to glorify death with all sorts of insane rationalizations about how it makes us noble or makes our time more precious or whatever. I just realized the whole thing is on the author's website. I'll just copypasta a relevant snippet: “It was the naturalistic fallacy at its most extreme - and its most transparent, but that didn’t stop anyone. Since any child could tell you that death was meaningless, contingent, unjust, and abhorrent beyond words, it was a hallmark of sophistication to believe otherwise. Writers had consoled themselves for centuries with smug puritanical fables about immortals who’d long for death - who’d _beg_ for death. It would have been too much to expect all those who were suddenly faced with the reality of its banishment to confess that they’d been whistling in the dark. And would-be moral philosophers - mostly those who’d experienced no greater inconvenience in their lives than a late train or a surly waiter - began wailing about the destruction of the human spirit by this hideous blight. We needed death and suffering, to put steel into our souls! Not horrible, horrible _freedom_ _and_ _safety_ !”

[@juliejanesmith57]

Sorry but life gets tiring at a certain point. Not the same point for everyone, but allowed to live ling enough everyone will experience a disaffection with life. It’s exhausting. And we are built for death- no organism anywhere lives forever. We die to make room for the new, and for change that is necessary to our species. I mean, the other option is eternal stagnation. Just look what happens when a bunch of geriatrics who are set in their ways are governing a country- they no longer represent the majority of societal beliefs and are out of touch with actual modern problems.

[@zakuzeon7382]

@@juliejanesmith57 Life is tiring at every point. It's a constant struggle and unending tug of war with death. It's only through life that you eventually learn to abhor death. Because it takes time to make progress. The last laugh of the universe is to just strike you down when you're finally starting to get life figured out. All of medicine exists to cure this ultimate plague once and for all.

[@moonrock41]

@@juliejanesmith57 , we won't have to stagnate if we have enough (extraterrestrial) resources to propagate and expand civilization beyond our home planet. This will be a realm where life extension is critical for long term survival, principally because it's difficult to shield our bodies from the much high levels of radiation anywhere outside of Earth's magnetic field. There's no guarantee that we'll gear up soon enough to make the move, but if we can suppress the worst effects of global warming (with sulfur particles in the stratosphere) we'll buy enough time to make it a reality.

[@jonadams8841]

Tnx @eyedunno for the suggestion on Egan and Border Guards! I found the story online. Very interesting way to approach the topic of life and death. I think life gives meaning to life!

[@stevejordan7275]

@@juliejanesmith57 Your data appears to be incomplete. 1)Turritopsis Nutricula ("Immortal jellyfish") is not built for death; it regularly reverses the age of its cells. You can kill it - it is not *invulnerable* - but it will not die on its own. 2) Ennui can onset at any age, but it has a treatment; find something new and interesting. You should find something that engages you to care about living.

[@mimistar1427]

I love the topic, but I would suggest looking at the newer research papers (conducted by unbiased researchers) about the ineffectiveness and in some instances adverse effects of healthy people taking Metformin and Resveratrol. Unfortunately, other research labs have been unable to replicate the results from Dr Sinclair's research on Resveratrol.

[@neutral_narr]

It seemed he wanted a lot of press and attention

[@willofone2120]

I agree. personally, I think the 3 things that must be fought tooth and nail is aging(inevitability of death), depuration(self destruction), and physicals limitation(space travail/flying/tools).

[@Sillyhands1]

Yes because if there’s one thing we need is a population that never ages or dies. That will fix the issues of housing, young people paying social security for an old population, and overconsumption of resources.

[@SMHman666]

@@Sillyhands1 Yep, the last thing we really want is a population that can live much longer. We have enough issues as it is. I wonder how people would react to forced sterilization because there's too many people that can't be provided for adequately?

[@lainvohndyrec962]

@@Sillyhands1 if we ever get there, humanity will find its place in other planets or in space. but I always thread in caution for anything extremes, like removing aging/death completely. It can get dystopian real quick.

[@thomashiggins9320]

Wow, the cynics showed up in force, here. Firstly, people who age and remain *healthy* just keep working until they've achieved financial security. That means they either reach a point where they *don't need* Social Security or other aging pensions, or they just keep working, because they can, until they die of accident or misfortune. The young won't support them, because they'll support themselves. Secondly, more than 80 percent of medical expenses accumulate in the last two years of life. What happens if that can gets kicked down the road for three or four decades, and the aged person has that much more time to accumulate the wealth needed for when that long-delayed end draws nigh? Finally, we see a pretty solid pattern of declining birth rates in a society, as that society industrializes and grows more affluent, thereby. If people know they can work for a century before they have to quit due to age-related problems, how many children will they feel the need to have? One, or maybe two at the most? So, tiny families of long-lived people who accumulate wealth, through work and then investments, many of whom have minimal health-care costs because they die in auto accidents or lightning strikes or something, as the odds just catch up with them. I mean, the notion of dying instantly after 120-140 years of healthy life seems pretty good, to me.

[@custos3249]

I've long held that if humanity has a purpose, as, as far as we can tell, the only beings born of the universe while also able to study and understand that universe, we should be looking into this whole "inevitable" heat death of the universe stuff. Kinda hits all three of your tenets.

[@fredreeves7652]

Bingo, you nailed it again, Joe... "Life wants to survive", and yes, those genes responsible for bringing an organism into being in the first place, will do everything in their power to return that body or organism to homeostasis if injured, ill and diseased, and live on until it is physically impossible to do otherwise. This is the power and nature of life. We collectively know this because life can be found literally everywhere on the planet, no matter how cold or hot or unforgiving the environment; life has always found a way to exist and to thrive because of life’s fortitude and resilience to simply be. Life, in some shape, form, or fashion shall always thrive on our planet long after mankind has obliterated ourselves via senseless wars and environmental destruction. The power of life on this planet is in fact, pound for pound the most powerful force in nature and in the entire universe. “Life” is precisely what gave rise to everything known in our universe… and that force, in truth and fact, lives within each of us. The problem is that Western modern society, cultures, and civilizations are designed to be the antithesis of sustaining normal life, mostly political to pit us against each other, which has come to fruition now in America, and around the world can be seen in all the civil unrest, wars, and population displacement around the world. All of these violent, biased, judgmental, and prejudicial forces that have been unleashed against its populations are antithetical to life and harmonious living, where nurturing, living, life, and homeostasis cannot take place or be maintained or sustained, which is why our world is dying in real time every second of every day. The catastrophes that we are witnessing take place around the world shall befall the U.S. sooner than we think, and more powerful than we can defend against. There are zero winners in this deadly and catastrophic game of tug-o-war that nations are playing with one another. Are there solutions and means to prevent these foreseen catastrophes? Oh, you betcha, will they be employed in time to save these nations in conflict around the world, including our own? Not likely, for unfortunately, hate is more powerful than love, history has proven this biological disorder in human genomes since mankind first set foot on Earth. This desire for war and bloodshed against our neighbors is a feature, not a bug, of human evolution that shall never be fully contained nor controlled, for it is eternally buried deep within our DNA/RNA. The most we can do is monitor it and mitigate it when and where we can, if not unleashed for too long. In the case of Israel and Palestine, it has been unleashed for too long to mitigate or control now. Sadly, mankind’s prognosis is not promising; the end of times does indeed appear to be upon us, so live, love, and prosper while we can. ☹

[@DeadMarine1980]

I exercise 6 days a week for about 40 minutes. I've been doing this since 2019 and I love it. I'm 41 and I feel like I'm 20 something.

[@diogocarreira5079]

Extending a life with a good quality of life sounds great! I have to say that I definitely don't want to dictate who dies and who doesn't. But I do know that some societal progress does happen when the "from a different time" holdouts pass on of old age. I think we can find a way to adjust to it, but I do see that as a negative of longer lifespans. We need actual change at a quicker rate right now, but we're moving at a glacial pace, and sometimes even taking a step back.

[@d.b.4671]

Counter-question: how much do you think biological aging contributes to a person's resistance to change, and would being able to stay young for longer help us as a society become more open-minded and willing to try new things?

[@NeoNthriller]

Professor Sinclair actually talks about it in his book. And it has some interesting points. For instance take some of the career politicians or supreme court members in the US that stay in it for life. If they don't pass on because of aging, will they feel like changing their mind on certain topics. Will you keep voting for that one "old" politician that has been representing your state/country because in general he has been doing a good job even though he has aspects that are just a bit outdated.

[@merrymachiavelli2041]

On the other hand, an older society might be more stable. Societal change can be a very disruptive, and even dangerous, process. Whilst something like the French Revolution might have produced a 'better' society, the Terror is called that for a reason, and it spawned a Napoleon hell-bent on conquering Europe. What you ideally want is a society that can change and progress in a somewhat more stable manner, as a consequence of debate not whoever was angriest killing those who were in charge before them.

[@diogocarreira5079]

@@ImperfectVoid8479 that's a good point, it'll make a problem that seems for some to be the future's problem, a more pressing issue. It could have that effect, I think he even mentioned that as a counterpoint. And I want to be that optimistic that'll it'll be helpful.

[@diogocarreira5079]

@@d.b.4671 I haven't even thought about that. I think it's a relevant point that changes how I should think about it.

[@feline.equation]

3:00 my mom is a vet and she says to people ALL the time- “age is not a disease”. people get worried about their older pets and she constantly tells people that being old isn’t a death sentence. i have a 17 year old cat and whenever i ask how he’s doing, she tells me he doesn’t have a disease, he’s just geriatric. very reassuring.

[@ARMY_LA-MIGRA]

I also have a 17 year old cat, but I've noticed she's been getting very weak and i haven't seen her in 2d since she went outside. I'm guessing she's gone now.

[@RedboneUnincorporated]

So you mom doesn't understand science? Weird. Age is literally a disease.

[@renato360a]

@@RedboneUnincorporated age isn't "literally" a disease because there's no widely adopted technical convention for what a disease is. But it certainly can be made to fit most definitions.

[@Kevin_Street]

I understand your Mom is just trying to reassure people that their pets aren't ill and don't need unnecessary treatments, but there is an actual scientific study looking at ways to help dogs live longer lives. KZbin doesn't like it when I post links in comments, but it can be found by Googling "dog aging project"

[@RedboneUnincorporated]

@@renato360a Facts disagree, how about you actually watch the vid, or at least do a google search bc you are WRONG!

[@CyclingM1867DubbysMama]

"Word salad" - I like that! I shall have to use it. :) :D I work as a care aide in an assisted living facility here in Canada, and I first worked as a care aide in the '90s. I took a long time off from this work. I have noticed differences in people's lives as they get older in the past three decades. People are living healthier longer, and this includes physical and mental healthiness. People are able to stay in their homes longer, and they don't have to succumb to things like diabetes and heart disease and other typical aging conditions nearly as early. Yet like you said, Joe, a lot of focus on life extension is making sure that people live longer as elderly people, despite all the things that happen to our health at that time. Yes, there are people who continue to live fairly healthily a lot longer than others, but even with all our advancements in modern medicine and healthcare, there are still a lot of people who end up with major health issues that make it more difficult for them to continue living as well as they could have. I don't know if I'm making sense here. While it's great to see people living longer and the like, I would love to see a focus on life extension happen more for young adults and those of us in our middle age years. I'm not saying that we shouldn't still care for our elderly folk - we should - but why not focus on having people live with as good health as possible while we're younger instead of focusing on maintaining life when we're older? Why not extend the years when we're physically able to do more and the like? Also, why not focus on trying to find ways to eradicate, or at least lessen a great deal, mental decline and try to work on getting rid of dementia? It's heartbreaking to see people's mental faculties leave them and to see people so confused. I hadn't thought about this topic in the way you're talking about it here until this video. Thanks for giving me and everyone else watching this some much needed food for thought.🤔

[@mugwump7049]

It's quite uncanny how sci-fi is quickly becoming our reality in this century. I hope they manage to figure out this "cure" for aging during what's left of my lifetime. As Freddie Mercury sang: "I want to live forever"...

[@draggy6544]

Pretty damn close actually they are making rapid advancements towards eliminating aging

[@kirknay]

He was gone way too soon. Stupid Reagan and ignoring a pandemic because it only killed gay people at the time...

[@bbbf09]

???? He sang 'Who wants to live forever?' it was from the 1986 movie Highlander - and stands as a warning of the sadness and perils of immortaility

[@matheussanthiago9685]

@@bbbf09 talk about missing the point by mile

[@mugwump7049]

@@bbbf09 Oops! Well, I do. Always thought it was "I". In my defense, english isn't my native tongue and I never paid much attention to the song's lyrics. That said, "a warning of the sadness and perils of immortality"? Only people who either lack imagination or don't know how to enjoy life would think that! There's just too much to experience in this universe for a billion lifetimes, let alone just one...

[@ndowroccus4168]

My favorite joke about aging is: “Oh my leg hurts when I wake up” Doc “well, just stretch it out in the morning for about 30 minutes” “Okay, how long will I do that” Doc “oh, no…you just do that from now on.”

[@PavltheRobot]

Why is this a joke, exercising is healthy at all ages. I really don't get what's funny about that

[@whimsinator2982]

@@PavltheRobot The joke is that he needs to do it now when earlier he didn't

[@hunterlavish]

@@PavltheRobot It's Louis CK, the delivery matters

[@sizlax]

Doctors are getting better when it comes to curing diseases, and recovering patients from emergency scenarios, but when it comes to the most common ailments of "why does this hurt?", "Why am I constantly aware of this part of my body when I never was before?", "Why do I occasionally fall on my face while trying to stand up?" .etc, they're about as useful as rubbing dogsh*t on an open wound..

[@PavltheRobot]

@@whimsinator2982 No it's not, the joke is that patient thinks exercising will only be a temporary treatment. Reluctance to healthy movement is just being lazy and I really don't find anything funny in that. Despicable attitude.

[@cody100181]

My grandfather was Curtis Henderson, a pioneer in cryogenic science and also was extremely interested in life extension. I don’t know if this part is true but I heard from my dad he was apart of an experiment that kept mice alive almost indefinitely. Their immune system became extremely limited and they had to live in a sterilized environment with their food regulated

[@rainbowhyena1354]

This is partly true. The immune system is designed to keep you alive in harsh conditions. And it leaves collateral damage, that undesirable in milder conditions. But removing it won't make you immortal, it will only extend your life by 10% or so, cause it is not a major mechanism of aging

[@bbbf09]

Cryogenics is legitimate scientific study of ultra cold and low energy states in physics. Cryonics is the busineess or 'art' of freezing human meat long term using cryogenic engineering means in the extremely likely bogus belief that it will be somehow resurrected as a functioning human consciousness one day. With due respect, from what I see Curtis Henderson was a lawyer, businessman and interested in life everlasting. He never appeared to pioneer or produce any fruitful discovery or invention in the field of cryogenics - or in any legitimate scientific endeavour.

[@JustPeaceLoveAndKindness]

We’ve been doing suspended animation for surgeries for over 25 years. We can cool a person’s temperature and stop their circulation for approximately 1 hr while vital structures are repaired. Then, using machines to re-engage circulation and initiate gradual warming, the heart can then be restarted. It’s a big operation and complex process anesthesiologists can make possible. Impractical unless it is the only option for a surgical problem too risky to undertake otherwise.

[@markdodd1152]

Interesting stuff. I'm in for doing anything I can to slow down aging and be healthier. I'm going to be 61 in August. I still look very young for my age. Most people are surprised. But with high blood pressure and a few other issues. I need to focus on some of these things contained in this video

[@zeekjones1]

*In 500 Years;* Concerned mother: "You're 102 years old, why don't I have any grandchildren yet?"

[@smith1849]

Son : mum are you living in past ? Children are made in lab from 100 years 😒

[@keyholes]

Thank you for highlighting the difference between life span and health span. I've been collecting chronic illnesses for several years now and my interest in extending my life beyond what's expected is nil right now. If that time is spent in good health, that's a completely different ball game - and man, do I want to play.

[@catherinebirch2399]

I really think that we've all been let down big time by medical science. All the scientists cared about was inventing drugs to treat, not cure diseases, so creating millions of sick old people instead of trying to make later life a pleasure rather than a pain ruled by the need to take ever increasing amounts of medications.

[@royzlatanestevez9843]

I'm sure many of us don't actually care to live forever. I don't think "mortality" disturbs a lot of people - contrary to what psychoanalysts and writers constantly go on about. What disturbs us is that we have SO LOW quality of life for the MAJORITY of our lives. Think how shortly we are young - and I don't even mean being a kid or teenager, but 30s (which is old to children). Most of our lives, we are OLD - unable to do the things we got used to doing as a kid and still love, tortured by constant pain, getting ugly, getting sick... and this continues from 30s for 40-60 YEARS. I am sure most people would be fine with the lifespan they have if we could live well. 80 years WELL LIVED would be so precious and amazing. I'm sure "mortality" is okay for most people if we actually got to enjoy life and not just get a few minutes of yard time at the beginning of life. Excuse my language, I'm an ex con, did 6 yrs in the pen in my relative "youth".

[@gregoryholland6126]

I think most people either don’t think about it or are actually disturbed. It’s pretty bullshit to be born, with no say in the matter, just to suffer and toil to try to find the things that make your life worth living only to inevitably have them all ripped away regardless of anything you could possibly hope to do about it. It’s kinda a scam honestly

[@JessyBunnyyy]

Been going through a major depressive episode on the concepts of guaranteed death and aging but this video seriously gives me hope. Thank you :,)

[@Fredjoe5]

Aubrey de Grey has been pushing for attitudes to be changed in this area for 20 years now. It was a slow start, but things are changing, and accelerating. There's no going back to the old fatalist mindset.

[@JessyBunnyyy]

@@Fredjoe5 I agree entirely. Im still so young (just turned 21 this year) and still have alot to learn about this life of ours but it baffles me how little attention mankind pays to concepts like these. The studies and findings of individuals like Sinclair and Aubrey absolutely fascinate me and honestly inspires me to get into a different education course and change my career path to do my part and help accelerate this field of research. I really appreciate your like-minded thinking and uplifting words James C. ❤

[@Fredjoe5]

@@JessyBunnyyy You're welcome! Don't forget to look into cryonics as a Plan B. At my age the odds of making it aren't as good as yours, so I put my plans in place. Here's hoping they won't be needed :)

[@JessyBunnyyy]

@@Fredjoe5 Definitely will do as a last ditch resort once I'm financially stable enough to afford myself (and hopefully close family) a slot in the tank. :) Its a bright future ahead of us, im sure of it. ^^

[@Fredjoe5]

@@JessyBunnyyy Keep in mind, you can start the paperwork side of it now, and the sooner you can lock in insurance rates, the better. I left if far later than I should have, but still just managed to do it. It can be done, but set yourself up for success by planning ahead.

[@JoshDoingLinux]

Odd I was literally having this conversation yesterday with a coworker. I don't fear death, I fear the aging that leads to it. I had to get glasses at 26 and the last 2 years of glasses has just been annoying. I just want my body to be healthy for a long time until I'm ready for it to stop.

[@JoshDoingLinux]

@@AndrewBlucher yeah looks like body turned into both. I'm assuming that's what u were referring to. I'll fix it.

[@666pa]

i love you. your analysis is always spot on. no one makes me wanna be a patreon member. you are worth it

[@Kevin_Street]

Thank you for this most excellent video! This is a subject I know a little about, so I'm impressed by how balanced and informative your video is. It's an excellent introduction to the subject. Like any scientific field there's a lot more detail under the surface, including researchers that disagree with Dr. Sinclair. Though I (an ordinary layman) find his ideas quite compelling, there's still quite a bit of debate over the causes of aging among the scientists. One of the things I find really interesting is the relationship between mTOR, bodybuilding and longevity. Basically bodybuilders want to activate mTOR to build muscle, which is the opposite of what people want to do for longevity. It seems like there's some sort of balance required between building and keeping muscle (particularly in later years when muscle wasting can become a serious problem) and inhibiting mTOR. As to your last question, I absolutely agree that a long-lived society would be a more moral one, precisely because people would be forced to confront the consequences of their actions. The aging process perverts human nature, and is a contributing factor to many of our worst tendencies.

[@StarlitSeafoam]

I don't know, I think people live with the consequences of their actions all the time. Every single choice we make every day has consequences. Watching my uncle struggle with drug addiction his entire life showed me very early what living with consequences looks like. The problem with saying that longer life would make us more moral is that we will always be focused on the timescales that we live, and we always have the choice to ignore consequences. Maybe a 500 year lifespan would make us pay attention to 500 year long consequences, but what about something that won't show up for 1,000 years? There will ALWAYS be consequences people can decide not to care about. Regardless of lifespan. Because no human being will ever live for all time.

[@Kevin_Street]

@@StarlitSeafoam That's very true, but I think the most important consequences we face as a species are limited to a time horizon of centuries at most. Only things like nuclear radiation will last for thousands of years. You are right, though. There's no guarantee that immortality will make people more responsible. But I think it's an evolutionary leap our species needs to make to face up with the magnitude and effects of our own technology. Right now our short lives mean we never learn enough to deal with it properly.

[@Kazooples]

Hey, this is sort of off topic, but when you mentioned Metformin I did a little research and realised my endocrinologist is not giving me the right treatment for my insulin resistance, and I wanted to thank you, thanks Joe ✌️ Edit: it occurs to me some people are stupid, so I'd like to say google is a tool, not a doctor, it can help you ask your doctor questions, and if you're like me and have struggled for a diagnosis only for doctors to tell you "lose weight", that's not okay, keep digging, challenge them, get a second opinion if you feel you're being dismissed because there are better doctors out there.

[@turdferguson3400]

Oh, you figured out with a little googling what your endocrinologist couldn't after about 11 years of training?

[@rainbowhyena1354]

@@turdferguson3400 Sometimes patients know the disease better than the doctor. A doctor has a thousand diseases and several years to study them. The patient has one disease and all life time to study it. Although the study should be carried out strictly by reading scientific publications on topic in a good medical journals. Not sure if this a case.

[@Kazooples]

@@turdferguson3400 yes

[@Kazooples]

@@rainbowhyena1354 thank you. And it's not like I'm going to go to my doctor and say "you're wrong, google told me", I am going to open a dialogue with him, it has given me questions to ask.

[@davidhuber6251]

That's cool that it prompted you to have a more detailed discussion with your endocrinologist. I'm sure they have many things to consider balancing the pros and cons of many different drugs and treatments for a variety of patients. just because you do a little research doesn't lead directly to asking for Ivermectin 😜 Some people are happy just taking the doctor's advice, some would rather have a more detailed dialogue. Good luck in your treatment.

[@socoman99]

I would love to see Joe do a follow-up video on how these life extension therapies would play out over time and how society would react to such technology being introduced. Unfortunately, people being what they are, it will probably be another "have's vs. the have not's" scenario. Those with the means to obtain such life extension therapies will use them to live longer, healthier lives and the "have not's" will live shorter, less healthy lives. It may not be the same in every country, as is evidenced by the subsidized health care systems of other industrialized nations and the USA's dismal health care "system", if it can even be called that. This subject was touched on in a different way in the film, "Gattaca".

[@michaelkeefer5674]

What making you think, some of the haves are not already doing that. You do not have to do a lot of research to realize that a rich old person could rejuvenate their system using a healthy young person. You are a young person starting out and what appears to be middle aged gentleman or lady offered you several thousand dollars and free room and board at their estate. Would you be interested. All you have to do is swap blood with them once and awhile.

[@GreenIsTheWayForward]

If you are into computer games, I can recommend Deus Ex - Human Revolution. It explores a next-door topic, human augmentation by way of nanotech and bionics, and a huge conspiracy that comes along with it. It is created against a hyper-capitalist background, not unlike the US nowadays - only those with money have access, no matter their intentions.

[@katm9877]

Yep, I'm not even in the US and I strongly worry about haves vs have nots in this scenario. The only way to avoid it, imho, would be to subsidize life extension for everyone equally, and even that has issues (people with other medical conditions, especially those strongly affecting their quality of life, might NOT want to have their lifespan extended... case in point, myself, even though I am fairly mobile for someone with cerebral palsy I'm not sure I'd want to live 50 more years, especially as that would almost certainly be past my healthspan, which is almost guaranteed to be much much shorter than a fully abled person's)

[@longarmsgiraffe0955]

I'm sitting her wondering what comment I should put about, "is it really a good thing to drastically extend life?" the Joe drops the bomb about how we would act if we had to live with our consequences. That's such a good question. I don't know the answer and I don't know the answer to how we can sustain life if everyone can maintain whatever age the want, but it's such an interesting discussion. Thanks for pointing out an angle I hadn't considered!

[@Nicole-xd1uj]

I went Keto and started intermittent fasting last year, got off my meds and improved all those health concerns that had been creeping up as I aged. The one medication I wanted to keep was Metformin because it regulated my menstrual cycle and improved my sleep bit it also requires a prescription here in Canada. Next time I go to Mexico, I'm going to be looking for it. I'm not sure whether I've extended my lifespan but I'm hoping I'm shortening the time I spend unhealthy.

[@davidanderson_surrey_bc]

Raises an interesting question... would you rather live ten very healthy years, or live twenty years in poor health?

[@kleyyer]

I went on Keto for a single month (couldn't go longer than that) and my IBS completely went away. I also noticed I had way more energy while I was on it, my only problem is how long it took to cook every single meal, idk, I don't like keto food that much, so a good recipe took forever. Before Keto I had already done intermittent fasting quite a lot (since it was the only thing that managed my IBS), in fact when it was pretty bad I used to fast for longer periods (3 to 5 days), and although it helped, only with keto was I able to overcome IBS.

[@Nicole-xd1uj]

@@kleyyer I did a lot of the fancy keto recipes at the beginning too but soon got tired of it and now I just eat simple meals. I found that some of the keto condiments helped make it more enjoyable.

[@pgjbsn]

@@davidanderson_surrey_bc easy answer-ten healthy years

[@cargilekm]

I have been doing intermitten fasting since last July. I have lost 25 lbs and hope to lose more. It isn't very hard but has weeks pass when the loss flattens out. I think the body needs to get used to the loss and then it moves on the next month. I only eat between 11am and 6 pm. Though most of the time I stop eating before 5 or 6pm. I am 69 and this is working for me. Although I need to go out for 1 to 2 mile walks several times a week to get my best results. I hope this will work so that I lose 50 lbs in 2 years. That is my goal. And I hope I can maintain it after that. Cheers

[@smfreij]

That’s awesome! Great job and doing it slowly with exercise makes sure the weight won’t come back.

[@cargilekm]

@@smfreij Thankyou, I plan to continue until I loose the 50. It helps with my diabetes and back pain. You just got keep moving if you want to walk into 90. Cheers

[@stevefitz7934]

I enjoy almost every minute of my life. Why wouldn't I want to have more. I hope if we discover how to stop aging we could also youthen 80 year olds.

[@XcaliburReborn]

if i could live 150 healthy years instead of 50-60 I definitely would. I'm in no rush to kick the bucket and its an exciting time of human history, while i may just live long enough to see the important breakthroughs, i would like to live long enough to also see them implemented worldwide. id be more at ease closing the door on my life and leaving my children in that world.

[@hightierplayers2454]

Glad you covered this topic. I've been enamored with Dr Sinclair's research for years and I can't wait to see what this revolution brings to lifespans for this century. It has happened before and it could happen again.

[@mattkaczorowski3099]

An important question that needs to be answered would be how accessible the treatments will be. Will the cost of the treatments be only accessible to people with large amounts of wealth or will the treatments be similar in cost to other medications? Another angle would be how regular would the treatments be in combination with cost? Will this be available to common folk and would they be held hostage to high dose costs (similar to insulin in the USA)? I think there is a right way to do this, we have living examples today of this problem. It would be nice to have these solved before we introduce another technology that may create yet another advantage to wealthy and powerful folks or a new form of exploitation.

[@lasagnakob9908]

I 100% bet this never goes public as treatment unless you give the hospital a couple million in benjies, then they invest in a lab to manufacture the medicine. Just seems like the Elites would never allow something this important to go public, then there's the question of unintended side-effects that might be present, like maybe you're more likely to develop terminal cancers, who knows. That being said, a lot is uncertain for the future, and this could just end up not going anywhere due to previously mentioned side-effects creating earlier-than-suspected mortal illnesses for example.

[@arcaneinane]

demand would probably be immense, which would (probably) make it very expensive

[@Cincinnatus99]

100% agree with you. I was looking for comments like this and didn’t see many which is kinda scary to me. Mostly people rejoicing in the idea of extending life. Doesn’t make sense. Death is a natural part of life. It is there for a reason. It ensures that we will be constantly changing and evolving in terms of the way we do things and the way we think about things. The younger generations are typically more open minded when it comes to change and new ideas due to the fact that their views have not quite solidified compared to older generations. This technology (like pretty much all new technologies) would only be available for the wealthiest or most powerful individuals in the beginning until it was able to trickle down to the people. The idea that it would even be given to commoners at some point is a HUGE ‘if’ for me as well. This is what leads to the idea of ‘God-King’ like dictators, bureaucrats, and oligarchs who can outlive many generations of their own people. All the new scientific breakthroughs on the horizon from this to the CRISPR gene editing stuff really makes me fear for our future as a species.

[@lasagnakob9908]

@@Cincinnatus99 Certainly. We do not, as people, assert as much control as we'd like to believe in the grand scheme of things. I'd be willing to bet any successful productions of these medicines would be produced in silence and never talked about, only being given to the highest bidder. One day, we'll question why there are so many 150, even 200 year olds, living among only the highest echelons of society, and we won't get an answer back.

[@SteveHazel]

if you don't mind buyin rapamycin from India, it's available right now.

[@shadowdeku6926]

The way I've been taught to think about aging is this: nobody dies of old age. everyone dies of some disease. So yeah, aging is a disease.

[@Flaschenteufel]

well the older you get the more free readioactivity also influences your whole structure. The older you get the more likely you will become something like the vampire from Nosferatu. hf!

[@danfontaine8179]

Disease implies something is going wrong. Atrophy is unavoidable though - but that’s why we reproduce and make shiny new copies.

[@Fredjoe5]

@@Flaschenteufel The problem isn't the "free radioactivity". The problem is biological systems that at 20 years old could fix it can no longer do so at 80 years old. It's a biology issue, not a temporal one.

[@WatcherofVids]

i would argue it is more of an acquired immune and cellular function difeciency syndrome

[@inhumanepie1]

If such medication was truly implemented one day I would take it without hesitation. I'm already trying to make the world we live in better everyday and I would like to be able to do this as long as I possibly can. I honestly wouldn't mind living 500 years if this was possible.

[@fluffybunny7089]

But is this good for society? A few hundred years ago we thought slavery was ok and even the people who didn't like slavery were an average super racist. How many people back then could be influenced to accept modern standards? Is there a point at which older people just refuse to change and cause major conflicts with younger generations? Also if you had a never aging population wouldn't this contribute to the worsening wealth gap.

[@Liberty309]

@@fluffybunny7089 Why would it be older people causing major conflict? You don't think younger people cause major conflict? What about younger people refusing to change?

[@AvB.83]

Would it change our behaviour if we knew we'd have to live with the consequences of our actions? I think largely not. After all, people have known for decades that smoking will kill them, and has a very high chance of making their later life significantly more miserable, to give just one example. Most of them are very much aware of that before they even start. People know that a horrible diet will cause problems later in life, and by "later in life" in same cases I mean "mid 20s". It would probably take a very long time for society to change to a point where this awareness manifests itself in the behaviour of the people. After all, those who go "what do I care, I'll be long gone by then" display pretty anti-social behaviour in that. I don't see those people diminishing their comfort, and with the possibility of a massive rise in population due to lack of dying it would have to be reduced quite drasticly, for the greater good. Much rather they'd try to reduce the comfort of others, so they can keep theirs... as much as I'd want to live forever, I don't think it would be all easy going at all.

[@lindaseel8633]

You are so right brother. Ageing is B.S. because it hurts. From a 64 year old grandma. 😎

[@uriahz]

So David Sinclair also has a really lovely video podcast series on here where he goes in depth on all of this stuff. It's about 10 hours but well worth it if you're interested in the state of the science. If you're looking for the TLDR, for maximum effect under the current science, eat a mostly whole food plant based diet, skip breakfast and evening snacks, keep your glycemic load down, do periodic extended fasts of several days, walk every day, do strength training and heavy cardio on a regular basis, do hot and cold treatments, try hyperbaric chamber treatments, get up to high altitude sometimes, and get plenty of sleep. For drugs/supplements, resveratrol and metformin have good evidence, NMN is probably worth the expense if you can afford it, which works better than similar NR, which works much better than straight NAD+. The others are still a little early, like rapamycin, spermidine, low dose HGH, etc.

[@dylanduerre6402]

The quality of human clinical data for non-regulated supplements like NAD+ precursors which have loosely defined endpoints and poor bio markers of effects put it behind all of the clinical evidence in support of rapamycin and metformin. NAD+ boosting supplements have no strong evidence to suggest they’re really anything but a waste of money at this point.

[@owen755]

It surprises me that people don't want to live longer, I've always wanted to live as long as possible, to see society develop.

[@Yrch16]

Amazing video Joe! Really, I'm a biologist and I loved it! Thank you for such a well embased content! Greetings from Brazil! 0/

[@odin5255]

I love your videoes Joe. Always waiting for the release on Mondays when I got my time off. Thanks :-)

[@TheAndroidNextDoor]

Assuming I could live indefinitely in a healthy and prime condition, I'd take it if I could elect to die at a later point. Myself and one of my friends are the two weird ones who wouldn't be opposed to immortality. There's too much awesome stuff I'd like to do before I die. Maybe that's the nature of humanity, to always leave the party with always one more horizon to strive for but I'd rather not die without knowing I had become all I could have become.

[@krashd]

Eventually you would no longer be able to store new memories or you would have to write over old memories with new ones.

[@TheNoldaz]

100% with you. I feel like we die just as life is beginning. For me 100 year is ridiculously short, and ill be disapointed to live under 1000 years lol

[@natesmodelsdoodles5403]

@@krashd Excellent, that means I can forget the things that keep me in pain now and rediscover the joy old things once gave me.

[@AAjax]

Aging is a genuine horror show. You grow old and watch all the people you love suffer and then die, unless you're "lucky" enough to suffer and die first. Saying "no. not if I can avoid it" to that bullshit is a natural and honest response. But thanks to societal indoctrination with messages like "death gives life meaning" most people give up their honest response to aging, and buy into the death cult thinking. Screw that. If soon as it's a real option, I'm raging against the dying of the light.

[@AAjax]

@@krashd We already lose memory over time, except for memories we periodically recall and refresh. I'm not sure if this a problem that actually needs to be solved.

[@dualCalibur]

I see two possible futures with anti-aging: either medical companies are going to make even more obscene amounts of money selling it at exorbitant markups, or some kind of governing body will step in and provide this technology to anyone who wants it either for free or a reasonably low cost. I desperately hope for the latter but fully expect the former.

[@DressySeagull]

You can expect this technology only to be available to the 1% elitists of the world. They'll monopolize it and make it available only for them and their constituents.

[@KiltedShepherd]

The rich will live long lives and the working class will live age normally. It will get to the point where the rich are like how we see vampires in popular culture just without the bloodsucking, Maybe.

[@Thoughtmage100]

Or the third possibility: We don't solve it. Though I like your optimism. I'd enjoy living a good couple thousand years if I could.

[@erikelenstrom9685]

Or it will depend on where you live. In most of the rich democracies anti-aging will most likely be a part of universal health care.

[@TuAmigoElMorrocoy]

If you're in the US chances are that you're gonna get the latter. Yall don't even have basic Healthcare and have a median life span of 77 years old, while the rest of the developed world has universal health care and a median life span above 80.

[@NostalgiaBrit]

Hey, the way I see it is, if they can stop/cure/reverse ageing, then _maybe/possibly/perhaps_ they’ll also be able to _stop/cure/reverse_ *Fibromyalgia!* Any scientists reading this comment, I volunteer to be your test subject for finding said cure! If there's even a _tiny_ chance that I could end up _pain-free,_ and with no more fog, fatigue, or any of the other myriad symptoms, I'm 100% down for that! 🙏🏻

[@Zomious]

Another fantastic video as always Joe. Also, David Sinclair is a pretty cool dude. Worth checking out his interviews/podcasts on youtube.

[@zappababe8577]

Regarding the consequences of living longer, you might want to read "The Trouble with Lichen" by John Wyndham. Obviously a fictional story, but it goes into the socialalogical problems it would cause from different points of view.

[@AmaraJordanMusic]

Thanks for the rec! I’ll check it out!

[@Globovoyeur]

/Trouble with Lichen/ (no article "the") is a novel first published 1960 by Ballantine. It can also be found in the John Wyndham Omnibus (ISBN 0-905712-46-3)

[@AmaraJordanMusic]

Weirdly enough, the Kindle version is on pre-order. For a book published that long ago! Dang!

[@majestic-domination]

All of those issues can be solved by reproducing less and less, and making new laws for both education and work to accomodate.

[@Dirk_Taggesell]

@@AmaraJordanMusic Do they have to print some more Kindle books? :)

[@teddystoner8288]

I've been digging a large project by hand. I'm 52. The ground is rock hard. I use a digging bar to chip thru the rock hard earth. Yesterday I got 50lbs sacks of feed for the farm. I'm swearing the sacks are not 50lbs. I can straight arm them. I think the physical work made me younger.

[@Parietal-Polymath]

Side note: "Intermittent fasting" is literally how most poor families eat daily. One meal, portioned for size and age. Caloric restrictions from day 1

[@jacktravers5049]

Nah

[@dstinnettmusic]

Define poor. I know true poverty can and does exist in the first world, but i don’t think your description is what first world poverty looks like overall.

[@dstinnettmusic]

@@michaelgriffiths4498 this also isn’t true lol What is with people these days? It’s like they are too busy getting all their information about the world from their phones that they can’t even talk to people to figure out what their lives are actually like… I was in food stamps for a while. $250 a month for a family of 3. That is enough to get by, but you aren’t getting obese on that.

[@Shadi_Wajed]

That's not Intermittent fasting that's malnourishment. If you don't get enough nutrients every day in your meals with fasting, you'll develop various diseases and even won't live that long. Fasting is not just "not eating".

[@draggy6544]

Its kinda the opposite in america the poor people end up eating a lot of low quality food

[@WistrelChianti]

I've been of the same view for quite a few years. I feel the only reason we accept aging is that to not do so would be akin to running before we can walk. In other words, we accept it because there is so much else to fix first that no one got to thinking about what actually causes all those other things properly yet. To worry about aging feels like to worry about science before we have clean water. But to have science can lead to having clean water and the analogy probably extends to aging also. Another reason people accept it is society is structured around death. If people dying became purely an act of chance/accident in a short period of time this would mess up a lot of models. In much the same way, people once challenged the church and started to not accept that the earth was the center of the solar system, we need people to challenge the status quo and ask why don't we not age, rather than simply accepting that we do and believing there is nothing that can be done

[@HLR4th]

Or more likely…insurance companies can specifically deny coverage for unapproved treatments of age-related conditions. Great topic/video.

[@leviroch]

US citizen I presume lol?

[@francois853]

@@leviroch Most insurance companies globally don't pay for unapproved treatments 🤨

[@HLR4th]

@@francois853 agreed. In this case the medication could be approved for its usual use (metformin). I’m concerned the “age related disease modifier” if associated with the Rx, the insurance will not cover it- unapproved use of an approved medication, otherwise known as “off label” use.

[@HLR4th]

@@leviroch Yes, and a physician.

[@Fredjoe5]

@@HLR4th Why would they deny it? Insurance companies are taking the bet you *won't* die. If these treatments can be brought to market, they stand to benefit greatly. The reality of how insurance functions is going to lead them to approve.

[@jameslangstonevans]

I was thinking about this in 2016 or so when I read some news about this potential. I think people would really start buying only the most durable products. If a house is designed to last about 100 years, and a person has outlasted 2 of those houses, I bet they would start looking at how to get a house that lasts 500 years, or maybe even 1000 years. It seems that human psychology has generally caused a self-limitation of over-population. Of course, some births will still be necessary, since there would still some deaths by unnatural causes. It would also be interesting to see how people realize that they have plenty of time to solve the big problems of the world. Without the impending deadline to build a retirement before being too old to work, people could be more free to take risks on big projects to solve problems. Hey, if I can live 1000 years, why not spend 50 years developing farmland in starving countries? I can always work in an office later, or work in an office now, and still be young enough to join the peace corp after 50 years of this.

[@bdbensley]

yes, living longer most likely will make people think harder about their actions. I wanted to go to college to become an environmental engineer back in the 1970's. Very concerned about environment and climate and energy. But didn't get to go on as they had too many engineers. Still today I am very conscience of my actions in the environment, but much less so cause over those 50 years it wasn't such a big deal or people didn't care until recently with climate change being accepted. I was ahead of my time! Anyway, I became an IT pro and well even though I still feel strong on environment, I am sure that extending life is a good thing. If not to make people actually live longer, but help them live better with less aging problems....(the following is a joke....really a joke, please remember a joke)...then at a certain point..we just bump them off!

[@bedhead4728]

Yea the ppl I talk to about this and have issues are religious (im religious) but even the Bible addresses death and talkers about it as a disease and talks often how man are suppose to live forever. And it's clear it's not just a spiritual life. This is a old concept that has been warped. Yea I think it is like a Stockholm syndrome deal.

[@FatCatCooper]

@@bedhead4728 probably makes accepting death easier and if someone told you they just invented a cure for you dying you'd probably be alot more worried about the little things hurting you

[@thedude5294]

I feel like you vastly overestimate peoples desire for long term thinking.

[@roelofjacobs5807]

I think I disagree with the "didn't care until recently". We had problems with acid rain and the whole in the ozone layer. These two issues have been addressed. So we as mankind have actually cared about the environment and taken actions in the past. A [possible middle ground: You could argue that we only start to care once we can see the effects. But that for as long as we do not see the effects (or have higher priorities like getting food and survive), it will be too abstract for most to really care about. By the way, if not mistaken, in the seventies there was still some scientific debate going on if the earth would heath up or cool down, the latter due to air pollution in the top layer of our atmosphere. It was a decade later, in the eighties, that this debate was settled.

[@dan203]

I'm sure they’ll figure this all out right after I die 😕

[@RainbowRenegade]

Have the same feeling tbh

[@wish]

even if they figured it out tomorrow its not like regular people would have access to it

[@JohnWehrle]

Would behavior change if people knew they'd be around to experience the effects of their inaction? That is an incredibly good question.

[@charleslivingston2256]

They don't seem to be able to make good trades regarding fun now vs healthy later in life

[@jeremywvarietyofviewpoints3104]

Temporal Discounting is the idea that people value the near future more than the distant future even when considering their own future.

[@saslumpff]

Your closing question is golden. Makes me reflect.

[@gogreengameon2146]

The sad thing about consequences-induced behaviour change in light of living much longer, is I don't think that will be enough to induce wise decision making. I always thought that existential threat would motivate people. However the pandemic opened my eyes to this assumption. Denial is incredibly strong, even to the point of one's own demise. Several people even in my family denied Covid-19, and died of it. They inevitably spread it to others too.

[@libertyprime1614]

Covid wasn't and existential threat, not even close, it didn't even affected total death rate.

[@birgerjohansson8010]

I recommend the articles in Nature November 11th where the genome of a rockfish able to live 150-200 years was discussed. There is also a mammal- the bowhead whale- that can live up to 200 years. If nature can fix the self-repair mechanisms for other organisms, there is no reason humans might not emulate their life spans.