How to Slow Aging (and even reverse it)

Scientists like Prof Sinclair have evidence of speeding up, slowing, and even reversing aging.
Thanks to LastPass for sponsoring this video. Click here to start using LastPass: ve42.co/VeLP
What causes aging? According to Professor David Sinclair, it is a loss of information in our epigenome, the system of proteins like histones and chemical markers like methylation that turn on and off genes. Epigenetics allow different cell types to perform their specific functions - they are what differentiate a brain cell from a skin cell. Our DNA is constantly getting broken, by cosmic rays, UV radiation, free radicals, x-rays and regular cell division etc. When our cells repair that damage, the epigenome is not perfectly reset. And hence over time, noise accumulates in our epigenome. Our cells no longer perform their functions well.
To counter this decline, we can activate the body's own defenses against aging by stressing the body. Eat less, eat less protein, engage in intense exercise, experience uncomfortable cold. When the body senses existential threats it triggers longevity genes, which attempt to maintain the body to ensure its survival until good times return. This may be the evolutionary legacy of early bacteria, which established these two modes of living (repair and protect vs grow and reproduce). Scientists are uncovering ways to mimic stresses on the body without the discomfort of fasting. Molecules like NMN also trigger sirtuins to monitor and repair the epigenome. This may slow aging.
Reversing aging requires an epigenetic reset, which may be possible using Yamanaka factors. These four factors can revert an adult cell into a pluripotent stem cell. Prof. Sinclair used three of the four factors to reverse aging in the retinal cells of old mice. He found they could see again after the treatment.
Special thanks to:
Professor David Sinclair, check out his book "Lifespan: Why We Age & Why We Don't Have To"
Assistant Professor David Gold
Noemie Sierra (for polyp images)
Genepool Productions for telomere animations from Immortal: ve42.co/immortal
Epigenetics animations (DNA, histones, methylation etc) courtesy of: wehi.tv
Animation: Etsuko Uno
Art and Technical Direction: Drew Berry
Sound Design: Francois Tetaz & Emma Bortignon
Scientific Consultation: Marnie Blewitt
Courtesy of Walter and Eliza Hall Institute of Medical Research
Filming, editing and animation by Jonny Hyman and Derek Muller
Music from epidemicsound.com "Clearer Views" "Innovations" "A Sound Foundation" "Seaweed"
Additional music by Kevin MacLeod from incompetech.com "Marty Gots a Plan"

[@qwerty600]

Once again, science has cured every illness known to mice!

[@2by3]

Exactly

[@punmun8008]

That makes me sad

[@Apersonl0l]

Pun Mun that makes me happy

[@Apersonl0l]

For once, we turned something we hate to something that can help us live longer, better Edit: forget everything you just read mice are cool, just not the ones shitting on my grandma’s pots before she makes dinner

[@DocRobotKey]

This message approved by the Mice Longevity Program Initiative.

[@piosenki001]

It is physically impossible to say "mitochondria" without adding an explanation that its a "powerhouse of a cell".

[@JB2JO]

Mitochondria

[@JB2JO]

It's a powerhouse of a cell

[@JB2JO]

Damnit, I was close

[@piosenki001]

@@JB2JO I see what you did there

[@MiGujack3]

Mitochondria

[@Caapi_Vine]

I don't think you needed to clarify the mitochondria's function. Every baby comes out of the womb with the ancestral knowledge that " The mitochondria is the powerhouse of the cell". Great video! I was very excited to see Sinclair contribute, he's one of my biggest role models.

[@wish9559]

Who is micodondria

[@thesauce1682]

the powerhouse of the cell

[@Gaani2026]

​@@wish9559 The powerhouse of the cell

[@BocchiSensei]

The day when people start forgetting mitochondria is the day of extinction and the end of humanity

[@mikehu2451]

@@wish9559 I'll do you one better, why is mitochondria?

[@matteolaurano2297]

its been 2 years now, can we have an update video on prof. sinclair? i think that this is one of the best video you've ever done and i cant wait for an update

[@what9621]

Agreed its now 4 yrs

[@VozimoSe]

@@what9621 Is the profesor 4y older, or 1y older now? :P

[@neonchronicles]

🤣 I love the internet

[@HartyBiker]

Derek starts going grey: "so how do we stop aging?"

[@zer0b0t]

Yeah can't blame him

[@martiddy]

Derek the Gray

[@stevethea5250]

@@martiddy Gray fox

[@missionpupa]

Well, thats not really something you ask when youre 16.

[@awdrifter3394]

He's fighting the dragon.

[@emsam3457]

“I was biologically sixty and than I changed my life and become 31” that seems like something an evil scientist would say

[@walperstyle]

I want to know his diet and daily routine!

[@WhereRaul]

Cringe

[@pottingsoil723]

@@walperstyle 1,000mg β-Nicotinamide Mononucleotide 500 - 1,000mg Resveratrol 1,000mg Metformin Good luck getting the Metformin (it's prescription only), but that's what the Resveratrol is for. NMN = Sirtuin pathway Resveratrol = AMPk pathway Eat less red meat = mTOR pathway Of course plenty of water & physical activity cannot be substituted, but you asked his daily routine. And yes I've been doing all three for a little while now. 😉 Tips: Resveratrol is cheap and plentiful. Get some. NMN is ... sometimes pricey. My advice is to source it well. It's a special form of Vitamin B3 found in things like cabbage, avocado, broccoli. Of course you can't eat 1,000 avocados in a day, so you buy the NMN. Physically it is a white crystalline powder with a slightly bitter taste and very soluble in water. Also eating less red meat is free and might even save you money. I recommend upping your plant protein instead (peanut butter, cashew butter, sunflower butter, almond butter, things like avocado, hummus etc....) Pretty sure the good doctor also likes his fish & chicken. He doesn't abstain from meat entirely. Just make a burger, steak or ground chuck an occasion thing, rather than a daily or weekly thing.

[@joy-of-chemotaxis]

"I turned my 96 year old body into a mostly 28 y/o and no one knew until a Tinder date went down on me & tasted the one thing you can't reverse."

[@Gunshinzero]

@@walperstyle Exactly. I was like wait, stop the video. This is what we need to be discussing.

[@charlie7333]

Dr Sinclair was famous within the biomedical community as far back as 12 years ago for ingesting Sirtuin (a molecule that he was researching on) despite lack of clinical studies . Professors at my university used to tell the class how reckless his action was, but fast forward 12 years it looks like his self-medication is working. (Source - a biomedical science student at Monash University at 2010)

[@imarchello]

We'll find out in 50 or so years if it's working or not. Either he surpasses 100 or not. A mouse would take even less time.

[@qrzone8167]

He seems to be extremely confident in his research. All the power to him, I hope the self-medication doesn't turn out to be a huge mistake.

[@alonsoACR]

A true scientist. But I've certainly heard worse from my own little country. In the 19th century a Peruvian scientist Daniel Alcides Carrión voluntarily contracted a major disease of the time to prove *how* it was spread. I mean, _someone_ had to do it, i guess... He found out eventually, it was through warts. Despite being sick, he continued writing detailed descriptions of how the disease develops from inoculation, even through fever and delirium. He died a few weeks after.

[@sleepinglaffey3886]

​@@qrzone8167I'm following his strategy because *it works*. yes. I do eat lots of meat, No. I don't eat nonstop. even waking up to snack on yogurt like the Dutch Giant does. That's how I keep my Mtor low (Yes, you can sprint fasted and still adapt Sinclair's methods to your own. It does not need to be about the meat vs plant zealotry)

[@apophissoftware]

It took two watches to see it, but, Dr. Sinclair actually confirms this in a short statement, and seems quite... laughing at the fact that he more than knows its veracity. Rewatch it, and look at his expressions. You'll see.

[@gilbertponder5307]

Bad news: tired, cold, and hungry. Good news: you get to do it for a long time.

[@sleepinglaffey3886]

Doesn't mean you have to do it. that's if you focus on healthspan above all else. I just low protein keto and take resveratrol along with fasting. - Meat based KD sprinter

[@milktheshark1226]

this man really dropped a mitochondria is the powerhouse of the cell into this

[@rocketassistedgoat1079]

Huh?

[@noneofyerbisness8702]

Mitochondria is plural. It would be "mitochondria *are* the powerhouse*s* of the cell" , or "A mitochondri*on* *is* the power house of *a* cell."

[@rocketassistedgoat1079]

@@noneofyerbisness8702 I finally understand what he was trying to say. Exclamation points around "mitochondria....of the cell"; makes it grammatically make sense. Without said exclamation points; it's a word-salad.

[@tehrobotjesus]

@@rocketassistedgoat1079 You're a bit mixed up on your punctuation marks, friend.

[@rocketassistedgoat1079]

@@tehrobotjesus My grammar's flawless mate. You're probably buthurt, because you speak ONE language...and yet can't put a sentence together.

[@ToddHowar.d]

Sometime in the possible near future: “Doc, I’m feeling a little too old, what can you do for me?” “Have you tried turning your epigenenome off and on again?”

[@lutyanoalves444]

it just works

[@lolatomroflsinnlos]

This is a very good joke

[@tingtingin]

Literally died reading this so gonna need to restart the genome

[@alanmalcheski8882]

hold on... ok... now I'm a giant tumor. Wait... I think i did it wrong.

[@absolutemadlad8603]

thanks todd howard

[@skylerbowerbank5847]

This video immediately reminded me of the question "if you were offered immortality, would you take it" And i have learned it always depended on if it was just you, or if your friends would be too

[@gs-nq6mw]

You can always make new friends,and many people live happ without a biological family

[@suspicioussand]

People without friends: *I don't have such a weakness*

[@user-co4px7tx1p]

@@suspicioussand People without friends usually want friends.

[@flufffluffer3517]

Its a sign of inteligence that someone can explain a really complex term using simple words

[@jackwraith3504]

so basically, if you live an uncomfortable life, you can be uncomfortable longer

[@umutruzgar2923]

Ahaha, can't be argued

[@AntimatePcCustom]

i feel bad for the African population now :'c

[@charlescarabott7692]

Would be very disappointing if you lived uncomfortably to live longer then die young

[@thecwd8919]

If you live without happiness, have you really lived at all?

[@xcsege]

when you actually get to a point of enjoyment and accepting the uncomfortable, it doesnt seem that bad at all!

[@blyaticon8190]

So aging is just all cells of the body having an identity crisis

[@shan_singh]

Hahahahahah

[@aikoyanai5933]

Sounds like it

[@regem9121]

and death is when your cells go through a life changing journey and decide to change their life long career from brain cell to testicle cell

[@wegner7036]

@@regem9121 "Brain cell from testicle cell" That's puberty!

[@regem9121]

@@wegner7036 puberty and dementia, name a more iconic couple

[@codycurzon1762]

This video is now 4 years old… I would LOVE an update video of how they have progressed with their research in this time.

[@alfonsodacullo3040]

What I love about your video is that it is not too short nor too long yet compact with information! Keep it up! Thumbs up!

[@theamigoman]

These KZbin tutorials are getting more and more advanced

[@Avighna]

GAHAHAHAHA

[@kylefer]

I have to note here he never said 'caloric restriction' yet Derek took it that way, the doctor said Fasting, eating less. Restricting calories can be hazardous as proven in the Minnesota Starvation experiment. There's a huge difference there and one leads to the benefits of anti aging while the other does not.

[@HHNguyen96]

It actually can summary to don't live too comfort. That all. Always wonder why most of the soldier live longer than normal men ? Now I don't understand why.

[@user-qu1rx8oc6t]

I laughed hard at this

[@johnchristian7788]

@@kylefer Can you explain the difference. I don't understand the difference and am confused. I'll also try to search Google.

[@ydrinkcoke]

"there's mitochondrial dysfunction" Don't do it.. Don't you dare- "Those are the powerhouses of the cell" GOD DAMMIT, DEREK.

[@panzerofthelake506]

Explain

[@jumpander]

God dammit, he did it again. And I like it.

[@Thematic2177]

@@panzerofthelake506 - mitochondria are the powerhouse of the cell

[@chrissantos9725]

@@panzerofthelake506 It's usual of him to say that in many other videos, that's why a veritasium video is not a veritasium video if he doesn't cast those very words. It's like a tradition.

[@ruslan10]

Vivek Acharya it’s a common thing they teach at schools

[@justinstebbings6711]

Wow I can see why you have so many followers. Im hooked on some of these videos already, which I've stumbled upon this afternoon. This is better than I remember educación being at school all those years ago.

[@user-tj7mi4yo7d]

The mitochondria is the powerhouse of the cell.

[@kushagrasaxena8454]

Feel like Derek is starting to notice his white hair

[@doaa7941]

Midlife crisis :(

[@mycutepetshrimp1532]

F

[@prajwalnegi22]

Lol. I was thinking same

[@kylesplace]

Haha, I was going to make that comment too.

[@Yous0147]

Aren't we all? Though I feel Derek has always been calm and cool thinking about it, which is the best way to go about it I think :)

[@DanielAleksanderJensen]

It's all fun and games until you find out that David Sinclair's real age is 150 years.

[@Kassieq]

correction: 1500 years

[@zachary7897]

Cool Air by H.P. Lovecraft

[@DeepThinker193]

@@Kassieq He is the one who built the Pyramids.

[@CobaltLancer]

@@Kassieq Correction: *_1,500,000 years_*

[@sixela6]

@Franz Xaver Fuchsberger the queen is his daughter

[@PerceptiveAnarchist]

This video is one of the best on whole KZbin! I saw it first time about a year ago and after that have I promise to be at least 130 years old!

[@KarlaKandy123]

I would die to work there and learn more about this everyday

[@dsdy1205]

ironic

[@Hatchatorium]

@@dsdy1205 Not really ironic. It would just defeat the point. ;)

[@Walduhu]

"Taking a 70 year old and making him run faster than a 20 year old, further" Russia has entered the chat

[@aaronnaidooan]

🤣🤣🤣

[@DoodleDan]

Bruuuh now I understand why they're capable of doing that, they're constantly exposed to extreme cold and they don't even give a damn about it Edit: also, have you ever seen a Russian eat anything? I DIDN'T THINK SO

[@Vladimyrful]

:Awaken Pillar Men playing loudly in the background:

[@spoonikle]

President for all eternity - Father Putin

[@mattherhorn290]

The chat: bans Russia for four years.

[@justuslm]

I think Professor Sinclair will be a key figure in aging research for at least the next 300 years or so.

[@marcapparatus]

well done. well done. ;)

[@CivRichieP]

He does look like he Benjamin Button'd parts of his body and face.

[@emmaphilo4049]

@@CivRichieP he looks his age. Even he can't stop his own aging. But I hope he finds a way.

[@bluesealol]

@@emmaphilo4049 He said he changed his biological age from 60 to 31

[@Jaydinskee]

@@bluesealol Correct, and he gauges this using a method established in recent decades for determining the amount of erroneously accumulated molecular methyl groups in our cells' DNA bundles, called the "Horvath Clock" The reason this is significant is that DNA methylation has one the most consistent links between overall biological damage an organism has accumulated over its life, and Based on statistical data, When an organism is most likely to experience "biological mortality" (most people refer to this as dyeing from old age)

[@sumanthmunikrishnappa9703]

Love all your videos bro.. the content is systematic, structured and you never false title your videos just to bait people to watch.

[@AtomicPunk23]

I love how failure in applying epigenomic therapy is just "become a tumor". That's the spectrum of possibilities for anti-aging therapy in tissue: grow older, stay the same, grow younger, or become a tumor. I imagine becoming a tumor as something like Star Trek the motion picture where the transporter failed and "what we got back didn't live long"...

[@VaradMahashabde]

Derek : * grays * Derek : How to reverse aging

[@BunnyCentauri]

Hahaha. Exactly. Bless him.

[@Mr.lions3.14]

I'm not gay but he can definitely rock that gray

[@wesbecool]

@@Mr.lions3.14 zero reason to preface the statement. The man is indeed rocking the gray.

[@bayareajokester9456]

@@wesbecool it seems like your sense of humor is dying? How can we reverse that

[@carlpilkington]

Sinclair looks suspiciously young for his age, him being a 50 year old professor that studies anti-aging. Maybe he’ll one day turn into a super villain called something like “Professor Baby” or “Doctor Embryo”

[@jcdenton1868]

professor immortal sound more badass.

[@carlpilkington]

@@jcdenton1868 nah, its too badass...

[@caprimann87]

The Timeless Toddler

[@jettspyder]

Doctor Fetus in real life

[@noori2105]

I like how you picked most horrible names possible

[@jackp2088]

your videos are nothing but amazement to me, I can see how passionate you are about every of your videos, may you have a good life

[@SidharthGat]

Derek seems so productive. Consistently making consistent quality videos without a dip. He should perhaps also make productivity vdo too, giving advice (that works) to make the most out of the time we already have.

[@HkFinn83]

Adderrall

[@user-ux3jl7bl2p]

i agree the most!

[@41-Haiku]

"That's the powerhouse of the cell" Great meme with a straight face.

[@Erik20766]

What do you mean? The mitochondria literally is the powerhouse of the cell

[@euanmcdougall1917]

@@Erik20766 well yes but actually no

[@odin_3]

Euan McDougall why?

[@FunnyMemes-dr3se]

Literally what people learn in school... mitochondria = powerhouse of the cell...

[@euanmcdougall1917]

@@FunnyMemes-dr3se well school simplifies it a bit but most of the process of respiration (which uses sugar to convert ADP to ATP which can be used in life processes for energy) takes place in cytoplasm and is a lot more complicated then just boom energy. But the part for aerobic respiration (the super efficient one which requires oxygen) is completed in the mitochondria. So yes it is the powerhouse, but it's actually a lot more completed, plus some bacteria and other cellular lifeforms don't need mitochondria, which would be like using a phone without a battery as a powerhouse of the cell, so yes but actually no

[@ZInChat]

Professor Sinclair looks like he’s been the subject of his own research.

[@obbbob4911]

You look like amado from boruto

[@hwt-ka-pth]

@@obbbob4911 Haha wow you're right

[@tristanmitchell1242]

Well, he originally appeared as 60 to his tests, and now appears to be in his thirties to the tests.

[@mado5957]

@@tristanmitchell1242 yes but his eyes are 15

[@ryanbrown982]

He is. He's publicly said that he skips breakfast (intermittent fasting), eats basically no sugar, and takes NMN (one of the chemicals that was injected into the mice) daily, along with a few other supplements.

[@pigalex]

Altered Carbon is a novel (has a pretty good netflix adaptation as well) which tackles classism born from immortality. pretty good work

[@BhimChawhan]

one of the best video that I have seen in this year.

[@lyan9923]

“Freakishly exciting” is the right description for everything in this video.

[@Mystixor]

I wanted to comment exactly that 👌🏽

[@dislike__button]

Other fitting description would be "too good to be true"

[@psyche7049]

​@@dislike__button Pessimism is the first step to guaranteed failure.

[@dislike__button]

Being gullible and falling for things that sounds too good to be true is a sure way to get scammed. Saying that critical thinking leads to a guaranteed failure is plain stupid.

[@psyche7049]

I didn't say critical thinking leads to guaranteed failure. I said pessimism does. What's more, how does one get 'scammed' simply by believing in a better future for humanity? Hopes can certainly be crushed by failure - but other than being let down I can't see how any harm could come of being optimistic for a better tomorrow. It's not as if I donated to them or anything. I lose nothing by encouraging progress here. But cool, continue to be condescending.. fine by me buddy. It won't help get anything constructive accomplished though. And I know for a goddamn fact I'm more intelligent than you are. Lol. :) The science is there. Nothing is completely impossible unless you make it so by assuming things are hopeless and giving up. We just need to use our intelligence to our advantage and create solutions. It's not 'too good to be true'. It's just complicated as hell and hasn't been done yet. There is a clear difference. There are real people working towards real scientific answers each day. No one wants to die, so you can bet they are giving it their absolute best effort. I am not saying defeating aging is easy or going to happen overnight but it should be possible when the right minds come together and all the biological puzzle pieces are made to fit just right. The scientists behind this research aren't getting paid to sit around drawing doodles in a notebook. They are working day and night to figure it out. And yes - that means certain individuals or companies may have to sponsor them or fund their work. That is the cost of progress. Some goals outweigh whatever misgivings you may have about the end results. It should still be attempted. With time and clinical trials I have no doubt this research will provide more insight and therapies to extend lifespan. But that's why people with this mindset are not working on these projects. To them it's all science fiction and not worth their time. That's for the best anyway - I doubt there is any room for close-minded individuals on the team.

[@Levigumba]

So to slow aging, all I have to do is be a vegan in Alaska surrounded by polar bears

[@hannahlennertkristiansen4797]

eat fish only hahahaha

[@agentsteve8263]

@@hannahlennertkristiansen4797 But you gotta be careful not to eat too much of the fish with mercury, otherwise you can get brain damage and just end up having a slow death with a screwed brain

[@TheAecke]

Yep if you‘re surrounded by polar bears in alaska you‘re guaranteed to never get old

[@valorienapoletana4063]

95% vegetarian, water fasting and moderate exercise with a changing environment yield longer life. A bit easier... feed any creature on earth 1/3rd less and it lives 1/3rd longer. This experiment has proven true for any creature on earth. Improve the quality of that food, and the ability to move/digest it more effectively and it can live up to 2/3rds longer.

[@hannahlennertkristiansen4797]

@@TheAecke I live in Greenland, we eat the bears

[@GeraldPUR]

I can only wish for this and I'm 49 now in good health. Those concerns will disappear as soon as we start taking to the stars 🌟

[@JanetSmith900]

Hmmm. I just watched part of an interview with a man from University of Illinois who said we need more protein as we age. If have to go back and look him up again. He looks fantastic for his age.

[@rhyljones1391]

Sinclair: "You can clone monkeys, dogs, Barbara Streisand the actress..." Me: "I KNEW IT!" Sinclair: "...she cloned her dog." Me: "Oh".

[@pammym1825]

😳🤣👏

[@huyifan83]

@@pammym1825 It'd be interesting to see that actress clones herself and adopting her as her child. So weird.

[@pammym1825]

@@huyifan83 🤣👏

[@noone2262]

@@huyifan83 you are talking about kanata no astra

[@IshanKashyap001]

Damn this is so underrated

[@reminiscent1865]

"4. Be uncomfortably cold" -Immediately turns off space heater next to me "5. Be Uncomfortably hot" -GAH!!!

[@sethbishop6890]

What about comfortably numb?

[@AlexysRM]

No, no. He means you should be cold and attractive.

[@lapidations]

@@sethbishop6890 I think it should be uncomfortably numb (I know the song I get the reference but imho you should've said uncomfortably because that's what the video is about)

[@stevethea5250]

@@sethbishop6890 timestamp?

[@stevethea5250]

@@AlexysRM what's 1 2 3

[@thedude6405]

Go professor! I wish I could keep my parents forever.

[@funforall9741]

So if i am understanding correctly, the goal of intermittent fasting and amino acids restriction is to make your body believe you are in a dangerous environment, activating your longevity genes responsible for repairing the parts of your cell that represent your age. the longer your body stays in longevity mode, the longer your epigenome preserves your age. That would explain why monks in temples without air conditioning who eat intermittently and very little, also have longer lifespans and healthier bodies. I can't wait to see how this research develops. Please keep us updated i would love to see more on this topic.

[@lawliet2263]

And practice celibacy too !

[@GlueTubber]

Oh well, there goes long life!

[@switchlaserflip9243]

I do this naturally to save on food stamps and electricity so I should live to be 1000..

[@charlescarabott7692]

Fun For all maybe its because they dont eat procesed food and actually are less stressed in their simple life then people living in modern society.

[@neron98]

Read "The longevity diet" by Valter Longo

[@iphoneandnick]

"Mitochondria are the powerhouse of the cell" Me: *nods head*

[@IMe7x]

A missed opportunity...

[@LinkEX]

I honestly couldn't tell whether or not he was referencing the meme.

[@TheTheoser]

@@LinkEX what meme

[@LinkEX]

@@TheTheoser The very statement fastboy619 made. See also kzbin.info/www/bejne/q4TPdqB4mq2fnck

[@Corn0nTheCobb]

Don't get it & don't care

[@MinatoNamikaze-kf5tp]

They released the Paper this month! Fascinating

[@borombab4816]

Imagine how much someone could help if they had a longer life.This sounds amazing.

[@GenghisClaus]

I want the opposite of that. I want to die immediately.

[@imarchello]

Imagine if Hitler lived for 1000 years. Yeah, not everyone is out to help. The great equalizer at least kills off all the cunts of the world.

[@sew_gal7340]

Most people do nothing to help , one video of a public attack where everyone just stands around recording on their phone.

[@jarrahkron9]

Yeah sorry, the realistic view of anti-aging research. If they were developed properly into working anti-aging treatments in humans, such gene therapies are going to be incredibly expensive, and thus are going to overwhelmingly benefit wealthy people... The world is going to continue mistreating and exploiting working-class people and those in the global south etc., whilst wealthy families will be allowed to live for hundreds upon hundreds of years. It's literally taking us closer to a sci-fi dystopia setting. The people who will be able to afford this therapy best will be the ones who already cause so much damage to the world.

[@wren_.]

@@GenghisClaus you can wait a little bit, you’re going to die eventually. What’s the rush?

[@EdWalzak]

“I changed my life and then the test said I was 31.” This throwaway comment at 9:07 needs its own video!

[@EdWalzak]

Oh ok you get into it at 10:24. I just got excited.

[@MilopolisTV]

He said he is 50 yrs old, he actually looks 40. He also said he was biologically 60 and brought it back to 31. Yes, his journey on how he did that needs a video of its own.

[@bilthon]

@@EdWalzak Still I'd like more details about the specific ways in which he "changed his life" because he does look younger.

[@Unpluggedx89]

When he was on Joe Rogan he said what he does. He takes 'Resveratrol' with some yogurt in the morning and he takes 'NMN' (they finally started making it commercially) and he does intermittent fasting. You're welcome. 😊

[@ranevc]

He wouldn’t let us know. Such an info costs billions.

[@BobSkiz1]

Apparently it's impossible to say "mitochondria" without following it with "they're the powerhouse of the cell".

[@kyrlics6515]

IT IS the powerhouse of the cell 😎

[@danfg7215]

Ouroboros what are you talking about? I can easily say “mitochrondia” without mentioning that they’re the powerhouse of the cell.

[@BobSkiz1]

@@danfg7215 checkmate!

[@mdsr640]

I think it is being thought like that everywhere. Here in India too. We were like made to mug it up while in 5th grade or something lol.

[@johnsmith-eo3nz]

@@danfg7215 hah fool! You've activated OP's trap card

[@tonygilbert73]

Awesome video man! great work!

[@unofficial8585]

This video is really easy to understand! I appreciate you

[@alexandrumarinescu8018]

Had me at "the powerhouse of the cell"

[@10ahm01]

Was going to be disappointed if he didn't continue the tradition

[@arjunjing3491]

Long live mitochondria

[@BrunoLejdfelt]

That was my favorite part

[@Jarrod0067]

YOU FOOL GOLDEN GRUUL THE 🅱️ANCIENT ONE

[@johannes7412]

He said the thing!!!

[@agert6416]

Nobody ever misses “it’s the powerhouse of the cell”

[@SurasmitaMeher-ch3lo]

Lol yes!

[@YouMe-mf7ed]

the only thing everyone that took biology remembers

[@julianmrtns1819]

Mitochondria 😎😎

[@blubobbie]

I learned it solely from the internet

[@vchellos2249]

Those are The powerhouse of the cell Me: *nods head* yeah this guy knows what he’s talking about

[@kiwi6421]

Oh interesting! A lot of these points are mentioned in a book called "The Forever Dog" that explores how we can make dogs live longer, and how it reflects the aging of humans since there are so many overlapping environmental factors.

[@Brandi.Nicole]

Thanks for sharing! I will check it out.

[@WatTheFinn]

I really want an update on this video as this is 2,5 years old already which isn't that much in general but in the field of scientific biological advancements it is a lot.

[@undeadarmy19]

Moon jellyfish: starts getting old Also moon jellyfish: time to reload to an earlier save point.

[@stevethea5250]

14:18 why does it start zero

[@coreybarbato8891]

Steve Thea coding habit of making lists, I assume 🤷‍♂️

[@DineLade]

@@stevethea5250 also probably because 0. has nothing to do with the cell state whereas the other points are all about getting your cells into the survival state

[@samandati3858]

Must be where Rick got the tech from

[@ahnrho]

Biological factory reset.

[@alp2610]

To summarize - cold temps and warm temps help - Eating less, intermittent fasting - exercise - avoid dna damage- sunscreen, eat antioxidants, etc

[@GO-su3lf]

go vegan, yr system could detect how much protein u take in.

[@byamboy]

let's not forget avoiding eating too much protein....

[@yourlogicalnightmare1014]

Sounds horrific. I'll pass. Gimme disease and death

[@byamboy]

@@gorazdtrauner1314 where? Can't see the comments

[@shahriarhakim6673]

@Yam Knight he is a hillibily

[@Inactive1987]

Very interesting and informative. Thanks !!

[@DarkprinceA]

we need an update to this video

[@VaibhavSnehi]

Me: I Have the Worst Memory. Epigenome: Hold my Skin Cell...

[@danielfarfudinov3193]

Is it a skin cell? I don't remember...

[@VaibhavSnehi]

​@@danielfarfudinov3193 Skin Cells, which have old stage Epigenome (arrangement of DNA) lose their memory and don't act properly,

[@danielfarfudinov3193]

@@VaibhavSnehi ok

[@sturmifan]

@@VaibhavSnehi how funny would it have been if they made a joke about that

[@iloveamerica1966]

Epigenome: well, if you had taking care of us the last 70 years, we would have taken care of you... However...

[@KITOMERO]

How to age slower TLDR: Be perpetually uncomfortable

[@gps9715]

Yeah, lol, kind of conundrum. You can live forever but it must be a shitty life you lead. Hrm...decisions, decisions...

[@BillyViBritannia]

Added benefit, time perception becomes slower. Imagine living to be 200... That would feel like a millennium of suffering.

[@TheChadPad]

All the people with anxiety rejoice!

[@TheTopMostDog]

Comfort is overrated. Happiness is what you should seek. They're often opposites; a person might eat because they're unhappy, or stay in a bad relationship because it comforts them. Once you strive for happiness instead of comfort, your life will turn around completely. Do what makes you HAPPY, put yourself out of for comfort zone.

[@MartinBalaz89]

@@BillyViBritannia Actually, time perception becomes FASTER the older you get, not slower. When you are 5 years old, 1 year is 20% of your life. When you are 100 years old, it's just 1%. That's why old people wonder why everything flies by so fast.

[@betsybarilla3752]

This is quality content 👍

[@Matteesside]

Have you revisited this ? 3 years old now. Would be interesting

[@RyanTheHero3]

‘Doc I don’t feel so good’ ‘Yes it appears your brain has turned into a ball of foreskin’

[@gabrielsimon7944]

There was actually a story where a guy burned his scalp so bad so the doctors had to take a chunk of his scrotum skin (yes, a piece of his ball sack) and stretch it over his head to replace his scalp

[@untitled6391]

@@gabrielsimon7944 was that guy in Men in Black

[@joelstanhope7231]

Lol ! In short became a politician

[@waterspray5743]

@@gabrielsimon7944 So, what does he smell like when he sweats?

[@francesbadger3401]

@OP I hate it when that happens

[@2563dicko]

50? I think professor Sinclair has been dipping into his gene therapies.

[@guzu334]

He did say he has a biologicaly age of 31 after he previously had over 60. So I guess those vegans are on to something. 😂😂

[@achintyaupadhyay5528]

@@GerardMenvussa Orr he isn't? Who knows. maybe he's onto something here

[@breakfast-burrito]

*pops NMN pill* I dunno what you’re talking about🤷🏼

[@LousterPlays]

@@achintyaupadhyay5528 He's not, watch his Joe Rogan interview.

[@tufaradugabriel]

Watch his podcast with Joe Rogan. He talks what he does to slow aging

[@BeatBoxBrian]

Best part. 4:30 “Mitochondria: power house of the cell.”

[@AntonioMendezGonzalez-rh9ks]

Vital information, literally. But how does sleeping well or bad affect the process of maintaining the epigenome?

[@RudyLouieTayong]

Jellyfish: my secret to immortality is having no brain.

[@alexanderkasten9713]

The trick is not being aware to be a jellyfish...

[@sullivandeffinger4970]

No brain eh? I know quite a lot of immortal people then.

[@aswincvenu3958]

@@sullivandeffinger4970 Donald trump is immortal then

[@ktkc1o7]

@Tater Tot Actually, jellyfish do not have a central nervous system. They have what is called a nerve net. I'm not sure what that implies as far as consciousness.

[@janiemiller825]

lol 😂

[@hithere5553]

I’m going to live forever or die trying!

[@judgment5090]

We all do, don’t we

[@thevcountdown9824]

LOL

[@psaure]

@@judgment5090 y

[@rainofrest7778]

@@psaure y

[@joeshmoe7967]

I am going to live for ever, or try dying....I can decide, 'cause if I do one, I can't do the other.....

[@ellarae7575]

🤯🤯🤯 mind blown about the reversal of aging.

[@jackthomas3221]

Thank you so much for this video Derek & David! After listening about genes in this video, I'd love a video around the dec2 gene.. or even about why we require sleep exactly in general.. 👌😅

[@null-1]

How to live longer: Be as uncomfortable as possible

[@M3iscool]

Live a sad shitty life.

[@vitvitcher2782]

Cat From The Future *long and shitty life

[@theovandaele3220]

@@M3iscool 150th birthday here I come!

[@aphr0d]

Prince Risen only on occasion. Eating less makes you feel better as well, exercise is so good for your body and especially your brain (focus, concentration, memory, etc) The hot and cold stuff seems like you do it occasionally. Like going into a sauna (which sounds nice) or take a cold brisk shower maybe? It doesn’t have to be a shitty life, it’s like when you take cold medicine sometimes. It’s gross or uncomfortable in the moment but in the LONG RUN, you’re so much better off. And once you get used to it, it doesn’t become that terrible. It only seems that way now if you’re not used to it.

[@stardolphin2]

Within reason. A somewhat lower than comfortable temperature may be good (and I do that mostly for my utility bill...I have sweaters), but I'm not going outside naked today (which is about 33F at this moment).

[@OtoGodfrey]

Mom always said "eat your dinner, dress warm, take your time" and instead to listen to her I have been skipping food all day, then getting on a bicycle at -20c in a sweater to sprint to hot yoga and then back out again in -20c". Nice to know I been doing it all right all along.

[@lincolnoliveira3041]

Explain

[@TheTheThe_]

@@lincolnoliveira3041watch the video

[@marshcandy6359]

why you both have a black pfp

[@TheTheThe_]

Black is beautiful 😳

[@emmateisseire1493]

Please do not apply these advice without further scientific evidence. Some scientists pointed out flaws in his work and we really shouldn't play with our epigenomic while we still know so little about it. A correlation has been found between heart diseases in descendants and ancestors undertaking starvation. I know all of that is exciting but don't jump to conclusions and wait for the scientific community to express its opinion. Your health is at stake, be wary !

[@anildhage]

This study and knowledge is priceless man. I am thrilled after knowing the process of aging. And I don't why but I recalled the memory of Avatar movie for some reason.

[@mauricetremblay1324]

Amazing topic. Thanks.

[@Nirossen]

When you said that mitochondria is "the powerhouse of the cell" I felt that

[@Gogglesofkrome]

when I see someone copy paste a literally single lined joke over and over on the web I feel it

[@OrchidAlloy]

"You'd turn into a giant tumor" Deadpool intensifies

[@pvic6959]

as if im not already a giant tumor :(

[@The_Gallowglass]

IT'S NOT A TUMOR!

[@diamondcat7587]

Too many carbs will turn you into a giant tuber.

[@mikewolf78]

Gallowglass *toomah

[@iwillfightyousir6479]

*big lez intensifies*

[@AgitpropPsyop]

Wish we could have an update to this video!

[@steflift5165]

Thank you Veritasium and Nicolas Flamel

[@amanasci2481]

When that music starts and you know this video is at its climax!!

[@decorticate]

that's not the only thing climaxing at that music

[@TauBuuVuong]

“Be Hot” to live longer. Well looks like i’ll die pretty soon

[@Anonymos185]

You just gotta be cool instead bruh 😎

[@COGGYCOGSY]

find a sauna

[@aniawo5119]

🤣🤣🤣 Good one.

[@kudosbudo]

If you are not hot, just be cool.

[@SrmthfgRockLee]

i do situps in snow n ultramarahtoner..run in cold times all the time. hot is very bad and unhealthy make u age faster.. they freeze ppl for 20+years in future, u dont see em heat up ppl in films/series n theories to conserve em longer.. physics- hot increases movements in a certain place. But tey do freeze ppl..cryogenics or whatever. I have a different than Wim Hoff method to resist ocldness-rather i do feel cold but simply associate it in certain ways+know that unless its super cold like around -21+.. or -21- .. it's not a problem - ive ran in -15 c, It was bad when iw ent fo rsit-ups at such a cold time but if i just ran at -15 c it's fine.

[@80amnesia]

Great video, great topic

[@Zanroff]

This is amazing stuff. I'm fully convinced this will happen in the next 10 years. Technology is advancing so quickly.

[@user-sh4hd9nn3k]

this cant be done in real life sadly

[@julius_trifinity]

"Starting with 0" *Computers liked that*

[@MichaelKubler-kublermdk]

Hahaha. Totally.

[@mrofftopic2802]

Great way to drive my OCDs crazy. Tell me you have 6 things to tell me, start at 0, stop at 5. I'm still aching for #6. 🤣🤣🤣

[@carcasapistacho]

*beep boop* :)))

[@forasago]

@@anonluca3971 He made the list younger.

[@Nelo390]

Ok, but Professor Sinclair totally has the name of a Super Villan, and looks/acts like one too.

[@shawn680]

He's a snake oil salesman. He has no clue what he's even talking about.

[@AsttoScott]

I'd like to meet the guy. He seems like a top bloke.

[@fishiefish6179]

Shawn and you do?

[@JohnSmith-ox3gy]

Shawn Okay, I'll bite. How so?

[@benschebella673]

Yeah something feels off about him.

[@pietroelliott510]

I would love to see the resulting effect of cortisol from putting your body in stress/protect mode. It seems almost counterintuitive to put your body in stress mode which resides your cortisol that in turn results in negative effects

[@rodimusmaximus3912]

The music around 17 minutes is definitely some sort of Winter Contingency remix from the Halo: Reach soundtrack, I'm calling it

[@hinoakuma6386]

Dr. Sinclair: "the key to long life is to eat less." Starving college students: Hurray!

[@MrSidney9]

As with everything, it's not as simple as that. Malnutrition will make you sick and and cause other complications for your health.

[@missionpupa]

eat less doesnt mean eat ramen and you would be fine, it means portion size and frequency, but you still need to eat nutritiou.

[@ramymelhem]

Low protein? Do u even lift?

[@Vysair]

Homeless & African: whoopee

[@Lillith.]

Make soup. If you need more, just add water. It'll keep you going a long time.

[@Niggels1404]

"The Mitochondria is the power house of the cell" - Yes. Yes, we know

[@javierortiz82]

is that a parasite eve reference?

[@algame3]

I read your comment while he was saying it

[@oeerturk]

hahahagaha

[@SixOneZil]

came here for this.

[@maximonslaught2580]

That was literally the only thing we knew when we left school.

[@alphahurricane7957]

ending aging is the best blessing we could have from modern science. So much desperation and pain (and money/ resources) could be saved by this technology

[@SomeoneNone123]

I would love a follow-up video for this mice research.

[@troyreyes8349]

"They're not part of the scope of this video" Basically me in the thesis defense

[@TheGuerrCZ]

+

[@SupremeBooyah]

How do you pull that off?

[@Rulettaja0]

Imagine aging and then dying This post was made by immortal jellyfish gang

[@kajmak64bit76]

Lol

[@jumpander]

weird flex, but ok

[@SF-li9kh]

Ok.. I think the jellyfish bit was stupid. The world existed for billions of years. If none of them die, our seas would have been infested by them

[@SnakeTheBoss13]

@@SF-li9kh as he said, if you had one of those jellyfish in perfect conditions, safe and well fed, biologically it would never die However, out in the wild, they still get eaten, disease takes them down, and mutations can also cause them to die.

[@sally700]

Wow.....thank a fine mind for working to improve our lives

[@demonslayer9016]

Sinclair takes alot of criticism from the scientific community because he is clearly on to valid theories , literally he is breaking boundaries and showing us that living longer is totally achievable with our current state of tech

[@oliverlangrall2014]

@@Paonporteur It's not that people aren't just enrolling, it's that they can't. Education in the US is a business and the financial level of entry is prohibitive relative to even just 25 years ago. I agree, that is a travesty!

[@bradydill4767]

There's no way that's why he's getting criticism.

[@kirillstp]

​@@bradydill4767never underestimate the power of groupthink and in-group signaling, even in allegedly intelligent people like academics.

[@HSHamster]

me: doesn't take care of myself, doesn't eat enough, doesn't wear more clothes when cold out of pure laziness also me: apparently going to live to 150 years old

[@aphr0d]

Well a crucial step is to take care of yourself. At least eat foods chock full of nutrition

[@goku445]

if you also eat junk out of laziness you can be sure not to live long. calorie restriction only works when you eat nutritious food.

[@DANGJOS]

@@goku445 Not sure that's true, but the unhealthiness of the junk food will certainly fight against what you're trying to do. But I imagine calorie restricted junk food diet will lead to longer life than high calorie junk food diet.

[@goku445]

@@DANGJOS you're right.

[@mred7030]

he did mention exercise

[@andretsang7337]

"We didnt use all 4 of the reprogramming factors. We leave out MIC which causes cancer" Probably for the best

[@jibranhakak]

MYC

[@kimgkomg]

This was their first mistake

[@dominus6695]

MYC drop

[@waltercabanillaslopez6467]

Ihas passed 3 years, can you make an update video with Dr. Sinclair???? Thanks!!!!!

[@codiecola3636]

This has blown my mind…

[@highlewelt9471]

4:28 I love how fast he slips in "this is the powerhouse of the cell" after saying mitochondria. The word may never be spoken without this sentence

[@GeorgeDCowley]

Mitochondria feels oppressed.

[@BrianSantero]

@@GeorgeDCowley I believe you mean: "Mitochondria, the powerhouse of the cell, feels oppressed."

[@areeeash1124]

69th like

[@amurape5497]

It's kinda equivalent to "peace be upon him" in science :-D

[@areeeash1124]

@@amurape5497 XD