John Ioannidis - Why most clinical research is not useful

[@yannis9790]

Prof. John Ioannidis is probably the most capable doctor in the world nowadays, also extremely good in Mathematics&Statistics and absolutely integer and human. We need people like him urgently. Thank you Professor!

[@fredwpf]

Unfortunately the remaining researchers are just bought over by vested interest.... it’s all about $$$

[@jukee67]

When the worldwide event began in late 2019/early 2020 I looked for this man's opinion immediately. I am an average guy, no degree on the wall and in 2021 many may call me a bum. Call me what you will but I am without any debt, no children by choice as I was aware of the world not being a place in my opinion to raise a child. I am one that surround myself with my books of old and I am selective when reading anything new. Corruption in medicine due to greed is disgusting. I was studying to be a biomedical engineer and walked out as in 2000 the writing was on the wall that money was the most important aspect for those in that career so I couldn't do it and would not throw my soul out for a couple hundred grand a year. This man is a true doctor and a good man. No one is perfect and that is why evidence based medicine is the topic at hand right here. His videos from early 2020 regarding covid were buried and shadow banned. Why? He is not a sell out like most in medicine. Pay attention and you will learn from a wonderful human being. Thank You Doctor.

[@sriramm7465]

True🙏

[@yeah7598]

Ioannidis is a brilliant scientist and researcher and a man of integrity who is exposing a lot of coruption in science. Well done !

[@Fomites]

What corruption?

[@yeah7598]

@@Fomites are you stupid ? The corruption is all around you, read www.healingcentres.org/law.htm and whole web site

[@huverdoose]

@@Fomites Denial of the power of Essential Oils, for one.

[@anonkasper7937]

@@Fomites manipulating data during clinical trials for medicine.Publishing only positive trials and ignoring the negative trials.Selection bias like cherry picking data due to conflict of interest.This applies to science but very specifically applies to medical science and pharmacy industry published clinical trials

[@drmuhammad9462]

So true.. actually 90% of socalled "research" is NOT out of necessity but for personal gain, promotion, recognition or monetary compensation by pharmaceuticals.

[@truthprevails4386]

this man is my hero!

[@RefugeeOfModernity]

same. i've watched every video of his on youtube

[@fatimas2067]

We need more MAN like HIM

[@hugo_kruger]

Nutrition Epidemiologists were criticized for using models and not testing them properly by Gary Taubes when the low fat high carb diet was exposed as pure BS. Today we are seeing what happens again when we follow Imperial College’s modellers down the drain.

[@psychnstatstutor]

Such a fantastic talk about why we need to focus on effect sizes, not NHST

[@JCResDoc94]

on the metric main page there is an entry on exactly why we should go slow w/effect sizes bc psych is already too wrapped up now, and they are becoming exaggerated & independent replication has brought up some novel problems (new is old again re sampling)~5min clip: kzbin.info/www/bejne/eZ3XlHpjrLCljJY

[@devstat]

Professor Ioannidis is at the same one of the most hot proponents of the NHST and goes against "ditching statistical significance" strongly, so it's not that easy. He proposes other measures to address it, but stays within the NHST. BTW effect size has little or no connection to the MCID - the practical significance (minimal clinically important difference), which is the major filter of clinical relevance. Moreover, different methods of calculating of the effect size (for parametric and non-parametric methods) may (and usually do) yield very different outcomes. People overrate effect sizes and quarrel on their "thresholds" no less fervently than about any other measure.

[@JCResDoc94]

18:10 Conflict declarations: Are you declaring you are bowing out of this field (& any influence on guidelines youve had should to be removed). Announcing you are "conflicted" doesnt allow judges to rule on their own cases. And science best have an even higher standard.

[@Dan-iy8ig]

Are Va¢¢ines Safe? 12 FACTS You Should Know Before You Va¢¢inate docs.google.com/document/d/1XATaypLDFlRblqESL3FCAwjtcO52tt3-spZDENxVlbQ/edit

[@davidmauro]

@@Dan-iy8ig In a 2012 meta-analysis paper co-authored by Ioannidis, entitled "Effectiveness and harms of seasonal and pandemic influenza vaccines in children, adults and elderly", the primary conclusion was (Ioannidis's own words): "Most influenza vaccines have been shown to confer some protection against naturally acquired infection and no evidence for major harms has emerged. In adults and children, the efficacy/effectiveness of current seasonal vaccines was generally high for laboratory-confirmed cases (especially for LAV in children aged 2-17 y), and modest for clinically-confirmed cases and for the elderly." - Dr. John Ioannidis

[@Dan-iy8ig]

@@davidmauro I can say the exact same thing for vitamin d3, except my body needs vitamin D, it doesn't need a concoction of poison called a vaccine

[@foggymedia]

Wonderful how a mainstream prof at Stanford is questioning the whole mainstream paradigm and vested interest culture of mainstream medicine and medical practices. I'm surprised though he hasn't yet got the boot.

[@JCResDoc94]

20:30 Therenos - all old is new again (Thanatos)

[@romanszefler7479]

How do we chenge that hmmm... ? Just one qestion who pays for any research and what do they expect of it? Always follow the money and eager to control

[@JCResDoc94]

then they will rush to replicate to not have to think for themselves. all gr8 ideas

[@Saed7630]

Excellent on target points!

[@RefugeeOfModernity]

he doesn't even mention that he was the first person to call out Theranos. what a great, humble man

[@laurachristensen9126]

Interesting listening to this now, in light of the COVID situation, where a participant in the back ground is sneezing over and over and over......

[@CJinsoo]

Yes, amazing how covid-19 political football has made people suspicious and fearful of seemingly normal activity. Sincerely, Seasonal hay fever

[@romanszefler7479]

It's so disgrace that most of clinical MD stop having Curiusoty

[@peterdowney1492]

How many had data available? 0. How many had a protocol available? 1. Let's be optimistic, that's 100% - don't knock it!

[@kcreagan9799]

Finally, now in 11/2022 the CEO of Theranos, EH, is going to prison for 11 years. Finally, some justice altho it should probably be 30 years.

[@JCResDoc94]

15:40 useful & safe - dangerous & harmful on reanalysis

[@anonaki-mt6xb]

The Lancet ranked themselves squarely within the ranks of the National Enquirer since the great Covid Plandemic. See Event 201...

[@donaldsmith6804]

In Engineering, we have to consider a factor clearly missing from Professor Ioannidis' claim of overreach in the reaction to the Coronavirus pandemic, which is the "significance of failure." I applaud your contributions to society, I deplore your dissemination of erroneous accusations of overreach, which I also question as a politicization of a tremendously horrific occurrence in the already limited existence of mankind.

[@keithwhitlock726]

Incredibly poor math for an engineer. The virus has run it's course in China. 3,200 dead. That is less than 1/10th of the death toll of the flu in America during the same time interval, 34,000 plus. Wuhan has na population of 12,000,000 and is the transportation hub of China, nicknamed the Chicago of China. Taking into account the housing, sanitation, food handling, and medical fields of China, this pandemic is the definition of hype and propaganda.

[@Kerpeles]

That lip smack 🫨🤯

[@naseralriyami2568]

Discovery is a nuisance 96% of clinical papers since 1990 documented “significant” p-values and claimed to discover something new... Most “discoveries” don’t end up with any new “solutions” to help change clinical outcomes There’s a difference between what is “statistically significant” and what is “clinically significant” but we don’t have a standard way to differentiate the two yet...

[@shanksdante]

is he NASA partner?

[@judden61]

Give a like if you're here for an assignment.

[@RefugeeOfModernity]

what a great man. so underappreciated. he doesn't even really say that he was the FIRST person to publicly call out Theranos in a serious way @ 20:30