DeepMind AlphaFold 3 - This Will Change Everything!

📝 Check out AlphaFold 3 here:
dpmd.ai/yt-tmp-alphafold3
📝 Or try it out through AlphaFold server for free:
alphafoldserver.com/
This video was made in partnership with Google DeepMind.
My paper on simulations that look almost like reality is available for free here:
rdcu.be/cWPfD
Or this is the orig. Nature Physics link with clickable citations:
www.nature.com/articles/s4156...
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#AlphaFold3 #AlphaFold

[@Hitjuich]

Alphafold changed bìotechnology forever. This is huge! Looking forward to working with the new version

[@Z0MBUSTER]

Could it be also used as "chemtrails" to "eat" CO2 from the atmosphere to transform it into a harmless gas?

[@ScottzPlaylists]

​@@Z0MBUSTER God designed molecular nanomachines to do that, it's called photosynthesis❗ No human involvement needed. If we have twice the Co2 in the air one day, plants will grow twice as fast. Co2 is a harmless gas --- and we would die without it. Don't believe the propaganda. Historically, Co2 levels have been much higher in the far past. ❗❗❗❗❗❗

[@dertythegrower]

We have done this foldingathome using gpu since 2002... hardforums team, especially. We used to teach people how to do it at home, long before bitcoin mining using gpu, which we did back when bitcoins were useless except to other bitcoiners.

[@dertythegrower]

​@@Z0MBUSTER co2 is not the issue, its methane... many commercial growers ON KZbin dump co2 into grow areas, and a lot of it escapes. Methane from factories and smog byproducts is far worse....and a major concern, which breaks down into more co2, ironically.. you can capture it in a balloon shape object, and power generators. Methane is 28x worse greenhouse gas than co2.

[@juhor.7594]

​@@Z0MBUSTERone big problem with this kind of climate engineering is that it's hard to predict what long term side-effects it can have. I imagine that the plastic-digesting example can't be used outside of highly controlled environments.

[@itsjusttmanakatech1162]

I wasn’t impressed until I heard AlphaFold had implemented Dark Mode. What a time to be alive!

[@austinvw1988]

I was literally about to make a joke lol

[@Ren33469]

I've been waiting for BOINC to add dark mode for a while😂

[@hrihori_art]

"Dark Reader" extension for browser (free)

[@snooks5607]

fairly big reason for why I've been using mostly linux since the 90s was inability to control blinding background colors in other OSes. now 20+ years later windows11 and macos are finally able to display most window contents with dark background, it was a pretty momentous achievement (their highly paid UI/usability "experts" are idiots)

[@crubs83]

Just imagine where we'll be just two papers down the line!

[@Favmir]

4 minutes earlier than the official Google deepmind channel? That was indeed fast, you're right

[@TwoMinutePapers]

🙂

[@JohnDontFollowMe]

TwoMinutePapers be like: *sniffs white substance*, "lets read these papers!"

[@asdads3948]

@@JohnDontFollowMe I think our man needs the white substance to get *down* after reading a really good paper.

[@realmetatron]

Version 4 can fold your laundry. Version 5 can cut onions without crying.

[@xaroz904]

version 6 can out-pizza the hut

[@marcomoon6062]

Wearing contacts keeps you from crying over dead onions

[@EdT.-xt6yv]

Version 8 will get the fusion reactor going,,,

[@johnjones8330]

This is Nobel prize, Turing award level work and “Dark mode!” Life is strange.

[@dibbidydoo4318]

well you don't award those until after the chickens hatch then you count them.

[@LarsRyeJeppesen]

Dark Mode alone is enough for a Nobel Prize

[@merlijnfolkerts3066]

Stuff like this saving lives is why i am going to study artificial intelligence when im out of highschool

[@TwoMinutePapers]

This really made my day. Thank you so much! 🙏

[@pandoraeeris7860]

Artificial intelligence will study YOU!

[@gato_omega]

you could already begin studying it! I started learning how to program even before high-school , and I now realize that although I didn't have a real clue of what I was doing back then, it actually helps a lot to already be in the water 😃

[@MecchaKakkoi]

Why wait?! 🙂 A good grounding in high school maths will get you a long way in AI

[@KatoNamus]

This is where you learn to be a wizard, Harry! (PS: Ignore the trolls under the bridge, concentrate on your studies).

[@thunderinvader9031]

What a time to hold on to my papers

[@ElOroDelTigre]

I'm around 50 now and seeing that the field I love is doing real change (not in a "generating revenue" way, but in actual "improving humankind" way) brings a tear to my eye. Maybe a 20-something years old kid does not realize how big this is, but for me it is, truly and marvelously, an amazing time to be alive. Gives me a bit of hope that before I kick the bucket I'll get to see some of that utopian advancement and eradication of diseases we used to dream about.

[@_sky_3123]

I am 30 ad I too am amaized. I remember reading SCI-Fi books where we were able to simulate proteins and their interaction. And you could give a cancer genome to the computer and it would give you a blueprint for protein that is poisonous to the cancer, but not to the host. (So like a perfect cancer treatment, you just had to drink/inject the "poison" :D) And now I might live to see something like that come to life.

[@tortysoft]

@@_sky_3123 I'm 66 :-) Need I say more? I hope I can extend my time being alive. Could it fix Long Covid please? I'm less than a bit alive at the moment, I'm after quality rather than length, but I'll be happy with both !

[@ksprdk]

What could be a scenario that you could imagine happening now after this? And when? :)

[@ronankearns381]

20 smth college grads are developing AI lol

[@squamish4244]

I'm 45 and hope that this means that our generation will not have to endure the chronic illnesses of old age that plagued our grandparents and are hitting our parents now. Maybe this means Alzheimer's and dementia will not end up costing TRIPLE what it currently does by 2050, which it will according to current predictions. And maybe even reverse aging to some extent. AlphaFold - 2018. AlphaFold 2 - 2020. AlphaFold 3 - 2024. Nobody saw anyo of this coming a whole _six years ago._Who even knows what's coming now.

Bet AplhaFold 6 will be folding reality itself 😎

[@Argh0pirata]

not if it keeps being closed-source with carefully curated examples

[@globurim]

It will fold my mind into smithereens.

[@frederickmiller6431]

You are AlphaCreate 6 duhh this is what the Egyptians knew how to craft reality

[@thegreenxeno9430]

Alphafold 6? More like Betafold 2

[@NuclearTopSpot]

@@thegreenxeno9430 Sigmafold Ohio Rizz edition

[@PranavPunuruFilms]

i'm pretty sure they're participating in CASP16 because of this. My lab is participating too. We just agreed that they've already won

[@azrael5648]

ChatGPT was fancy. Now this. This is revolutionary.

[@DreckbobBratpfanne]

It's gonna be massive once we can combine these, either a next gen chatGPT helping to create a next AlphaFold or direct chat to Protein 😂

[@w花b]

Yup. A guy that's all talk but this is all bites

[@magpielive]

Well its takes 12 to 15 years become undisputable like the journey of iPhone 1 to iPhone 15 . They are just started there main objective is to make AGI if agi come it revolutionise the humanity .

[@dexio85]

It's not. Just a few % over last technique. The guy is presenting it as if it's a second coming of JC. Probably because he partnered with Google on this. Google has sunk Billions into Deep Mind and the shareholders start to ask questions. They are trying to make their investment look good.

[@eprd313]

​It's coming faster than you think. They call it the technological singularity

[@Sashik]

Oh I'm holding onto my papers now

[@Rajivrocks-Ltd.]

Everyone is talking about LLMs, But this is really where impact to the future is being made!

[@tingtonggamer4901]

This is made by an LLMs you know that right "Alphofold AI"

[@tingtonggamer4901]

LLM*

[@Rajivrocks-Ltd.]

@@tingtonggamer4901no, I was correct

[@Rajivrocks-Ltd.]

@@tingtonggamer4901 Oh really? I haven't read the paper. Thanks for pointing it out, I'll check it out

[@mark9294]

LLMs are at the root of all these developments. Their emergence is an epochal event

[@kaspernordlund6828]

I get shivers every time i work with alphafold! to think that it is free. A true testement to the Greatness of human civilisation!

[@lucasreis6251]

Hey bud! While watching the video I had a question pop up, and seeing that you work in the field maybe you know the answer: From what I could understand, Alphafold is able to take "letters" as input (aminoacids or something like that I believe, but correct me if I'm wrong), and outputs the 3d shape of them right? If so, how does that helps with development of things like, the plastic eating enzyme, and other things? Wouldn't you already need to know which letters to use beforehand? How does knowing the shape of everything affects the development? Pardon me if I'm saying nonsense. I'm an automation engineer and know almost nothing about biology.

[@jadynhasstupid2275]

@@lucasreis6251you look slightly autistic

[@bolatm22]

​@@lucasreis6251 answer of ChatGPT: Yes, you understood correctly. AlphaFold takes a sequence of amino acids (these are the "letters" in proteins) as input and predicts their three-dimensional structure. This can help in the development of various biological processes, such as creating a plastic-eating enzyme or other enzymes. Knowing the three-dimensional structure of a protein can help scientists understand how it interacts with other molecules and what changes in its structure could improve its functionality. Thus, even if we know the amino acid sequence beforehand, predicting the three-dimensional structure aids in understanding its function and designing improved versions of the protein.

[@kaspernordlund6828]

@@lucasreis6251 So yes you are abselutly correct, you would need to know the amino acids beforehand. That is luckily a pretty standard thing to get to know. You can do a buch of differnet test (like mass spec) to figure out what amino acids and in which order they are placed. The almost impossible part to figure out is how the protein folds. It has been a core theory that the the chemistry of the aminoacid chain is what makes proteins fold in specific ways and hold their shape and activity. But breaching the gap from sequence to folding is a huge task that until alphafold many times took years of research to figure out. What most people did to get as accurate readings as alpha fold was to do crystalografi. That is a very complicated task that needs pure crystals of your specific target protein, which was almost more art than science to make work honestly. Alpha fold skips this years of wait and hard labor, letting us play with how mutations affect folding in a timeframe of hours. It is hard to overstate the impact of this ability in research. Hope this answered your question ^-^ edit: realized i didn't answer your question about how protein shape affects development. All proteins have basically the same amino acids in them. The amino acids are actually not what makes proteins able to interact in a biologically active manner. It is the shape of the protein that does. So to know how a protein interacts chemically you need to know how it folds, and not what amino-acids it has.

[@andydataguy]

​@lucasreis6251 love the curiosity. Great question! I hope the gentleman responds

[@larrychanhangpei9292]

You made me love papers and start reading it. It means a lot to me and thank you for the excellent work as always!

[@TwoMinutePapers]

This really made my day. Thank you so much! 🙏

[@ajay_krishna]

Same for me.

[@projectarduino2295]

If a protein can be manufactured to repair human dna, or to recover damaged telomeres, that would probably one of the most impactful biomedical results of all time. To help the elderly regain their strength to live healthier and longer lives by reducing cellular damage and cancer risks would be profound. I recently lost my grandfather because of age related weakening and loss of autonomy. If something like an enzyme injection could have kept him more autonomous by keeping his fatiguing body healthier, he might even have been alive today. I lost all my other grandparents to cancer, so if dna repair could help inhibit cancer development from mutation, it would be amazing to see no one ever have to go through what I have gone through again.

[@js_es209]

Death is inevitable and so is the timing of it. Will take u time to understand..

[@antongazizov8473]

any sources?@@js_es209

​@js_es209 Death may just become a probability that can be mostly mitigate. One day you'll understand.

[@Gelatinocyte2]

Our cells already contain proteins that repair damaged DNA. The reason we're even dealing with cancer nowadays is because we live long enough for one to eventually develop in our body, and our own repair systems can't keep up with the rising amount of damage we are now sustaining: carcinogens in the air and in our food, irregular lifestyles, and overexposure to substances and radiations that humanity had otherwise not have access to prior to technological advancement. Without those three conditions, our body's own proteins is probably more than good enough to protect us from cancer, although growing older still means increasing likelihood of developing cancer (because that's just the inevitably of aging).

[@valberm]

​​​@@js_es209 not really. There are ways, at least in theory, to become what they call biologically immortal. So, while your assertion may still be true on this day and age, maybe in the future it won't. Ok, probably real eternal life won't be achieved or even desired, but, periods of time which we consider to be long enough might be in the future.

[@Rkcuddles]

Absolutely love these longer videos. Can’t get enough of your enthusiasm and the paper news

[@EVILBUNNY28]

I can imagine a system that can sequence your personal genome and through tons of training be able to discern how exactly you’ll react to certain drugs and what dosage you need. It’s crazy to look back at how far Medicine has come in the last 20 years, it’s impossible to even begin to image the capabilities in another 20 years time. All advancements start somewhere, and releasing a paper is usually always the first step

[@notsojharedtroll23]

That's is a very cool concept 🎉🎉🎉

[@scoutbane1651]

You just re-invented the field of pharmacogenomics, congrats. I can literally go do said test right now. It's just currently in its baby stages. I got offered to do said test for 500€ by my psychiatrist, with said disclaimer. The tech will only keep getting better though and once your genome is sequenced, they can just update the treatment with any new way to analyse it.

[@alexandregaultier8313]

Do you have any need in mind ?

[@johanlarsson9805]

Wow, DeepMind almost listened! I've told them since releasing AlphaFold that what is needed is a neural net that predicts the structure of a hypothetical ligand for some selected area of the protein. Meaning, you give it sequence A and it calculates structure B. You would then highlight an area on B that you want to bind to (like the reactive site of an enzyme) and it will then generate ligands that would fold in such a way that there would be geometric and chemical affinitiy with the highligted area. This isn't exactly as good as that, but atleast we are getting the joint structures, which is an improvement. Anyone with connections to DeepMind, please share my feedback with them, seems they have not seen the comments/emails during these five years.

[@cureadvocate1]

Seeing AlphaFold 3 design ligands to help the brain and spinal cord regenerate would be cool, as myelin (and a few other tricks) inhibit neural regeneration Another interesting use case: exploring SIRT6 variations, its impact on aging, and finding ways to enhance its functionality.

[@alphaomega154]

it WILL HAPPEN.

[@shezcmayo]

Finding effective remyelination therapies to help people with MS like my daughter.

[@krox477]

Are you talking about Lizard man

[@dawiedekabouter5733]

If that as a medicine can be programmed into a fruit or vegetable or maybe a group of fruit and vegetables eaten together that can be grown it would really be amazing. Also changing the snakes DNA so it can have hands and legs and fruit from a tree that can help women reduce the pain at child birth and robots that can do the hard labour in the sun whose hands cannot be pricked by thorns.

[@lacklvster4512]

im so glad that i was born at JUST the right time to enter college for biotech in the infancy of all these new programs. cant wait to actually work with them later in life

[@vectoralphaSec]

Yeah AI will revolutionize Biotechnology forever.

[@CloudCoderChap]

You’re our future and I wish you luck.

[@bluesmanshoes]

I recommend working with them now already!;)

[@haianabou-karam4430]

Hary! AI will work alone when you finish the university! SUPERINTILIGANCE

[@spambird68]

Amazing work again from DeepMind! As a protein researcher, I'd love to see custom enzymes designed to bind PFAS, or the 'forever' chemicals that interrupt biological processes. Designing an active site to break them down chemically would be next level, but difficult due to the chemistry involved. However, there are other pesky environmental toxics listed as the Stockholm Convention Persistent Organic Pollutants (POPs), that may be more attainable. AI to design enzymes to breakdown environmental toxic chemicals? Sign me up! I'm in.

[@JohnVance]

I wanna dump truckloads of this on old landfills, come back in a few years and maybe it'll all be free compost...

[@alexandregaultier8313]

@@JohnVance I guess that it won't work like this before some time.

[@and_I_am_Life_the_fixer_of_all]

Got my hello world on the AlphaFold 3 server!! Thank you for this video Two Minute Papers! WHAT A TIME TO BE ALIVE!

[@WackyGameEngineer]

I hope longevity medications coming soon for mum and dad :)

[@goodfortunetoyou]

100% agree, I think research on interventions to the aging process needs much more attention and funding.

[@davidpereira9058]

Same, my dad is getting super old!

[@nic.h]

Pretty sure that would come with a rather large can of worms.

[@GaryMillyz]

@@mnomadvfx Nope- they will take human volunteers on their death bed.

[@brexitgreens]

Why for mum and dad and not for individual men and women? 🤨

[@JoshTheWhale]

I fold my papers... Too good... ... and actually Imagine where we'll be just two more folds down the line!

[@bvoros361]

41 more folds to reach the moon!

[@postscriptum9856]

I thought it’s impossible to fold paper more than 5 or 6 times?

[@acpatel9491]

Nice information..! Thanks for the video. I am an old dude, but still love to see the progress.

[@KnightsWithoutATable]

This is huge. There are so many illnesses that we know what the mechanism is right down to the proteins, but we just don't have any drugs for that are effective other than for treating the symptoms. This could also allow us to precisely target treatments to the illness much easier.

[@cyborgar15]

Curing people doesn't make money. Creating new illnesses makes money..Guess which one is coming your way..

[@andynonomous8558]

Sigh, it's amazing how everything is about to 'change everything' and yet nothing ever seems to fundamentally change.

[@samuelgibson780]

If you had a president take a space race approach to this technology you'd see a lot change. Something like "let's fundamentally eliminate biological failure as a cause of death within 10 years", and throw space race money at it, and you'd probably be able to pull it off. Would require a lot of planning though. Problem is that much more is *possible* than anyone has the authority or administrative capacity to implement, when it comes to all that sci fi stuff. Would require a society making a decision, which is a bigger barrier than the technology itself at this point.

[@user-mp8fd8em3z]

Our politicians do not work for the people. They work for corporations. That's why they're trying to be careful not to eliminate just worker jobs but also not make their industry or business obsolete in the future. They are going slow not only to be safe but to line their pockets with profit

[@adissentingopinion848]

I mean, we said the same thing about the internet and the smartphone. Sure we have hype about eventual flops like NFTs, but you can't say something like email hasn't fundamentally changed the world in 30 years. And even stuff like enzymes are all in your detergents and your cosmetics. It doesn't change until it does, all at once.

[@andynonomous8558]

@@adissentingopinion848 Sure, but one just tires of the constant rhetoric that everything is always being revolutionised while day to day life is more of a struggle than ever. I think we just need to tone down the rhetoric a little.

[@tachywubdub2469]

It is also a game of patience. Lots of these are like designer custom made parts. You'd need to market it to scale it up enough for people to afford it, and that requires large initial funding... Which requires a Monetary incentive to do it. Basically, unless the enzymes break plastic into gold or companies/people(worst case) are taxed for plastic waste accumulated, there is no incentive to break down plastic until it is a dire threat

[@mehakmittal]

This is incredible! I really hope all undergrad colleges could incorporate Alphafold-3 in their research so that the students of this generation can take advantage of this revolutionary technique!

[@StandardName562]

I have been using AlphaFold 2 for my thesis and it helped me so much understanding the protein I was researching. I am so hyped for this ❤

[@Oriell]

What a time to be alive! 🎉

[@jamesmorrison4976]

Just company bullshit. Protein folding accuracy needs much more than only this program. They just sell nonsense!

[@AA-iq6ev]

And the Nobel prize goes to Alphafold! - in what? - yes

[@anmol1713]

Very excited, I am working on a project where i used AF2 to predict better binding antibodies mixed with some reinforcement learning. I emailed everyone I know in university about the AlphaFold3, so excited.

[@lucasreis6251]

Hey bud! While watching the video I had a question pop up, and seeing that you work in the field maybe you know the answer: From what I could understand, Alphafold is able to take "letters" as input (aminoacids or something like that I believe, but correct me if I'm wrong), and outputs the 3d shape of them right? If so, how does that helps with development of things like, the plastic eating enzyme, and other things? Wouldn't you already need to know which letters to use beforehand? How does knowing the shape of everything affects the development? Pardon me if I'm saying nonsense. I'm an automation engineer and know almost nothing about biology.

[@user-nl4el8fc8q]

@@lucasreis6251you are right，but same ‘letters’ can consist different shape and this shape detect different fraction.

[@gumanelson2007]

​@@lucasreis6251i have a rough idea but lets wait for him His must be better

[@vitalyl1327]

The very fact that AlphaFold even works is huge - it means that behind the insanely complex Van-der-Waals physics of millions atoms interacting, there is some really good analytical approximation hidden with a tiny computational cost. If machine learning could uncover such a system, there is a good chance that we'll eventually discover it analytically, and this will be the real game changer.

[@pavguy]

Have been following Deepmind since Alpha Go days...and am really inspired by their AI for Good approach. Thanks for sharing it. Do consider doing a AMA online sometime for all of us. Cheers

[@SOTPOD]

what a time to be alive! thank you so much!

[@TehNetherlands]

Folding on to my papers!

[@David-ct]

Honestly I would like to see some annotations about the function of the differents parts of each protein structure. That would be so cool!

[@mattbrandon9157]

had to mute the voice and turn on cc but in the end it didn't matter cause i really didn't see the big deal . guess i'm not well informed about this whole protein folding science.

[@jamesmorrison4976]

I think it is merely bs. Protein folding by computer is not precise enough - a lot of interactions (h-h bridges) are just crudely approximated and you still would need a super computer as a neural network even bigger as every element of the universe to make it fold like in real time. The most precise models are when you combine protein x-ray crystallography with protein folding programs.

[@PlaylistsOnly-ox5hp]

I've already told you, but I'll tell you again: you are doing a lot to make tomorrow a better world, an enzyme to recycle plastic. The world lacks people like you.

[@scottmiller2591]

Ligands for breaking cellulose out of wood for paper manufacturing that reduce smell and waste discharge.

[@XiangWeiHuang]

can it help to make cat girls

[@JohnSmith762A11B]

The highest of all high technologies; the final technology man will ever invent (because he can't be bothered with anything else after that).

[@yakirfrankoveig8094]

It can make all the proteins but i dont think it can use them to build your cat girl

[@wlockuz4467]

I can't wait for the applications of these models to never make it to general use because of politics, or have them completely monopolized by big companies.

[@umbertomann]

Great video as always! I have a question. Is there a platform I can "subscribe" to read new papers in my fields of interest? AI, Psychology, etc. What are some good platforms I can subscribe to? (I am not a university student, so I don't have access to the main libraries of papers without having to pay for them 😢)

[@JankJank-om1op]

arxiv

[@Ikkarson]

Will these systems be leveraged as commons for the better of mankind, or foreclosed by a bunch of heirs atop predatory funds? I am positively happy that such progress is made, and ever so pessimistic about who will reap the benefits.

[@smellthel]

This is one of the coolest things I've heard of in my life.

[@sedthh]

all of life's molecules mapped

[@FlySpleen]

"How could it possibly be better?!" As a protein scientist I can safely claim that AlphaFold2 was useless to me. Very happy to see the research charging forward in this field

[@jan7356]

This.

[@jamesmorrison4976]

You should know (as a protein scientist) that those computer simulations are still not even close to predict accurate folding of a protein!

[@travellingsarek3982]

I love your podcasts even thought I cannot understand much. ❤

[@Sonny_McMacsson]

"Letters go in and a 3-D structure comes out. You can't explain that."

[@perplexedon9834]

Dude! I'm actually flipping out at this bar chart!

[@SteveRowe]

I'd like to see an enzyme that could break down interstitial amyloid plaques to prevent or slow the progress of Alzheimer's.

[@4grammaton]

Amyloid plaques appear to be a symptom of AD, not a cause. They seem to be a kind of defensive or homeostatic mechanism in response to insufficient nutrition in brain cells, with the function of downsizing brain volume to keep more important areas of the brain well-supplied. Treatments which reduce or prevent amyloid plaques have shown to be ineffective, and in fact counterproductive, in halting or reversing the progression of the disease. Tau protein tangles and buildup of protein in cerebrospinal fluid during the prodrome of the disease seem to be more material to the pathogenesis.

[@SteveRowe]

@@4grammaton Interesting. I read (5+ years ago now) that the plaques naturally build up and eventually encroach on synapses. I will refresh my knowledge.

[@4grammaton]

@@SteveRowe Please do, and feel free to inform me if what I said is inaccurate. I also remember reading that plaques are found even in the brains of young children.

[@ludologian]

Pardon me if I got this wrong, so now it can predict complex molecular structure ( that are docked into proteins)? And if so .. does it use a docking engine or it can predict molecular shapes only ? or randomly generate 3D structure[ from noise] for predicting a complex protein structure ( no docking required)? Only two input ( protein+ mol ) like blind docking methods

[@E2_1B]

Thankyou for sharing!

[@__SKYNET__]

Fantastic paper, thank you

[@derasor]

Definitely looking forward for other molecules, along with their interactions (the dynamism you referred to) is imo the most exciting possibility. The fact that this may be doable in the next few years, given these truly amazing developments, is just totally mindblowing.

[@bloodbound696]

I LITERALLY Made a 5-page paper.. on mealworms specifically superworms that broke down plastics and got calories from them and were able to reproduce from the plastic diet thanks to their enzymes. Finally, this is getting attention, making those enzymes into like an artificial stomach to at least turn plastics into Glycol is better than nothing!

[@EaziGX]

Meanwhile Apple has made a squeezable pencil

[@gumanelson2007]

😂😂😂😂

[@aperson2730]

Thanks for the info 👍🙂

[@Filaxsan]

The "tree bark" truly killed me

[@sobbski2672]

Best part of this was them supplying all the pseudo code and training datasets. Hopefully Rosetta Commons will drop an open source version soon

[@robertoaguirrematurana6419]

Just a few more papers down the line and it'll figure out abiogenesis, what a time to be alive!

[@marcelinomoreno4506]

Can it predict computer algorithms? Or maybe simulate constants if they had different values?

[@danypell2517]

this is crazy exciting for the next update damn

[@aleipiano]

This is beautiful!!!

[@SevAbante]

Alpafold: we made something that will change the world Government: 🔫

[@test-uy4vc]

What a protein time to be folded alive! 🎉

[@dref_one]

Amazing! What a time to be alive! 🧬

[@snailedlt]

What a time to be alive!

[@weishenmejames]

I "held on to my papers" and am impressed

[@sebby007]

Thank you for your work!

[@JNJNRobin1337]

i want to 'test' that sima model. it plays games, after all; what can it do? *What are its limits?*

[@vincentpelletier1246]

I love how in a couple of years, all of this channel's content will definitely be done by AI. Even his voice sounds already auto generated already. What a time to be "alive" !

[@leejerrett8268]

How dare you! Only a human is capable of sounding this stilted and unnatural! XD

[@brexitgreens]

I want Dr Károly's voice in GPT-4o.

[@brexitgreens]

I want Dr Károly's voice in GPT-4o.

[@chipotle2417]

How did they come up with these building blocks in the Pairformer module? Astonishing work!!!

[@MaybeTogether]

This kind of progress may be more important than all those other AIs. Medicine > Other stuff

[@loremipsum9448]

Have you tried if it is not only over fitting dataset?

[@aidenaune7008]

we are on the verge of custom gene editing at home, creating our very own new species, forming single cellular life to perform tasks, and even optimizing the genetics of our own children.

[@ajaykumar-ve5oq]

great progress lets see if it can bring back hairs

[@academicalisthenics]

I love our human ingenuity! ♥️

[@NostraDavid2]

Does that mean that Folding@Home (as a project) effectively has been deprecated? Or do these two projects do different things?

[@MatthewMcKenna1]

Do you plan to do a video on the KAN: Kolmogorov-Arnold Networks paper?

[@ShanilPanara]

Absolutely huge!

[@spinninglink]

HOLY mother of Fpapers!

[@goodtothinkwith]

For the non-biologists here (myself included), how close does this get us to designing more specifically targeted drugs without undesirable side-effects?

[@andreavitale2845]

A friend of mine is curious to know, too.

[@jamesmorrison4976]

In a nutshell: To predict correct protein folding is absolutely insane. In reality: You need actually to concentrate the real protein and use x-ray crystallography and a simulation like this to get a quite precise glimpse how it fold. I think this advertising for this program just ignores that. A solely simulation can’t predict folding of a protein (not even close). Peptides (very short proteins) are eventually possible so take this advertising with a grain of salt. Yes it will fold your proteins and give you some insights but no real scientist would put their hand into fire that he/she trusts a program like this.

[@simonpenelle2574]

WOW this is amazing. Wonder if we can build a text to protein transformer with this technology to find new proteins based on textual descriptions of use cases and associated receptors...

[@OperationDarkside]

What a time to fold proteins!

[@lemonke8132]

Can alphafold be used to design an enzyme which direct captures CO2?

[@coloryvr]

This seems to be great! WOW!

[@Youften]

question to any scientist reading this comment of mine; can this program also be used to understand viruses and their inner working? im specifically interested in autoimmune deceases and their potential causes. e.g. lots of research suggests the EBV could be a factor in MS. do i understand this correctly, that this technology could help understand these microorganisms, microstructures etc? and ultimatly help us cure some of these debilitating deceases like parkinson, alzheimer ms etc? or is there still a piece of the puzzle, pieces of technology missing.?

[@TetrahedreX]

How many times has something changed everything without anything actually changing?

[@nicolaslima3724]

this arrived way earlier than i imagined :0

[@viniciusmoura9105]

In 2004 I was ingressing University to course Biological Sciences. If you asked anyone there how much time they'd think it would take for mankind to see an applicable tool with the capabilities and accuracy of Alphafold you wouldn't hear "20 years" even from the most optimistic.

[@PS-vk6bn]

Awesome!

[@lakshyarajkhatri]

Any idea how to get pdb files it is giving Jason files

[@matthewpena4169]

Has anyone shown that the ensemble of alphafold solutions (slightly different because of the inherent randomness of the process) represent different states of the dynamic structure?

[@debayondharchowdhury3001]

Holy Mother of all Papers...

[@RoulDukeGonzo]

I'd like to repeat the seminal work of Chothia and Lesk, laying the groundwork for protein structure biophysics with a couple of dozen protein structures in the 1970s, re-applied to the vast universe of new protein structures. This would be a tribute to the late Cyrus Chothia, who saved my PhD (and probably my life).

[@marcosfuentes980]

I would love to see it use to create a nootropic, some thing like the NZT-48 of limitless

[@zelrex4657]

Can it work with multi stable protein structures now?

[@4kirsten]

What are the processes for obtaining ethical approvals for new applications of this technology?