Ketamine in Psychiatry: How It Affects Depression, Anxiety, and More (Introduction)

Ketamine, an anesthetic and pain reliever, has rapid-acting antidepressant effects that last 3-7 days after a single dose. Those effects are present even in a large portion of treatment-resistant patients. Efficacy has also been shown in anxiety, bipolar disorder, PTSD, and OCD.
PDF of the review article: drive.google.c...
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[@TheDrugClassroom]

It’s nice to be back! This is the largest project I have worked on so far, as it includes a 250-page review article that goes into much more detail about ketamine’s efficacy in multiple psychiatric conditions, along with its mechanism, safety, background information about depression, comparisons with other drugs, and more. The article is linked in the description. Additional videos will also more comprehensively cover ketamine’s mechanism and its use in psychiatry.

[@willbrown1220]

It’s nice to have you back!

[@christopherthibeault7502]

This is the first video since I Subscribed and Bell'd your Channel. You should up your timetable, because hearing about the possibilities of Ketamine (something I had not heard since the House MD season two finale) has renewed my hope in there being a more viable alternative for treating bipolar depression than quetiapine fumerate, which has a nasty side effect of total insomnia if you go off of it for just a couple days.

[@TheDrugClassroom]

@@lenorevelez6563 It works.

[@emd344]

@@lenorevelez6563 Can vouch that it works. I've been getting treatments for the past 7 months and it's worked better than any of the 886533677 antidepressants I've been on.

[@thekiwiclipper1113]

So happy you’re back❤️

[@thechief5670]

The Drug Classroom was in a K hole for 6 months now he’s back, glad to see you again.

[@imreallydead.23]

😂😂😂

[@bond6132]

This comment deserves more likes 😂😂

[@iamup5et]

😂😂😂

[@Granitte]

Holy Halibut, it’s The Chief! K holed in makeout reef! WOO HOO HOO

[@CH0MP4]

if only

[@bulkbogan4320]

They should replace fluoride with ketamine in the water supply..

[@alberthofmann2911]

Relatable

[@mroinoin]

idk man id rather be retarded and filled with estrogen than have tht shit recrystalizing in my bladder everytime i drink water until im pissing blood

[@bulkbogan4320]

@@mroinoin ok little boy.. you know so much..

[@mroinoin]

@@bulkbogan4320 i dont but i do know ket recrystallizes in da bladder and causes problems in long term users which would b everyone drinking tht water

[@spitzkopflarry159]

I‘d rather have a calcified bladder than a calcified pineal gland

[@mike-0451]

He's alive

[@PseudonymAliase]

can you start using motherfuka at the end of your sentences? I think it would fit your photo better!

[@gmrads]

Glad to see you back with such a fascinating topic! Hope everyone is doing well.

[@lrrrruleroftheplanetomicro6881]

Much better since the Ketamine, thank you! ;-)

[@jbuddyman]

Damn you're voice seemed to gotten deeper. Couldn't have been that long since your last upload

[@o00thunderhawk00o]

maybe new mic

[@emd344]

Our little boy is all grown up

[@vwluvin9164]

Or some trt

[@krabbelton]

homies balls dropped

[@sean..L]

He's been experimenting with drugs and his voice has changed as a side effect.

[@anitabath8315]

To bad I couldn’t share this during the LEGO yoda hype.

[@samueldurham3709]

Your dedication really shows TDC, thank you for your videos. I've learned so much important information

[@jakehobey1346]

If it wasn't for this channel, I would have watched too many friends die due to overdoses and stupidity. Thank you for the information an knowledge!

[@jaybird8009]

So good to have you back!!! When you get time away from college. Could you do a video on vicodin or ativan?? Or the potent blood pressure medication propranolol??? You rock dude!

[@davidmelendrez5489]

This is one of the most widely anesthetics, it deserves some respect. It's the best to handle depression and many more in no time. Quality also matters, get it taphpharma.com/shop/buy-ketamine-hcl-powder/

[@kalebdye4378]

You're finally back!! I missed you so much!

[@user-hy6hi7fg5m]

I had no idea this is what you've been working on for so long, but I'm so glad it is. This is also something I've been following for a while!

[@markog1999]

Best thing about having a night on Ketamine rather than Alcohol: You wake up less depressed instead of more. Stay safe people.

[@BongLeach]

So true! I'm happy, literally happy that ketamine is in my life!

[@jbuddyman]

Right

[@tytheguy1660]

I miss ketamine

[@rhaulsparrow6644]

Invaluable research for me. Thank you so much. Great timing as i was just looking into a ketamine treatment offered by psychedelic enhanced psychotherapy clinic in Toronto Field trip health.

[@steffenvongrabau7260]

I seriously admire the amount of work you put into you videos

[@bigchrispiness]

Welcome back

[@Lakobas]

You went hard on this bad boy. Fantastic

[@Brickinasock]

Hey. Thanks. I really appreciate this. I know you can't offer medical advice but this is infinitely more helpful than just being handed a bottle.

[@emd344]

Ketamine saved my life. So glad you covered this!

[@Blkac-pill-Black-Life]

Exactly mine too

[@TIGER-yq2og]

@@Blkac-pill-Black-Life how

[@thecuriousquest]

How long have you been depression free after ketamine?

[@emd344]

@@thecuriousquest I wouldn't necessarily consider myself depression free because I still have my battles with the disease. But I'm definitely doing far better than I did before ketamine. I finally found my will to live and to live the best that I can (most of the time at least). Definitely recommend.

[@ccrydurrr2958]

@@emd344 I was put on K after I died in the ER 3yrs ago, suffering a heart embolism due to the effects of Sepsis had on my body, creating a blood clot in my leg, where two out of three joint replacements had to be removed, leaving me in a wheelchair & using two canes to walk until I am able to have my replacements revised. It has been EXTREMELY challenging. I did not quite understand the severity of my situation until I was slowly weaned off of the meds that kept me in a drug-induced coma for two weeks. When I did come to, I realized that the HELL I went through was indeed a battle, SPIRITUAL in Nature, for my SOUL!!! It was a game changer. Then I found a temporary connection on the street last Spring & started experimenting with dosing. Having a Bipolar diagnosis, suffering from OCD, Depression & Anxiety for over 30years, K brought me out of that doom & gloom thought pattern, however the shit is so damn expensive. I live in the US & am currently residing in NJ but am a native NYer my entire life up until 4years ago. I am now 54 & am fed up with all the psych/pain meds that have me bound & gagged by Big Pharma. The results are in & I am now ready to change the course of events that actually led me to this video. What is in my best interest in finding a Dr. or a Hospital that provides K treatments, that hopefully will be covered under Medicaid(fat chance, huh?)........I appreciate any advice & I apologize for the long reply. Ty🙏💜🙏

[@documentofchange]

I AM SO HAPPY TO SEE ANOTHER VID BY YOU, SETH. I thought you dropped off the earth or got too busy being a big smart dude. Again, glad to see this. 👍

[@WildBillCox13]

Fascinating. Anxiety disorder here, with friends subject to Bipolar and Depressive states. Have liked and linked to my FB.

[@thecuriousquest]

Seth, thanks for the upload. Most of the videos uploaded have been docs (mostly anesthesiologists crossing into psychiatrist territory) plugging their infusion clinics. Admittedly intrigued by this as a means for resistant depression for myself. Thanks again! (Edit) and you probably have done more research than the docs pushing this stuff in the high dollar ket clinics. In any case, have to be grateful for the bold ones willing to provide an effective treatment. Hopefully, in time, as we gather more positive outcome data, insurance companies will become willing to reimburse for such treatments.

[@rwerwee]

The antidepressant effect reminds me of the week lasting afterglow effect of DXM

[@TheSaival]

they have similiar mechanisms, tho dxm has a stronger serotonin inhibition effects

[@Sebvibevanse]

@@RobLewis3 holy shit haha

[@Sebvibevanse]

that happened to me when I took delsym for the first ( and last ) time. HBr still has a long afterglow tho

[@TheMasterTelevision]

@@RobLewis3 oh shit, I just got perscribed a wellbutrin perscription. Time to go to the Robo-trip zone

[@cyrilio]

Thanks for these great videos. Video idea: a recent paper reported nitrous oxide use trials for PTSD treatment (another disso).

[@emd344]

Really? This is great news! I hope it shows the same promise as ketamine has with treating depression.

[@TheDrugClassroom]

Very interesting, thanks for the suggestion! I had not heard about the study.

[@heartspacerelaxations6924]

I think the thing is with the substance is it creates a therapeutic window of remission, in which to process and open up, and engage in compassion focused therapy and open up to positive social experiences in nature. I’d probably lean towards empathogens like mescaline / MDMA used in family group therapy, proffesionly facilitated.

[@Inresistant]

Could you do a video on the variation of effects displayed by different marijuana strains? Particularly the mechanism of action causing the change in effects.

[@rolandkloka]

I searched your videos a week ago for Ketamin... What a coincidence

[@paperslap47]

I love how ol boy (mr teacher) started talking about k and then went quite for 2 years, something got me thinking lol hes having a great time

[@SuperSeriousSayan]

started my ketamine infusions for nerve pain and treatment resistant depression a few months back and all I can say is... wow. I didn't understand how ketamine could be used in this way because i've done it recreationally in the past but it is a game changer. for the first time in almost 10 years I have hope again.

[@thetablecloth98]

Welcome back, missed u

[@lock123456]

Great videos as always. Nice to see you again man. We were staff on the drugs discord server and used to chat, hope you're well

[@maxwade97]

Glad to see you back Seth!

[@chanelbrixx8987]

New mic? Sounds kinda harsh on my ears, might be the echo. Welcome back though! I just came back from the khole to see this video. Perfect timing

[@TheDrugClassroom]

Same mic, but it has been a while since I last recorded, so the levels could be different.

[@cocoleti4474]

Omg he’s alive!!

[@FRIEDYOGURT-s4c]

Wow, I was in the middle of writing a piece in ketamine for depression myself, what a coincidence

[@jeffgorski6754]

So glad you posted this one! I went through 6 months of ketamine treatments about 2 yrs ago. I’m always interested to hear about people’s experience with this wonderful molecule.

[@birdlawyer6191]

Sorry about commenting so late, how was your experience with ketamine treatment? Why 6 months of treatment, did you not need it anymore?

[@jimmygervaisnet]

Congrats on your 250-page review, that's impressive work!

[@ToLWaM]

He’s back, he’s better than ever, and he’s picked up a ketamine addiction! Not talking about the drug classroom, just jordan peterson

[@eustacecranch]

so good to see you back!

[@H.R.E.A.M]

glad you’re back man!! very informative and educational as always! thank you for everything you do.

[@Simon-fm5gy]

So glad you published a new Video

[@BongLeach]

Much appreciated! Invaluable information!

[@alexandervangelderen8109]

Happy to see another video of yours!!

[@azaraniichan]

Very informative and well put together, thank you

[@justine8558]

anyone else binge these vids for fun

[@pablomarin-marquez1028]

Yesssss drug classroom i was wondering where you went man

[@sachk6065]

super interesting! i did research on this topic a while back!

[@hunterailey6575]

Dope I love learning from your videos 🙂

[@alexjoens5014]

I feel like having somthing take after on your depression that quickly would be overwhelming

[@MetalicSlayer666]

Memantine and amantadine are also good for depression especialy when coadministered with classic antidepressants

[@viz2790]

YOUR BACK!!! Please do a video on "2-FDCK" NOT "DCK". My anti-depressant effects lasted longer from 2-FDCK than normal Ketamine.

[@dylanparr6880]

2fdck is fuckin rad

[@typez5548]

Amazing video as always good to have you back. Your voice has gotten a lot deeper. Interesting . Sounds good though :P

[@nostalgictunes4445]

Seth can you do a review on the ADHD treatments avalible.

[@mysteryY2K]

What are your thoughts on the efficacy of other non-PCP analogue, ACH dissociatives such as DCK or 2-FDCK for the same purpose?

[@randomguy7503]

In my experience DCK beats S-Ketamine for antidepressant effects.

[@serenity_zero]

FWIW I've not tried ketamine (yet), but dissociatives like 2-FDCK, DCK, O-PCE, 3-HO-PCE, 3-MeO-PCE didn't work for my depression for more than a day (LSD and some common "antidepressants" didn't work either) :(

[@younganddumb6909]

@@serenity_zero smoke weed 💨

[@hyperboreanarchives7299]

@@younganddumb6909 No, that is not the answer. Although helping in the short term cannabis worsened my depression in the long term as well as impairing my ability to effectively cope with stress. I get that many people (including those I know) enjoy using it recreationally and that's fine; I just wouldn't use it to self-medicate for *_mental_* health specifically.

[@samskill9626]

I am not knocking the anti-depressant effects of ketamine or its importance... but isn't it weird how we have to show these chemicals have benefit for the most suffering of populations for it to even be considered to be given to the rest of society? Cannabis for cancer patients, MDMA for PTSD, ketamine for the depressed, and LSD for the near-death? Just legalize, regulate the stuff, and let the adults swim.

[@eneye7888]

sooooo glad u covered this topic!

[@TIGER-yq2og]

I'm about to start my infusions

[@TheDrugClassroom]

Good luck, I hope it works well for you!

[@lile4life713]

Man let me tell you I had triple bypass heart surgery add a surgery they put me on ketamine and Dilaudid pump I was super fucked up . Was seeing shit and I thought I was playing video games my system recorded them lol I never wanna be that high never again 😂

[@ccrydurrr2958]

Same here.

[@finnanutyo1153]

Holy fuck I just finished watching your etizolam video and the voice difference is jarring

[@leahdavis8446]

Thank you for covering this drug! I was trying to find more on this drug and I'm glad you posted it up. 😊😊😆😆 Do you think you. Could go over methadone as well? 😊😊 Thank you!! 💛💛

[@TheKing-nu4fk]

Try percocet its alot better than methadone

[@erlendgerhard4905]

What a job you have done, thank you! Really appreciate it, hope you are doing good:)

[@Saphirasara7]

Very nice and informative videos! You should make more, perhaps to complete the ketamine series you could also talk about 2-fdck? Would be very interested to see that one

[@dylanparr6880]

I need this :( been on paxil for 12 years. Basically hit a big wall in depression/anxiety treatment.

[@daviswhitlock9198]

I was recommended to a specialist who helped me out..

[@daviswhitlock9198]

Tripsauthur

[@daviswhitlock9198]

Shes on instagram¿¿

[@irishrebel1976]

I wish the Department of Veteran's Affairs would approve Ketamine for mental health issues. Their reason for not approving its use: They don't want to commit doctors to the time it takes to provide Ketamine therapy. Since patients need to be monitored during infusion and then for a few hours after, they say that's too much time to keep a doctor with one patient.

[@emd344]

Look into trying the nasal spray or sublingual dose. They're cheaper and therefore something you may be able to swing out-of-pocket until the VA finally comes around. I know that Spravato (nasal spray) will help with costs too. Good luck 👍 💓

[@kylerhoskins3046]

em dee can you get this in United States 🇺🇸

[@emd344]

@@kylerhoskins3046 yup! It's legal to use for medicinal purposes.

[@Cylindropuntia]

Great new video!

[@jimmygervaisnet]

I'm still amazed at how powerful the placebo effect is ...

[@Michael-lc8yl]

Many times people think they're better but are not, the same way a person getting a supposed ketamine infusion that is just water might feel high.

[@jnewmark41]

Ketamine really changed me.....it is a special medicine

[@adamgcnk]

miss u seth

[@luizz_k]

Great work! Thanks for the update!

[@angelas65]

Dude yesterday I checked if you had any ketamine videos. What a coincidense haha.

[@goa699]

I've never taken it. I do have depression but as a recreational matter I want to try the high. I hear it's amazing. Unless you go into a K-Hole

[@MostGratefulOwl]

I started these treatments but my 2nd appointment was awful. I feel he gave me to high of a dose, and insisted on more after I told him that should be enough as I was starting to feel the effects. My anxiety was high before every appointment afterwards and I rescheduled till eventually I just decided it's not for me. These treatments were supposed to be twice a week, 2 hours each at the clinic. I believe he did a total of 7 nasal sprays, 3 in one and 4 in other side. I said enough at 6 and he told me I'm able to have more so I did. He was going to do another but listened when I said no more. Then 2 hours of hell followed after. The effects at least came down quick at the end but I had a dull ache in my forehead for a few days.

[@azulgarrett6305]

Are you familiar with ketamine's use for people with covid-19? I myself am Rx internasal ketamine for my Interstitial Lung Disease. With this application as well as for depression, ketamine has a long after glow effect. I've done lung function test weeks w/o using ketamine and lung function test using ketamine days just a few days before and it's impact on better breathing is remarkable. Ketamine is amazing in that it has several therapeutic benefits. Ketamine also helped me get off Rx opioids years ago. Ketamine is a great medicine if used properly.

[@00HoODBoy]

Damn. That's some work ethic

[@jackbootshamangaming4541]

I have treatment MDD, with bad Anhedonia. I was on the Phase 3/4 trials. I was doing so great. After the trails ended, awhile ago now, everywhere wants like 1k per visit.... Sucks

[@sadman5916]

Random question, what is the mechanism by which ketamine causes bladder problems?

[@ambertim5240]

Omg i literally bought some ketamine for my first time todayyy. Low dose recreational purposes tho

[@Blkac-pill-Black-Life]

Got an ampule as well

[@dylanparr6880]

Have fun??

[@mike-0451]

Your voice got deeper. What happened?

[@anthony639]

Maybe a new microphone

[@starcloud4959]

Ketamine induced steroidal-hormone activation?

[@21stCenturyDub]

Testosterone

[@IuliusAnacyclus]

NoFap?

[@mike-0451]

Iulius Anacyclus I wish that were true. It used to lower my voice when I was doing that when I was younger. Now I just get extremely horny. Nothing else changes.

[@p1ll]

anyone else notice his voice is lower? :)

[@martin8639]

Hey, ur channel has taught me that drugs are just tools for this brain of ours,i love it, but can you make a video on LAMOTRIGINE ? its and interesting toppic and i think its widely used more and more every passing year.

[@emd344]

I love Lamotrigine!

[@gudmunduragustsson5872]

Your voice is getting deeper

[@AkraticElitist]

Bruh, you seriously should just get a Phd if you haven't already cause you've basically done multiple theses.

[@emd344]

Seriously!

[@heartspacerelaxations6924]

Very interesting subject. Memory harm concerns me, as does wider cognitive issues. I think a one off or few session in therapeutic setting whilst taking special care of yourself could be best balanced option. I want better mood and memory. PLEASE DO A REVIEW ON ANIRACETAM, and NOOPEPT, taken with choline sources like ALPHA GPC.

[@connorsirmon6844]

Love your videos can’t count how many times your what your need to know videos have helped me or others I know stay safe while experimenting with substances. I was wondering why your what you need to know videos about mushrooms and lsd have been removed from KZbin but the videos talking about studies for them are still posted.

[@yolobathsalts]

I've been seeing a psychiatrist for a few weeks now & he's mentioned using ketamine a few times. I think after watching this video I'm gonna give in and tell him I'm ready to try.

[@TheDrugClassroom]

Good luck, I hope it goes well if you do decide to try it.

[@yolobathsalts]

@@TheDrugClassroom thanks, I've been trying to find a treatment that works for years, so hopefully this will be the one

[@emd344]

It's definitely worth it. Good luck!

[@bellabear653]

It's confusing to think that most of the science is based off seratonin when dopamine is such a larger player within serious depressive disorders.

[@Tinger_90]

Ket with put u in that no pain trance 🤩

[@MikeyBAAZ]

Im doing my first R-ketamine treatment in 2 weeks

[@heartspacerelaxations6924]

I think shirt terms results data can be very misleading. We want to know about remission after 6 months, 2 years etc, not 7 days. I have a remission of depression for 8 hours after 3 glasses of wine! But that’s good little long term therapeutic effects, or maybe a glass or two of wine in good company once a fortnight does have antidepressant effects. For an alcoholic it could be life threatening. It’s so personal, and therapy needs to be personalised, and well rounded.

[@mallardtheduck406]

I had an Appointment with an Anesthesiologist for a Ketamine infusion, but had to cancel, my brother and Sis-in-law abandoned me, I don't drive and the Doctor is about an hour and 15 minutes away.

[@matthartmann2697]

Since ketamine is such a dirty drug (effects many receptors) it would be very interesting to see the effects of different analogues or targeted NMDA antagonists. That aside, ketamine is a beautiful substance because it has the ability to do so much.

[@TheDrugClassroom]

Other NMDAR antagonists and glutamatergic drugs have mostly failed to match ketamine's effect, including memantine, riluzole, MK-801, rapastinel, and lanicemine. I discuss a number of these drugs here: thedrugclassroom.com/video/ketamine-in-psychiatry/#Section_10_Comparison_With_Other_Drugs

[@banton9368]

Ive been on antidepressants on and off since sept 2018, and been on sertraline since January, i hate it i get no sleep most nights and rarely notice a difference. Ive recreationally used ketamine and id say personally its not made much of a difference. Its fun though

[@villiantwo]

same here. doctor got me on citalopram a few months ago. while it has helped with anxiety a little bit. im always tired, have far less energy. and actually feel more depressed than ever. think im gonna stop taking this crap,..

[@UniversalMysticsOfChrist]

I'm looking to get assistance on this. A research study or so. The treatments are expensive and I've been destitute. You should post the 250 pages as a book.

[@21stCenturyDub]

I believe esketamine is what has been approved by FDA for treatment resistant depression. Interestingly, it's more potent than ketamine apparently.

[@TheDrugClassroom]

Yes, S-ketamine (Spravato) was approved in 2019 as an intranasal formulation for treatment-resistant depression for use with a daily oral antidepressant. From a dose perspective it is more potent, particularly as an anesthetic. It *may* be inferior to R-ketamine for depression and 3/5 clinical trials performed by its maker failed, though it was approved nevertheless. Both S- and R-ketamine are useful and because they have somewhat different mechanisms it may be best to use them together, as with ketamine infusions, though that's hypothetical at the moment as they have not been properly studied against each other. I discuss this here: thedrugclassroom.com/video/ketamine-in-psychiatry/#74_S-Ketamine_or_R-Ketamine

[@21stCenturyDub]

@@TheDrugClassroom I am assuming that they are enantiomers? And wow that's a great write up you have at the link, is this for a psychopharmacology dissertation/thesis?

[@TheDrugClassroom]

They are enantiomers. S-ketamine has long been viewed as the more active enantiomer because it's ~4x as potent for anesthesia and has a 4x higher affinity for NMDARs, but antidepressant-relevant research has shown a lot of activity with R-ketamine. Still an active area of debate though, no clear answer as to which is 'better.' This is just for TDC, I enjoyed researching the topic so I figured making a larger than normal resource for it would be worthwhile.

[@21stCenturyDub]

@@TheDrugClassroom it's impressive work nonetheless, thanks for everything you do! Oh and one more thing, I had read somewhere that ketamine is a MOR antagonist. Kind of odd if true, especially given it's used for anesthesia.

[@emd344]

The bioavailability is much lower, though. Having said that, I personally had a good experience. Despite the big difference in bioavailability, the therapeutic effect is comparable to what I get currently get with IM injections. I probably would have just stuck with Spravato, especially given how much more cost effective it is, but it irritated my nasal passages to the point of nose bleeds and the drip made me a nauseous (both, from what I understand, are rare side effects).

[@White90ice]

good to have you back!

[@TheDrugClassroom]

Happy to be back!

[@hihello-sx1sx]

Why does it sound like you’ve gone through a second puberty

[@jerrybuckingham6594]

Phenylethylamine (PEA)

[@TheSaival]

wont work without an inhibithor

[@Danaredlp]

Thank you for your work

[@DihelsonMendonca]

*Seth, can you make a technical video explaining WHY drugs cause the body to adapt to them ? Why the first time is like a christmas tree effect and subsequent doses are never like the first ? Why this happens ? How to reverse tolerance and receptor downregulation ? How to upregulate receptors artificially ? How to make an amphetamine dose effect as it was on the first time ? How to prevent the body to develop this awful tolerance and the pharmacological basis why this happen ? Are there genetic basis for homeostasis or can we upregulate to a new homeostasis set ? Thanks.*

[@-Timur1214]

Please more videos, I miss your content. Idk do videos about some very well known drugs to get more attention like Diamorphine or so :v