Keynote Presentation: The Clinical Progression to Optimal Outcomes for Beta-Lactam Antibiotics...

Presented By: Marc H. Scheetz, PharmD, MSc, FCCP, FCP
Speaker Biography: Dr. Marc Scheetz attained a Doctorate of Pharmacy from Butler University, earned a Masters of Science in Clinical Investigation degree at Northwestern University, and completed his pharmacy practice residency and an infectious diseases fellowship at Northwestern Memorial Hospital. Dr. Scheetz is an Associate Dean of Research and Professor at Midwestern University College of Pharmacy and holds a joint appointment in the Department of Pharmacology, College of Graduate Studies. Dr. Scheetz is the Director of the Pharmacometric Center of Excellence at Midwestern University. He currently practices clinically as an infectious diseases pharmacist at Northwestern Memorial Hospital in downtown Chicago, IL.
Webinar: Keynote Presentation: The Clinical Progression to Optimal Outcomes for Beta-Lactam Antibiotics: from Prolonging Infusions to Precision Dosing
Webinar Abstract: This presentation explores the pharmacokinetics (PK) and pharmacodynamics (PD) of β-lactam antibiotic dosing, particularly in ICU patients. To optimize PK/PD targets, two strategies are possible and include population level and individual Precision Dosing approaches. This presentation emphasizes the critical need for precise dosing strategies to optimize β-lactam exposures to improve efficacy. Variability in PK, driven by high inter-individual variability in clearance and volume, translates to poor target attainment and underscores the importance of tailored Precision Dosing approaches. The presentation also touches on Bayesian probability concepts, showcasing how conditional probabilities can aid in decision-making for Precision antibiotic dosing strategies. Challenges related to therapeutic drug monitoring and its role in refining antibiotic administration are addressed. Alternate population level approaches such as prolonged infusion methods are discussed for the ability to increase achievement of therapeutic targets in sepsis.
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