Platelets and Von Willebrand Factor animation

[@alexleatherdale711]

I realize this is meant to be an introductory video, but I think it would be worth noting that VWF is present in multiple components of the blood and the vessel wall in multiple forms. It is present in both the Weibel-Palade bodies of endothelial cells as well as platelet granules. On top of that, large VWF multimers flow freely within the plasma. Immunostaining has also shown VWF is stored in the subendothelium (presumably bound to collagens), which further primes the exposed vessel wall to be pro-adhesive. Lastly, fibrin tends to accumulate closest to the vessel wall and decreases toward the lumen, effectively preventing total vessel occlusion by the hemostatic plug.

[@adamjones1780]

Alex, thank you for your comments. You are right, it is difficult to get all the science across and still create a good narrative of the processes for the student who is new to the subject. I think clotting is particularly challenging in this regard!

[@iloveu975]

Those who are confused: Adhesion = vWF - Gp Ib Aggregation = vWF - GpIIIa/IIb

[@DoinMaBestt]

This is genius! Thanks❤

[@danicaamano9778]

Is it not the glycoprotein Ib that binds to vWF and IIb-IIIa that binds to fibrinogen?

[@kapulachifunda2011]

noticed too

[@Abbasbaby-girl]

Daniel Caamaño no. He is right.

[@Andr295]

No, he is not right. Gp IIb/IIIa is a receptor for fibrinogen. Gp Ib is a receptor for vWF.

[@lybomanolov5054]

GP Ib => VWF GP IIb/IIIa => fibrinogen

[@boredtodeath741]

yeah you're right. i was freaking out cuz i thought i memorized it wrong.

[@noone8583]

I think its "Gp 1b ix-v" receptor on the platelets which binds von willebrand factor and "gp IIb/IIIa" receptor which binds fibrinogen! Any correction will be appreciated!

[@hakanozduran7534]

von wilibrand tip 2b

[@swatipatel8948]

It is both actually. Vwf binds Gp 1b ix v and helps in cell adhesion to vessel wall. Gp 2b 3a, is in resting state, when Vwf binds to it, it gets activated and vwf forms a bridge between two gp2b3a receptors on two platelets. This helps in aggregation ( along with fibrinogen)

[@wenw2140]

this video is veyr clear and informative, very easy to understand. thank you so much

[@romeolhk1008]

Clear as distilled water!!! Thank you!!

[@burakozvit7480]

What a nice explaination Sir ❤

[@nehapatel6006]

Awesome 👍👍👍👍👍👍

[@markoilickovic4884]

Great video! Thanks!

[@vaishnaviramakrishna265]

it was very useful!! thank you sir! 😊👏

[@sclair10]

Thank you for the excellent explanation.

[@DavlatBek-x2k]

great👍👍👍👍

[@gjzztrrettmmggrrertzhgyena4950]

Incredible 🌹🌹🌺🌺🌺🌺🌺🌺

[@bio366geethasankar7]

🙏

[@koolilaura]

The background music was distracting.

[@kapulachifunda2011]

very distracting!!!

[@abdullahhussain9589]

Thanks mate

[@prachishah2304]

Great video and a great addition to my notes, but please get rid of the music in the background!!

[@jed5356]

nice video, thanks a lot

[@lindanorris2455]

HOW COME VWF IS NEVER BROUGHT UP WITH ENDOMETRIOSIS PATIENTS?

[@pinkray7052]

Thanksss💕💕💕

[@debabratamanna1863]

Does paracetamol also inhibit cox pathway...I think it doesn't...it is centrally acting drug

[@TheFujiwuji]

This is a great video, but the music is too loud and distracting, making it harder to follow.

[@sherifelfeel1495]

❤

[@VonJay]

Why don’t you have a billion followers? The world is mad

[@bomhayhay]

thanks

[@inayatulkhoiriyah66]

i think im in love with you doc

[@imenboukhefardji3540]

merciii

[@jullian95m]

mint

[@SonmerfieldWendell-e4q]

Miller Brian Garcia Karen Thomas Steven

[@juliusgrecu8887]

nice

[@Silverwing_99]

this guy is HOT

[@americanbee]

I couldn't understand the accent because of loud music

[@monirayusuf30]

thanks