Lifespan - David Sinclair, PhD (overview & thoughts)

[@doratheillegalalien9183]

you need a hell of a lot more subscribers and views

[@moshefabrikant1]

1:30 Your cells getting old is like a cd which is new getting more and more scratched till it's not useable 3:30 Caloric restriction helps live longer 7:00 MMN is great drug 8:00 Exercise more. 8:1/ Go out the termonetural zone. Do cold shower Go outside when it's cold. Do sauna 10:30 Interesting 12:13 Old age is a diesase

[@susymay7831]

Thank you!

[@ThePathOfEudaimonia]

Searching for "Lifespan summaries" got me here, and I am so happy for finding your channel!

[@Natalia-Millan]

Thank you, i don't have any background in science therefore it was hard for me to follow this Author, however you summarized the information in a really simple and visual way! Also, since I am not a native English speaker, seeing how you write the words and pictures on the screen facilitated the job and made it very visual for me so now I can retain a few concepts .

[@yusunliu4858]

After listening to your several videos, my eyes can not stop following your sketching and writing.

[@intaek60]

I bought the book and read the first part of it. Your concise video is very helpful in summarizing the book. Thank you!

[@jayahn9399]

Thank you very much for the concise and artistic presentation. I liked also your English accent.

[@christopherellis2663]

It's an English accent, one of many in daily use in England.

[@larrykraft2743]

I’ve recently come across your channel and I’ve greatly enjoyed several of your videos. Thank you very much for the energy and time you have put into A, getting so smart and B, making such important information accessible to the rest of us! If I may make one suggestion (and please excuse me if you’ve already adopted this in later videos), could you please add like a 2 second pause whenever you get done building an image before jumping to a new image? For example, at about 4:45 in this video I had a hard time discovering what the final E in that acrostic was for. I finally had to slow it down to 1/4 speed to see that the final E in CALERIE (sic) was for “energy.” I look forward to watching your video on calorie restriction. For a good laugh take any speech from anyone and slow it to 1/4 normal speed. It makes them sound like they’re half asleep. Thanks again!

[@deasmiles]

I loved this, you broke it down and made it easy to understand. Thank you!

[@TheSheekeyScienceShow]

Thanks for your comment! 😊

[@scottherf]

Thanks Sheeky, Lifespan is jampacked but really fascinating reading.

[@G3orgianSoldier]

I am a mathematician and have just made a presentation about Claude Shannon's works in my university. It's so cool to see it here :D

[@robertscott1660]

Dear Sheeky , I enjoyed Sinclair's book very much and your review is helpful. Sinclair is a serious researcher who has devoted his career to understanding the biology of ageing. But after reading Andrew J Steele's book "Ageless" and delving into the literature, partly with the help of your channel, I find Sinclair's perspective rather narrow. He claims to have found the theory of ageing, yet other researchers in the field seem to tell a more complicated story. The 2013 review article by Lopez-Otin et al., seems to be quite influential with over 7000 citations on Google scholar. They cite 9 halmarks of ageing, one of which is epigenetic alterations and seems to include Sinclair's work on sirtuins. In other words, perhaps epigenetics is important to ageing but there is much more too it. For example, one might ask how are pathways involving sirtuins going to help us live longer if we die of a heart attack or stroke because of increased blood pressure because the artery walls lost the flexibility to expand?

[@dawnwhitehead]

Sinclair describes the ingestion of resveratrol as the answer to this issue. The mice autopsies of rats studied in his lab experiments being fed resveratrol had exquisitely clean and flexible arteries which prevented cardiovascular events.

[@ZombieProdigyUS]

I have a question! :) He claims that we need to put our body into "stress modes", to activate our sirtuins, and that by doing so, they will help repair damage caused by "epigenetic noise." The thing Im not understanding is that he says sirtuins going back in the wrong spots sometimes and slicing genes not meant to be sliced, is what causes aging. So why on Earth would we ever want to send out more sirtuins??? Maybe I'm confused here, but why is moderation good? I know it is, but why is almost all activity not harmful?? Say even weight lifting, where you tear your muscles to build new ones. He says that fine, but why?? Would that not causes sirtuins to repair and then maybe go back into the wrong places??? Thanks so much for helping! :)

[@bjorn2fly]

Nice video, still a problem with the microphone, but better than last video. Also In many countries Metformin is without prescription. Also loved your last video on aging, pity you dont get a bigger audience here on youtube, but maybe you can live forever, now that you know so much about reversing ageing :-)

[@TheSheekeyScienceShow]

Thanks, am planning to get a new microphone soon which will hopefully fix the issue. And haha, if i ever reach 100, maybe will have a few more views by then.

[@adriansolis7760]

Feels like I'm back in my college adv. Bio Chem class 💯 great video

[@hollywoodianiit516]

Hi Eleanor! May I suggest you to read the book "Cracking the aging code" that presents a very original theory of aging that I found very compelling. It is not much about the biochemical mechanisms but more about the evolutionary underpinnings. That could be another video idea...

[@TheSheekeyScienceShow]

Thanks for the recommendation!

[@DiliaMarques]

Interesting, thank you. I think you did a very good job, I'll be back

[@katiescarlett5249]

Great review! Who was the scientist that came up with the Free Radical Theory of Aging? Each copy of the cell that is made after the Free Radical Damage has been done, is like a bad xerox copy till the original is very different from the copy. Inflammation is the same premise. Then the activation of the SIRT 1 Gene has been something that has been discussed in the past as well. Mitochondrial has not been addressed by anyone except physicians active in Chronic Fatigue Syndrome. So that would be interesting.

[@simplrhealthctf]

For the resveratrol side, the issue is with bio availability. And wine and absorbing through the lining of the mouth is the most bio available process. And while true as to the amount of wine required to be effective, dr Phil Norrie has developed “the wine doctor” wine and resalixer. So in the case of the resilixer, you take 50ml and rinse around your mouth for a few min and it’s the equivalent resveratrol to 10 bottles of red wine. While the bottle of wine doctor wine contains the equivalent resveratrol to 20bottles of red wine. Feel free to contact for more info

[@simplrhealthctf]

And when I say “more bio available” we’re talking 250x more than being taken orally.

[@yavuzbahadrtaktak8020]

nice and precise. here is a thing: if scientists manage to achieve prolongation of life and if it will be accessible to anyone, human population will exponentially grow (do we have enough energy to keep growing and keep nature clean :P); if it stays as a privilege in rich guys' hands -as Harari mentioned- we are creating superhuman beings.

[@christopherellis2663]

I'm reading the Romanian edition. (The editor cannot decide whether it's Sydney or " Sidney. The Spaniards are similar confused" The FDA is an American problem.

[@emmanueltrejo3531]

Excellent, thank you very much

[@pickaxingoneuropa8457]

These book reviews keep getting better and better. 🐳

[@ascensionlab]

Nice video and work

[@TheSheekeyScienceShow]

Thank you! 😊

[@walterjab]

Nice, thank you.

[@TheSheekeyScienceShow]

Thanks! 😊

[@Jz-en9pi]

Thanks!

[@huydao9802]

thank you

[@adizioglu]

Thanks

[@Buzz231094]

This was interesting

[@shivamvaidya1782]

Audio is very bad