Lifespan Discussion with Dr. David Sinclair

Three years ago, Dr. Sinclair published his book Lifespan: Why We Age and Why We Don’t Have To. Lifespan has remained a very popular read over the years, and based on the hundreds of thoughtful questions we received, Dr. Sinclair’s fans are very familiar with his research, book, and podcast. In this Q&A session with Dr. Sinclair, we dive into a few of the most commonly asked questions from our listeners.
1:15 - Intermittent fasting:- who is it for, who is it not for, and which blood biomarkers indicate it is right for you?
4:22 - Which specific biomarkers do you track over time for longevity?
7:28 - How are Resveratrol supplements associated with the aging process?
9:55 - Is it possible to participate in endurance events while also pursuing longevity?
11:45 - One of the most exciting things about science is that it is ever evolving. Since writing Lifespan, have you found new longevity insights that will be featured in your next book?
13:35 - What is the future of epigenetic reprogramming?
16:27 What’s the relationship between metformin and homocysteine levels?
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[@patrickvanmeter2922]

Obesity is an epidemic. Longevity is important to everyone, and obesity should be the first thing addressed IMO. I have read the book and have followed Sinclair ever since. Love the video.

[@m.w.3692]

Madly adore this guy!

[@exxzxxe]

So, Dr. Sinclair promotes the widespread use of NMN (developing a big market), then, as a key member of a startup marketing an NMN derivative, asks the FDA to regulate NMN (cornering the NMN market using the FEDS)- very creative, Dr. Sinclair!

[@Sulaiman-xh8wx]

I don't get it, can you explain more?

[@exxzxxe]

@@Sulaiman-xh8wx First" Google 'glaxosmithkline sirtis' or 'gsk resveratrol'. You will read Sinclair's involvement in promoting resveratrol as a 'wonder supplement' and induced GSK to spend $720 million acquiring Sirtis- a company founded by Sinclair. GSK could never reproduce results claimed by Sinclair. It was a fiasco. So here is where it all starts. More recent Sinclair has promoted NMN to thousands (millions?) . Then he forms a company to advance NMN chemistry and, at the same time, requests the FDA to regulate NMN.

[@virginiaferrarini]

Thanks: more of that!

[@m.talmagemoorehead]

Great interview! Wish it were much longer. Keep up the great work, Dr. Sinclair.

[@AL_THOMAS_777]

Better wish our l i v e s being MUCH longer - then we would have CENTURIES to listen to that smart guy . . .

[@wellnesslady9586]

How wonderful! Thank-you.

[@InsideTracker2]

So glad you enjoyed the interview!

[@j_grieshaber]

Dr. Sinclair can you expand on your Albumin comment. What levels are optimal? What are they indicitive of?

[@nevermore242]

Thank you Dr. Sinclair for your work, for your passion, for everything. Thank you

[@kathleenschlecht3371]

The quality of my life has improved since I came across Dr. D❣️ ♥️💗♥️ Katy

[@tracymatthews3267]

Hi. I am interested how the thyroid is affected, and what can you do if you have existing thyroid issues for me hypothyroidism.

[@Mimi-vegi2go]

Hi David thank you for all your educational info for the public I have been following you and I can’t thank you enough …… my question is what are your thoughts on a supplement called DHEA

[@glowluz1]

Can I do fasting if I am over 70 year’s Old?

[@Schutzmassnahmen]

Ich denke der Blutzuckerspiegel darf nicht zu hoch gehen darum nach jedem Essen Kalium chlorid 70 Prozent und Natrium 30 Prozent

[@stephenrodwell]

Great chat, thanks! Be great to hear about the new compound/product that it is rumoured Dr Sinclair is working on. The one that is better than NMN.

[@shamsmueen3373]

I do dry fasting 14 hrs and breakfast with fruits like watermelon, mandarin, apples and grapes. Thereafter, I drink 1/2 cup buttermilk. Please advise if this is good...?

[@starfox300]

"Curing blindness and reversing age - that sounds really exciting!" What do you mean exciting? This sounds like the most insane thing that has happened in the history of mankind

[@AL_THOMAS_777]

Why insane ? Its the w o n d e r of nature (in this case of human brain) !!

[@AL_THOMAS_777]

If you cant believe a thing, it won´t happen. And Dave believes in many things . . .

[@nayeefachowdhury]

Hi David, I joined the Tally Health beta program quite a while ago, plus I've joined the Inside Tracker team. I'm based in Dubai and missed out on the beta test kit. I would very much appreciate it if you could kindly shed some insight into what kind of DNA test should be my topmost priority among the pletora of DNA tests avaialable here. Thanking you in advance! Enjoyed the clip!

[@thatchessguy7072]

I’d love to hear more on the progress of animal testing to reverse aging. I know it has been done in mice, but what about other animals? Additionally, how’s the progress on making more ‘yoda’ mice? Finally, are there any results I can reference on NAD precursors in dogs and cats? I vaguely recall there was a study going on currently but I couldn’t find it on the web.

[@murrmurr765]

"that chess guy" - you must be really smart and cool m'lady

[@rickycademartori8481]

Yeah. Lol. It seems like interviewers never truly grasp the weight of this discovery. Would love to understand more about the pill progress. I’m sure that is very early and mainly in pre calculations and talks. But the gene therapy discovery is mind blowing

[@pinkiepinkster8395]

Leave the animals alone. They don't deserve to be tortured in laboratories just because you are selfish.

[@_Nostalgic_Thoughts_]

May you have all the strength to develop those age reversal pills for us David 🙏

[@wegtennis8740]

Is there any advantage to dividing doses of NMN or resveratrol, say twice a day instead of all at once?

[@m.talmagemoorehead]

Great question! Here's mine... Before I started taking a gram of NMN every morning (with a tablespoon of C8 oil), I slept 8 to 9 hours a night. Now I sleep 6 to 7 hours. Is this response healthy? Is it a common response?

[@nayeefachowdhury]

@@m.talmagemoorehead The change in sleep duratrion, exactly the way you mentioned, happened to me, too. So, I guess it's a common response.

[@InsideTracker2]

Hi there, this is an interesting question. Since NMN research is still emerging, we can't speak specifically to dividing the doses. However, you can check out our NMN related article for more information! blog.insidetracker.com/nr-nmn-longevity-supplements-work-humans

[@MichaelStrachanowski]

Great interview. Some of the changes in my daily eating habits will be painful at the beginning.

[@baconinvader]

mood

[@charlotterusson2885]

Great interview. Thankyou David. Can you please 🙏 tell us what to do to reverse or cure maccula degeneration? I think you have mentioned fasting. What supplements would you recommend 🙏

[@EasternRomeOrthodoxy]

Your Sinclair is a snake-oil salesman - a гаt, plus he looks like a f*** old dude with a hair transplant lol

[@CycloneCowboy]

Would hope at some point to see a discussion about over the overuse of antioxidants. Too many people are taking supplements they don't need to try and cover all the bases. As you know, taking too many antioxidants is not good.

[@gomcocramp]

how many is too many and why is it not good? thx

[@AL_THOMAS_777]

@@gomcocramp You CAN´T get e n o u g h of them. Any surplus simply will be exited by your system . . .

[@crystal3160]

@@gomcocramp because it could allow the bad cells to grow instead of the body normally having them die off.

[@joyaborthakur9407]

Can you please do something to increase muscle mass in aged peoples??..

[@dcjohnson2208]

As an old retired scientist I’ve found I must consume 1.5g of protein per kilogram of weight. Exercise about 1+ hours per day including walking for 25 minutes, DDP YOGA 16 minutes, core exercises 20 minutes. Exercise every other day or two. Walking 1 mile 6 days per week.

[@dcjohnson2208]

As an old retired scientist I’ve found I must consume 1.5g of protein per kilogram of weight. Exercise about 1+ hours per day including walking for 25 minutes, DDP YOGA 16 minutes, core exercises 20 minutes. Exercise every other day or two. Walking 1 mile 6 days per week.

[@kathleenschlecht3371]

Drinking Kombucha will give all the RDA of B vitamins, especially B-12. ♥️💗♥️ Katy

[@professormoriarty6875]

I didn't know the mascot, Alfred E. Neuman, from MAD Magazine was a professor at Harvard.

[@petercoderch589]

Sinclair looks really really good for a 53 year old man. The only visible sign of ageing that he has is that the roots of his hair are going grey. But he looks overall literally 15 years younger than his chronological age.

[@kittyhooch1]

Look at his older videos from 1o years ago. He looked older then.

[@AL_THOMAS_777]

No problem. Just stictly avoid PRE-aging substances. . .

[@chrisbusby4395]

skin smoothing video affect, similar to what you can do to photos with software, you can see the clarity has been turned down

[@TheHorrorsPersistButSoDoI]

@@chrisbusby4395 lol

[@mggt4684]

Yeah, having a shitty camera and smooth lighting in your room really does make you look younger

[@theostuin9745]

If i do intermittant fasting Can i taken a cup ogen kefir occasionly during the fast?

[@InsideTracker2]

Good question! It's recommended to keep any intake under 50 calories during a fast.

[@marijusofficial]

Fascinating QA.2 years for curing blindness in human and maybe soon reversing brain in 5 more years.That pill would be existing if it exists,sounds like pill of life then.No need supplements just turn a decade and that's it.

[@inhocsignovinces8061]

I want an automated body measurements tracking integrated into the toilet like they did in the Discovery Channel series "2057: The World in 50 Years" (2007, episode 1 - "The Body"). Somebody make this happen.

[@tonynes3577]

Interesting. I have intermittent fasted and it's even more effective for boosting my health than any of the supplements than you recommend although I do use certain supplements that you mention. My only main problem is that I work the night shift, although part time, and hopefully only for a few more years until I retire. But could I read anything about being naturally nocturnal like some animals are?🤔 Meow!

[@roniesousa1587]

Brayan Johnson looks way older then David Sinclair. David Sinclair looks very hearty and young 😊. I have same age then him and I look younger then my age too!! Imagine if I could afford the supplements he takes

[@swisstrader]

Sinclair got ppl hooked on NMN and they had the FDA ban it so he could develop his NMN based product and corner the market. Genius but skanky move.

[@Moons_mooniverse]

Hey David, can you please share more insides behind your divorce? I know it‘s a very personal question and a sensitive topic. But since you made your relationship a topic in your book and also the importance of relationships for longevity it would be interesting to hear. Also since this happened after your book release. Would appreciate it 🙏

[@miracoli16]

Are you ernest? He will never answer this question. It's far too personal.

[@dcjohnson2208]

Probably the same reasons Jeff Bezos gave his former wife 70 billion dollars to divorce him.

[@glowluz1]

What an insensitive question!!! Unbelievable!!😢

[@par_si_fal]

had to laugh so hard on davids facial expressions during the read out intro. reminds me so much on my startup LoL Anyway, on this diet since 18 months and looking like it fully works.

[@par_si_fal]

When I look at the conversation, I have the feeling that the mood is not good. Would like to apply for Chief Happiness Officer at InsideTracker's.

[@kea7721]

I’d love to know what he eats in a day.

[@dcjohnson2208]

He tells us what he eats in detail if u watch enough videos on KZbin. As an old retired scientist I spend much of my time watching longevity videos (probably over 1200 videos by now) I’ve made good progress in reversing my age. Nutrition is number one.

[@gagadonim3354]

Wait he is vegan?

[@dcjohnson2208]

He is moving to become vegan. He still violates vegan definition occasionally.

[@ivandansigmun3891]

I'm not sure why anybody takes Sinclair seriously after the Resveratrol scandal.

[@AL_THOMAS_777]

Please explain "the R-scandal" !!

[@dcjohnson2208]

As an old retired scientist I take him seriously because I can analyze his published work and that of many other longevity scientists’ published results which indicate he is a leader in the field. He would not maintain his prestigious position at Harvard if he was a charlatan. Instead of looking for negatives only, try balancing your prejudices with looking for positives as well.

[@vickybiagini8623]

All this talking and he still hasn't reversed a single aspect of aging. Not one age reversal pill in thirty years of yapping.

[@vickybiagini8623]

@Mark Mitchell , of course it does nothing

[@miracoli16]

It seems that you don't understand what he is talking about. There are already some substances that obviously slow down the aging process.

[@vickybiagini8623]

@@miracoli16 I've been following age reversal for twenty years. There hasn't been one aspect of human aging that has been reversed. Humans live an average of seven decades if able bodies. Thirty years of those decaf s is spent decaying. I don't know what decade you're in, but I'm going on my fifth in two years. Aging will start around 38 and drastically decline starting around 43. I can say that, because I'm living it. I do moderate exercise and have taken nmn for years. Believe me I hate aging, it's gross, pure and simple. I can't fathom how much a body decays in just a decade. David is all about keeping his millions flowing in. He's a charlatan, and nothing more.

[@miracoli16]

@@vickybiagini8623 Did you only take NMN or also TMG, Resveratrol, ...

[@vickybiagini8623]

@@miracoli16 , I took one time nmn and resveretrol together. This was a couple years ago. The resveretrol was the white powder David recommended. I'll be honest, I was 46 at the time, and started just sprinting when I was out for my daily exercise. That combination together did something. I honestly haven't been able to find the right resveretrol. Twice I ordered it, and it was the brown powder inside. I just got another bottle of gen x nmn 250 mg. Been taking it a few days now. Will see any results in a couple weeks. One thing that did happen because I took nmn the last time about six months ago. About four months ago I had full blood work done. Now I'm not the healthiest eater, with hardly any fruits at all. Every bit of my blood work came back within the range limit. Most of it was on the lower spectrum. My cholesterol was 161, trig 93, hdl, 71, ldl 71.4, glucose 89, carbon dioxide 28, total protein 7.3. I probably contribute possible nmn a little.

[@jimbob4456]

Looks like he’s getting grey hair