NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Lifespan with Dr. David Sinclair #4

In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters (these being NR, NMN, NAD IV drips and shots), resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted.
Correction and clarification: At time point 1:07:37, Dr. Sinclair says he takes 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. We apologize for the confusion.
#DavidSinclair #Longevity #Lifespan
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Matthew LaPlante's Social:
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Timestamps:
00:00:00 Kicking Off Episode Four: Longevity Molecules
00:02:15 Thanking the Sponsors
00:04:46 An Additional Boost Beyond Adversity Mimetics
00:05:52 Drugs vs. Supplements and Highlight Points
00:09:54 Longevity Molecules Target the Survival Circuit
00:11:33 NAD Boosters
00:13:32 Nicotinamide Riboside
00:21:26 Nicotinamide Mononucleotide
00:29:22 NAD Intravenous Drips
00:32:45 Bioavailability of NAD Boosters
00:33:40 NAD and Cancer
00:35:33 Resveratrol
00:42:26 Red Wine and The French Paradox
00:43:08 Fisetin and Quercetin
00:47:09 Rapamycin and Rapalogs
00:49:10 Spermidine
00:51:27 Metformin
01:00:27 Berberine
01:02:43 Dr. Sinclair’s Protocol for Longevity Molecules
01:08:51 Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge
01:09:52 Options for Subscription and Support
Links:
The Sinclair Lab website: sinclair.hms.harvard.edu/
Nicotinamide riboside is well-tolerated in humans: go.nature.com/3G1blbb
Nicotinamide riboside is a sirtuin-activator: bit.ly/3FUWWxa
Mice treated with nicotinamide riboside are longer-lived: bit.ly/3KD5L2h
Nicotinamide riboside protects mice against obesity: bit.ly/345E4hF
An inflammatory signature is attenuated by nicotinamide riboside: bit.ly/3Aum78I
Nicotinamide riboside, pterostilbene, and ALS: bit.ly/3nYdxK6
Nicotinamide mononucleotide combats diabetes in mice: bit.ly/3AwakXx
Aging is slowed by nicotinamide mononucleotide: bit.ly/344jGgW
Nicotinamide mononucleotide in prediabetic women: bit.ly/3H1vv6b
NAD and cancer in mice: go.nature.com/32xl1wp
Resveratrol protects mice against a high-calorie diet: go.nature.com/3G2pZyE
Resveratrol in patients with type 2 diabetes: rsc.li/3Aupk8h
Supplementing resveratrol in metabolic syndrome patients: bit.ly/3IE6C0Q
Fisetin enhances longevity in mice: bit.ly/3o10hom
Quercetin and fatty liver disease: bit.ly/3H4KWdF
Dasatinib and quercetin decrease senescent cell burden: bit.ly/35pCHuY
Mice fed rapamycin late in life live longer: go.nature.com/3F0yud3
Spermidine induces life extension and cardioprotection in mice: go.nature.com/3fXL5nn
Spermidine and older subjects with cognitive decline: bit.ly/3IG0MMy
Healthspan and lifespan in mice are improved by metformin: go.nature.com/3JSRZbs
Metformin, age-related diseases, and mortality: bit.ly/3KG0iaS
Targeting aging with metformin (TAME) trial: bit.ly/3eU9ABk
Treating mice with berberine extends lifespan: bit.ly/3AwkO9l
Lifespan in fruit flies is prolonged by berberine: bit.ly/3nYpwYt
Berberine and metabolic disorders: bit.ly/3KUpwCC
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

[@DavidSinclairPodcast]

Correction and clarification: At time point 1:07:37, I said I take 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. I apologize for the confusion.

[@brianruppert1071]

You mentioned physedin or fysadine, but I can’t seem to find the correct spelling. If you could spell that I can investigate. Thank you for your time.

[@ExbotHero]

@@brianruppert1071 Fisetin

[@brianruppert1071]

@@ExbotHero , thank you!! For some reason my computer couldn't track it down. I appreciate it, mate.

[@ExbotHero]

@@brianruppert1071 You're welcome my friend. 😊

[@HarveyCastroMD]

Can you share what brands he recommends

[@NicholasOdinson]

I aged a full week waiting for this podcast 🙃

[@fitafita7931]

Well, you can reverse it back now 🤣🤣

[@barbarafairbanks4578]

🤣😂😳

[@StarBoyyX]

double dose for a week and you will have gained an extra week ,im dreading the leap year I can't order enough

[@barbarafairbanks4578]

@@StarBoyyX you have some time...nxt L/Y 2024...🙃

[@barbarafairbanks4578]

@@fitafita7931 yup! Sinclair speaks and we're instantly younger😅

[@geromefischer9795]

I’m a simple man. I see a new Video from Dr. Sinclair and I immediately hit “like”.

[@melayan9127]

This comment will age well, I predict

[@vladimirledenko8922]

Me also, like first😂

[@ericwiese7479]

As do I !

[@debrobinson857]

Me too!

[@NRNF1776]

This comment is great on the molecular level 🤐😅

[@davidm1411]

The co host is great. He has a very effective way to be both a “layman” as he asks questions while at the same time, generally savvy on the topics. Also, I congratulate you both on not taking yourselves too seriously. We already get enough of that with certain scientists.

[@Eric-it4we]

I couldn’t agree more. Cohost totally makes this a next level podcast/conversation.

[@spindleblood]

Agreed 100% - you took the words out of my fingers. 😁

[@Thebusysuperhuman]

Yes I thought that too - big shout out to Matt

[@modelsupplies]

Agree. He’s lovely as Sinclair mentioned 🥰

[@scottk1525]

Technically he's the host, given that he's the one conducting the interview. But you're right. It's like nearly every time a question pops into my head, it's the very next question out of Matt's mouth.

[@boydhooper4080]

Great that you go deep into dosage, timings and other details on the supplements. So frustrating when others don’t do that.

[@jenneferwillard7758]

I’m obsessed. I’m so excited about this research. I’m 50yo. I haven’t had any living parents, grandparents etc in over 10 years. I’m determined to change this for my family!

[@w3w3w3]

cute pic

[@DoubtingThomas333]

My uncle was more educated than this man, and in the same field, and he died in his late 50s from cancer. I promise you none of this stuff has any real effect on your longevity. Live a healthy life, don't go taking a bunch of pills and potions and spending a load of money. Take care lovely.

[@lizzie2301]

@@DoubtingThomas333 what does your uncle being more educated have to do with this. How was his lifestyle???

[@tulparpusat]

You re so cute fem

[@TinyGiraffes]

@@lizzie2301Look up criticisms of David Sinclair. There is at least one drug he claims reduces aging that has been proven over and over does not.

[@akhisalaam]

I can't believe this is free content

[@judipapendick2460]

This is all so very fascinating! Thank you for speaking to the public directly without the media filter! You are both of a lovely generous spirit

[@BurtWalker100]

David Sinclair and his Co author have produced one of the greatest blog for those managing their health. Bravo.

[@redpilllense7125]

Thank you, Dr. Sinclair! I look forward so much to this podcast series. You truly are helping me 🙂

[@johnwilhelm]

Have been following David since the early Resveratrol days. Was super excited when this series started. Thank you for your continued efforts to expand our knowledge on this topic. You and Matt make a great duo and I hope this series continues beyond the current scope.

[@KyleMcDermott3]

@@johnf4680 what do you mean?

[@rhognaldmcdognalds1806]

Thanks for providing health and wellness on a massive scale!

[@winskypinsky]

Really looking forward to the Centennial podcast! brilliant podcast, you two are a great team!

[@jaihanjqx1140]

I have been taking resveratrol for several years now. Unfortunately I am confused. Many evidences suggest on the contrary. Why doesn't Dr. Sinclare clearly answer the question raised by Dr. Brad Stanfield. I think there are many worried people around the world who have been taking resveratrol waiting for Dr. Sinclair's response. Please!

[@mrLoftladder]

I'm taking a similar supplement regime myself and have been doing it for a couple of years now. 67 Y.O and feel more energetic and certainly fitter than any time since my early 50s. loving these podcasts learning so much from them, thank you.

[@edakovaci537]

Hi can you tell me please some names you take I need more to know the spelling , when he said Nmn quercetin and visetin or I don’t think writing right he mention desitin too, if I’m right. Thank you in advance

[@DalidaD]

People should look into the FDA nmn supplement ban and its connection with Sinclair.

[@peterellis4262]

I did. Nothing burger.

[@jawadkarim6615]

Biggest Salute to professor David Sinclair...

[@roadrunna.]

Finally an interviewer that makes good use of time by letting Dave talk without interrupting and pushing off tangent. Thanks

[@r.davidyoung7242]

Thank you! I appreciate your information and the sense of respect you seem to have for human kind and life in general. I wish both of you vibrant health and long life. 💚 I listened to your book on Audible. It's great.

[@rapamycinnews]

Great to see David covering rapamycin a bit more than in the past.

[@roberttorrie2651]

I HAVE BEEN ON NMN FOR 2. MONTHS AND HAVE NOTICED A DRAMATIC IMPROVEMENT IN MY ENERGY & A DECREASED NEED FOR SLEEP. THANKS FOR YOUR AMAZING CONTRIBUTION ❤❤❤❤❤❤❤❤❤❤

[@BlackPearlMona369]

Good for you 👍✌️. May i ask if you noticed any changes with your face skin? In terms of acnes and scar marks, if you have.... hopefully you don't have though....

[@roberttorrie2651]

Huge benefits for my face and skin

[@BlackPearlMona369]

@@roberttorrie2651 thanks a lot, appreciated 👍

[@reeshs9296]

Which Brand please?

[@618grow]

@Meem Aly wow I've been using it maybe 10 days and I swear my birthmark on my neck which is light in color is fading.

[@yummimaus]

Thank u! Really appreciate you being so direct about how to supplement these ingredients. And David you look amazing for ur age and that make me believe you… and love the fact that u do so much in your own labs… instead of reading from others’ report only!

[@sylvieasics6570]

I really like the chat/questions format with this super knowledgeable co-host that makes it so much more valuable than with a real layman! Thanks both

[@ashleyjwilliamshand]

I was so stoked when I saw you started this channel. Loved watching you as a guest on other podcasts, so this is a treat. Great job so far!

[@mixalis6168]

Why ?

[@ashleyjwilliamshand]

@@mixalis6168 Why what?

[@manolisworld]

@@ashleyjwilliamshand very good point!

[@bozorebebo9422]

@@ashleyjwilliamshand why, so you can grow a brain and ask better questions lol

[@ashleyjwilliamshand]

@@bozorebebo9422 I didn't ask a question in my original comment post on this video, I asked "why what?" to the person that commented "why?"

[@rosiesmallshaw]

Love your podcasts! The synergy is always courteous and encouraging. Keep up the great work 👏🏼👏🏼👏🏼

[@bozorebebo9422]

ya, you guys make a good team.

[@jeremydavidevans]

Your partner contributes a lot to the interview! Excellent match, glad to see this information presented in an accessible way.

[@philc6331]

Id been waiting for this one . Thank you so much for these podcasts, keep them coming .

[@Dimer95]

The co-host is such a nice guy!!! Makes the podcast just perfect

[@francischen3819]

Thank you David - I am a huge fan of your work!

[@pkstiever]

I really enjoy these two and how well they get along. I learn so much in each of their podcasts.

[@partakith3673]

I truly appreciate everything you are working toward, even if much of it you have to hint at in over 40 hours of videos :). Who doesn't love a puzzle? You bring the thoughts and ideals of a future unlike any I would have thought to see in our lifetime. Thank you!

[@MJFUYT]

I discovered Dr. Sinclair from Dr. Andrew Huberman's youtube channel. This is amazing information from Dr. Sinclair. Thank you for sharing your knowledge!

[@tomwawersich809]

Love the podcast- great episode! I have heard I should be taking TMG with NMN - would love to hear if you do this. Thanks again for your work in the area of aging!

[@howardlui9943]

Fantastic co host! Great questions .. great balance of talking and allowing David sinclair to speak!

[@christinagior42]

I’m so grateful for having discovered you!! I hope to find the right manufacturers for these products.. 🙏🏼

[@lindawalker2092]

Love this series of episodes. Very informative and hopeful for those of us in their 70s. Vanity would have driven my interest before, now it is quality of life. Especially cognitive function as I'm watching friends in their late 70s and 80s, mentally declining. Not all but so many.

[@urpgag2]

7-Oh and I drive a van full of handicapped and You and I both want my brains to work at capacity lol We could talk about Huperzine A

[@deboraheliseperrinwheeler9201]

Right behind you! 68 mother of two. Need to remain here as long as possible with healthy body and mind! My son passed during COVID. Being a mom of a 9 & 8 years of age need all help available!

[@kimboslice2821]

Grateful for the information you guys are offering 🙏

[@GodofStories]

Cohost is great! Matthew great job explaining and discussing the finer details! Bravo senor!

[@Thebusysuperhuman]

Thanks for this - I love the way you and Matt interact - All scientists need a Matt to help explain to lay people

[@juiianadebeers8230]

I just finished your incredible book Lifespan-for the third time. First reading was an audio version and I stopped every hour to cry hard. I read a lot for a leadership program that I teach for the Air Force and thank you btw for mentioning USA air supremacy. LITERALLY THE MOST INCREDIBLE INFORMATION!!!! I tried to relay it all to my own adult professional child and her husband and sounded like a blithering idiot bc I get so emotional. I am thrilled to find this podcast so I do not have to try. Your optimism is a leadership trait; you’re an educator, not merely a scientist. Your book’s messages were mostly about longevity, but also part existential, part environmental, and part economical. As a teacher myself a huge obstacle is keeping my students and coachees happy about humanity. I am as wound up at the end of your book as I am at the beginning. Thank you for your genius and your optimism.

[@apocryphalsubfusion]

Thank you for another amazing podcast! The shows notes, the timestamps and the explanations were very digestible (pardon the pun). Seriously thank you David, Matthew, And the team at Harvard medical school working hard to bring us the best longevity science to date. I can't believe that this information is freely available for all of us

[@lx556]

This is pure gold, thank you so much!

[@dropclutch1]

Thank you Dr. Sinclair! Be well!

[@eyeandmind]

Hi David and Matt- class is in session. Get here early and sit in the front of class!

[@donotageteam451]

Another excellent podcast David - we love your work!

[@nickl826]

A few drugs to add to your inventory list where possible ;)

[@donotageteam451]

@@nickl826 We already have NMN, resveratrol, quercetin, fisetin, berberine & spermidine which he talks about here. Jump on our email list, we do the research so you don't have to 🙂

[@shcs2010]

@@donotageteam451 I don't see the email here. Should Berberine be taken in the morning too? What happens to traditional supplements, take them also or not?

[@user-sb9ml1ef4q]

came here to post this

[@rosesolis2306]

Hello. Are these products refundable if we don't like them. The do not age..

[@estoy1732]

Hi doctor. Thank you for your intellect! Thank you for existing ! Thank you for posting all this content. It’s so rich with knowledge. Thank you for your work.

[@zaralushlush5903]

Prof. Elena Goun, a chemist at the University of Missouri: ,,High levels of NR can increase the risk of aggressive breast cancer and the likelihood of metastases, including to the brain" !!!😮☹😟

[@FutonsJapan]

Great stuff. Hopefully we can get a list of blood test to take and how often to measure effectiveness and if it causes any problems. Apart from the physical or mental impact

[@88Jenpal]

Thanks for this podcast, I appreciate all your work and I been trying to follow your regimen. I wish that you could tell or advise us which you think is the best choice NMN supplements. I been paying a lot for it and still not sure if they are true to their advertising or I pick the right one.

[@jeffmiddlebrook5251]

Agreed, a podcast on NCEs will be important.

[@JohnDeanMusic]

You guys are changing my life.

[@katharineofarrogant7805]

Highlight of my week. As soon as I listened to these I started OMAD, changed my diet and exercise routine. I've sent this to all my friends and family. Pure gold!

[@cmsotube]

What is OMAD?

[@jazzisback]

@@cmsotube One Meal A Day = OMAD, IF = Intermittent Fasting. You're wellcome.

[@cg4806]

NMN increased estrogen levels in a mouse model. An in vitro study that inhibited NAMPT resulted in increased p53 levels and acetylation, up-regulated BAX and p21 expression, and induced apoptosis in estrogen receptor positive breast tumors. Adding exogenous NAD+ removed these effects. In the absence of clinical trials, women with a history of estrogen positive breast cancer would be wise to avoid supplements that increase NAD+, until sufficient long human studies demonstrate their safety.

[@natashatelfer5778]

ya, experimenting with nature--I think clean food, diet, and fasting is the best way to go!

[@rdallas81]

@@natashatelfer5778 Thats the truth Natasha. Most people are playing Russian roulette with these chemicals, while utterly failing at maximizing their health in all other ways.

[@danielmccarthyy]

In the absence of human trials, keep in mind that you are the N=1 Guinea pig (or Frankenstein, depending on which metaphor you prefer

[@lakshmiprakash4068]

Great to know all of these molecules. Thanks for the information

[@wolfpack8193]

Thank you so much. This information not only helpful to me but also to my parents and family. 🙏🙏🙏

[@daventhegreat]

Thanks David & Matthew absolutely amazing series. I have a very important request: Can you do an episode on what molecules/drugs are safe if we already have cancer... some of the common cancers .. prostrate, breast, bowel, lung cancer .... that would b gr8.... if that's possible given the huge diversity that's present in these disease processes & stages. Are there any universals for particular molecules or types of cancer? Etc

[@jeffmiddlebrook5251]

I knew this podcast would change everything...I would need to know about my lifespan.

[@stephenlucier]

Looking forward to next week!

[@vickydaisy_rose]

Love all episodes of your podcast.

[@winbalingit8502]

I saw Dr. Sinclair on a podcast giving a lecture on Resveratrol, it was for a wine convention, everyone, including Dr. Sinclair was drinking red wine!! The lecture was very educational and entertaining!!🤩👍🏽

[@johnalbers8020]

I am a physicist by education. I used to think the biology was an easy subject. Not any more. Listening to this very interesting podcast, I marvel at the complexity of biological systems. This podcast is very informative and easy to understand. I plan to use some of the supplements outlined in this podcast. Excellent

[@armaniwebb4467]

Wow exactly my thoughts. Physics and mathematics is very simple compared to biology. I came to the conclusion biology plays with physics the way we play with math, which makes it very difficult to predict and understand

[@armaniwebb4467]

You should look up quantum biology.

[@creativesource3514]

@@armaniwebb4467 This is incorrect. Physics and maths are not simple in comparison. They are the hardest subjects.

[@armaniwebb4467]

@@creativesource3514 perhaps. But it is an elementary matter. I can explain to you the orbits of planets, their gravitational pull, their magnetic sphere. I can plot trajectories across the stars, how the stara form, hell i can make a star here on earth. I can tell you the age of the universe. In the same breath I cannot tell you in a fundamental level how a cell transcribes genes, I cannot tell you how the proteins are transported and constructed, I cannot tell you how a protein is folded, I cannot tell you how a cell structures it's self, I cannot tell you how all this produces consciousness, I cannot explain the quantum mechanical effects of biology and how cells utilize it. My point isn't that we don't know per se, as there are things we don't know about physics. But my point is more so to showcase that to understand how these biology systems fully function is nearly impossible due to the complexity. I can breakdown the solar system and its functions and interactions much more easily then I can explain a drop of blood.

[@creativesource3514]

@@armaniwebb4467 I'm a head and neck cancer surgeon. I find what I do pretty basic compared to what you do, general relativity and quantum and what's going to be next. I study undergrad physics in those two in my free time and my mind boggles at the complexities.

[@dominiquezivkovich-brady]

Love it team. Well done. Thanks.

[@nadioluk]

Thank You Dr David Sinclair.

[@halnineooo136]

Any Q&A session some day on your channel? Thank you for the invaluable information.

[@johnwright4040]

David, when are you going to comment on the recent rumor banning NMN?

[@christianl.lorenzana8095]

Thank you for sharing your knowledge based on facts, sir Sinclair.

[@belindaluu1]

I love the pod cast and the supplement and practical tip recommends to stay forever young :)

[@sunshinecitypersonaltraini7228]

Great episode, thank you!

[@spirtfire6004]

What are your thoughts on apigenin? Especially in a post menopausal female on estrogen replacement-thank you for this terrific podcast and lending us your knowledge

[@paulaaquino5847]

Just randomly found you here on yt and into the world of longevity and I'm never going back!! About to buy your book as well! 🙌🙌

[@triciamedora9274]

Lord David really does look younger and his Skin is glowing.. Gosh hopefully he will do a podcast in the near future regarding supplements that are effective and proven to be safe that we can consider using at this very moment .

[@aussiecfo]

Great work, great information.

[@lotfibouhedjeur]

I wait for these videos as if my life depends on them. Wait, it does!

[@migtowredpill6950]

I'm glad I read "Lifespan", thus I understand much better this conversation

[@puppygirlfm1483]

David, thank you for sharing your knowledge to help others! Question about Berberine- when should I take it? At night, the same as when you take Metformin?

[@newpersonal3762]

I'm looking forward to listening to this. I hope you talk about olive oil and avocado oil. Many health benefits.

[@JoeCool0510]

It's a real shame about the FDA's stance on NMN. Here is something that could help a lot of people, is relatively safe (correct?), and now it looks as though it will no longer be available OTC. Is this fair? Why publish books and podcasts about this wonder molecule if it isn't going to be available to the masses -- unless they can convince their GP (who maybe had one class in nutrition and is already skeptical of supplements) to write a prescription-- also by which time the price will be extraordinarily high!

[@bellehamilton3395]

It's difficult to evaluate something with no visible consequences, but the research points to a positive outcome. It's probably best to utilize while you're under physical duress. This product has met my expectations in that it has made me feel more energetic in the morning and throughout the day since I started using it. I'll keep taking Vitruvin Health Anti-aging supplement since it keeps me energetic throughout the day.

[@angev60]

Final!! Waited forever for this episode! All episodes are very interesting. Just got the book!!!!!!

[@uberandreman]

Second comment: I want to add that I am following much of your protocol and I have so much energy it is incredible! I am relatively young (33), but have been dealing with fatigue for a long time. Particularly the day after intense exercise (BJJ). I have trouble focusing and getting through the day even with heavily optimized sleep. I am currently alternating between 16 and 22 hour fasts. When I do eat, it is mostly a low protein, high carb, plant based food (with some junk thrown in because I'm human and still working on things). I am taking NMN, resveratrol and Metformin. And I feel like a million bucks! I am recovering well, focused, creativity is up. I am honestly shocked and hope this is able to sustain itself for the next few months (I do not plan on doing all of this indefinitely).

[@s3731711]

Same!! Wow

[@cmsotube]

What brand of NMN, reservatrol amd metaform are you taking?

[@coman349]

Where do you get those? Is there reliable source?

[@belkisrazai5380]

Brand name please

[@Steven-ze2zk]

You're fatigued AND spend your days doing "intense exercise?"

[@user-ud4do1hj5t]

Dr. Sinclair, hope you will discuss how NMN affects kidneys. Kidneys are crucial to life but are not discussed often. Thank you!

[@lasvegasplease]

How does it effect the kidneys?

[@lucabrazi36]

Great info!! Looking forward to more videos!!

[@paulwn2023]

Really loving the podcast series. Great refresher for the book. Finding some of the supplements in Australia is harder than the US. Any recommended labs?

[@thomasbiom]

I was hoping that you would discuss Methylation concerns and the use of TMG to mitigate. Also, I find the piece that’s often missing from Such discussions is for pregnant & breastfeeding mothers.

[@lelle9901]

Women in general are always missing from specific discussions. Because of hormones, women may respond to fasting differently than men, for example.

[@goldgold4943]

Sinclar, the god of anti aging

[@lucycooper55]

Just finished his book . I was glued the entire time. I know he’s working on another. Anyone know it’s approximate release? I can’t wait 🏋️‍♂️

[@HarpreetKaur-dw2me]

Thank you David Sinclair 😊🙏

[@captainpike2468]

Important to emphasize ‘the threshold level’ as David discussed in his interview with Rhonda Patrick PhD , the ‘natural clearing process ‘ of the body that will eliminate NMN supplements , Resveratrol from the body - and David’s idea of ‘pulsing ‘ these supplements every other day , then fasting and exercising

[@jamesevans4781]

In that interview with Dr. Patrick he mentions that young mice lived longer if the protocol was pulsed rather than if they received the supplements daily, but he doesn't pulse his own protocol. Is that because he's middle aged and every day is more efficacious, or did you come away thinking that the pulsing is an emerging idea which he is still vetting before switching his own protocol

[@aaliyahlee1265]

My life has changed after taking NMN supplement... I was very sickly and weak years ago, but when I learned about this product, it gave me hope to progress all the things I stopped doing before, like gardening.. I feel so alive and well with vitruvin NMN and trans-resveratrol..

[@robynhope219]

You must be rich..I can’t afford these supplements ☹️

[@mariamessina550]

Awesome information, thanks so much for sharing your knowledge 🙏🏻🙏🏻👏❤️

[@Articulate99]

Always informative, thank you.

[@ewastykowska3460]

As a person without any medical background I really wonder how to check my body response to the supplements recommended in this podcast🤷🏻‍♀️. I would like to know what blood parameters/blood tests I should check before taking the supplements and when to check out the results by retesting. My kind wish is to have the professor’s opinion whether the recommended supplements are safe for people with celiac disease? Could you also recommend supplements for people with serious problems with knees (deficiency of collagen and how to reverse that ?) Thank you for helping people understand what is going on with their own body❤️

[@therealtimray]

NR consistently raised my alt and ast liver enzymes during a year's worth of regular blood tests. NMN lowered my enzymes even lower than they were before taking NR in the first place.

[@larnapike6992]

Hi Tim :) given what Dr Sinclair said about Pancreatic Cancer and NMN, I’m wondering if you screened for that genetic propensity and if so what test you used? It’s my only concern regarding starting that supplement. Thanks!

[@therealtimray]

@@larnapike6992 under my 23 and me account, I don't see anything that would indicate a propensity for that or any other form of cancer. There are others who've had this issue with NR, since NR requires additional methyl groups in order to be converted into a usable form. To get these methyl groups, your body has to borrow them from other molecules in the body, taxing the liver more. Which by the way, I'm discussing the liver, not the pancreas. As far as my pancreas goes, all of those health numbers, such as A1C are optimal.

[@ginacardarella]

Thank you thank you for this podcast and especially the show notes

[@adamloepker8057]

The 20 seconds of trolling starting at 38:07 is my favorite by far... this series is great!

[@Josh-ev6nb]

Can you elaborate more on metformin and berberine for (aging) athletes? What is happening with glucose? Is the total amount of glucose storage in the body reduced? Are we excreting it? Or do the molecules just help glucose more effectively get into tissue? So let's say I have a big ride the next day and I'm trying to tank up on carbohydrates. What's happening if I take one of these molecules with my high carb dinner? THANK YOU!!! LOVE YOUR WORK!!!

[@woubshetwoldemariam9574]

I would really like to express my appreciation to z work u guys are doing. Keep up z good job! Bravo!

[@aladin3669]

I am asking why the following was not entered into? February 2022, Sinclair raised widespread controversy in the longevity research community by rejecting to communicate in an academic debate in which his resveratrol research was criticized after months of mounting evidence against reseveratrol as a longevity intervention,..... Science after all was exchanging information and viewpoints correct?

[@rickemmet1104]

Tweets, "David just tell us what to take." LOL! I've already implemented a bunch of lifestyle changes. These interventions will change medicine (which many will be unhappy with) but you all better change what you're eating and get to the gym too. Thanks David for the awesome podcast!

[@waldineytorres8578]

I'd love to know Dr. Sinclair's opinion on stereoisomers of resveratrol and pterostilbene, wheter it is just marketing or something else entirely. Fascinating conversation as always.