The Hallmarks of Aging: Loss of Proteostasis | LifeXtenShow

The human body is like clockwork: finely tuned, intricate, and complex. Just like a clock, things go awry when its inner mechanisms, proteins, begin to malfunction. This is what happens to us as we age, but as Giuliano says in this episode, there may be ways around it.
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Intro jingle courtesy of Kevin MacLeod - Incompetech.com
"Hungarian Rhapsody N.2" by Franz Listz, licensed under cc-by-sa Germany license by Bernd Krueger, www.piano-midi.de
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Sources and further reading:
Hallmarks of aging
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217. (www.ncbi.nlm.nih.gov/pmc/arti...)
Implication of dysfunctional proteins in Alzheimer's, Parkinson's, and heart failure
Bloom, G. S. (2014). Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA neurology, 71(4), 505-508. (www.ncbi.nlm.nih.gov/pubmed/2...)
Stefanis, L. (2011). α-Synuclein in Parkinson’s Disease. Cold Spring Harbor Perspectives in Medicine, 2(2), a009399-a009399. (www.ncbi.nlm.nih.gov/pmc/arti...)
Ruberg, F. L., & Berk, J. L. (2012). Transthyretin (TTR) cardiac amyloidosis. Circulation, 126(10), 1286-1300. (www.ncbi.nlm.nih.gov/pmc/arti...)
Ubiquitine-proteasome degradation system
Lecker, S. H., Goldberg, A. L., & Mitch, W. E. (2006). Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. Journal of the American Society of Nephrology, 17(7), 1807-1819.
(jasn.asnjournals.org/content/...)
Prions ("infective" proteins)
Watts, J. C., & Prusiner, S. B. (2017). β-Amyloid Prions and the Pathobiology of Alzheimer’s Disease. Cold Spring Harbor Perspectives in Medicine, 8(5), a023507. (www.ncbi.nlm.nih.gov/pmc/arti...)
Grifols
www.prnewswire.com/news-relea...
GAIM
www.proclarabio.com/our-programs
Arethusta
www.leucadiatx.com/science
• Doug Ethell | Alzheime...
About glucosepane:
www.leafscience.org/undoing-a...
Monnier, V. M., Sun, W., Sell, D. R., Fan, X., Nemet, I., & Genuth, S. (2014). Glucosepane: a poorly understood advanced glycation end product of growing importance for diabetes and its complications. Clinical chemistry and laboratory medicine, 52(1), 21-32.
(www.ncbi.nlm.nih.gov/pmc/arti...)
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#Proteins #Biotechnology #Aging #LifeExtension #Biology #Proteostasis #Rejuvenation
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[@LifespanIO]

If you wish to help us end age-related disease, please visit ► www.lifespan.io/hero Join the conversation on our ► Discord Server: discord.gg/HwTX7gR and ► Subscribe: kzbin.info

[@Millzie-wf1ql]

Great work, links in description!

[@Pyriphlegeton]

Another informative episode! Thank you!

[@quinnsmith8421]

Well done, Giuliano. :)

[@nozhki-busha]

Great job guys :D

[@Danath1982]

Awesome video as always! Very informative and I appreciate when you guys help us measure our expectations while still giving hope for the future. If any of this were easy we would've solved this problem long ago. I love the blooper reels at the end of the newer episodes as well. Giuliano's voice gets impressively high :D

[@mayonnaise7547]

These videos are a godsend to my essay.

[@EpicGir1]

It breaks my heart how small your audience is :(

[@nozhki-busha]

Spread the word and help us grow :)

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[@flashgordon6510]

Very informative, thank you!

[@falst573]

Such an informative video! I can't believe you're so underrated

[@LifespanIO]

Glad you think so! We'll do our best to keep it up :)

[@Julia_H101]

Wow. These episodes are really helpfull for an 80-hour long essay i have to write. I had to choose a subject myself and i chose immortality. So this really helpfull. Thank you very much. :)

[@user-sd2fl9mk9r]

Сделайте перевод, пожалуйста!))

[@CamelxRavenNova2]

I want my synthetic prosthetic body with synthetic human like skin covering over which I can turn on and off.