Lobular Breast Cancer Uncovered: Expert Insights With Dr. Liz O'riordan

If you've got lobular breast cancer, then you need to watch this video.
I'll tell you what is is, how it's treated, how you should be followed-up and the ongoing research and studies into immunotherapy to treat and stop Stage 4 disease.
00:00 - Intro
00:43 - My lobular breast cancer story
01:41 - What is lobular breast cancer?
03:15 - Why are they hard to find?
03:56 - How are they diagnosed?
05:21 - How is lobular breast cancer treated?
07:25 - Does lobular breast cancer have a worse outcome?
08:30 - Should you have MRI as a follow-up?
09:43 - Stage 4 Lobular breast cancer
11:27 - Future research for lobular breast cancer
I'm Dr Liz O'Riordan, a breast cancer surgeon who's had breast cancer three times. I'm an expert in all things breast cancer. If you've got a question - I'll answer it for you
Lobular Breast Cancer Alliance
lobularbreastcancer.org
I’m now an accredited Trusted Information Creator!
The Patient Information Forum (PIF) has awarded me an Individual PIF TICK, which means my health content is:
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www.piftick.org.uk/about
♻️References
reachmd.com/programs/project-...
www.onclive.com/view/invasive...
breast-cancer-research.biomed...
lobularbreastcancer.org.uk/wh...
www.frontiersin.org/articles/...
Website - liz.oriordan.co.uk
Author ‘Under The Knife’ and ‘The Complete Guide to Breast Cancer’
Podcast - So Now I've Got Breast Cancer
👉Instagram @oriordanliz
👉Twitter @Liz_ORiordan
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[@julia37777]

Thank you so much for this informative video. I think it will be helpful for my family to watch. I am an oncology nurse practitioner diagnosed with an 8 cm pleomorphic lobular breast cancer in 2022. I had bilateral mastectomy followed by chemo and radiation, now on anastrazole and abemaciclib. I was heartbroken when I saw the path said pleomorphic 😢 Genetic testing found a germline CHEK2 mutation. I hope there continue to be trials specifically for lobular and that we find out more info about pleomorphic lobular as well.

[@amyhoppock6071]

Thank you. I appreciate your clear, calm, communication. I was diagnosed last year with ILC. Appreciate all this information!

[@DrLizORiordan]

Glad it was helpful!

[@vilmavelazquez1979]

Thank you so much, Dr. O’Riodan! Your videos on ILC are so good. Great info. Easy to follow. Thank you so much ❤

[@marymazzoni2079]

I got so anxious watching this Invasive lobular carcinoma 2 tumors both 2and a half centimeters and also in my lymph nodes. I had a clear mammogram the year before I got diagnosed.

[@FrugalTravellers]

Thank you for another excellent, informative video. I too was diagnosed with lobular cancer after seeing a strange indentation on my left breast. I am so pleased it was caught early & that I had an SMX, as it ended up being 3 multifocal cancers, with the largest being 0.9cm, and no lymph nodes involved. Here's hoping the liquid diagnosis comes through soon 👏🤗

[@dorothyquarles1982]

Hi the mammogram did not show my cancer i had a ABUS that showed. Two surgeries later. So far I'm okay. I pray your doing well. Love all your educational utubes. Thank you

[@nicholamayer4174]

Informative video, thanks.

[@bchmom03]

Thank you, awesome video. I had a breast reduction and pathology showed low grade DCIS in 2 areas in rt breast. I opted for a bil mastectomy and a 4mm ILC was found in the left breast, Grade 1, Stage 1, nodes negative, lymphovascular fluids clear. My mammogram was Clear prior to reduction. I was 63. This was 5/24/23.. I tried letrozole and it was horrible. I am not sure what to do, my med onc is not knowledgeable. I already have osteopenia. Trying to take natural AI’s supplements that MD Anderson Cancer Center has done studies on. My estrogen and testosterone levels are basically non-existent as of now. I am very thin and active. No hereditary factor, awaiting testing for that.I am in Florida. Retired RN.

[@bchmom03]

I also had atypical lobular hyperplasia throughout both breast according to pathology from breast reduction tissue that was removed, that is why I chose a dbl mastectomy. I had 3 kids young and nursed them and lived a healthy lifestyle. This has thrown me for a loop. Have 2 daughters in their 30s.

[@shamudogsmith1751]

Letrozole made my life miserable. The surgery and the radiotherapy were a doddle compared to taking Letrozole. I am trying another A.I. at the moment. I'm 57, and I'm not overweight, don't drink, never smoked, and breastfed both of my children yet ended up with Lobular Cancer. I hope everything goes well for you.

[@bchmom03]

@@shamudogsmith1751 Have you tried anastrozole? I tell you, I just do not know what to do. I already have decreased quality of life due to pelvic mesh disaster that was used to lift my bladder. It has all been removed but my pelvis is forever damaged. Have horrible deep muscle spasms and scarring. The thought of my taking a medication that will further make me miserable is really too much to bear. I hope everything goes well with you too. I wish there was a diff approach to help prevent recurrence than meds that have such dangerous SE and QOL issues. All for a 4mm group of cells found incidentally in my left breast. The med onc never mentions the DCIS.

[@gracepopoviciu313]

would you mind letting me know what natural AI supplements are you taking? I have atypical lobular hyperplasia in one breast.

[@rebeccakarlsson1395]

I wonder the same. Have had digestive and bowel weirdness now for the past few years (dx in 2020). They keep sending me to a gastroenterologist who does a lot of scopes but never finds anything. But I wonder if these doctors even know what to look for. Lobular mets must look very different from other cancers. I just don’t know how to be sure I’m being properly monitored especially since PET scans, MRIs, mammograms and CT scans all can miss lobular cancers. So frustrating.

[@staceyvaas1210]

Thank you Dr Liz. I was diagnosed with ILC of the pleomorphic variety 2 years ago. I had a unilateral mastectomy, underwent chemo & Radiation. I’m currently on a targeted therapy for a total of 24 rounds along with Anastrazole. Metastatic disease is a daily or frequent worry. Thank you for this content. I will continue to watch & learn.

[@SQAE]

Thanks! I’m now a healthy 77 diagnosed two years ago with 8 mm lump (!) of lobular and nothing in sentinel. Had a lumpectomy & radiotherapy, no problems with letrozole and so far so good. But thanks to you I’m more informed than my doctors on ILC and will be extra vigilant. You may just have saved my life.

[@jacquelynconnor6992]

This is the 1st time I've heard about the different symptoms to look out for with metastatic lobular cancer. How do I know if the constipation and bladder issues I've been having since taking letrozole are just a side effect of the drug and not a metastatic symptom? I've been switched to exemestane with estiol cream to see if this reduces my side effects, but am starting to have the same bowel & bladder issues as I had on letrozole.

[@helenjunell6271]

Thank You for this great information. I have invasive ductal stage 2. 100% estrogen

[@helenjunell6271]

Thanks!

[@elaine3020]

Thank u Dr Liz.

[@cml9797]

❤❤thanks for your sharing

[@aleta5024]

This video was amazing. Thank you so much Dr Liz.

[@DrLizORiordan]

You're so welcome!

[@elitehills1544]

❤thank you so much for this great video!

[@DrLizORiordan]

You are so welcome!

[@lailasalm6159]

Very informative, thankyou! I am now stage 4 after only a 14 month hiatus from cancer…what about those of us with not just lobular but as well triple negative, where hormonal therapy doesn’t work?

[@ClareMBrowb]

I was diagnosed in 2015 with stage 3 er positive lobular cancer. Diagnosed late 2022 with metastatic disease in shoulder but receptors changed to her2 positive had a shoulder replacement but had abraxane chemo as mets in pelvis too. Have been on both letrozole and phesgo since with slight progression but a recent pet and biopsy now shows I'm Her2 low. Cancer is ever changing in my case!

[@ChubbyPabloDiablo1]

Super video. It would be helpful to know if there's anywhere we can sign up for future trials/research. I know you can see it on Breast Cancer Now but does anyone know of anywhere else we should be looking?

[@Bettina_Bettina]

I have invasive lobular breast cancer grade 2 and I just got the news yesterday 😞 thank you for sharing this information

[@ChubbyPabloDiablo1]

I'm sorry to hear that. That's the diagnosis I got too back in Dec. It's hard going

[@christinaxj]

Thank you. Can’t switch from tamoxifen to letrozole just yet until menopause reached but cdk coming soon

[@LM-336]

Thank you for your content You mentioned Adjuvant! Online… however it’s been quite a while since this tool doesn’t seem to be accessible anymore ?

[@ebnanaann5644]

Thank you for this clear informative video as no one in my oncology team? has given me any information as the the why I am being given this treatment currently on Letrozole and about to start Verzenios at 50 mg as both 150 and 100 have sent my liver function to abnormal heights.

[@dontbeaturd763]

I was just diagnosed with a benign complex fiboadenoma. Should I have it removed? What are my chances of getting breast cancer with if the lump remains in my breast?

[@SimonDanson]

Last video I saw was a couple of days ago. I thought Ms O'Riordan looked like she was suffering a grief reaction although we wouldn't know that for a while according to psychology thinking. I have only known two people in my life with this. Both didn't want help at that time so I write this unconnected to the video in question. I would say sorry. Perhaps that's why the Dr deleted the video because of not wanting to read a whole load of strangers like me saying sorry. I would say 'look after yourself'! The one thing grief sufferers don't want to hear. I live in Wales so I would say to anyone living anywhere like this check your Vitamin D and Magnesium Levels apart from others like eGFR. Surgeons I have met like Ms O'R don't like blood tests but here in Wales people who have had cancer get depressed with low levels of these and if corrected can feel a little better. Of course it doesn't bring back wife, father or any other lost loved one. I just think a grief stricken Welshman should be taking at least 4000Units vitamin D a day. It is difficult to get GP's to check Vitamin D (expensive) but here in Wales the results I have seen have always been low and grief seems to always be worse when it is. Ideally everyone with bad grief (in remission from cancer or not) should see GP whether surgeon or not! (I know what many readers are going to say: magnesium is an intracellular ion and difficult to test whole body levels. Perhaps it would be wise for GP to attempt to test this in a person who has had chemotherapy.) Even if Ms O'R cant take this genuine sympathy at the moment I hope her partner can.

[@cml9797]

What is the skin look different lobular type?

[@rachelstrahan2486]

👍

[@user-wp5gu2sy3f]

Breast cancer: Reference by the mathematician (it's me), who worked with Albert Einstein's only assistant and also with the probability and Venetian actuary Bruno De Finetti, the Kolmogorov-Smirnov statistics and their stochastic axiomatization in category theory relate the key figures of the patient's alleged breast disease to the question of whether to operate or not - otherwise it is medical malpractice.