Local Anesthetics - Mechanism, Indications & Side Effects

[@XIX38]

Thank you! Please continue these videos. This channel is a gem

[@physiopathopharmaco4190]

You’re welcome and thank you very much

[@diazepam_11]

This is interesting. By far anesthesiology is one major key to successful surgery.

[@tarminsultana429]

Excellent explanation, it clear my basics

[@someonedd9052]

Thank you very much , nice and brief illustration , very helpful

[@Mirameowty33]

Awesome 👍🏻

[@akashsingh5972]

Awesome video 👍👍 Plz make a video on general anasthetics

[@atziratig]

Is it normal to still feel numb after 2 days of local anesthesia because of my wounded finger got stitched?

[@shvonned.burkemsncrnpagpcn619]

So excited. Passed all questions at the end. I deserve a KitKat :)

[@physiopathopharmaco4190]

Awesome 👏 😊

[@fatimahm9553]

You are amazing , so we give the LA first in the ionized form right?

[@humphreylugenya4352]

All LA are unionised until they enter the axonal membrane they become ionised and produce their effect.

[@wendywu2199]

thank you and i hope it will help me to do better with next this coming Friday Surgical Day care unit job interview! wish me luck.

[@physiopathopharmaco4190]

All the best with your interview!

[@mahedihasan3809]

Benzocaine is used in "U & Me" brand condom. Is this harmful for body or not please answer it.

[@PriPradhan]

What happens if you administrator 1.5ml of LA into bloodstream? It seems I injected after a positive aspiration. It was a mistake that I didn't realize.

[@taghreedrulia5168]

How did you know that it was infected to the bloodstream? Im suspecting the same thing but how can we know?is there a test that could be done?

[@PriPradhan]

@@taghreedrulia5168 because aspiration was positive which I didn't notice at first

[@glammedbynatalia]

Whatever kind of cocaine they give at the dentist makes my heart pump way too fast, way tooo fasttt

[@shantell4847]

What about the numbing gel or spray

[@SkylarsTerribleMemes]

lidocaine isn't cocaine lol. it's probably the epinephrine, it's also known as adrenaline

[@techtime2922]

@@SkylarsTerribleMemes its this

[@greenearth4657]

What if the person has lever problem ?

[@SnacksTime]

Two months ago, I had Lipoma Surgery on my right shoulder. Doctor used local anaesthetic. I have been feeling difficult in breathing... Is this side effects of local anaesthetic?

[@physiopathopharmaco4190]

Since it was 2 months ago that you had surgery, the local anesthetic would be gone by now

[@SnacksTime]

@@physiopathopharmaco4190 Thank you so much for your reply! This problem started to me after two weeks of surgery and still its continue.. so I thought It could be side effects of overdose of local anaesthetic...

[@bramhanioza3009]

Thank you 🙌🏻

[@pilarguevara5178]

hello Very good video, I only have a question, I tought that myelinated neurons were affected faster-easier than non-myelinated ones. thanks

[@physiopathopharmaco4190]

The local anesthetic has to get inside the neuron to exert its action. The myelin represents another layer that must be crossed.

[@pilarguevara5178]

@@physiopathopharmaco4190 Thanks for your answer. This is a different explanation that I had found "Imagine a pearl necklace. A myelinated nerve looks like that; with myelin "pearls" on a string. Electrical impulses occur at the string, and "skips" over the pearls. If the pearls are too big, or too close together, the impulse cannot "skip" that far. Myelin sheathes portions of the nerve, forcing the action potential to "skip" along the axon. The myelin sheaths are just small enough to allow the skipping to occur; any larger and the AP simply cannot "skip" that far. If an area of a myelinated nerve is blocked, the length of the "skip" is too long for the action potential to make it, and the AP dies. If you blocked the same amount of nerve fibre in a nonmyelinated nerve, the AP can just "skip" over it. In a non myelinated fibre, the area of nerve blockage has to be large enough to prevent that skipping. This is harder to do because you have to block a much larger length of the nerve".

[@reneetan4454]

2:51 why a precipitate will form in the body if it's not protonated? Can you explain further? :o

[@icarusfalls4806]

In market when they sell vial it’s available in Non-p form only. And we directly inject that into the area/ecf. It’ll be taken up by the Nociceptor. Inside the cell (icf), it’s acidic, which has plenty H+, it’ll act at Na+ channel now. Advantage of Non P drug in market is that, this is lipid soluble, helps in rapid uptake by the cells. We don’t inject in P form. We inject in NP form only.

[@gachailly218]

after having local anesthetic for the second time I could still feel the pain? can someone tell me why

[@Supernova-217]

Its possible that the drug was either being metabolized really fast, or was injected really superficially... also it could be that a very short acting drug was used... or maybe too small amount of drug was used, and it did not penetrate to deeper nerves and nerves adjacent to he immediate site of injection

[@irenekrisdyandagsindal9504]

@@Supernova-217 is it a drug man

[@MusicJammer607]

@@Supernova-217 thanks for this...maybe that's why my boy shouting, feel pain during circumcision.

[@SkylarsTerribleMemes]

@@MusicJammer607 genuine question, what the hell is the point of circumcision?

[@abel3557]

@@SkylarsTerribleMemes late response but it lowers the risk of infections and makes it easier to pre as well and easier to clean the area

[@monosizrahaman0321]

why intravenous route is not suited for local anesthesia ?

[@Isabel6194]

Because you don't want the anestheticum, and/or the vasconstrictor (usually adrenaline ) directly into your bloodstream. The vasconstrictor will have negative side-effects when given intravenously.

[@Eman-hv2hn]

Thank you so much 🙏🏼🙏🏼

[@physiopathopharmaco4190]

You are so welcome

[@Rozela16]

Yesterday I was administered lidocaine for a dental filling. All of a sudden I started to pass out during the procedure and I had no way to communicate that I was feeling off. I struggled to move and everything sounded very weird. I felt very warm, talkative, fatigued, relaxed, and I had blurry vision. My tongue was completely paralyzed for hours. I didn't realize until I researched that I may have a problem with lidocaine. Why may a patient be sensitive to lidocaine?

[@glammedbynatalia]

Yes for Sure. Its adrenaline I’m lidocaine. Just like cocaine. I don’t get that at the dentist but I do get super fast heart rate, my blood pressure goes up too. I hate going to the dentist bcuz of the reaction I get from the drug

[@muziq99]

Glammed by Natalia hello

[@portafortuna3645]

​@@glammedbynataliadid it go away? The raised heart beat?

[@Jonathan-ef8uy]

Thank you so much 😊😊😊😊😊

[@physiopathopharmaco4190]

You’re welcome 😉

[@sajedabdulkhaleque3275]

thanks a lot

[@Kem9s]

Much thanks💕💕

[@morm2173]

Tetracaine is the strongest I've tried

[@kevinwiltshire3526]

Is it safe for pregnant mother used lidocaine injection

[@Isabel6194]

Yes, lido is safe. Prolicain (citanest) should be avoided during pregnancy.

[@Saphira_21]

How much mg is to much of benzocaine?

[@SandeepKumar-nt6yl]

Can I cut my frenulum yourself by lidocaine cream....plzzz

[@eabharedmond3563]

NO

[@mashaelm2343]

thxxxxxx❤❤❤❤❤❤❤❤❤