Low-dose Naltrexone (LDN) & The Gut Microbiome: Kent MacLeod, RPh., B.Sc., Owner & CEO of NutriChem

Keynote Speaker: Kent MacLeod, RPh., B.Sc., Owner & CEO of NutriChem
Topic: Low-dose Naltrexone (LDN) & The Gut Microbiome
Kent MacLeod, RPh., BSc.Phm., is a pharmacist, as well as the founder and CEO of NutriChem Compounding Pharmacy & Clinic in Ottawa, Ontario. He is an international thought leader and award-winning pharmacist, with over 35 years of clinical experience delivering patient-centered healthcare.
He is globally recognized as a hormone health and nutrition expert, has lectured at many health conferences, published research, and developed course materials for many professional clinics based on NutriChem’s success. He is the author of the book, “Biology of the Brain: How your gut microbiome affects your brain,” and his focus is on the relationship of the gut microbiome to mental health and immune function.

[@jimgill5706]

I am 76 years old and I am healthier and stronger now than I was when I was 50 years old. There are two main reasons for this. I have taken LDN for the past 10 years and I keep my vitamin D level high by taking between 10,000 and 20,000 iu of D3. I keep my D level between 100 and 150 ng/ml. I also take magnesium malate, K2, B complex, turmeric, alpha lipoic acid, a good multi-vitamin, and a good multi-mineral supplement. I am also on a keto diet for the past year. The LDN and high D3 levels cured all of my many previous health problems.

[@normawright4339]

Would you share what multivitamin and mineral you take?

[@jpcsfp]

What dose of ldn?

[@jean6460]

That’s fabulous!!

[@theancientsancients1769]

Do you take your vitamin D with K2 MK7?

[@VictoreaLuminary]

@jimgill5706 Would you be willing to share your multivitamin and mineral supplements? Thank you in advance.

[@gunningriddybfest1610]

I have been using LDN since 2007 for my Crohn's disease. Haven't used any other Crohn's meds. Less sugar and more vegetables every day. My Crohn's was in a flare when I started LDN. Gradually I got better, some of the typical Crohn's symptoms improved immediately, and some needed a year. This is how LDN works, don't stop using it. Have patience, you will gradually feel much better.

[@Wds__99]

Perhaps try a carnivore diet. I see others resolving chrons with carnivore. Veggies can cause gut inflammation.

[@ranisen620]

Can u please elaborate more about your success with LDN and Crohn’s … Are u still taking it and in what dosage ?

[@ronelbosman8383]

What is the dosage of LDN?

[@bonniehill4299]

FYI. THE BEST FIBER I have found is Basil Seed 2 tblesp give you 15 grams of fiber. I put it in Coconut flavored water. My second is Accaia fiber 6 gra m s in 1 tblesp put it in cereal, smoothies or soups,etc. It really helped with gut issues. I am talking LDN which is helping deal with Sjorgren's and Hashimoto's.

[@brendabrenner2891]

This was gold!tu from my heart, gut, + brain😅..am celiac, gut dysbiosis, long lyme, long covid, was pre ned..studied gut/brain 2 years,+ see much common sense, logical approach to healing DIS-EASE, something wester dr not trained to do inmed school w out big pharma..must educate inters to think outside the box, tu❤❤❤

[@milkanovacevska2110]

He’s passionate because LDN works!!!

[@paulastein7031]

Is LDN a substance that might interact negatively with cardiac arrhythmia or drugs like propafenone, diltiazem,?

[@JenJen0582]

That would be a good question for your pharmacist

[@theancientsancients1769]

Never take LDN without medical supervision! They must do full medical exam and check all your health record and if they start you on LDN they must start at low dose until you get a dose that works for you

[@BeeBop1029]

Wheat and to a lesser extent dairy causes me arrhythmia. (Just fyi)

[@montanak7]

Yes!!! GI docs should have to watch this!

[@lindapelle8738]

My GI dr told have lots of kids no time to worry about it like his wife. Jerk

[@Hansen23900]

No kick backs so they won’t use it

[@eddieleong6490]

Using nano technology, scientists should be able to monitor the gut microbiome real time and transmit the info so that each person can fine-tune his microbiome. If we all eat the normal diet available, then how come our microbiome can differ? Some are well, some are sick, etc.?

[@lindapelle8738]

Well I grew up on sugar cereals, cake, ice cream ,meat potatoes peas n corn, ugh I was sick at four full explosion into autoimmune in early thirties. I was vegan, bad idea

[@theancientsancients1769]

We already have gut microbiome test

[@KarinSchweizer-b4g]

Even identical Twins have different microbiomes at birth. NB. We are all different.

[@CommanderBabe]

This interviewer asks very good questions.

[@estanford826]

Certainly one thing that has changed is the gross increase in the use of vaccines, flu shots etc of course refined foods, sugar, seed oils etc AKA: Food poisoning.

[@AlexSelf-Help]

Thx for the video. I have now weak orgasms and low libido after taking 3 weeks LDN. I quit immediately but symptoms persisted since over 1,5 months now. I did not take ANYTHING else, and never ever experienced such symptoms before. My testo levels are through the roof, there is no erectile dysfunction, it's just the sexual sensations that blunted. Climax is no real pleasure (20%) and sexual desire not really there. I suspect it came from the opiate receptor blocking mechanism of LDN, which also makes sense, as the drug is used to get people off other pleasures like alcohol and shopping addiction. I was wondering what I can do to counteract these effects? Taking opiates to stimulate from the opposite side? Really concerned these symptoms stay persistent, like some sort of PSSD. Btw. another reason why I can clearly attribute these side effects to LDN, is that I am no longer tired after climax (0%), like I can come twice in 30min no problem, which seems fun, but not if you're not enjoying the act. It is known that LDN messes with prolactin, so just another piece of evidence, just don't wanna hear from anyone: it must be from other things. (I am 34 years young)

[@dragoh7102]

What dose were you taking?

[@AlexSelf-Help]

@@dragoh7102 only 4mg for 3 weeks

[@dragoh7102]

@@AlexSelf-Help did you ever find a solution, thank you for your comment, I was about to take it and just didn’t feel right about it.

[@AlexSelf-Help]

@@dragoh7102 not really, did quit the med and thought it rebalances by itself, which it doesn’t . Will try to take morphine , as it does the opposite of LdN and it stimulates mu receptors….hope this might bring improvement

[@theancientsancients1769]

​@@AlexSelf-HelpYou took high dose that's probably why! This drug causes side effects if you take high dose at the start! You should have started at very low dose and slowly build up to dose that helps you. It probably will fade away . Finesteride for hair loss gave me such such effects and it took months to get better. Ginkgo Biloba and L arginine at 1000mg may help . NAC will probably detox your body from along with Chlorella. Update us ✌️

[@veramentegina]

excellent in depth look at LDN. thank you!

[@lindapelle8738]

Boy I would love to work with this guy one on one

[@browneyedgirlFL67]

Can you give some examples of soluble fibers and what is a good pre/probiotic? Thank you

[@luckycharmranch]

Fruits and Vegetables

[@jmc8076]

Lots of info online if you google.

[@R.D.E-ew6ov]

Popcorn is a good prebiotic and source of fiber(without all the butter and stuff) bananas are a good prebiotic and have fiber.

[@lindapelle8738]

Does anyone what type of fiber he is suggesting, Polyphenolic fibers, what is it, what specific nutrients heal leaky gut.

[@BeHappyBeHappybe1111]

Cranberry is a rich source of polyphenols including flavan-3-ols, anthocyanins, and flavonols. It contains more polyphenols per serving (373 mg polyphenols as catechin equivalents/50 g) [7] compared to other commonly consumed fruits such as apples, cherries, blueberries, blackberries, grapes, and strawberries. and pomegranate , green tea , real choc, fish oils

[@surfersparadise5615]

If you have leaky gut stay away from foods with lectins....do the research, it is fascinating....

[@kimberlykopetseg5154]

Marshmallow, okra, aloe, chia seeds, flax seed, hemp seed, etc. What improves ones health could be harmful and a poison for another.

[@R.D.E-ew6ov]

Soluble fibers, popcorn, beans, bananas are a few I know of. L Glutamine is supposed to be good for the gut and inflammation in the gut. At least that what my nutrionist taught me.

[@R.D.E-ew6ov]

Flax meal is good too

[@alancosens]

The folks at Paleomedicina in Hungary seem to have cracked the real underlying cause and have been successfully handling it for over 10 years.

[@patsycloninger2216]

Alan Cosens -- please direct me where I may find more information online from Paleomedicine. I have been on LDN only 3 months and can see some help, so hopeful for more as mentioned it appears to build up positive impact to a plateau, this for fibromyalgia, chronic myofascial pain and IBD. New studies (2020) out of UK and I believe Belgium (planned concurrently) reveal antibodies of people with autoimmune illnesses are very different and is a pathway for further pharmacology not yet utilized.

[@caroledevlin4436]

What are you dying? Do you have a link?

[@maryjohnson753]

@@patsycloninger2216 LDN is a life changer. I use the liquid preservative free (corn free) version before bedtime. If you use a large amount you will have the worst nightmares. Start low & slow. Some people get results quickly, while others it might take longer. A woman in England (dx with MS) got ms reversed after 18 months. Eventually you will get to a point that you should then slowly titrate down. I no longer need 4.5mg & use 1.25mg.

[@patsycloninger2216]

@@maryjohnson753 Mary, thank you for your knowledgeable and thoughtful reply. Currently on 0.03 mg, I am also sensitive to corn/corn products, and have compounding pharmacy also not use pork. I have a follow-up w/ prescribing M.D. in September. A Physiatrist saw recently feels should titrate up to 4.5 and see what benefits are evidenced. He said he administers some patients up to .0.06 mg. In your opinion, does this appear strong for most LDN application?

[@maryjohnson753]

@@patsycloninger2216 That sounds too high. I have not seen anyone using that high amount. I could not go that high without bad nightmares. I got to 4mg & had to go down to 3.5mg. Eventually titrated to 1.25mg. That process was slow.

[@glenmonks1]

Can LDN be used for M-biome support whilst treating H.pylori? Do you use ABX to eradicate HPylori or a natural approach to reduce proliferation?

[@BeeBop1029]

This is not advice. This is what I’d do in your shoes. Something I have seen cure resistant bacterial infections… a patent I found. I made it and used it past several years. I would not continuously stay on because who knows? Anyway… I googled “Revici tung oil patent”. 1/4 cup pure tung oil, 3/4 cup safflower oil. 2 drops am, 2 drops pm. 30 days. It’s the alpha eleostearic acid. Powerful stuff. I don’t know interactions or anything really.

[@dreamcastsoul]

Hi guys, thank you for this discussion., I have been suffering from seronegative spondylarthritis and central sensitisation for the last two years, that was precipitated by extreme fatigue and depression for the previous six years. I’m about to start low dose naltrexone after attempting to heal my gut naturpathically for over a year ,however, I’m wanting to know if there’s anything else that I could do concurrently, like an FMT transplant? And if LDN doesn’t work, is there anything else I can try? Thank you

[@hvspeed6102]

Did you ever get any success with this?

[@elsyalvarezr]

did the LDN worked?

[@lindapelle8738]

Hi just curious how the naltrexone worked for you? I have fibromyalgia, ibs..constipation, Interstitial Cystitis etc all autoimmune began with Epstein Barr flu lasted many months triggered for yrs. thank you…

[@lillyallen6559]

@@lindapelle8738 hi I also have IC, IBS, EBV.. I also have chronic Lyme , positive ANA.. I have started LDN a month ago . I’m curious if others are benefiting also?

[@lindapelle8738]

@@lillyallen6559 Hi how were you were diagnosed for Lyme..I did regular Lyme tests quite a few years ago with both functional MDs and regular MDs the functional doctor even ran a panel that was much more extensive for lyme cause he said he can be hard to diagnose it all came up negative. I was diagnosed in my mid 30s 20 years ago IC sort of gets better with time And of course sticking to the diet. I remember a leader of an AOLIC group yes it was that long ago lol saying that the bladder starts to heal it just can take years and she’s right I didn’t think she would be to tell you the truth. But I was real good with sticking to the diet now I can cheat quite a bit on the IC diet I still have to get up to pee at night and I pee more than the usual person but nowhere near like I used to when I started I was up every 15 minutes if not more during the day it was horrible. I stopped researching things because the less I researched the better I got, you know what you focus on grows bigger, but it’s time to get back into the game snd see what’s new. Like many with IC I developed fibromyalgia which became worse than the IC, another thing that many people told me that I didn’t think would happen to me. If I were you I wouldn’t trust one diagnosis for Lyme disease I would go to a functional medicine doctor if you haven’t yet and have him test you. Many people are diagnosed with lupus incorrectly, it’s not easy to diagnose. No harm in trying LDN

[@lindapelle8738]

I would love a one on one consult with this intelliegent man

[@bajone02]

Without detox including parasites, all inflammatory nightmare issues will continue and get worse. Fiber might help but the detox is KEY!! That is why Ivm and hcq were banned. We would all have healthier systems!!

[@JohnnyCoxTunes]

Great stuff. Really enjoyed this!

[@caroledevlin4436]

We are happy you did.

[@mat77084]

I have microscopic colitis and was told not to eat fruits and vegetables because of the fiber that can tear the lining of the weak large intestines. Now I'm confused do I or don't I. They said if I ate them it would trigger a relapse of diarrhea. Diarrhea which it did trigger.

[@JoeTobin-f3r]

Can I take lyrica and duloxetine with ldn

[@maituub]

If they are not opiods or opiod-like medicine then they probably go together, but start with RTFM, read the insert.

[@Joerpg84]

They are ok to take with it. It’s things like codeine, morphine, oxycodone etc that are to be avoided.

[@JoeTobin-f3r]

Thanks for reply Iv just started taking ldn

[@pramasauskas]

Integral rice is a good soluble fiber ? can I eat about 2 cups daily ?

[@mat77084]

I don't have a gallbladder, gallbladder makes the bile. Now would that still work for me?

[@benwallman5378]

also.. study shows more fiber consumes the longer you live. lets use our brains here....this basically is saying, the less processed food you consume, the longer you live. ALSO, if you are going to consume way too many carbohydrates... the more fibre within this food, the smaller you glucose level will spike, leading to less health problems from the carbohydrates. Another way to increase life expectancy would be to lower your carbohydrate intake... along with the unnecessary fiber... and you would see the same benefits.

[@luckycharmranch]

Agree!

[@mikeg1433]

What do you mean by unnecessary fiber? Is fiber good or bad?

[@debbieredfern2267]

​fibre from carbohydrate heavy breakfast cereals for a start. Organic phsillium husk is far beter added to food or mixed with water and drink it straight down . Low carbohydrate way to get your daily fibre.@@mikeg1433

[@elsyalvarezr]

Thanks for this amazing talk.

[@brianhill4153]

Are there any studies that show this being effective or is it all just anecdotal? I want to take it but I would like to see scientific evidence.

[@JenJen0582]

I am living proof that it works.

[@jmc8076]

Avail online just google it and studies or research.

[@R.D.E-ew6ov]

The research trust has a lot of studies listed on their website.

[@montanak7]

Thank you

[@sandraredmond4812]

Can you use ldn with berberine ?

[@mariabenjamin8018]

Of course

[@bonniehill4299]

QQQ If you take LDN sublingually ,would that help reilive constipation caused by LDN rather than taking a capsule through the digestive system

[@KarinSchweizer-b4g]

Just try

[@anju.mar4]

Hi :) I have the same problem with oral liquid LDN, it causes constipation. Did you try the sublingual version of LDN? 😊

[@framundajohnson2186]

hi there, is 50mg too much for an autistic child?

[@estar1277]

50 mg is not low dose. This is ldn that they are talking about.

[@surfersparadise5615]

you'd better go to a doctor for that...low dose is between 1mg and 4.5mg

[@framundajohnson2186]

@@surfersparadise5615 please help me.

[@framundajohnson2186]

they had him on 50 mg of naltrexone,risperidone to cover up the steroid psychosis he was suffering while on Budesodine for EoE…which they caused!!!

[@beautywithbrain7816]

@@framundajohnson2186 did you tried for autistic child?

[@michelita2704]

Ever since I've taken LDN, I've been experiencing vivid dreams. Clenching my jaw and muscles. I've lowered it to 50mcg. Does that mean LDN is not for me?

[@oceanark77]

I just got 50mg Naltrexone implant put in yesterday. Do you take 50mcg daily? They told me the 50mg implant works for 2 months. Just trying to understand this....

[@muinbear4702]

Also vivid dreams is a positive side effect as it increases REM sleep which is the refreshing sleep. Clenching I'm not sure about.

[@Hansen23900]

Bruxism is usually from a b vitamin deficiency. I’m wondering from reading the comments if LDN depletes certain B vitamins because another person got chilitis which is also a certain b deficiency. Maybe everyone should try to take a b complex while on LDN to see if these side effects go away

[@etc6615]

Isn’t 50 mg too much and not anymore considered as low dose ?

[@surfersparadise5615]

@@oceanark77 lOW dOSE nALTREXONE IS BETWEEN 1MG AND 4.5MG TYPICALLY....50 MG IS NOT LOW DOSE AND IS USED FOR DIFFERENT REASONS....

[@browneyedgirlFL67]

Polyphonic????

[@luckycharmranch]

Poly-Pharmic it’s taking too many drugs that are creating a problem. Always look at the drugs you are taking to make sure they are not the cause of a problem first. Also, look at the drugs you are taking to make sure you are not taking anything that has other drug interactions or causing specific symptoms. Many doctors do no look at other doctors prescriptions.. so, you have to be vigilant, and be your own advocate. If in doubt ask a pharmacist they know more about drug interactions than most doctors.

[@maituub]

he is not always speaking clearly; it is poly-phenolic . www.ncbi.nlm.nih.gov/pmc/articles/PMC2835915/

[@Dedimoldu9]

Polyphenols..

[@Dedimoldu9]

@@luckycharmranchsorry you are wrong. That is not what he said

[@gp9440]

I don't have 30mins to watch this and can't see any time stamps. Can someone please summarise the content? (I am taking LDN for Long Covid)

[@theancientsancients1769]

Has LDN helped your Your Long COVID?

[@jamiedorn4105]

Can I ask what symptoms of long covid you were having? And did LDN help? My functional med doc recommend it to me too for long covid

[@beatal5509]

Too much. 50mg is not Low dose and works differently then LDN. LDN is low doses - I take 2mg but you can go up to 7mg maybe depending On how it will work