Why does low dose Naltrexone need to be slowly increased? With Dr. Brad Goldsmith, MD

Precision Opinions Live!
Host Christian Stella (Pharm D, ABAAHP) sits down with Dr. Brad Goldsmith, MD, for a deep dive into low dose Naltrexone.
Dr. Brad Goldsmith (MD) enlightens us on everything you need to know about how low dose Naltrexone works, what it can be used to treat and the reasons why it's dosage needs to be slowly increased.
We want to thank Dr. Brad Goldsmith for coming in to share his experiences and insight with us.
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Have a question or topic you would like Christian Stella (Pharm D, ABAAHP) to discuss on the show?
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Dr. Brad Goldsmith can be reached via his website, mendocrine.com or by phone( 516-295-7400)
Learn more about Low Dose Naltrexone here: precisioncompo...
#naltrexone #lowdose #precisionopinionslive #pharmaceuticals #precisionpharmacy #pharmacy #precisionopinions #compounding #compoundingpharmacy

[@Katherine_02]

I suffered from Hashimoto's and chronic inflammation and fatigue for a few years. I started on LDN about 6 weeks ago (as well as hormone lotion and various supplements). SWEET RELIEF!!!! I am SO thankful for this medicine!!!! I no longer feel like I am dying. (And the dreams are pretty nice too! LOL!)

[@princessdee01]

Amazing! Just started and have the same issues as you. Hoping it helps me as well

[@marymastandrea2640]

What level does did it????

[@rommajiwan1972]

What dose do you take?

[@rommajiwan1972]

@Katherine_02 what dose do you take?

[@Katherine_02]

@@rommajiwan1972 One 4.5MG a day.

[@randyk7699]

The sound on this sucks!

[@Sungodv]

using a pop filter on a mic that has internal foam to prevent splosives is insane. Not sure they know much about audio on this channel

[@mystuff1405]

Thank you for relieving people's pain and other illnesses. Good man.

[@mzalenski1]

I've been taking it for about 2 weeks at a dose of 4mg. I messed up and started too high but it's started to settle and the positives have already begun to show. I became interested in ldn after I did research on repairing sensitivity to endogenous opioids. I've been clean off h/fent for just shy of five years, but I'm always interested in ways of repairing/improving my mind and body. Apart from the insomnia I experienced (and some agitation, I presume due to my not tapering), I noticed positive results on my mood within about a week, and my energy levels and physical endurance have also increased, and it gets a little better every day. I'll also say that it seemed to reduce my urge for nicotine as I also quit vaping since I've been on it and cut my cannabis use down to a tenth, I presume do to ldn's influence on dopamine as well as endorphins. Really amazing stuff. Would highly recommend to pretty much anyone.

[@ScottDieken]

how do you tell its too high?

[@davidkruse4030]

@@ScottDiekenyou get too many side effects and no benefit. I ramped up to 2mg. Over like a week I felt awful

[@PureExistence1]

​@@davidkruse4030yea i notice that i feel more achy when the dose isnt right..

[@SS-in1ts]

You’re supposed to be really careful with LDN. Can be dangerous to start so high that’s why they want you to titrate 0.5-1 every week or two. Glad you’re okay! It’s been life changing miracle for me.

[@KDB1500]

Thank you for this informative discussion about LDN. I’ve been researching it quite a bit, and this is the first time I have heard the aspect that LDN has two mechanisms of action due to the presence of the two stereoisomers.

[@debsarno2532]

I have Parkinson’s and looking forward to trying this! I hope it helps me. Great interview

[@fynn24]

I had great results from LDN for my lupus symptomatic but I have an elderly friend who suffers with parkinsons, I would be very interested in your results with LDN

[@francisbertolini2538]

Can’t hear the Dr!

[@Nutmegp]

With sleep disturbance I heard that it's best to take LDN in the mornings anyway because it increases cortisol? Sorry if this was covered in the video but surely it would be most suitable to stick at the lowest recommended dosage (0.5mg) for a few weeks just to be safe then titrate very slowly? This will totally avoid the complications you described with complete blockage of the receptor. But my question, speaking of this, is do we know when adaptation to the dosage will be fully guaranteed, in order to know you're not titrating faster than your body is able to adapt? Again sorry if this was covered, it was a great video but I did get sidetracked at one point

[@MM-ie7mj]

Great question ! But where is the answer Guys ? !!!

[@MM-ie7mj]

@Nut did you find your answer ?

[@Nutmegp]

@@MM-ie7mj I did not sir, my guess would be that it's similar to the time it takes for you to adjust to a dosage of opiates? Maybe that's an over simplification, but with that'd I'd say 2 weeks to be safe, take that guess with a pinch of salt though lol

[@hotsickle]

I've been titrating for 2 months, now. I'm up to 3mg naltrexone at night...every time I up the dose the dreams become vivid again, not necessarily nightmarish, but rather intriguing...then it levels off somewhat to more normal dreaming. I hope to go up to 3.5mg next if dr. OKs it.

[@57athina]

Three months in with LDN and had to lower my dose down from 4.5 to 3 and I started taking it in the morning. I just couldn’t sleep through the night. Now I feel much better. Sleeping like a baby but still feeling the positive effects.

[@LDelight77]

He’s too far from the mic

[@cindyshanks7141]

I was prescribed 4.5mg recently for neuropathy and back pain. Been taking for 10 days. After 2 days my pain is 75% better. But I am having terrible dizzy when I get out of bed it's like being in a blender and falling. Then walking is like on a boat at sea in a hurricane. This goes away during the day. It returns nightly around dark. I also wake up every hour at night. I don't want to quit because it works for pain. Pharmacist told me the side effects would only last 1 week. I don't know if this is related but also my temperature regulation is way off. I get surge of hot flash and subsidies to being chilled...all day long! I am not enjoying this.

[@jean6460]

Did you start at 4.5? I think they recommend to start lower and taper up. I’ve been afraid to start, worried about side effects! Please let us know how you’re doing!

[@sandragillman5496]

I had the same symptoms when my dose was too high. I had to lower the dose and increase it very slowly. I have been taking it for months and I have worked my way up to 1.5MG . I feel much better doing it this way.

[@PureExistence1]

Try taking your dose mid or late afternoon. Its not mandatory to take it at night and earlier dosing is common amongst people that get insomnia from it..i take my dose around 3 to 5pm as the insomnia was horrible and the dreams i had were really weird and felt like someone else's...i hated that...also, youre not peri or menopausal, are you? Some of your symptoms are very similar to women going through peri...

[@SS-in1ts]

WAY too high! Not even safe for some of us to start so high. Start at 0.5 and titrate up every week or even two weeks until you’re comfortable. If discomfort lasts longer than two weeks then go back down until you find your level. 4.5 is a max dose, yikes. Hope you’re feeling better.

[@lisashrout1797]

​@jean6460 it's all good no effects

[@janetjennings5802]

I can not believe what I'm listening to.I wish i could talk to somebody on the medical field where I live.Nobody cares where I live.I have hashimoto's. No help what so ever.I have back pain and not feeling great everyday.My doctor gas lights me.I think I'm more educated more than him.He doesn't even answer my Questions. America seems to b more informed.

[@christinarizzuto6842]

I wish we can hear multiple patients experiences with type 1 diabetes can’t find it anywhere

[@ctjmaughs]

50 mg sounds a bit much for a first dose.

[@rommajiwan1972]

What dose do I start at? My GP won't prescribe it.

[@debsarno2532]

You have to find a functional medical doctor

[@SS-in1ts]

Or go to a naturopath. Start at 0.5, increase it every week or even two weeks based on your sensitivity level by 0.5, do not go over 4.5 - my doctor says I probably won’t need more than 1.5, it’s changed my life in every way. If you don’t feel good at a dose for more than two weeks then decrease the dose and you’ll know that’s your personal amount needed for your endorphins.

[@jamiehowington3]

How would you be able to meter the 4.5mg if it was dumped into the public water supply???

[@PureExistence1]

Oh, you mean like fluoride is?😢

[@michelsturm1807]

Do you think it’s better to take it in the evening ? And if so , what time ?

[@SS-in1ts]

A couple hours after dinner. They say it’s best to take at night but if you feel better taking it in the am then do you. Everyone is unique. Start in the evening and see how you respond.

[@danzed1727]

Hi Guys, awesome episode. I recently got prescribed Naltrexone for Alcohol dependence, I'm doing the Sinclaire Method, which means I take Naltrexone 50mg, 1 hour before drinking to change the association of Alcohol and fun, so I'm not taking it daily, I take it once a week usually Friday drinking session, as I'm a binge drinker. I have also been taking LDN 1mg, for depression for myself, after 7 days I increased to 2mg, I will do this for 2 weeks and increase to 3mg. My question is, are both methods giving me benefits taking them simultaneously. So 2mg, daily before sleep and 50mg and another 50mg. The same drinking session after 4 hours. Am I getting the benefits of LDN and TSM ( The Sinclaire Method) ?

[@adorableadornments1101]

Is this Christian Stella related to George Stella who lost a lot of weight on low carb diet?

[@precisionopinionslive6700]

No he's not related to George Stella, please like and subscribe!

[@ErikFindling]

This drug made me very sick, developed tremors, fatigue, nausea, vomiting, after about a year of being on the drug and having no symptoms at all. Had apathy, depression, everything. Saw neurologists and my blood work was fine, I did testing for almost a year before I figured out it was the LDN. This is what happens with a drug that nobody really understands

[@rommajiwan1972]

What were you taking it for and at what dose?

[@SS-in1ts]

Antidepressants have done all you described to me, I’m sorry LDN didn’t work for you but It’s been life changing for me. My food allergies, histamine intolerance, depression, PTSD and food binging is 80% better and it’s only been a few weeks since I started it. Maybe you were on too much or maybe your body can’t tolerate it. This drug is used for acne as well, a lot of doctors prescribe meds not know how a person will respond, including psychiatrists which is even riskier. Again, it is a shame you had this experience but it’s been life changing for me as I’ve said. I’ve spent my life seeking help and nobody could, I have hope and a life again, from the moment I wake up, I don’t struggle to get out of bed anymore. That says a lot.

[@ErikFindlingMusic]

@@SS-in1ts antidepressants did worse to me. LDN was life saving for me for about 2 years for my PTSD/Anxiety/Insomnia, literally amazing. But over time I think my body had enough of the drug and just couldn’t take it anymore. There is no long term studies on LDN and for that reason anyone can develop an intolerance at any time. I hope it continues to work for you tho!

[@ErikFindlingMusic]

@@rommajiwan1972I was taking it for PTSD, and dissociation mainly. It worked wonders for 2 years, and then like I said I just started having terrible nausea and muscle tremors everyday. It took me like 5 months to figure out that it was LDN. Since there is no long term studies on LDN, there is no saying if it is safe long term

[@ciaramaccaro2527]

did the symptoms reside when you went off the LDN?

[@framundajohnson2186]

Is 50mg of Naltrexone too much for a autistic boy? What mg is a good dose to start?

[@BriBorgersen]

Did you watch the video? Lol 50 mg is for opioid dependence/reversal! You would need to start at 0.5-1mg.

[@framundajohnson2186]

@@BriBorgersen than why did my ex wife’s psychiatrist give him on 50mg at night for 17 months? they hurt my boy and I will sue them when I sell my place.

[@framundajohnson2186]

@@BriBorgersen I watched the video three times. why are they hurting children with 50mg?

[@ScottDieken]

does he have an addiction

[@framundajohnson2186]

@@ScottDieken he’s 12. no addiction. they gave it to him to block the steroid psychosis he was experiencing from Budesodine. I’m going to sue and go to the news to make sure they never hurt another child or family again.

[@johnathanabrams8434]

Low dose naltrexone = high scam subscription

[@SS-in1ts]

It’s actually changed my life. This comment is offensive to me because my entire life I searched for help and nobody could help me, I was just a pharmaceutical Guinea pig and ended up with memory loss from all the meds they tried to help me with. I’ve been to so many different types of doctors, specialists, naturopaths, Ayurveda and finally found one naturopath that suggested LDN has solved my depression, I wake up without dread every morning now, PTSD is significantly improved and not crippling, my food allergies and histamine intolerance is improved by at least 80%- I can eat salmon again! I don’t binge eat anymore either. So if you’ve tried this, just like any other medication, it doesn’t work for everyone. But it’s been life changing for me.

[@johnathanabrams8434]

@@SS-in1ts what compounding mill do you work for ?

[@beckyharris347]

@@SS-in1tsWhat dosage do you use?

[@jenhall7572]

@@SS-in1tsworked tremendously for me too!

[@debbieredfern2267]

Your opinion has no evidence.

[@elsagrace3893]

Welp, that comment about fluoride being added to the water being a disaster just wrecked your credibility for my. QUACK! QUACK! QUACK! 🦆 bye !

[@yogibear8686]

Flouride is a toxic poison. Why put it in the water supply? There's a good book called The Flouride Deception. Do your homework and fix your brain!

[@WwJd2tmthy1]

You’re still in the masses that believe our government!!! Fluoride is toxic!!!! Didn’t help my teeth!! Now they’re full of the toxin Mercury that was government approved for decades and has just finally been outlawed!!! Wake up!!! Call me Quack!!! But, I wear my tin foil hat confidently!!!

[@elsagrace3893]

@@WwJd2tmthy1 shoulda brushed and flossed regularly. Fluoride alone never promised to keep your teeth healthy. It’s not toxic. There would be no natives of Bahrain if it were toxic. The water there has such high levels of fluoride (1000x more than is added to our water that when a person lived to an old age their vertebrae fused together from it. They didn’t die of any weird causes or have Mercury poisoning or any other dang thing. You’ve definitely earned that tin foil hat, my dear.

[@marlenecampbell5439]

Flouride isn't good for your thyroid and was put in water at prison camps to keep prisoners docile. It shouldn't be in our water

[@BriBorgersen]

Might wanna research fluoride a little deeper honey.

[@cartkooweightlossdrugsonli3775]

Thank you for sharing.