Lowering Lipoprotein(a) in CVD Patients with High Lipoprotein(a)

[@robrae14]

Doctor I'm so glad you are dedicating so much time to solve this problem for those of us who inherited lp(a).

[@Malcolm-Achtman]

I don't think I'm overly at risk for Lp(a) but when I first got it tested in 2010 my value was 32 mg/dL. It was flagged as high since the upper limit was 30 mg/dL. Back then my diet was OK but not great - eating a fair share of carbs, etc. After reducing carbs and cutting out wheat and grains, my Lp(a) tested consistently in the 15 mg/dL range. More recently, my diet has transitioned a bit more toward higher fat and protein (more animal-based). Some of my recent Lp(a) levels have been as low as 10 mg/dL. I reaIize that my N of 1 experience may not apply to everyone, but it may be worthwhile to consider the role that diet can play with Lp(a). Note: I don't take any statin medications.

[@منحدراسية-ق8ج]

How can I contact you please

[@Malcolm-Achtman]

I don't believe that you can via KZbin.

[@منحدراسية-ق8ج]

@@Malcolm-Achtman email please

[@Malcolm-Achtman]

@@منحدراسية-ق8ج I don't think people are supposed to give their email out on KZbin (for security reasons). Sorry.

[@atomic_poppy]

lol, it was low to begin with. You’re not making sense. This is for people with actual HIGH LPa, not people like you.

[@vicissitube1972]

how about some ... NIACIN .. No $$$ to be made

[@RHt09]

Niacin did not show lowers of cardiovascular end points like myocardial infarct. That's why it's not used more.

[@taylorsonstrucking9118]

I’m 43yrs old I had a lipoprotein a test done 2 yrs ago, it was marked as 283 mmol, had calcium score done at 41 yrs old it was marked as 0 score, had lipid panel done 2 weeks ago total cholesterol 160 hdl 49 ldl 99 vldl 11 glucose 88

[@jakegise7728]

So what are you doing at this point? Considering coronary angiogram since calcium score does not identify soft plaque.

[@taylorsonstrucking9118]

@@jakegise7728 why would he be considering that, what in his profile warrants that decision?

[@jackpeng4203]

statin to lower ldl c

[@MrAndy9188]

@@jakegise7728 A 0 score at 41. I would just keep doing what you are doing. There is so much doctors still don't understand in this area. I personally believe that a high LPa only becomes an issue with other metabolic issues. High blood sugar, blood pressure, inflammation etc.

[@jakegise7728]

@@MrAndy9188 Doing the same I suppose. Had a zero CAC at 40 with high LPa.

[@dharamalrenga9325]

Niacin lowers Lp(a) 20-30% and Aspirin lowers it 20%. Wonder if the combination will have additive effect; if so, the combination of these cheap drugs will be better than very expensive PCSK9 inhibitors. Does someone know if the combination has been used in some trials.

[@nolanerunner1]

I thought niacin isn’t that effective and aspirin can cause bleeding so has to be weighed up

[@danieljrgensen133]

Niacin(about 2000 mg/day) lowered my lp(a) 5%.....and I was tested at 533 nmol/L as my natural level! 😥

[@bigred9428]

I take Exedrine Migraine for headaches. Do you know if the aspirin binds with anything in the pill, or can it still help?

[@bigred9428]

I've really got to stop looking at health stuff on the computer, because it scares the heck out of me. I've had health problems, including HBP that responds to medication for about a month, then goes super high, and a recent stroke to the back of the eye with no apparent artery blockage. Now I come across THIS (I have no idea if mine is high or not, but, still). And apparently MOST of what we know about cholesterol should be flushed down the toilet...AAAAAHHHH!

[@LauraK93]

Any new news about these RNA therapeutics? I'm a 64 year old woman with no CV history, good inflammatory markers, low BP and no insulin resistance, but an Lp a level of 239.9 nmol/L. How do I enroll in a study before being diagnosed with heart disease?

[@afrothiti234]

Have you done the Coronary Artery Calcium score test?

[@LauraK93]

@@afrothiti234 Yes. It's zero and both my transthoracic echo and twin carotid ultrasounds look great.

[@afrothiti234]

Great!

[@vrb340]

​@@LauraK93 how old are you and do you have a family history of heart disease?

[@RHt09]

There's a new drug being developed by I believe Eli Lily that lowers Lp(a) 80-90%. It should be approved and on the market in the next year or so for those of us with high Lp(a).

[@bigred9428]

Ii seems as though most our problems stem from too much of certain proteins in our bodies. Why? Anyone know an oversimplified answer?

[@zafar78600]

What is the role of gene therapy using CRISPR?Just like the sickle gene was altered?

[@salyx6687]

i am 22 and have hypothyroidsm. On a regular blood work my lipoprotein a was checked. It was 245 which shocked me. Currently I have heart burns that feel like a radio tgat is not working and is making the rough sounds. Could tgat be from lipoprotein a?

[@sheddkkhan6758]

How are you

[@albertjang6945]

The name of the trial? ENICHCOW?

[@ewang496]

TQJ230

[@reginamay2767]

My heart doc did a lipo A on me mine is value 15.

[@atomic_poppy]

Good for you

[@madisonone8929]

This guy is the uber Lp(a) expert. Used to follow him before I got off Twitter. He will save millions of lives. Brilliant he said the doctors should check their own Lp(a). I had to tell my Yale MD/Phd Cardiologist who I was referred to when I asked for Lp(a) test that he should check his Lp(a). I am on full flush Scientology Niacin at 1000mg. It cut it into half & I started looking like Tom CRUZ. Can’t go any higher, the super flush is a no go. I will stay on it check my insulin resistance & liver enzymes. So far so good 😀

[@20891]

Did the niacin work ?

[@StanDupp6371]

Maybe low levels of Lp(a) are not that good? The Lp(a) levels were inversely correlated with the CIMT in this population, suggesting that subjects with a low Lp(a) level may have a predisposition to carotid atherosclerosis. 2012 article: CIMT in asymptomatic subjects with low Lipoprotein(a) levels.