Making an FDA-Banned Fat Burner

Today we made DNP as it seemed like a cool synthesis and I gained some weight (bulking season).
Please do NOT actually take this supplement!
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[@chemdelic]

Notes: At 5:50 I did not mean to put the arrow breaking the nitrogen-oxygen bond in the center structure. The arrow was supposed to indicate the formation of a double bond between nitrogen and oxygen as water left as a leaving group. My bad chat. -10,000 aura

[@Gaymingsapien]

-0 aura, you figured out your mistake :)

[@heinerwutz3624]

Thank you for gently placing the stirbar to the beaker. A lot of chemistry videos are very upsetting to me because stirbars are dropped in.

[@ho0t0w1]

,But you DID mean to call yellow chemistry beautiful, correct? I'm just making sure... 😂😂 *Edit: I'm only kidding, target product is beautiful regardless of color, and Tom DID agree

[@BillAnt]

I read about this a while back. Some companies where still selling it after the ban and got caught with their little explosive. lol

[@allemands]

+1000 aura you corrected the only mkistake you have ever made

[@Chemiolis]

🗣 🗣 🗣 WE MAKING IT INTO THE POWERHOUSE OF THE CELL WITH THIS ONE 🗣 🗣 🗣

[@chemdelic]

WE BREAKING THERMAL HOMEOSTASIS WITH THIS ONE ☝☝(☞ﾟヮﾟ)☞

[@derenjoy3r]

WE STRAIGHT MOGGING THE ATP SYNTHASE WITH THIS ONE 🗣🗣☝🏼

[@isaacthedestroyerofstuped7676]

POV: you're a proton

[@Tapajoss]

We presenting into the emergency room with this onr

[@NuclearTopSpot]

Ah yes, 𝓓𝓲𝓮𝓽 picric acid

[@Kenionatus]

👏👏👏👏

[@0thewings]

just one nitro group away

[@isaacthedestroyerofstuped7676]

Picric Acid Lite

[@LuxAureus]

I would say this comment is based, but it's so acidic that I now have permanent chemical burns

[@ligmabaldrich485]

bro got scooped by pyrotechnical

[@chemdelic]

Very unfortunate timing!

[@ericmueller6836]

​@@chemdelicAlways good to see different approaches and deliveries on the same topic.

[@alext6933]

​@@chemdelicor maybe fortunate I was even more interested to watch yours after I had seen his

[@highlander723]

​@@chemdelicI wouldn't say unfortunate timing at all. But a premium example of what happens in research. You might have two people that are working on the same thing and one publishes before you do BUT Your procedure might be the more cost-effective easier one to do and people will reference your paper more.

[@BillAnt]

​@@chemdelic - As they say ... all yellow chemistry goes b......m! lol

[@0thewings]

A man made FDA-Banned Fat Burner. This is what happened to his channel.

[@ivant5054]

let's not pretend here, he got done with phenethylamines without actually getting to anything new and went to nita.zene instead

[@sobertillnoon]

I don't think "increased metabolic rate" is a side effect. I'm pretty sure that is the intended effect.

[@whatthefoust]

incorrect it was originally made for purposes of manufacturing dyes, wood preservatives, explosives products

[@grizzly36]

It kind of is because it’s not necessarily always good to have such effects occur. A slightly more legal instance is Wegovy and Zepbound both leading to ‘decreased appetite’ which is actually good in cases where weight loss is needed but it’s generally not that great in healthy populations

[@sobertillnoon]

@@whatthefoust well that is a hell of a side effect then. I will stand corrected.

[@joz534]

@@grizzly36 Wegovy works in fundamentally different way. How is that a comparison. "Generally not great in healthy population" is true about basically every single medication.

[@grizzly36]

@@joz534 read some literature and you’ll see that most of the intended effects are also reported as Adverse Events (AE)

[@boothbytcd6011]

'It likes to sublime, so fuck this reaction.' is a mood.

[@ho0t0w1]

Drakes been real quiet since this Chemdelic diss... You know it's bad when he's getting bodied by KZbin Wizards... 😂❤

[@LOVERZPLACE]

This drug is legal for a single use still, it is used to treat hypothermia during mountain climbing rescues. This use case and why it is used here should make perfect sense if you know how the drug works.

[@ChemCrafter]

Do you know the brand name? I couldn't find any mention of this on searching

[@sneakiertech]

You should make DMAA, please teach us the secrets of banned preworkouts!

[@NeuriLee]

Excellent suggestion!

[@Abdega]

It’s fitting the side groups say “OH NO”

[@totalsynthesis]

Nice one! This compound was crazy abused in the past but with GLP1 drugs you have to wonder if the days of people overheating in their bath tubs are hopefully soon over

[@derenjoy3r]

Honestly it does semm like a potentially useful drug if applied only under good supervision, similarly to lithium.

[@christianterrill3503]

​@derenjoy3r let's gets barbiturates back baby!

[@Daniel-gi1dp]

⁠@@derenjoy3rit absolutely is not. cataracts have been anecdotally reported in the “therapeutic” dose range of 100-250mg. but even still, you are constantly sweaty and burning and nothing can stop it. you also have extreme cravings as your body is trying to get energy it’s failing to make. it might burn 500cals/day but it wont be too effective because most people will give into those cravings. oh, and if you do, youll feel even hotter as those carbs literally burn. on top of it all, 1000mg can literally kill you with no ability to stop the poisoning. GLP-1’s are far better. why go through literal hell and even risk dying your eyes and bodily fluids yellow when you could just eliminate hunger from ever happening?

[@derenjoy3r]

@@Daniel-gi1dp i see yeah cataracts sounds horrible, i could see people dealing with the sweating though.

[@josuepagan131]

Just fast bro, enjoy the hunger pangs.

[@garbleduser]

Sounds like a spontaneous human combustion drug.

[@chemistryofquestionablequa6252]

I was talking to a local PD bomb tech a while ago and apparently one of his friends ordered a couple bottles of DNP out of curiosity. They stuck a #8 cap in one thinking there was no way it would actually det. Well, it did.... They got chewed out pretty badly by their supervisor because they hadn't bothered to announce they were doing it and it was WAY louder than expected.

[@xxxm981]

I was about to wonder, since its only one nitro group away from picric acid... and that is pretty spicy

[@ACME_Kinetics]

I wouldn't believe this, except I've dealt with local PD bomb techs.

[@chemistryofquestionablequa6252]

@@ACME_Kinetics they're kinda tards, huh?

[@hamishfox]

Lol, I was wondering if it would hame a good explosive. The comments always deliver.

[@blue5659]

Is it a high explosive? How does it compare with tnt, rdx, c4? If it was used for unaliving en masse, the residue of the explosion could be airborne and cook people to 44°c with their own nadph? GENEVAAAA. LOOK WHAT WE HAVE HERE

[@JohnnyBGood-cv1bg]

Hello all! I've done multiple DNP cycles! Let me know if y'all have questions. The short of the story is: don't do it. Not worth it. No, I didn't die or go to the hospital, I did everything right and it worked as it's supposed to but MAN the yellow sweat and hot flashes after eating were not pleasant. That yellow sweat will turn your clothes, bed, couch, towels, etc a nice piss yellow. Men, your...ahem...fluids...also turn a nice weak yellow, as well. It'll turn just about everything a human expels, yellow. Ever seen ULTRA yellow piss? It's pretty trippy.

[@ashe1.070]

How did it feel to be on this stuff?

[@Rickkhry]

PLEASE DO DMAA OR DMHA FOR US PREWORKOUT JUNKIES 🗣️🗣️🗣️🔥🔥🔥🔥

[@neb_setabed]

thought i was losing my mind for a second until i realized pyrotechnical had done this just hours earlier

[@Moritz___]

unfortunate timing

[@chemdelic]

Yeah unfortunate timing

[@ligmabaldrich485]

@@chemdelic at least the syntheses are different, so they are different viewing experiences

[@neb_setabed]

@@chemdelic I still watch yours, it's good to see a different perspective

[@stamasd8500]

@@chemdelic don't worry I like your procedure better :)

[@californium-2526]

2,4-dinitrophenol - fat-burner, explosive and precursor to explosive salts, a multiple whammy!

[@diablominero]

If DNP didn't have extra toxicity on top of the uncoupling effect, it'd be great to take small amounts of it in the winter to stay warm with less insulation.

[@allenparke5874]

if i remember my reading from Wikipedia several years ago, the Russians used to give it to their troops on the western front during wwii. the only reason i looked it up was the death of a friends brother who was using it for weight loss.

[@heulboje21]

4:00 it smells like benzene just slightly more cancerous. As a fun fact, id personally say bromobenzene is way less dangerous than benzene. Sure its flammable and toxic to aquatic organisms or upon skin contact but it is NOT carcinogenic!

[@Mulmgott]

That is true for many substituted Benzenes.

[@a.belladonna8316]

​@@MulmgottLike toluene

[@BDXextraction]

All I do is basicly yellow chemistry, it's finicky as he'll! Ill tell you many notable tryptamines go through a yellow intermediate as well as some notable phenethylamines (depending on route), and not to mention half the stuff in PIHKAL & TIHKAL!

[@thunderhorseiron-lung1428]

There's some DEA banned chemicals that are great for losing weight as well.

[@HaYeetBruh69]

I’ve seen someone in the emergency room for this and they had a body temp of 111. This stuff can most definitely kill you.

[@OceanBagel]

Managing to upset the FDA, the DEA, and Drake all in one video, impressive!

[@abivise7756]

Pyrotechnical also just did this from aspirin.

[@isekaiexpress9450]

You know, fire also makes you lose your fat. It just have that little side effect of making your injuries incompatible to your life functions.

[@nobody4248]

Now nitrate it once more and you will get a proper millitary fat burner.

[@Djoodibooti]

not drake catching strays in a chemistry video!

[@mikko-pekkaleppanen3761]

In case no one has commented yet, the brown color during the nitration was most likely due to nitrogen dioxide as it often forms druing nitrations. I learned that while doing a nitration at 180 C and accidentally inhaled it. Was not pleasant

[@OtherWorldExplorers]

Love the use of Coraline. And although all this chemistry is over my head I never stop finding channels like this extremely fascinating.

[@epicname1549]

So "side effects" appear to be "known effects" of METH ABUSE

[@anchopanchorancho]

I've taken DNP a long time ago. Its definitely effective, most effective thing I have taken. But you need to plan your entire life around it to avoid frying to death.

[@marcmaillard-salin1977]

I just got blessed by the algorithm. Absolutely amazing.

[@Alex-em9ij]

Next vid: testing DNP vs Normal fat loss suplement.

[@RedwoodRhiadra]

I was waiting for the Explosions and Ire reference 🙂

[@KristopherWhite-wm7zy]

Very nice! As a bodybuilder all i can tell you is thats what it looks like. Used correctly it is amazing that being said you could die if used improperly. Love your channel brother. Keep up the badass chemistry!❤

[@bensmith4563]

I think most anything used improperly will lead to death it's just a matter of how easily it is to be used improperly enough to cause death

[@_TheMentor]

Lets gooooo. Next video Semaglutide compound? I'm trying to make some money AND never eat again. I sweat trying to hold in a fart, I have a feeling this stuff would have me going super saiyan, except, in real life, it doesn't look cool and feels like that time you powered that exposed microwave magnetron on your lap.

[@PyroRob69]

Haha! Most of the side effects look like those for any other drug advertised on TV. Only things missing are dry eyes and ED.

[@shdwbnndbyyt]

A lot of ammunition factory workers in the World Wars got quite sick from exposure to this and other related chemicals....

[@baronvonkaiser9912]

this would be a decent alternative to freezing to death. hypothetically, if i was stuck in canada i the winter with no heat other than a lanter and a jacket, id probably take this in pill form as a last ditch effort to not freeze to death. "uhhhmmm actually no thats not how the human body works" stfu thats why i said last ditch effort

[@mattilindstrom]

Great video and a fairly simple series of reactions to follow even for me, just a dabbler in chemistry. The Chubbyemu channel has a nice chronic DNP ingestion case study video from about 3 years ago. Truly nasty stuff.

[@baladar1353]

It's very strange and interesting that Pyrotechnical uploaded his video on the same subject around six hours before you. Anyways, nitrates shouldn't be consumed by humans at all. If I have to explain the why's, it's enough to think about the destruction nitric acid can do to the skin or any organic materials. Also (mono) nitroglycerine has serious effects in the human body, so nitrates should be avoided if possible.

[@e3498-v7l]

The whole discipline of pharmacology is about giving toxic, lethal or radioactive substances to humans, just in small doses. The same goes for anesthesia, certain cosmetic procedures (botox), etc. Your argument should go beyond "it does damage". The dose matters, as do other factors.

[@johnathancorgan3994]

This route starting from the halobenzene is much cleaner and higher yielding than attempting nitration of phenol directly (the route pyrotechnical chose.) I've only ever seen this done with the chlorobenzene reagent; no idea what your side products were with the bromobenzene starting point. It would be useful to get a melting point on a small quantity and some other form of characterization.

[@PyroRob69]

Someone else just released a video on 2,4DNP this morning as well although they did it using a different process. Yours is much cleaner

[@randomlyusernamed]

Odd that 2 chem channels make a video on the same compound on the same day 6 hours apart. Different approach to the synthesis tho so kudos.

[@corbintheintern6229]

“It was extremely hard to break up, kind of like Drake and his love for minors” made me choke on my drink, so uh…well done

[@SlntFrtr]

My favorite part of your channel is how you point out where the red line is then proceed to put your finger directly on that line and say " I'm not over it, there is clearly 1nm left".

[@popescucristian8978]

a much safer way to spend atp and calories that is also free and nontoxic is to simply exercise think about it the muscle contractions require atp to work and the muscle has to burn nutrients with oxygen to get that atp therefore by simply exercising you will burn calories and it's healthy too ! so my advice is to go touch grass

[@e3498-v7l]

The body has evolved to be pretty good at adaptation, conserving energy and using every trick in the book to overcome periods of scarcity and hunger. Can you burn a pound of fat through exercise? Can you do it every day for a period of two, three weeks? Can you maintain your job and a life with that amount of exercise? Probably no on all counts. DNP can do that, though.

[@chrisbrent7487]

Its alkali salts also go BOOM! at around 80% of TNT.

[@cantreid800]

“Kind of like drake and his love for minors”

[@prototype9000]

if you keep the dose of dnp low then it can be safe

[@nosidenoside2458]

Hey wait didn't the us military want something like this

[@XceptionalBro]

You won't see me consume ANY yellow chemistry eugh

[@nero3k]

That’s a whole lot of real science for the bro-science crowd. A bunch of work just to cook yourself from the inside out.

[@charleshendrix3820]

ChubbyEmu did a video on the side effects of this.

[@Mr.Maszek]

Bro, this video is great. I didn't think I'm going to smile and laugh so much on this. Good job!

[@soulreaper359]

6:11 SIGMA MENTIONED 🗣🗣

[@Mulmgott]

Chemistry is full of SIGMAS.

[@soulreaper359]

@@Mulmgott muuuuuulllllmmmm

[@nobody4248]

I am guessing it tastes like methemoglobinemia.

[@ObsequiousV4]

why take a dangerous substance when you can just smoke a Jeffery?

[@jmi967]

I just thought of a legitimate use case for this stuff that could warrant an exception to the ban. Including it in emergency survival packs for cold weather areas.

[@neb_setabed]

jeez, I suppose you don't need a fire if you are the fire lol

[@stroopyy]

There are much safer thermogenics. DNP isn't inherently megadangerous if you're not stupid and your source is high quality (i.e. not overdosing) but that's obviously a big concern for a drug made in underground labs. The stupidity is a concern for genpop and/or people who are stranded.

[@garrysekelli6776]

They used to use it in WW2 mostly around Stalingrad.

[@Mulmgott]

Your heating bags don't do oxidative Phosphorylation bro. What you are describing is a bomb.

[@jmi967]

@@Mulmgott And heating bags don’t keep the whole body warm either.

[@WsciekleMleko]

Can you make 1 kilogram of amphetamine and then send it to my home address? Of course, for educational purposes.

[@Stonehawk]

so your body heats up, your heart rate increases, you get sweaty and dehydratetd, your body uses up some electrolytes, you get out of breath, and if you overdo it you'll get nauseous, dizzy, and weak? BRO THIS IS JUST THE EFFECTS OF EXERCISING TOO MUCH

[@prototype9000]

the people that died from it were taking like 40 to hundreds of miligrams of it when the effective dose was at like 0.5 mg every other day

[@joshuagarris2752]

I might be one of the only ones that watch this channel having no idea what he's saying 90% of the time but still enjoying the videos for some reason

[@bensmith4563]

I don't understand anything in chemistry but I watch alot of chemistry videos

[@blue5659]

Excellent work sir. Could you please explain why the second nitration goes to para not ortho? And also why does hydroxude attack halide not niteo and expell no2-? And also why did na2co3 work but not naoh? Did naoh do sn2 with nitro due to too much nucleophilicity? I am the chemistry version of vegan karens. I am a monger of green chemistry as such, would milk of magnesia work better than na2co3? As a cheaper base than na2co3

[@blakeday2030]

I'm interested in how you went about trying to clean up the first DNP final step. I would think that you could use a basic aq solution to hold the product in the salt form and then wash with an organic solvent to remove the dimer. However, if you lost the product, maybe you tried that and it ended up in the wash

[@Prometheushighaf]

Plot twist: its only effective if you boof it

[@chemistryofquestionablequa6252]

Butthole energetics. Don't do it, too toxic...

[@cvspvr]

I've used dnp up to 1.2g per day. it wasn't fun, but i lost 20kg in 5 weeks

[@cvspvr]

@@keelo-byte i mean, it doesn't have any lasting side effects, so time has already told

[@vapenation7061]

it wasn't fun why?

[@cvspvr]

@@vapenation7061 the dnp smelled horrible. it stung if i accidentally got any on my tongue. i felt exhausted all day. i was constantly sweating. my sweat stained everything yellow

[@cvspvr]

@@vapenation7061 1) the dnp smelled horrible 2) the dnp stung whenever i accidentally got some on my tongue 3) i was exhausted all day 4) i was constantly sweating 5) my sweat stained everything yellow

[@CaedmonOS]

​@@vapenation7061This stuff ramps up your metabolism and turns fat into heat. I saw somewhere else in this comment section that this stuff is used to treat hypothermia.

[@e3498-v7l]

Wow 38 g will fetch couple of hundreds bucks on the dark web.

[@djlykaen]

the chemical even says OH NO2 NO2

[@joshuaolander201]

If I want to lose weight will running a fever I'll just relapse on the meeth

[@NeroNORirl]

seem like a good fat burner when you keep it in a glass filled with water to avoid reactions if the substance get dry.

[@JohnDoe-gg6kc]

Seems like a great suppliment to use forswim training, water would regulate your body temp.

[@jamiemoore1056]

Why did you use bromobenzene? When just phenol at colder conditions will work

[@dimaminiailo3723]

dinitration of salicylic acid and decarboxylation? it should give reasonably pure dnp

[@kerimkstati]

when I saw the preview, I noticed that the pyrotechincal re-uploaded the video because of youtube rules ahahaha

[@Wavy_Gravy]

DNP

[@daniellassander]

Pathetic, its not even a proper christian stirbar i dont even know what to say :P Loved the video man!

[@ericgillespie2812]

Been wanting to take this for years but all the “guides” seem like they are written by 5 y/o

[@PotooBurd]

Boosting for the algorithm 🙌 Love your work, keep it up! 🌻🐝

[@crizzonet]

All the side effects are what I look for in a good time

[@spazmonkey3815]

Smells slightly more cancerous? Very good then.

[@IldefonsSkrzypifurtka]

impurity? or did you mean✨**TAR** ✨

[@burgersnchips]

DNP + a cold bath until the effects wear off = profit?

[@foxyfoxington2651]

You forgot spontaneous combustion in your side effects list.

[@Nobody_Cares913]

Drake chatching strays from anywhere and everywhere 😂

[@freewheelburning8834]

seams popular among young chemists to make this these days

[@nicolascuyato3580]

Love this video dude 👌 as usual, an amazing job. Fun fact: I once tried to synthesize picric acid from aspirin and nitration mixture, and it went... Somehow wrong :v everything seemed to work, but when I purified my product and tested it's flammability, it didn't went off at all. I guess what I obtained from the synthesis wasn't picric acid, but a mixture of 2,4-DNP and DNS (dinitrosalycilic acid)... Maybe that explains why my body temperature increased (yeah, I became hotter lmao)

[@D43vil]

So take DNP in the winter and run outside neked....got it.

[@JimmyJamesJ]

Yeah, you need the 2, 4, 6-trinitrophenol.

[@mgritsch]

Excellent job and finally a clean route! Everything that starts from a phenol is a programmed runaway reaction, so way better to do it like this. The stuff isn’t that explosive unless you use a primary charge, no worries. Would be interesting to partially reduce it to amino-nitrophenol which is a very useful precursor for dyes!

[@成吉思汗-y3x]

Chemistry Sweaggersouls before gta 6

[@DrNiekPhD]

mmm looks tasty 😩

[@aduty23]

Pretty sure increased metabolic rate is the entire point.

[@republikas]

do a synthesis of ozempic in home lab just for shit and giggles to show middle finger to patent regulations

[@chemdelic]

If I could I would💀

[@XceptionalBro]

5:50 this shit is the kind of thing Magic The Gathering players think is normal gameplay

[@tasteslikepennies2549]

John Pinette wishes you showed up at his gravesite

[@Greg-l3j]

Lol i love this channel,i know nothing about chemistry but i truly enjoy everything about your vids.

[@novano1d]

12 dislikes from drake supporters

[@YeeModz]

How to synthesize mdma with normal store things