Making Ethoxypillar[6]arene - The Future of Drug Delivery?

[@win32terminator]

Well done, mate! first time hearing about pillararenes! Although I'm an inorganic chemist, I can see a great potential in these

[@rogermeyers4815]

its basically a "simplified" cyclodextrin, which are used in drug delivery and food processing already for quite some time. And you can also modify them very intensively.

[@rafawyrebiak189]

That's something new, I've heard only about calixarenes

[@seaDeep-x1w]

Indeed, it is a type of molecule that has been developed in recent years

[@austinhixson625]

These look really promising for future medicine and pharmacology; I think it's fascinating that we'll be able to hide "stowaway" drugs within the pillararene to sneak it through the blood brain barrier, like some kind of chemical Trojan horse lol

[@redphoenix120]

yeah its an odd thought. the only usage i can think of though is like when you have something like loperamide which is known to be a full mu-opioid agonist in the myenteric plexus in the gut which makes it effective for incontinence but it cant cross the BBB. So if put in a pillararene, which isnt swept away by enzymes like P-glycoproteins or monoamine oxidase, it could be used in a different way than normal. But obviously used with something more practical and useful.

[@renikun6243]

@@redphoenix120 i feel kind of guilty that i had the same thought instantly.. well phenethylamine maybe 2

[@Humbulla93]

@@redphoenix120 loperamide which makes you really high is something practical and useful i would say

[@petrmasek4506]

Loving that !!! Trojan horse :))

[@cvspvr]

man, i've seen heaps of papers about novel drug delivery methods, but i've never seen them used in actual drugs

[@SeekingTheLoveThatGodMeans7648]

If it's for drug delivery, could it be called a pillararene pillbox?

[@skeptical_thinkers]

A pillarbox

[@slimp4644]

Wow this is actually amazing, thank you for showcasing the synthesis and bringing it to our attention as the chemistry community! 😎

[@skeller90]

Man I found this Channel today and watched all videos. What a piece of art for chemistrys.

[@timecode37]

That's so cool, never heard of pillararenes before!

[@-w-.]

Maybe I'm just blessed with NileRed but it's hard to imagine the undergoing reactions without showing the chemical equations. 😅 Also, pings >:/

[@Chemiolis]

There’s a lil equation in the link but it’s very simple, unfortunately couldn’t find exact mechanism since it’s so new so didn’t want to butcher it 🥲

[@kid_missive]

go back there then. or maybe make some of your own content :)

[@-w-.]

@@kid_missive Meanie ;w;

[@That_Chemist]

3:40 forbidden cookies and cream

[@experimental_chemistry]

Stracciatella! 😆

[@supersophisticated9943]

I thought the same.

[@sciencoking]

3:42 Ah yes, forbidden cookie dough

[@petrosstefanis6234]

Just when I thought I knew a lot about chem. You humbled me. This sounds very promosing.

[@nenben8759]

Ice cold dcm looks oddly refreshing

[@Zenzicubic]

Cool synthesis. I wish I could do that...

[@tracybowling1156]

I hate when people say that there is not such thing as magic. Uh chemistry! That is real life magic.

[@douro20]

DCM is a really good low-pressure refrigerant which we may start seeing used again in large centrifugal chillers.

[@user255]

Nice! I would have liked to see some demonstrations of the properties and/or reactions of the final product.

[@herwew7476]

Excellent Video!

[@NoahGooder]

that stirbar reminds me of the fundip sticks

[@ielZxro]

Educating, and entertaining. Good video

[@Franklin-jj4jz]

It looks like a promising substrate for ester nitrolysis and aromatic nitration. With twelve possible nitric esters and 6-12 aryl nitro groups per molecule, it would be quite energetic.

[@goryao]

Interesting AF! I wonder if you could use a metal with the right size to "build" the pillararene around it; maybe get higher yields of the desired [6] product?

[@SoulDelSol]

You make it look easy!

[@hcklclr]

Nice work, well done. But I think you should provide melting point analysis or sth like that (if NMR is out of reach) to prove the final product. Because directly writing pillar[6]ene was seemed a little bit self-righteous.

[@guystokesable]

What if he did and didn't post it because THAT would be self ritious, you do the chemistry and test it, let him make videos with retention and click through rate to pay his bills.

[@csalad992]

Super great video, love for supramolecular hosts

[@bdnugget]

Are you sucking DCM through your pump? This ruins the membranes super fast if you use membrane pumps, and even though they are disposables, they are expensive as frick to replace for a hobbyist

[@frankmercer7009]

Nice work.

[@Conex145]

Nice work! Looking forward to more interesting content 🙂👋

[@viorp5267]

The green is so pretty

[@experimental_chemistry]

Well done!👍 However, the solvent consumption for the procedure is quite high.

[@clintongryke6887]

Really interesting.

[@kid_missive]

"whole bottle" chemistry is relaxing!

[@benmcreynolds8581]

Woah, so you can possibly get medicine that doesn't cross the blood brain barrier to cross the blood brain barrier 🧠👍🏻 that can be very beneficial for medication use.

[@PopHjalte]

I don't know if it is just because of the camera or whatever, but that is definitely blue on my screen:P nice video though:DD

[@derktewinkel]

Very nice!

[@6150RE]

Awesome!

[@mfrederikson]

Nice video!

[@kagamer21]

That was so cool!!!!

[@hugoescobar4956]

Nice video

[@KakashiBallZ]

Pillararenes, the joy of every Chinese organic chemist.

[@palamalama]

I need a reaction diagram!!! Otherwise you're just adding reagents to a flask for me 😢😢

[@michaelzumpano7318]

Have you had it analyzed?

[@Sultan-ff4fi]

i don't have any idea of what that is but i want to make some

[@johnbonjov1491]

Really great video :)

[@BODYBUILDERS_AGAINST_FEMINISM]

3:41 forbidden cookies and cream ice cream

[@ZoonCrypticon]

Incredible !

[@jcolinmizia9161]

I’d be awesome if you could test the purity of your product. Do you have any access to analytic equipment? I’d love to k ow how well this chemistry actually worked without any chromatography.

[@kawaiiintelligenceagency3889]

Are the pillar[6]arenes safely metabolized?

[@ruruchan8881]

It would be better to add a possible scheme and explain it at the beginning of the vid. Thank you.

[@octanitrocubane]

Now make the Alzheimer’s medicine and test wether your product really works /j

[@kashifhussain1781]

Thank you for the synthesis demonstration. I have quires that, if we use bromocyclohexan instead of chlorocyclohexane then its work? What do you think? please reply

[@Chemiolis]

I think it only works with chloro

[@leo.simensen]

Why are the larger pillararenes more strained than pillar[5]?

[@NoahGooder]

0:39 makes me think of hemeglobin

[@marcomenghini327]

For the mechanism, isn’t it some sort of friedel crafts reaction followed by a dehydration ? Idk about the template effet though bc no pi stacking is possible

[@marcomenghini327]

Looked into it a bit looks like it’s just inclusion of chlorohexane (during the closing of the ring) that yields the 6 over the 5. I suppose the polarity of ClCy is key bc to have the pillar5arene they use 1,2-dichloroethane

[@crabcrab2024]

Damn! How can I like it a second time? Can’t find the button.

[@jimheadbanger]

Very very intresting .... is the mechanism known;

[@daviddavidson2357]

3:57 I must have skipped over the point that you said you were acetylating morphine.

[@notez420_]

it look like some gooood diamorphine

[@supersophisticated9943]

Legendary comment.

[@6alecapristrudel]

They didn't shorten the name to pillarene, that is just disappointing. But since the nomenclature is free, I propose pillarenes be actual pillars, like at least two layers of pillar[n]arene rings on top of each other. Kinda like a shitty short carbon nanotube. Then if we close the tubes with a flat top like a benzene ring we can have pillar-pillarenes. If we close them with "rounder" caps like a trialkylamine we can have pill-pillarenes. In a general case I propose pillarenes to be relatives of carbon nanotubes which lack conjugation along and/or around the tube. IUPAC, get on it! Make it canon.

[@andrewjin6618]

Bold to use BF3 etherate with exposed wrists

[@WorkyGaming]

It seems to me as some Covalent organic framework which i am making. Cool video though

[@nurikaraavc8082]

Do you have work on cyanoacrylate adhesive?

[@mkimball6]

Nice vid! Do you have an oil-free vac pump? I would be worried for your pump oil if not

[@mkimball6]

I don't mean to be negative, it's a great synthesis and taught me a lot. I just have PTSD from my first couple syntheses and oil changes. I once tried similarly pulling off water from sieves, but it ended up being more water than oil by the end

[@Chemiolis]

Yes I have a membrane pump

[@P108A]

3:42 delicious oreo ice cream

[@davidli6931]

What's that bluish green thing?

[@GRAYgauss]

Yeahs I'm cool with putting DMT through my BBB, but I'll stay away from having to Trojan anything in, holy loose ends I messed my body up just with what was natural.

[@MikeJones-mf2rt]

How does this differ from fulvic acid?

[@PotooBurd]

Cool science bro! I hope I’m not on a watch list now-

[@seaDeep-x1w]

To be honest, I'm worried about its biocompatibility

[@ashkan_1339]

nice

[@clrwtrmusic]

Why did they add the extra ar

[@garthmcgibbon4285]

It is really disappointing that you get such low yields.

[@dominicburns9989]

DCM through the pump???

[@Chemiolis]

It’s a membrane pump, they are made to handle it. Inside is all PTFE, no oil.

[@pagorami5253]

cool!!!

[@chikianglim3632]

It looked like cookies and cream at one point

[@p1nkfreud]

I always like to see 2,5 di(m)ethoxyphenyl moieties get used in non-illegal applications

[@nurikaraavc8082]

Do you have work on cyanoacrylate adhesive?

[@froz9069]

I liked

[@hkkhgffh3613]

What glassware is best for anal insertion? Can you recommend advanced stuff as well as something for beginners ?

[@Chemiolis]

beginner: NS14 straight vacuum adapter advanced: NS29 dimroth condenser np

[@experimental_chemistry]

Wow to both: what kind of (brown) humor! For all viewers who don't take this as a joke - only use massive glass devices that are specially made for this purpose, if you don't want to bleed to death internally before you reach the emergency room... 😱💀

[@supersophisticated9943]

Reporting to the emergency room. HK is someone that wanted to have a little too much fun with their chemistry equipment. “Best of both worlds”, they thought.

[@alvinkwok587]

why does the residue look like cookie & cream?

[@supersophisticated9943]

Wow, so this is how new businesses can be created. I'll be sure to never take notes about it. (I am joking)

[@derchromebacher4366]

I have no idea what going on. I just watch those videos to hear people say those ridiculous names.

[@ayrendraganas8686]

woah

[@Anar10n]

pls condense dcm not just evap so much

[@karolus28]

cool

[@pannekook2000]

Appalachia 🤝 Netherlands “warsh”

[@jopmens6960]

Hopefully it doesnt make you deaf like HPBCD? :p

[@Zanzuibarth]

I‘m actually amazed how you get your hands on all those chemicals. In Germany a swat team will knock on your door when you call politicians „1 Pimmel/ one dick“. I don’t want to know what happens when you try buy this stuff on the internet. 😄

[@loganosmolinski4446]

Boop

[@viorp5267]

> 50 years old > New