Which Chemical is the Worst Carcinogen?

[@s.v.berezin1562]

I am deeply shocked. Thank you for this crucial information - that alcohol may not be healthy. I may need a drink to help process this information...

[@WowUrFcknHxC]

A shot of heroin would be far less carcinogenic.

[@JacobHidding]

Same :/

[@dylanblomme4679]

I think I need a smoke..

[@johnbeton4058]

Cheers🍻

[@aarontooth]

Way ahead of you bro

[@lookitsluke433]

22:50 completely agree. It always pissed me off that cleaning chemicals, and other products that can be bought at hardware stores, grocery stores, and so on, never list the chemicals included. If food products are required to list ingredients, then so should other products. I always try to find an ingredient list for chemicals I buy that I’m not familiar with, but it should 100% be listed on the package

[@Sniperboy5551]

Most of them have an MSDS sheet you can look up if you’re truly determined to find out. Most people wouldn’t care enough to read a label, let alone look up the MSDS, but to me it seems like “survival of the fittest.” Let Darwin do his job!

[@JohnSmith-fq3rg]

@@Sniperboy5551 Alot of things have blank or near blank datasheets, if they dont have to list an ingredient because its not recognized as having a danger, they wont.

[@eank3429]

@@JohnSmith-fq3rg true but plenty of cleaning supplies got em. Plus can't have the Gen public knowing anything at all

[@JohnSmith-fq3rg]

@@eank3429 It's not so much a concern about the general public knowing, as much as the competition. If you show the exact chemical end product of your "secret recipe," reverse engineering your profitable and efficient process becomes trivial for industrial r&d chemists.

[@alecasone]

@@Sniperboy5551 true. I try to use the MSDS sheet to find alternatives to expensive or namebrand products when online searches fail me. (some examples are removing burned tar/wax buildup on moulder bits, dealing with surface rust on different materials, non Teflon/silicon dry lubricants that won't fisheye stain or paint finishes)

[@brandonklotz1207]

The idea of a “Carcinogen Tier List” is just so ridiculously funny to me.

[@MrRUSINA]

Why?

[@Newguyatwork]

​@@MrRUSINAIt's unexpected considering how to a normal person, ranking carcinogens could make you look like a psycho.

[@laudableplain4282]

​@@Newguyatworkim a psyco and I want to know all of the carcinogens out there😂

[@charlotteblack777]

if keeping tabs on how deadly substances are makes you a psycho then its better than being a dead idiot. even within dumbass capitalism you can sue over your now shortened lifespan

[@katielowen]

So funny you could 💀

[@mcrut111]

I have to say, out of all the warning labels for safety, carcinogen has to be the most eerily creepy/terrifying

[@Dorsiazwart]

It’s so well designed

[@Laundry_Hamper]

Creeping death

[@toastothetoaster7949]

I feel like safety warning labels might be a good future tierlist???

[@alman5718]

@@toastothetoaster7949 GHS tier list would be fun for sure.

[@stefangadshijew1682]

Im quite unhappy with this symbol, it also labels comparatively benign things, it's not for carcinogenes specifically, but for all kinds of lasting damages, from dry skin to allergies to heart failure to cancer. A specific symbol for carcinogens would have been greatly appreciated. I feel it's a step back from labeling carcinogens with a skull in the old system together with acutely very toxic compounds.

[@LemurG]

As someone who accidentally ate a moldy cherry tomato yesterday, my body very quickly notified me of the potential health risk

[@reelgangstazskip]

my sides

[@SoulDelSol]

That's terrible. Top of tier list with it

[@kobold7763]

I accidentally ate about 20 mg of 2-methoxy-4-nitroaniline (a known mutagen) last year. Is this bad?

[@SoulDelSol]

@@kobold7763 he should ask us all to submit dangerous mistakes we've made and rank them on tier list.

[@ryanxu9983]

@@kobold7763 the best/worst part about your comment is i cant even tell if this is real or not 💀

[@mr.b5187]

Radiation therapist here. The most common exogenous factors we see strongly contributing to cancer development are: heavy smoking, heavy alcohol consumption, HPV, and high sun and exposure. Here’s common examples: I smoked a pack a day for 25 years. I drink 5-6 drinks a week. I do both of the above. (This one is far and away the biggest cause of preventable fatal cancer) I got HPV in my throat, and never knew until I got cancer. I tan or get prolonged sun exposure a couple times a week. Avoid these risks and you’ll skip everything you could possibly prevent on your own. The rest is luck. Just don’t eat cadmium or whatever. Also, quit vaping. We don’t know what it does to the human body, yet.

[@monkeyglocks]

I think vaping is probably worse for you than cigarettes tbh

[@snomcultist189]

Bu…b..but what about my artificial fruit rings that taste worse than fruit?!

[@Less0331]

Reminder that this is usually the case for white people. People of color have better protection to sun rays. In fact, the recommended sun exposure may vary depending on your skin. For white people, it's around 15-45 minutes minimum in order to generate vitamin D (and higher doses of sun rays may prevent eyesight issues; there's evidence that show that children who spend 1-2 hours outside are less likely to develop eyesight problems), whereas black people may require a few more minutes of exposure to the sun. Also, another issue is vegetation and trees. If you're able to protect yourself from the sun with trees, you're able to be out for a longer period of time. This is an issue in car centric cities as there may not be green areas nearby, and sun exposure may be more harmful to all forms of life.

[@thurbine2411]

@@Less0331of course it ain’t strictly about being outside but being in the sun. Staying in the shade is safe

[@nightshadegatito]

Good points except the last. Vaping is fine.

[@jimmytiddlytoo8160]

Fun fact: most carcinogens have multiple aromatic rings because they intercalate between DNA base pairs through Pi stacking. This often leads to gene silencing by blocking translation

[@danthompson5797]

Fun fact for people with PhDs maybe

[@karama5562]

So basically it stops the gene from geneing, truly a carcinogen of all time

[@zachingram04]

@@danthompson5797 this requires a basic biology class, and 1 (maybe 2) semesters of basic organic chemistry in college

[@angelopauli1961]

@@zachingram04 thank you for leaving this comment, I'm going into college and interested in what classes I should take and this helped me think

[@disconnected2043]

@@angelopauli1961 best of luck! its a lot of fun

[@expertoflizardcorrugation3967]

You can avoid carcinogens for your entire life and there is still a very real chance that some cell somewhere decides that it is having a bad day and decides to make that your problem. no amount of caution will ever reduce your odds of cancer to 0 (obviously there is merit in reducing your risk). In my mind it's far more productive to improve your odds of surviving it if it happens, and chances are most of those are things you should probably be doing anyway.

[@TheBackyardChemist]

And if you do manage to dodge both cancer and heart disease, congratulations! You win the grand prize of getting to die from Alzheimer's.

[@craigpater6278]

All it took for me to develop skin cancer was getting sunburnt too many times but I got lucky and had surgery to remove the skin cancer from my chest (upper left corner) and I still have regular skin checks every six to twelve months as a precaution or more regularly than every six to twelve months if I find any lumps or legions that I am concerned about but so far no sign of any skin cancer. It wasn't major surgery having the skin cancer removed from my chest just done under a local anesthetic at my GP's (doctor) clinic and I only needed three stitches

[@r.guerreiro140]

@@craigpater6278 may I ask you what latitude you live?

[@craigpater6278]

@@r.guerreiro140 I'm not sure about what latitude as I'm not familiar with latitude but I can tell you that I live in Adelaide, South Australia (South Australia is a state in Australia and Adelaide is a city in South Australia)

[@r.guerreiro140]

@@craigpater6278 I'm from South Brazil Seems your latitude is not so different than mine Up to now I can name 5 people who had skin cancer I do my best trying to follow a sunsafe attitude

[@annanikolic413]

For the mold one, I am disappointed you didn’t mention how prevalent black mold is in buildings across the world. Obviously no one will purposely eat a ton of moldy food. But I myself have experienced living in an apartment infested with black mold and within 2 months I became extremely sick, constantly had respiratory issue, extreme brain fog especially when entering my bedroom (where the mold was most concentrated), mood disturbances and even developed asthma. I would cough up phlegm that would literally, no exaggeration, have spores inside it. When I saw that in the bathroom sink I couldn’t stop crying. When I saw how much black mold was in my AC unit alone I was terrified. Everyone I show the pictures to I have to give a warning because it’s that disturbing. And that common. I know so many other people who have experienced the same-this being NYC, which is supposably the best city in the world. There is very little tenant protection for this despite mold being a huge tenant’s rights violation in NYC. I am so lucky I was able to move out of my lease. Many people don’t have that option and have to live for years in toxic environments. There’s even a phenomenon called “Sick building syndrome” where people who feel extremely ill inside their apartment buildings feel better once they go outside. This is due to toxins such as black mold and water damage as well as a lack of airflow or light in many “modern” apartments, which in all seriousness rival tenement housing in terms of toxicity. Mold is a huge human rights issue that remains ignored in favor of landowner profit.

[@dreamweaver4183]

Damn. Well now if literally The Last of Us starts happening, we know who to blame 💀

[@floors8122]

❤

[@terryt9833]

This is the case in my building in Vancouver as well. It is milder in my home but I am constantly sniffling and coughing phlegm because of it. I can't wait to move so my pets aren't affected any longer

[@Codduct]

Mannnn I live in nyc, if y’all don’t start getting that bleach vinegar water (majority should be water to prevent making dangerous gas) combo with a scrubber with a mask and start scrubbing☠️the type of mold I had was brown n had no long term effects (I think) but every time I spot one, I get to scrubbing!

[@StyleshStorm]

Mold is underrated as a problem that people always underestimate. Thank you for this comment.

[@captaincat1743]

I used to work for a shoddy company in the UK that made printer inks. We were instructed to clean ourselves with MEK ( Methyl-ethyl-ketone ) . i trusted my supervisors as a young man. I know now that it is toxic, causing neurological illnesses. No long term studies exist for it's carcinogenic effects. I felt nausea often after finishing our shift. Thank you Lyson Fluids ! I'll be seeing you in court soon if you are reading this.

[@midship_nc]

MEK is extremely flammable, and vapors in certain concentrations are explosive. If you were wearing synthetic clothing you could have discharged static electricity and caught fire, or worse.

[@thorstenmarquardt7274]

Go get em!

[@prod.am3thystt]

Good luck! That sounds terrible 🤢

[@medicah]

They are not reading it

[@michaelross1452]

We at Lyson Fluids will be seeing YOU. See that car outside your house? That's us.

[@johnSmith-my9yj]

30 years ago, before the internet, I wanted to try out an old synthesis I found in the library. Went to the chemistry shop, asked for a bottle of benzene, not knowing sales of the stuff had been restricted decades ago. They did sell toluene, which was fine, since the benzene was only needed as solvent, not a reagent. Ten years later, when I did my military service in the military pharmacy in Evere (Belgium), I came across bottles of pure formaldehyde. The doctors prescribed it as treatment for sweaty feet: dilute with water, and soak your feet for 15 minutes every day.

[@That_Chemist]

you can still buy it, you can buy almost anything, they just hike the prices up

[@L3uX]

Also, if you have the Asian flush or cannot process alcohol normally (like red flushing + other side effects), acetaldehyde stays in your system far too long and in essence, drink for drink (vs normal process) increases your exposure to cancer :/ Important UPDATE: While the ALDH2 enzyme primarily targets acetaldehyde, it is also involved in detoxifying other aldehydes, including 4-HNE (associated with cancer, etc). So, individuals with the ALDH2 mutation may have a reduced capacity to metabolize and eliminate 4-HNE effectively. 4-HNE essentially comes from the peroxidation/consumption of Polyunsaturated Fatty Acids (PUFA). So we suck at alcohol, but we also suck at foods high in PUFA's. Lol.

[@Alex-fc8xn]

My partner is filipinx and I have to keep nagging them to avoid alcohol because they're in denial about having the Asian flush because it's not super visible with their darker skin tone. But I can definitely see their face change in color and look a little puffy when they drink

[@L3uX]

@@Alex-fc8xn I took took way too long to realize I shouldn't be drinking alch, but it definitely is damaging. Giving up alch is hard when everyone around is drinking, so I would say, there are other stuff out there when consumedd in very careful moderation should be relatively safe.

[@Alex-fc8xn]

@@L3uX Like cannabis products, depending on method of consumption and how your body reacts to it. Considering it's literally prescribed as medical treatment, and shown to have benefits, it's a good alternative. Smoking/vaping it isn't good for the lungs, but edibles and sublingual oils/tinctures are pretty safe and can help with social lubrication without causing the same sort of disinhibition or risking overdose unless you are truly consuming ridiculous quantities

[@Human-san]

note!: This does not apply to everyone of Asian descent. My dad is Korean and he can drink alcohol like it's water, I have literally never seen him blush.

[@sganicocchi5337]

​​​@@Alex-fc8xnplease dont use filipinx. filipino is already gender neutral. as a filipino, (im very sensitive to alcohol overall too) its a pretty similar case for me

[@custos3249]

This video has been know to cause cancer in the state of California

[@drakesdentures]

“…and birth defects or other reproductive harm”

[@miurasvlamborghini]

California is cancer.

[@that0nedegenerate]

Just set your VPN to elsewhere, it can't hurt you if it doesn't know you're in California

[@roscoejones374]

Or worse. Might cause California in the state of cancer.

[@masterTigress96]

I think that is mostly due to the Californians themselves really.

[@lissettelopez8331]

For years, I was the sole Chemical inspector for Ortho-toluidine coming into the Houston ship channel. I remember a few times the whole plant was being evacuated into inside safe zones because I was just getting samples from the ship. One time while the ship was in port, myself and the ship “pumpy” were pulling the samples and my SCBA ran out of air midway in sampling. But I’ve worked hundreds of chemicals in my career so it was nothing extraordinary. We transported them in rubber coated bottles for in case they broke. And it’s MSDS numbers were all 4 to the max. The best thing that ever happened to me was leaving that career field.

[@purplealice]

I had an uncle who was a career Marine. He spent a lot of time at Camp LeJeune. Once I saw all the ads for legal defense regarding the polluted water at LeJeune. I googled his name, and discovered an obituary. He had lived in an assisted-living facility before his death, and cause of death was "complications of Alzheimer's." The last time I saw him was at my wedding, 49 years ago. But he had five kids.

[@That_Chemist]

Amazing!

[@purplealice]

@@That_Chemist I just hope he wasn't still living there and exposing himself and his kids to the benzene, chlorinated solvents, and other mutagens/carcinogens in the water.

[@coda56]

i hate those ads, they play every 5 minutes

[@JohnSmith-fq3rg]

@@That_Chemist Commenter: "my uncle died D: " KZbinr: "Poggers :D "

[@ADIIIIIIIIIIIIIIIIIIIIIIIIIIII]

@@JohnSmith-fq3rgi doubt he meant it that way

[@teknofreak2387]

I work in pharmaceutics and the impact of pure suspicion of being carcinogenic can be the death sentence for any otherwise harmless and usefull drug

[@ghostrider433]

Must hurt your profits. Boo hoo.

[@Tacet137]

@@ghostrider433 yeah sure a worker is the problem, not the 0.1% billionaires

[@gilbert4394]

Actually comforting to know!

[@masaeffy]

@@Tacet137 sure NPC, 0.1 % of worlds population are causing problems the other 99.9% are saints and good christians 😭😭😂😂 gtfo with that political bullshit #NPCbotsocialist

[@chervilisbetterthancilantro]

@@ghostrider433 A drug that could save people's lives, or make it much more bearable. And all you can think about is "pharmacists are out to get us"? You conspiracy theorists need to stop attacking health care.

[@ruthhorowitz7625]

I used to work as a health and safety officer at a university. I once did a breakdown of what's wrong with wd 40 sds to teach researchers what to look for and how to find missing information. A video on how dangerous is the chemical in your home would be great. WD40 btw is pretty dangerous. That sds is downright criminal in my opinion.

[@azerty1933]

I'm a health and safety officer as well and I'm always laughing when I look at wd40 sds It's insane how they are getting away with it

[@Brainman_2331]

What's wrong with WD40? You're talking about that multi purpose industry spray, right? I often work with it and I don't know how to safely use it.

[@ruthhorowitz7625]

@@Brainman_2331 it's very toxic, especially if you inhale it. Use it outdoors only and wash your hands well. If you can use neoprene or nitrile gloves even better, but still wash your hands. The sds is full of misinformation and disinformation.

[@NathanDudani]

​@@Brainman_2331 Then, why are you using it???

[@ANTHONY-cz9ut]

@@NathanDudaniclearly wrong cuz the sds doesn’t say how to properly use it… come on man

[@scottyV1000]

I’m surprised you didn’t put benzene higher since we treated this as one of the worst things you could get exposed to in the lab. We pretty much treated it as liquid leukemia.

[@NaruTheBlackSwan]

Lab exposure to pure benzene ≠ the exposure risks normal people face from trace amounts in gasoline.

[@comradegarrett1202]

tbh most of the public outcry over benzene when its carcinogenicity was discovered was just how frequent occupational exposure was for so many workers who used it daily such as dry cleaning workers. occupational risks dwarf the risks of single exposures by many orders of magnitude.

[@gamemeister27]

@@comradegarrett1202 Sounds similar to asbestos in that respect

[@dieSpinnt]

@@gamemeister27 Don't talk bad about others. Just put your own kids in that environment you think it is over-exaggerated fear mongering and shut up:) Also @comradegarret1202: How disingenuous can one be? That "outcry" wasn't alone because of the fear about the own health(how is this even a point of debate from bystanders?) but how blatantly and inhuman the pollution was done. ... oh and by whom! I you are okay with it that a third party, like Bayer (greetings from Germany, btw:)) ) does eff up YOUR health ... then I am, too. I mean when they do that BS to you! Hehehe, sorry. I am joking and in no case I wish that a company poisons you out of sheer greed for profit.

[@gamemeister27]

@@dieSpinnt I think you replied to the wrong comment

[@C4pungMaster]

The DNA bases when they see an electrophile: is for me? 🥺👉👈

[@JimmyJamesJ]

In 2000 I was a 21 year old apprentice in an auto body shop. As the young apprentice I got the crappy jobs of cleaning stuff like paint guns. We use a strong industrial paint thinner for this that was "Not To Be Sold to Consumers". The rubber gloves we had in the shop were useless against thinners and just bulged up and broke within 60 seconds of exposure so all cleaning took place with bare hands. I spent hours with my hands soaked in these paint thinners that were a mix of acetone, toluene, benzine, methyl ethyl ketone, xylene and dozens of other highly volatile organic compounds. After 6 months of doing that the skin on my hands was thick, dried out and cracked. I started having nervous system issues, shaking hands, inability to sit still, high anxiety, loss of concentration. I didn't even realize this was what was happening until about a year or two after I left the job when all the symptoms went away after I was no longer being exposed to these chemicals. That was 24 years ago and I still don't have liver or kidney cancer but the chronic exposure only lasted for about 12 months. Working in the auto body shop some of the guys used to joke that you don't see old body men, they don't live into old age. Today, all the paints are water based and can be cleaned up with low VOC polar molecules, AKA H2O.

[@That_Chemist]

Im glad to hear you made a recovery! I hope we can help stop people who might otherwise be exposed

[@KenzertYT]

I have to stop fucking with automotive paints and solvents. It is such a hobby of mine but after covid and long term exposure to this stuff you just really opened my eyes to problems I've been having and chalked up to "stress" or "after effects of long covid." :/

[@JimmyJamesJ]

@@KenzertYT Yeah dude, it's no joke. These things can ruin or end your life. Take precautions. Take care of your body, you don't often get second changes with organ damage.

[@Aviate68]

We use acetone heavily in our composite shop to clean tools and tables after wetting out cloth with epoxy. We always wear gloves. I can't imagine using a mix of all those solvents with bare hands. Admittedly I've gotten acetone on my hands before once or twice and it really dries them out.

[@rossfriedman6570]

I had a landlord that liked to spray paint in the basement where me and another person lived The basement would smell like spray paint and we inhaled this shit constantly

[@matfry2310]

My grandfather that died at 44 of multiple organ failure but the lung cancer killed him first... He grew up in auto body shops in the 50s -90s always washed they're arms and hand with xylene or lacquer thinner. Supposedly both enter the bloodstream within milliseconds of exposure to the skin. They think that partly why he had so many issues. Plus they painted and sanded without masks.

[@French408]

Dying at 44 from cancer and organ failure is absolute insanity. My condolences.

[@peterjf7723]

My grandfather developed stomach cancer a couple of years after retirement. He had been an engineer all his working life using milling machines and lathes so he had long exposure to cutting oil mist, now considered to be carcinogenic.

[@nerd1000ify]

A lot of older cutting oils contained chlorinated components as extreme pressure additives. Machining makes a lot of heat, no doubt decomposing those compounds to all kinds of nasty stuff...

[@fionafiona1146]

My mother restores furniture for fun and has accordingly much lower exposure than people doing so for a living. She refuses to lead-test paints and has very low adherence to the breathing and hearing protection to an extend that makes me worry about her quality of life in future decades

[@lithunoisan]

He was also old enough to retire.

[@jens5906]

Having worked with 2-Naphtylamine: You have to synthesize it yourself cause no one sells it. It's an autoclave synthesize and you get greeted with a red paste, it is impossible to filter creeps up the walls of everything you want it to recrystallize from (steel, glass, filterpaper and plastic) crystallizing on the edges and falling eventually of them in the fumehood. The crystals are so fine, they immediately spread over your entire fumehood, breaking apart into much finer dust that manages to simultaneously stick to everything yet also aerosolising really quickly, this and the articles i read about it, conveniently causing bladder cancer in like every subject it comes across makes me never want to work with it again :3

[@That_Chemist]

That is awful

[@KP-sg9fm]

You....shouldn't

[@alexbaidak2475]

Back in 2005, it could be easily ordered from Sigma Aldrich. I used it during my PhD in Germany.

[@Trishlikefish99]

The :3 adds a flavor to this comment that i absolutely love

[@Rust_Rust_Rust]

@@alexbaidak2475 Of course Germany would have it

[@JohnnyWrongo-b9l]

Cancer is not always a death sentence. I had lymphoma at stage 4 when treatment started. Almost nine years later I am alive, healthy, and hove great fondness for medical science, in spite of its issues.

[@Sway55]

happy for you man 🙌

[@Rjjamess]

Hell yea!! That's incredible to hear. May you continue to stay healthy!

[@whatamidoingwithmylife4108]

Personally know someone who survived a stage 3 super rare cancer, angiomatoid fibrous histiocytoma to be exact. Medicine is cool 👍

[@Biffting93]

Congratulations !! I love seeing stories like this Cancer is such a dirty word outside of the medical and science world, people hear it and instantly think the worst but it’s just not always the case

[@189643478]

Formaldehyde story, a colleague told me that when he started his research career in the marine biology, they would go on the sea and catch fish and other animals and put them in buckets of formaldehyde. When they came on land the animals were transferred to new containers and when they went to the sea the next time, they would pour the buckets of used formaldehyde into the sea... We're talking here about like 30 years ago in a Western country... Crazy...

[@That_Chemist]

👀👀👀

[@TheBackyardChemist]

If there is a silver lining, at least it is not persistent

[@R.T.and.J]

In the 90s? Crazy

[@TheBackyardChemist]

@@R.T.and.J We used to boil CCl4 in the 2010s without a fume hood.

[@anthonygreenfield123]

Meh, the ocean is a big place. It won't do anything probably. And it's not super duper toxic in tiny amounts

[@Yukinebi]

One of my coworkers used to wash his hands with naptha at the metal shop I worked at. We worked with soldering lead daily, there was a custom order that thought required a "soak" in "cleaning vinegar. So what they actually used was GLACIAL ACETIC ACID, and they used this to wash parts every time despite me trying to convince them it was stupid (I don't wanna get into the nuances of lead chemistry, but just know we already used hydrocloric and it worked better). These guys didn't know chemistry, anyways on that custom order we left a mixture of acetic acid and some other things and lead pipes soaking over the weekend. I told them not to, but we ended up growing lead acetate crystals. That place fucking sucked lol

[@That_Chemist]

Wow!

[@astrataway7077]

We'd use shit tons of that naphtha in commercial roofing. We use it to clean surfaces and since we'd spread it so often on such large areas we had fun breathing it, it evaporated quick like minutes. And we had giant tar melting furnace. I worked with a guy who exclusively loaded, mixed and dropped hot tar from this furnace. It doesn't smoke so much in small bucket amounts and in transport but near the furnace it's terrible. This guy would stand there with a stick stirring it with a cig in his mouth and would cough and spit into the hot tar. His face was yellow like Bart Simpson yellow. I think that dude is gonna die he's the only one who'll do it get paid allot for it.

[@viermidebutura]

mhm sweet crystals

[@flossordie2256]

My dad used to wash his hands with Benzene in ochem lab in the 70s.

[@catboy_official]

@@viermidebutura forbidden rock candy 🤤

[@leonardovittori293]

24:00 Sucralose contains chlorine atoms but the presence of nearby oxygens (-OH and -OR groups) exerts an electron-withdrawing effect that reduces the ability of chlorine to act as an electrophilic group; sucralose also has a more complex and stable structure then 1,2-dichloropropane, making it less likely to be alkylated and lowering the probability of toxic or carcinogenic effects.

[@kolmenoitaayeet]

As someone who works in a lab, I'm always super surprised (and terrified) how many people handle carcinogenic chemicals without the proper ppe. I've also made it a point to avoid any and all shampoos or body products with include any sort of variation of formaldehyde becuause that is also just crazy to me that that's even allowed. This was such an interesting and fun video to watch!

[@xXDESTINYMBXx]

That is allowed? Can you list some variations?

[@kolmenoitaayeet]

@@xXDESTINYMBXx Do you mean about formaldehyd being in cosmetics? I'm aware that Diazolidinyl Urea, Quaternium-15 and DMDM Hydantoin are products that are based off formaldehyd and are often used in Shampoos (like Maui Moisture, Axe, OGX, but also many others). Some of these ingredients are banned in the EU (like Quaternium-15).

[@steveneardley7541]

I worked at NIH in 1966. The labs were full of radioactive material in giant glass bottles. Since practically all the scientists were heavy smokers, the radioactive stuff was small potatoes.

[@MultiSciGeek]

You clearly missed the whole "it's the dose that makes the poison" and benefits vs risk explanation at the beginning. As for formaldehyde, I'd rather have those negligible effects than die of mould poisoning. Like the dose is so little it's safe for even babies. I mean would you never drink coffee or sit by a campfire again as well? Sounds ridiculous cause it is. Heck the friggin sun is a cracinogen and people don't just cancel the sun lmao

[@ImpmanPDX]

I knew an old mechanic guy who liked using volatiles to clean his machined parts. One time after doing a port/polish on a little lawnmower engine he just doused the thing with gasoline and started rubbing it down like we weren't in a little garage. Fumed out the whole shop until we got everything opened up. My dad worked on the California offshore rigs I'm sure he has some wild stories.

[@Lauren_C]

The SDS for gasoline is actually pretty scary, especially for something we interact with regularly.

[@c0rr4nh0rn]

There are volatiles that give you cancer and there are volatiles that set you on fire and incidentally can give you cancer. Choose the former not the latter.

[@zekanner]

When I used to build aircraft, we would soak bearings in gasoline to clean them (we basically put them in a tub outside the hanger where no one was working, and used gloves to handle them after, but still)

[@nerd1000ify]

There's a safer alternative in the form of shellite (aka 'white gas'), it has similar volatility to gasoline/petrol but minimal aromatics content. Not a good substance to put in engines however, the octane rating is around 60 so most engines will 'knock' if you use it as fuel. In some parts of Australia service stations only sell 'opal' fuel which is similarly a low aromatics petrol, albeit with an octane rating equal to normal fuel. This was introduced to combat the petrol sniffing epidemic, the aromatics in regular fuel are responsible for most of the intoxicating effect so sniffing Opal won't get you high.

[@zekanner]

@@nerd1000ify fascinating and good to know. In my case it was less a "this is the exact thing we need for this job" and more a "we had it to hand and it works." Was also not a job and was about 15 or so years ago. Really enjoyable, though, small aircraft are really interesting. Lots of cool simple, yet ingenious, engineering on them. And skin dope was probably more dangerous than the gasoline.

[@lophiiformed4628]

It used to be fairly common for people to buy used railroad ties to use for projects, since the pentachlorophenol basically makes the wood last forever without breaking down. My grandparents bought some a few decades ago and used it to build a tiered garden in their backyard. I grew up eating home-grown veggies from that garden, and when I found out that railroad ties have toxic chemicals in them, I of course freaked out and started Googling. Thankfully, from what I've read pentachlorophenol doesn't really leach into the ground after the ties are laid, and even if it does it isn't absorbed by plant roots. So the danger of exposure to humans comes mostly from the manufacturing process.

[@KenzertYT]

Dude I'd have been super worried too. Did you know people used to use an oil and solvent mixture to preserve fence posts and other in-ground posts? It totally works but it freaks me out.

[@Cloveis]

You should do a tier list, based on absolutely nothing other than your own opinion, on what the overall best chemicals are. Not sure why but it’d be cool

[@gachivalantine3792]

Pretty sure he already did that.

[@SoulDelSol]

My home town has massive agricultural fields called bogs for a mono-crop berry. Helicopters would drop pesticides and herbicides and we'd be informed to stay inside as it catches in the wind and fields are right next to, in front of, or behind most houses. They used round-up heavily for many years, not sure if they still do. But as a small town everyone also uses wells for drinking water. Additionally the cranberries are harvested every fall by flooding the bogs via pump houses that pull from the numerous ponds around town (berries float). After winter the water is emptied from bogs and pumped back into the ponds. In high school pretty much the entirely English department got cancer and librarian died of cancer too. I have friends from high school who got cancer and one had testicle removed shortly after graduation. My dad just finished 6 months of chemo for a blood cancer. Round up is no joke, especially chronic exposure to it..

[@matthewbadger8685]

Man made horrors beyond our comprehension

[@mertonallowicious]

Should of marketed glyphosate as “ocean spray” 🙃

[@SoulDelSol]

​@@mertonallowicious you're right, ocean spray contracts with vast majority of growers/bog owners in area

[@willbrown5197]

My whole state uses it for weeds on sidewalks 🤦

[@KenzertYT]

Do you live in South NJ or on the southern East Coast? The pinelands of NJ are huge for cranberry bogs. Edit: and of course, Ocean Spray

[@cathalsmyth6366]

regarding 24:03 i believe a study has recently came out stating that sucralose is in fact carcinogenic but the concentrations that cause cancer are around 8,000 times greater than can be found in a can of fizzy drinks.

[@fastlifebmx9292]

Yes there's a metabolite of sucralose that is inherently carcinogenic when applied directly to a cell on a petri dish and you would need to drink hundreds if not thousands of cans to equal the serum concentration of the metabolite.

[@nathanielreichert4638]

Hey That Chemist, some of us laymen who work in construction and or machining deal with toxic inhalants. Would you ever do a tier list of such chemicals as may be common in such industries, e.i silica, solvents, aerosols, asbestos, MDF and/or wood dust, metal coatings, compounds with lead, etc

[@rory2112]

I second this

[@imtiredidk8757]

Omg this would be great

[@Ash-dd3kx]

Especially silica - it's become the new asbestos in Aus.

[@taylo1640]

Please!

[@MandenTV]

“Just read your SDS book!” -every union head ever Fuck unions, been working in construction for 15 years, union for 5. Never again.

[@andrerenault]

It’s funny, I normally don’t enjoy channels that do a lot of tier lists, but you have a knack for making them entertaining and educational. And I don’t even care much for chemistry in the first place!

[@That_Chemist]

I appreciate that!

[@Mnnvint]

It's true. It's horribly meme-y, his voice always sounded like he's saying everything wearing a Lenny face ( ͡° ͜ʖ ͡°) ... and from the videos with a cam, that's turned out to not be too far from the truth. Yet it's actually interesting anyway, and you feel like you learned something.

[@LachlanBaptie]

@@That_Chemist is *"Beautadine"* like Gassy version of *"Betadine"* 'cause's leukemia etc..' When I was a kid I got a "virus" REFERRED to as "School Sore's" Old wound's, scraped knee's/elbows, scratche's, like's of old mosquito, sand fly/sea flea', bite's etc ALL appeared IDK How got THIS *scab/scratch+* did 🚫 fall etc.. MOST of Sore's came up HAD had Betadine applied by Mum.. Dettol, the *Go to disinfectant/antiseptic but on wound's/'Sore's+* Often made itchy & 🚫 necessarily worked as should.. after{?+) Some people clean 🏠 House-hold item's with SUCH Antiseptic's+ 🤔 WONDER if it is What it tis'? ALSO whether kid baby-sat whilst Kid's slept as a teen, One of kid's being treated at that time, for *Leukemia* .. Know She/the Mother was bottle 🍼 feeding New Edition/Baby just My luck 🤞👍☝️✌️ rarely woke up while I was there.. {literally once, & 🚫 the 6mth Old Baby.. met the practically bald b'cos of Treatment, {Oldest of 3 Children more or less 🏠-Sat for.. Whilst Mum'+ went to Nightclub' for break Lucky Me long gone by time One of Mother's/Sister' Kid's also being baby-sat Kid's I Sat-Brother TMI ex of keeping it in fam.. Went MISSING.. Murdered:( Whilst went clubbing..) The Oldest of kid's QUITE SURE The Daughter Wondering about 🤔😈😉🧐🙃 the antiseptic.. thing NOW 😏🥴😬😅😏 if that's what it is.. Apparently ADVISING AGAINST Vapor-Rub in way that had a Q. Answered Year's before.. ASKED about Tetanus Shot's if NEEDED multiple/follow up' Nurse looked at😳😲 like was 🤪nuts the crazy.. No-way's One' FINE.. ALL need Way SAID That did when-encountered the Vapor-Rub commentor.. Like discoveries had been MADE.. ASSUME reason that The Old Chorine-practically Tab's USED to on box State USED to make Water clean AKA drinkable* Good to HAVE on hand for Camping or *Just in Case* 😉 🚫 as is NOW just to Sanitize Baby bottle's 🍼 🚫 for tank/clean-drinkable Water with stronger Concentration for cleaning Blah blah.. 🚫 staple for *"Survival Kit+"* as it had been.. Lung/breathing issue's 🚫 to mention if get in 👁️👀 Bad.. likewise with the Vapor-Rub.. apparently ingredient has in it technically a *Poison*.. little like the Peppercorn AKA willow tree rare to see BUG'S at Base of-where pepper *fallout* is.. might if anything come across 🕷️🕸️ under/sheet's of Paper-bark in primitive time's so to speak used as toilet 📜 Paper+.. or little like *Band Aid* was kind of antiseptic+.. Apparently. Keeps bug's off/out/away from wound'+ {given that *info* Surprised was 🚫 USED on Farm's, by Farmer's to Stop *"fly-strike"* when flie's lay 🥚's.. 🪰 Maggot's literally ate their "ace's" looking bit inside out😳😲😈🤪🧐😬😱😶😑😒🤔 Pestaside's/Dip in Blue 💙 Line.. Cut/BAND' OFF tails so is 🚫 build up to lay in/on.. Cock Ring {little Harder to take off.. Turned tail.. into nub or a stump.. but STILL got a rump.. Long Story.. Short & Sweet.. ;) of the Animal Kingdom.. 🐇🕳️ Sorry ranting a little.. off track From original Q.? is LIKE Betadine?

[@ryanxu9983]

@@Mnnvint i cant hear it

[@christos6014]

I can’t believe vinyl chloride wasn’t classified as a hazardous chemical and was allowed to be in the crash that Norfolk southern’s neglect and mismanagement caused. I wish the best and hope help can come to the people who will suffer because of it.

[@DeputatKaktus]

As a little kid I was at some time forbidden to play in the garden behind our house. The reason was that some of the flower beds had edgings made of - wait for it - old wooden railway sleepers that someone had gotten hold of somehow. This was in the early 80s. No idea how old those ties were but it looked nice. And when it rained there were beautiful shimmering puddles of water all over our garden. Looked nice but smelled awful as far as I remember. It turned out the wood was treated with a cocktail that included Pentachlorophenol and Lindane. The garden was off limits for the entire summer and heavy machinery was brought in to take off much of the top soil.

[@wibblytimey]

Interesting to know, given that a lot of my garden uses old railway sleepers as retaining walls and we had a big old stack that we used to play on as kids 😮

[@BTW...]

Jeeez.. and think about how many of those ties were cut up and burnt in lounge room fireplaces... and the smoking out the local neighborhood.

[@FirstLastFirstLast]

scariest story i read in comments, and imagine if you had not known

[@StereoTyp0]

Given how popular Betel chewing is in southeast Asia, arecoline is actually a risk to a significant population.

[@JohnDarksoul69]

Worse yet, it's commonly chewed with tobacco... Which is also known to cause cancer.

[@aarongagne8918]

Couldn't agree more on the listing of ingredients, especially in consumer markets. I realized how little information there was when I was trying to find information on what I could use to clean and lubricate tools properly and there's really nothing.

[@Elphyme]

The warning on a box of Lindane lotion at a hospital I worked at was interesting. It warned of possible major negative neurological symptoms, but I had no idea it was so carcinogenic.

[@That_Chemist]

interesting!

[@Xenogears76]

Wasn't lindane banned sometime ago? I learned of lindane by watching Love Canal documentaries.

[@SoulDelSol]

@@Xenogears76 love canal? Is that a vagina?

[@eucompsa]

@@Xenogears76 it was used for delousing troop uniforms during the 1st Gulf War

[@Mottleydude1]

Almost all halogenated organic compounds are toxic.

[@jacobm2625]

I have a couple of interesting anecdotes for ya: 1. I have Crohn’s disease, and most/all treatments for the disease require using immunosuppressant drugs. The first one I took was called Azathioprine, and increased risk of skin and bone marrow cancers 2. Lemme tell ya, you’ll be happy to wash your hands with a solvent if you’ve ever spent any amount of time handling roofing tar barehanded. I remember probably scrubbing hard with dish soap 5-6 times before one of my old bosses came by and said “hey, try some kerosene.” The tar came right off with one simple rinse and wipe. Obviously, don’t try this at home.

[@pizzablender]

I can recommend vegetable oil for that kind of contamination. Dilutes/mixes with greasy stuff, doesn't penetrate the skin so quickly, and is then easily washed off with soap. Work wonders also for paint - even if dried (but not yet hardened).

[@nicolainielsen7700]

UC and liver transplant recipient here. I'm pretty much just waiting for the shit show down the line......

[@costaldevomito]

Dish soap itself is toxic too lol

[@RichXVIII]

Can't help but wonder if point 2 is why point 1 is a thing.

[@jacobm2625]

@@RichXVIII almost definitely not. I was diagnosed with Crohn’s at the age of 8, and the “washing hands with kerosene” event happened maybe once or twice, around the age of 23. Definitely no correlation.

[@-unbreakeblecow488]

8:13, acetaldehyde is not ethanol, but ethanol is metabolized into acetaldehyde in the body during alcohol consumption

[@benmcreynolds8581]

I love the way you introduced the topic and how you expressed the importance of living a good Life, not a scared Life. You have a great way of getting this kind of information across 👍🏻

[@That_Chemist]

Thank you so much!

[@Megabob777]

Been looking forward to this one, I'm oddly fascinated with carcinogens as I would prefer to avoid them at all costs as I'm sure most would

[@That_Chemist]

I hope you enjoy! I put a lot of love into this one

[@custos3249]

Are you sure you want to avoid all of them? It's fine if you do. Just be sure to give me all your bacon and steak.

[@Megabob777]

@@custos3249 after watching the video I have come to the conclusion I can't avoid all of them but there are a few more things I will try to avoid

[@theRPGmaster]

@@custos3249 Save some bacon, steak, beer and a few ciggies for me! Also some chloramines, mmm pool smell.

[@waterunderthebridge7950]

I mean technically everything is carcinogenic, even the oxygen you breathe will certainly create free radicals that can be mutagenic to your tissues

[@flickcentergaming680]

Greatly appreciated the bloopers at the end of the video! Excellent tier list, as always. As a non-chemist, i appreciate knowing what I should avoid and what is safer than I thought.

[@iceman5117]

2,3,7,8-tetrachlorodibenzo-para-dioxin could've been a killer cheer. Also, you know it's a party when you have chlorine, benzene and dioxin all in one place

[@SentientDMT]

All you're missing is fluorine and then you'd have a party

[@MalenaGarcia28]

hey i remember one of my organic chem professor told us about a time when someone stored benzene incorrectly and, because of the fumes, the cancer cases at her university skyrocketed

[@sutpecna]

2:57 Came here for "hehe spooky chemicals", stayed for the valuable life advice. A surprise to be sure, but a welcome one. Thanks mate.

[@That_Chemist]

we have another awesome video like this one coming in a few days!

[@smusicchannel5174]

I really like this tierlist, but I would have formaldehyde at least in A tier. I worked as a chemist in the polyurethane and polycarbonate production and know that this stuff is everywhere. And if you’re not an Amish person it’s just really hard to avoid it in modern times

[@Alex-fc8xn]

Yeah a LOT of stuff produces it when breaking down, I remember reading that it's also frequently used in clothing production to prevent molding while the clothes are stored before sale

[@StampeSkovgaard]

I worked at the pathology department of a large hospital for a short time. Almost all tissue samples were treated with and stored in formaldehyde before dissection. This is why I know that baby brains turn curry yellow after a few days in formaldehyde.

[@user-kq6uz9qm5g]

Vegetable oils contain aldehydes and McDonald's frying oil contains a preservative that breaks down into formaldehyde. Stay away from fried foods unless it's peanut oil, olive oil or coconut oil but coconut oil is higher in fat.

[@dominicyelin]

​@@user-kq6uz9qm5ggood. Fat is good for you. Stop falling for the myth that fat is bad. The body turns lipids you digest into sugar. Human body fat is made of glucose. Stop falling for such a silly, basic ignorance. Sorry, but you're a scientist, right? So fat is good for you.

[@jadeaavia]

I was exposed to formaldehyde through floral foam. We had gloves, but no masks. I had to leave the room because my lungs felt like they were burning. I suppose I might just be more sensitive than others because only two other people had to leave, but we should at least have been given masks.

[@pyromen321]

32:29 I absolutely believe your hypothesis. I used to have a few cigarettes per year, and nicotine salt vapes definitely feel much more like a cigarette than freebase nicotine vapes.

[@fastlifebmx9292]

​@@SafetyLucasTobacco also has other phytochemicals with mild MAOI activity and other stimulating mechanisms.

[@samu463]

Surprised you didn't include ethidium bromide since every student running a DNA gel has been told this stuff is concentrated cancer.

[@Leuco23]

One of the professors I worked with said that if I dumped my hand into a bucket of ethidium bromide, it would be equivalent in terms of cancer to smoking a pack of cigarettes. So not great, but not a complete disaster. No idea exactly how true this is, but interesting nonetheless.

[@heinzerhardt7047]

I think this one mainly gets more attention and causes scare because you can literally see how it interacts with DNA. From what I have read it is not that bad in reality.

[@Hank..]

You make a good point about thinking critically and considering factors like exposure time. Sunlight is a carcinogen because of UV rays, but no doctor is going to advice against going outside, or going for a walk in the park. I think we'll have to agree to disagree about not wanting to drink Belle Delphine's bathwater tho

[@That_Chemist]

👀👀👀

[@H8nji]

🗿

[@peggedyourdad9560]

Just wear a good spf and reapply as directed. Also make sure to cover yourself as much as reasonably possible and you should be golden. And remember, that sun laser hits you in the shade too btw, just at a slightly reduced rate.

[@Sniperboy5551]

Yeah, she’s hot huh? 😂

[@pedrovargas2181]

F that, we need sunlight to synthesize vitamin D. And ms. Delphine's bathwater... I won't drink my wife's, why some 304's.

[@louiswelrod]

34:37 - "Death occurred as soon as 14 days after treatment and continued throughout the 35-day observation period." I would have been surprised if death didn't continue. 😂 Seriously if anyone is interested in cancer, I recommend the book "The Emperor of All Maladies: A Biography of Cancer" by Siddhartha Mukherjee. Won a Pulitzer and is an Excellent book on cancer for anyone.

[@carlgrainger2669]

I remember Trichloroethylene 1-1-1 very well. While in the military we used copious amounts daily to wash the work benches down - all within very confined spaces. I often think this may have primarily led to my kidney cancer .

[@richardwebb5317]

In 1979 whilst a biochemistry undergraduate, I walked from a job due to Trichloroethylene exposure - spending all day over a vat of the stuff degreasing metal. Was not having that.

[@introprospector]

Please do a video on addiction. It strays a bit from chemistry into human behavior but I think it'd be really interesting to learn about the pharmacology of known addictive compounds.

[@erikawanner7355]

Most of those addictive compounds involve stimulating the dopamine receptors in the brain. Dopamine is the “pleasure compound”. Research is still very primitive in this area thou

[@MonkoK14]

Check out Drug Classroom

[@Cbd_7ohm]

@@erikawanner7355 Dopamine isn't a pleasure compound. It regulates many things, motivation and drive in particular. The mu opioid receptor is the primary pleasure receptor, and mediates the pleasurable effects of food and sex.

[@yngfljm2277]

@@erikawanner7355 "Dopamine is a pleasure compound" I'll take way over-simplification for 20 please

[@crazyycm3d]

@@erikawanner7355 Its not the 'pleasure' compound so much as I like to call it the brain's 'Yes and no' receptors. In the central nervous system it controls your executive functions, motor control, arousal (Restful/wakeful body), and yes it controls positive/negative reinforcement of stimulation. Humans have comparatively smaller amounts of dopamine releasing nerve cells, however dopamine is used to communicate across many different areas of the nervous system. Again its not 'pleasure' so much as it is the body's way of releasing a message to other parts of the nervous system. It signals whatever you are doing is providing stimulation, which in a basic way would encourage something to return and 'repeat' what brought it stimulation. That's why dopamine is also a big part of the digestive system, as food is often the easiest and natural way to release dopamine from the brain to seek more food. Dopamine gets a bad rap for abuse because the receptors are comparatively small in number and controls a large part of your executive functions, meaning the uncareful abuse of dopamine releasing compounds effectively makes the brain change some of its pathways to encourage dopamine release (addiction). Also not all addictive compounds rely on the strict release of dopamine, pretty much anything you could imagine that an individual finds stimulating could be cause for addiction. Benedryl is a antihistamine and yet some are addicted to the abuse of it. Chemicals can make our body release or otherwise fail to recycle things we'd naturally produce, which is why addiction encompasses so many different things. Your essentially replacing years of work required to form something like a sugar addiction and replacing it with a drugs that accomplish that by a magnitude of 1000x.

[@prikas4313]

Came back to this video after hearing about the vinyl chloride spill in Ohio. I thought it sounded familiar and you had covered it here! Scary stuff, I wonder what the remediation process is supposed to look like and how well they're actually following it through.

[@That_Chemist]

Do you know anyone affected by the incident? What is the main concern/anxiety you have surrounding the incident?

[@prikas4313]

@@That_Chemist I'm worried they may be sending people (who have no other options) back to their homes too soon. Even if the general air, water, and soil measurements are as safe as they say, they should be doing a much better job communicating these results and reassuring residents. The EPA's power as a regulatory body, especially in recent years, is worthy of scrutiny and I understand people's mistrust. I do think there's a lot of misinformation out there, though, especially on the remediation process.

[@matfax]

The real question is how much exposure is necessary for a significant effect size.

[@atiqrahman7289]

​@@prikas431369

[@joshstaffen4649]

As long as you aren't working with vinyl chloride you shouldn't be exposed to it... That aged poorly

[@FishStank]

The formaldehyde comment made me laugh, because nothing about funeral directing/embalming was mentioned! Loved the video :)

[@yandereyan4990]

The „Carcinogens: anything fun“ hit too close to home 😅

[@That_Chemist]

we all know how it is

[@Sniperboy5551]

Yeah, this video changes nothing lmao

[@underplague6344]

We found the railroad tie licker

[@yandereyan4990]

@@underplague6344 what i just like Cr(VI)

[@lemons1559]

@@underplague6344 how dare you mock me for my hobbies.

[@kofatheballer5539]

I really appreciate that you admit the limits of your knowledge. So many KZbinrs speak as an unimpeachable authority on every subject they do a video on.

[@alextopfer1068]

As someone who often uses things for uncommon uses, it's nice to have the ingredients listed so i know what i'm doing.

[@davedoes1298]

When I was a flooring contractor a few years ago I'd hear stories of some of the old timers that would wash their hands daily with acetone and their hands and forearms would end up pitted as the acetone would leach through their skin and disolve the fats beneath their skin. Cant say if these stories are true, but it makes sense since acetone is common fat/grease solvent.

[@Cbd_7ohm]

Acetone is a very good solvent for many lipophilic compounds, like mitragynine and Delta-9-THC.

[@Cheepchipsable]

A new fat melting cure for the super vain.

[@drakeholmes7054]

I actually work in Formaldehyde testing for particleboard. I regularly use Bis(chloromethyl) Ether at least twice a week in order to test formaldehyde levels using a spectrophotometer. Most products released to market are well below the limit required (which sits around 0.1600 ppm/m³) and even before they are released all particleboard (that we make at least) is quarentined for several days to allow as much Formaldehyde to escape as possible. Fortunately most products by the time they get to a consumer will be below 0.0900 ppm/m³.

[@DavidJamesHenry]

This video has convinced me that the worst carcinogens have the cutest structural diagrams

[@karama5562]

God gives his cutest structural diagrams to his deadliest carcinogens

[@amberhawksong]

@@karama5562 Ha ha!

[@lukegaming86]

My grandmother was prescribed diethylstilbestrol for pregnancy support in the 60s & mother had several lesions removed a few decades back. Got out ahead of it fortunately

[@uncreativeperson8497]

1:41 WHO MADE THIS

[@sadtown]

Like 90% of my snacks have prop 65 warnings on them (acrylamide I think). I find this very interesting! One day could you talk about it? It seems like a sizable amount of the Korean and Japanese processed foods at the mart have cancer warnings!?

[@theRPGmaster]

Almost every CA product seems to have those warnings (I'm European, don't live there, luckily). Either literally everything is toxic, or they needlessly slap that on everything. Ironically, it probably causes a "boy who cried wolf" effect with people ignoring it altogether.

[@cervid_appreciator]

It’s on a lot of imported foods. I’m part Chinese and live in California so I get you lol. I’ve heard that it’s there just to keep lawyers happy and that there’s little actual danger, but I still eat those things in moderation just in case.

[@stefangadshijew1682]

I would absolutely not worry about that label. Humans have eaten burned food for a long time, there is a huge selection pressure for humans to tolerate that stuff better then lab animals. Some of the most carcinogenic compounds in the world seem to have no effect on humans, as far as epidemiological studies could find. I would, however, worry about heating up meat that was preserved with nitrite salts.

[@TheBoxOfRocksFTW]

@@stefangadshijew1682 I’d strongly suggest looking into acrylamide and similar advanced glycation end-products, the prop 65 label is often a bit overblown but potato chips specifically are by far and large the single most potent dietary source of acrylamide.

[@stefangadshijew1682]

​@@TheBoxOfRocksFTW Hey there :) Oh yeah, thanks for the suggestion, it seems I'm not up to date. To explain my previous scepticism: Last time I checked, state of the art was that acrylamid is a probable human carcinogen based on animal studies, but it couldn't be shown to be one for humans. It was however suggested that acrylamid is a reliable indicator for the formation of four specific heterocyclic amines that are among the most potent carcinogens known in certain animals, but again, it couldn't be shown that this is the case for humans - and furthermore, it was demonstrated that the mechanism of carcinogenicity (further metabolism by specific gut bacteria) does not apply to humans at all. So that seems to be old news, I'm going to read up of the glycidamid.

[@annaleel.8456]

I’m not a chemist nor do I love chemistry but this was definitely more entertaining. Personally im more interested in Biology but this is a very good informational video. Thank you and I appreciate all the warnings it’s very needed on the internet 😢❤

[@That_Chemist]

Thanks!

[@darrenparis8314]

Okay, so, 1. Go into the field to apply old fashioned pesticides to your obscure mushroom and wild ginger garden, and wash your hands off with some some beneze. 2. Wait for the food to mold while you apply antique makeup generously to the face and smoke vape pens. 3. Collect the moldy food and preserve it with numerous additives, until you are ready to eat it, at which point, burn it until completely blackened. 4. Tend to your garden near a coal-burning power plant for warmth in the winters. This will place you near the railroad lines you must lick on a daily basis with your tongue in order to meet dietary iron requirements. If the taste is too strong, preceed with a few good puffs from a cigar. 5. Experiment with numerous industrial chemicals you find in that abandoned warehouse over there, because you have watched X-Men, and figure your odds are looking pretty good. Plus, you remember that one of them (you don't remember which) is supposed to treat lice, and you recall that you have those too now as punishment for crimes against life and reason.

[@Kari_512]

Cancer speedrun any%

[@Jesus_Christ_loves_you_alot]

Hi there! Jesus says to you today: "Come to Me, all you who labor and are heavily burdened, and I will give you rest." -Matthew 11:28 May God bless you! 😊

[@doublenikesocks]

I think the monomers should be highly ranked as cancer rates around petrochemical plants and oil refineries are much higher than average and the people that live near these plants are often too poor to move elsewhere. Look up the cancer corridor in Louisiana or cancer rates in Pasadena, TX or Wilmington, CA.

[@leeksoup3199]

this comment sent me down a terrifying and depressing wormhole of googling. It’s awful how the profits of the oil companies are put before the health and lives of the people in these areas

[@andya7283]

Vinyl Chloride was what was in those tanker that derailed in East palestine Ohio. Something like 6 full rail cars were left just to burn because of fear of an explosion not to mention all of the treated wood rail planks that you also spoke of being treated with a carcinogenic.

[@blix17]

I'm happy that by watching this, I assured myself that my graded unit about the toxicity of different aromatic hydrocarbons last year was accurately presented. I feel even better about the A it got me now :)

[@That_Chemist]

Excellent!

[@dankhill6851]

I want this in a video! I remember a long time ago I tried to make ferric chloride with HCL and nails, in summer time outside, I noticed that it was so hot outside that the HCL was fuming this white smoke out of the bottle, I APPARENTLY breathed in WAY TOO MUCH HCL and basically what happened was this damaged the cartilage in my ribs to the point that breathing in made my ribs pop lock a knuckle and EVERY millimeter of breath I took was the most painful thing I've experienced, kinda like if someone beat your ribs with a baseball bat, after about a week later the pain started going down and my lungs/ribs started to heal, but to this day my sternum pops like a knuckle. 0/10 do not recommend breathing in fuming HCL

[@cazz]

This was wildly insightful. Thank you.

[@Mnnvint]

Things I actually knew about: * Benzopyrene. The author Francis Spufford wrote a chapter as part of a novel which stepped through the (or one likely) pathway benzopyrene causes cancer. Fantastic writing, also, absolutely terrifying. * Cyclosporine. Remember it as "that immunosuppressant drug that was isolated from Norwegian dirt".

[@miked4904]

Very much appreciated. It's about time we had this in a digestible format

[@That_Chemist]

That is exactly why I wanna make these

[@miked4904]

@@That_Chemist keep doing good work and maybe you can help grow a generation of informed and overall more cautious and healthy people

[@abc_cba]

Thank You for discussing this topic in this world of just b.s. health related videos we get online. Subscribed. Keep your content coming.

[@JrodVenzel]

I am on a pharmacy rotation through an oncology clinic right now, so a chemotherapy video would be very interesting to me. Can't wait for it! Thanks for the nod to cyclosporine and tylenol. Cyclosporine is used as an eyedrop for dry eyes branded as Restasis! I was hoping cyclophosphamide was going to make the cut in the video.

[@channelsurfer5348]

Me too.. im sure its cytotoxic.

[@jacobtierney4419]

This combines two of these subjects! My college A-level chemistry lecturer used to work on testing peanut butter for aflatoxin. The used to scrub out with benzene to remove any residues.

[@jonesuniversity3104]

What a fun experiment. We shall have to try it.

[@Whoareyoucalling]

Chloride groups in Sucralose or other artificial sweeteners attach to stray sodium ions in the body when consumed creating sodium chloride ( NaCl ). We don’t know why specifically this happens with sweeteners, leading theory is the chlorides in these molecules are substantially more negative than the entire molecule itself and effectively break off from the whole molecule and attach stray sodium ions. Coincidentally If you have hyponatremia and you consume Sucralose you can get very sick as the chloride ions on the sugar molecule stay as chloride, effectively giving you acute chloride posioning.

[@Rathmun]

2:33 You call it a straw man, but that's a _real concern_ of secondhand smoke. It's better than it used to be, there was a time not that long ago when you literally couldn't go anywhere in public without getting exposed. This was before the rise of Work from Home and all the home delivery services. So the choices were 1) Be a shut-in and starve, 2) go outside and breathe the carcinogent, 3) go outside and suffocate.

[@arnautarnautsen2564]

I am your #1 fan (and used to wash my hands with toluene to remove tar), but there are a number of misunderstandings in this otherwise great video. I shall not address the intrinsic problems with IARC classification (which someone really, really should), but rather: 1 - the areca nut is not obscure: I can buy it from a local speciality store 50 m from my home, and I live in Denmark. In E and SE Asia, probably around one billion people chew it daily. It's the only thing that really competes with tobacco for mass cancer causation. 2 - AFLatoxin (not aLPHatoxin) is not in every mould, it is in a very specific one, Aspergillus flavus, which grows almost only on nuts and grains. A. flavus is unable to grow under 5 °C, so the many moulds that spoil food in fridges are basically guaranteed to be free from it. It is true that there are other, more obscure carcinogenic mycotoxins in, e.g., some strains of A. niger, but one shouldn't assume something as terrifying as aflatoxin is present in all mouldy food, some of which is eaten intentionally (think soy sauce and blue cheese). 3 - where are the nitrites?

[@mynamo12]

Soy sauce? Fermentation is not the same thing as food with mold.

[@Redbaron_sites]

Thank you for the time you put into this, I had tried to do something similar a few years back for my personal use and was overwhelmed by the time to do the research. Here you have done it for us and this certainly is a keeper as it may help so many people if they will head the advice. Godspeed for the valuable information ❤.

[@sugondiesthephilosopher]

I've worked with ethylene oxide at production scale on an occasion. Our attitude towards it was a breach of containment, and accidental exposure would guarantee cancer. Who knows when? We joke that way about a lot of the reagents we worked with; however, we were serious about using supplied air when feeding, sampling, purifying, and so on.

[@nickxjudy_6021]

Can you do a video on poisons we use in our daily lives like prallethrin and such? I wish I knew better so that I could minimize the poison intake in my daily life. Thank you for your amazing videos anyways. You got yourself a new subscriber.

[@That_Chemist]

Apparently the pyrethroids are non-toxic to humans - they operate on the insect nervous system in a way that doesnt affect ours

[@weltschmerz_cairn9549]

One thing I thought I would hear about formaldehyde that I didn’t in this video is how common exposure is in certain medical related professions and in educational settings! I do a lot of anatomy labs and commonly deal with formaldehyde when dissecting specimens. Also, formaldehyde is also in embalming fluid. I worked at a funeral home for a while, and actually had to sign a waiver to not sue them if I developed cancer due to formaldehyde exposure. Scary stuff

[@Nuovoswiss]

Let me know if anyone has a better explanation for sucralose's claimed lack of carcinogenic activity. My suspicion is that the chloroalkyl groups do still alkylate random amines in the body, but the rest of the molecule is so bulky that it just results in non-functional junk that the body eventually disassembles. You add a methyl or ethyl group, it's small enough that you get a slightly mutated result that keeps the cell alive and dividing (a tumor). You add some halogenated disaccharide that can still cross-link to other stuff, and whatever it got added to just stops working entirely. I try to avoid sucralose.

[@MrWill830]

24:00 Regarding difference in toxicity of chloryl groups in Sucralose and 1,2-Dichloropropane, the homie ChatGPT gives the following : "Sucralose is a non-nutritive artificial sweetener commonly used as a sugar substitute. It is derived from sucrose (table sugar) by selectively chlorinating certain hydroxyl groups on the sugar molecule. This chlorination results in the introduction of chlorine atoms, which are covalently bonded to the sugar molecules. The key difference between the chlorination in sucralose and the chlorination in compounds like 1,2-Dichloropropane lies in the specific positions of the chlorine atoms and the resulting chemical properties and metabolic pathways of these compounds: Chemical structure: In sucralose, the chlorine atoms are predominantly present at positions 1, 4, and 6 of the sugar molecule, which are far removed from the carbon-carbon bonds in the molecule. This arrangement makes sucralose highly stable and resistant to chemical breakdown during digestion and cooking. On the other hand, 1,2-Dichloropropane has chlorine atoms directly attached to a hydrocarbon chain, making it more reactive and potentially more toxic. Metabolism: Sucralose is not significantly metabolized in the human body. The chlorinated sucralose molecules are not broken down into individual chlorine atoms, and the majority of ingested sucralose is excreted unchanged in the urine. This limited metabolism is a key factor in the lack of observable negative health effects. Dosage and exposure: The levels of sucralose typically consumed as a sweetener are considered safe by regulatory agencies such as the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). The permissible daily intake (ADI) for sucralose is much higher than the levels at which any potential negative effects might occur. In contrast, 1,2-Dichloropropane is a small molecule that can undergo more extensive metabolism in the body, and it has been associated with various health risks, including carcinogenicity, when exposure occurs at high levels or over prolonged periods."

[@Nuovoswiss]

@@MrWill830 There is so much wrong with that answer it's not worth my time to point it all out. The first thing that made that obvious was "In sucralose, the chlorine atoms are predominantly present at positions 1, 4, and 6 of the sugar molecule, which are far removed from the carbon-carbon bonds". The chlorine atoms in sucralose are no farther from carbon-carbon bonds in sucralose than in dichloropropane.

[@MrWill830]

@@Nuovoswiss Wow, that's some very precious time you got there buddy. Not as precious as mine apparently, since I took it to find an answer for you, and relay it to you, even though I derive nothing from doing that :) Whether it is wrong or not, I do not know. I just tried to help you. It's whatever, though

[@Nuovoswiss]

@@MrWill830 Sorry, I didn't mean that as a shot at you, but at Chat GPT when it comes to niche chemistry issues. I appreciate you trying to get an answer, but GPT's response reads like the Rockwell Retro Encabulator script.

[@MrWill830]

@@Nuovoswiss It's all good, in hindsight I probably should've figured that out. Sorry for taking it personally lol

[@seanchen2780]

"death was observed 13 days in and continued for rest of the 30 day trial"

[@JJSquirtle]

26:42 my fellow chemists, this is another reason to make your own shampoo even if unlike me you aren't allergic to canola oil and extremely sensitive to formaldehyde (I get sickly just being near formaldehyde products). the immense satisfaction of doing the research and and slowly tweaking out what works best for your hair using (mostly) inexpensive materials is a thrill and in thelong run saves a ton of money.

[@phantom4E2]

how about organic shampoo? you can buy it

[@JJSquirtle]

@@phantom4E2 I'm allergic to Canola oil, I can't use most products

[@trustmeimabiochemist3929]

"I am not a biochemist, I'm not gonna have as good of a background in that sense" Oh don't worry, neither do I... (my main major was engineering so there's that too. I guess that's what chemical engineers feel towards chemistry majors?)

[@dee_eff]

Agh. As a chemist working in an environmental lab and frequently running a GC/MS that's calibrated (by yours truly) to detect many of these semivolatile carcinogens (and more)...this hurts. I mean, I knew I was fucked, but just hearing this from another chemist really drives it home. Thankfully the fume hoods work when I'm making the calibration mixes and I always replace the GC vial caps of the calibration standards immediately after they're injected, but damn. I'm probably being exposed below occupational exposure limits, but in non-zero amounts. Can't wait to hit my 40s/50s/60s and develop a rare as fuck cancer that's untreatable/late-stage. Good times.

[@slayyyyyyyyyyyyyyyyyyyyyyyyyed]

☠️

[@michaelmayne6097]

It’s not so bad dude. One must not squint at what cannot be seen. You can’t see the future. Get check ups 1-2 times a year if you’re worried. And don’t think cancer upon yourself iykwim placebo is a real thing.

[@Whateverister]

Man I feel you, in the lab i work in there's a working GC and no fumehood. Shit's tough, been here for almost two years and seeing this video, I gotta start thinking of other options😂😂.

[@a1r592]

15:27 After painting the underside of ships we used turpentine (a paint thinner) to get the paint off of our hands

[@y66502]

several new fears unlocked

[@peterhrtg]

Outstanding presentation; a LOT of work - thank you! Way back, I spent some time as a bench chemist. Mainly (organo-) heavy metals, but also benzene and petroleum products, plus HF. I now have multiple myeloma. So, be VERY careful out there, folks… 🥺

[@julia_6924]

Areca nuts (betel nuts) aren’t actually obscure and chewing it is a popular social pass time in asia. A lot of people get cancer from it. I’d probably move it to high C considering that anyone can buy it off the streets and it’s addictive

[@Jamieden]

This video gave me the push I needed to stop vaping. Thanks That Chemist!

[@That_Chemist]

I hope it goes well! I believe in you :)

[@sekkuar]

Thanks so much for putting this video out there! This video was so boring it made me get up and go do my chores. If it wasn't for this video I'd probably sit around and watch KZbin all day and not get anything done. Thank so much, you really saved me.

[@GreenJeepAdventures]

Hmm...Vinyl Cloride? Where have I heard that in the news lately?

[@CompletelyNormal]

I won't completely avoid carcinogens, but I'll do asbestos I can.

[@expertoflizardcorrugation3967]

Asbestos is such a fun word too, such a shame that it has to be so terrible.

[@xoxorosequartz]

there was a town in quebec named that, i went there during my family’s northern us road trip

[@Strobie_one]

I worked for a family friend’s powder coating company for a few weeks during peak season to get him out of a labor shortage. I was about 18 and didn’t know any better. Part of the preparation process was that the recently manufactured metal parts needed to be cleaned and washed and dried prior to being sprayed in an electrostatic powder booth. To do this, a wash station was used which considered of a large 50L plastic container with a hole cut in its side, which acted as a crude solvent bath. The solvent was a 1:1:1 industrial solution of toluene ethanol and methanol. The PPE provided was a pair of standard rubber dishwashing gloves. That’s it. After washing for a couple of hours, the Vapor would mix with sweat and condense inside the gloves causing my hands to be very cold and “wet” which caused the gloves to stick and slip and slide and to generally be uncomfortable. The coldness also caused less dexterity in my fingers so I did what most can-do kids at that age would do and simply removed the gloves. After about a week of 7-8 hour days with hands spend in the solvent bath, and being very attracted to the sweet smelling Vapor (which was not vented in any way) I started to noticed very my hands becoming cracked and shrivelled even on the weekend. The solvent had pulled almost all the oil out of my skin and my skin had started to break around my nails. I was also not provided any PPE for my lungs to protect against the powder, which was (I found out later) about 35-40% lead. After realising this and seeing many other things that raised red flags such as people regularly smoking meters from the wash station, I decided it was not appropriate for me to continue to work there. To the best of my knowledge there has been no lasting effects, but at the time I did wonder if there could have been some trace amounts of benzine in the solvent from the manufacturing process. I guess time will tell :/