Malaria Lifecycle Part 1: Human Host (2016)

This visualization reconstructs malaria infection of a human child via mosquito bite, through invasion of cellular tissues including the liver and blood.
All features are to scale, including mosquito, blood vessels, human cells and parasite.
The visualization is the first of its kind to present live-behavior models, including the mosquito's bite technique, parasite invasion method, and patterns of blood flow.
Animation by Drew Berry
Walter and Eliza Hall Institute
Watch Malaria Lifecycle Part 2: Mosquito Host at kzbin.info/www/bejne/g6nMiKNuq9CFfKs
Visit www.wehi.edu.au/wehi-tv for more animations
Updated February 2016

[@ghayasali5512]

Human are the reason for the extinction of many species but why not mosquitoes

[@Slekejkwls-1819]

Also avocatoes depends from us

[@pakyo2x]

ghayas ali because mosquitos are above us humans

[@unclekanethetiberiummain1994]

Because they can cope with urban enviroment quite well.

[@ghayasali5512]

@@unclekanethetiberiummain1994 i meant it like why dont we purposely make them go extinct

[@unclekanethetiberiummain1994]

@@ghayasali5512 We probably can but either afraid to because it could cause somekind of enviromental consequeces (if we eliminate wild mosquito too) or no one really care enought to fund it.

[@robertbell8673]

My virus video addiction escalated during the coronavirus outbreak. At this rate ill be a consultant in 4 weeks. Who needs a head transplant??

[@getbeaned1538]

Farcry 2 is a great game

[@gioflores]

Robert Bell same here buddy haha

[@arasseo_wakarimashita3904]

Malaria is protozoa if im not wrong.

[@gioflores]

ArASsEO_ WaKaRiMaShiTa!!! Parasite

[@SulthanRrafi]

@@gioflores parasite is just a broad term for any organism that has a parasitic symbiosis with its host. Malaria is caused by the plasmodium protozoa

[@greatness260]

How can something so small, smart, tactical, and lethal exist

[@harshivpatel6238]

Well only best of them survive the claps, so yes.

[@cernugaming]

Are you talking about Humans?

[@crypastesomemore8348]

goodness this is one of the most idiotic comments I’ve ever read. What does size have to do with lethality? A virus is incredibly tiny, yet it can wipe out billions.

[@noahsenz854]

Brosef Brokowski You just proved his point in your last sentence.

[@game.designer]

Thats what my ex said.

[@dortiz81706]

My grandpa told me when he was in Vietnam fighting WW2 he got Malaria he was barely 20 years old he told me it was the worst he had it was like the flu but worst. Took him a month to recover.

[@willtheoct]

your grand dad is an asshole if he fought against vietnam or lied to you about vietnam being at the same time as ww2

[@deankwari4232]

The human immune system seriously needs an update

[@bigboypockets2041]

Dean kwari Nah😂😂 it defeats billions of problems a day.

[@kotaar8535]

@@bigboypockets2041 it should defeat trillions.

[@a-john9617]

Your immune system might slow down sometimes. Make sure you check your immune system is updated to the latest version. You can also restart it to help. And taking an antivirus might help as well, some of them go unnoticed and slow it down

[@amensaseasan1779]

Bloods t cell..b cell

[@MrHjacky]

The progress has been significantly slower since the invention of medicine allowing those with weak immune system survive and breed

[@matthew6533]

After watching this video im now afraid of mosquito

[@maryjane3348]

Great your lucky CUZ I have 100 mosquitos every 3 weeks in my bathroom

[@arunvarman6388]

I see this now in my class

[@paranoia_seek]

@@mthrqpi9758 how would you have ONLY 100 mosquitos when you have like 100 mice in your house

[@mthrqpi9758]

@@paranoia_seek Idk but congrats for being 3 years late i guess 🙏

[@jasonbucy]

Great work! I had an understanding of the theory, but great to see a visual representation. I wish this was available when I was in high school. Can't wait for part 2!

[@AtashiAcharjee]

Hi

[@txtyztxtyz1258]

I'm felling every thing on my skin when I'm watching this video

[@thedwarfthefirst8330]

Yes

[@junaidashraf5154]

Same mine condition also like you🤣

[@abbiepalmer4547]

Ahh thank you so much! I needed this for my science depth study! SO much easier to understand with the visuals

[@AtashiAcharjee]

Hi

[@cubeow1]

I did a lot of research on this for my biology project and this summed up everything and displayed it in a professional manner. Now I have the correct understanding of this because only reading scientific articles can get you to think about the wrong way sometimes

[@caelann2593]

Now Im scared. I stung by mosquito's many times and I was fine. Now i know that some mosquitos carry malaria, im terrfied

[@skycrapper5902]

Just in miss-higenic country's like Africa,mosquito's carry that virus.If you are in America,you'll be fine.

[@darinmelton8866]

The Malaria parasite is not a virus is the Plasmodium parasite family. Of the several hundred in the animal kingdom 5 affect humans. The U.S. averages 1700 cases a year from travelers returning from the Malaria Belt. Plasmodium Falciparum is the deadliest of the 5

[@caelann2593]

@@skycrapper5902 oh now i felt better. cause i live in usa

[@caelann2593]

Also no need to give me a science lesson

[@ArthurM1863]

@@skycrapper5902 You mean continents..

[@Kat-pb5lc]

Nobody: The mosquitos in my bedroom: *EEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE*

[@Barri2410]

Those ringing in ma ear, tho

[@Kat-pb5lc]

@@Barri2410 go see an ear doctor

[@Barri2410]

@@Kat-pb5lc nah, don't worry. It's not a big deal. Btw, it's just their sound when they're near us

[@Kat-pb5lc]

@@Barri2410 oh mk

[@Ying-yang6969]

Quality of this content is awesome

[@theworldhardestgame]

An observation: merozoites leaves the hepatocyte in a vesicle called merossome and ruptures far away from the liver. Despite that, it was a good animation and helps understanding the Plasmodium' s cycle in human host.

[@sab4259]

Yes! They should have covered the stages like merozoites, sporozoites ....anyways it was better then reading the textbooks

[@danielholowaty2648]

Make sure to watch this at daytime or you start panicking

[@dinerodademigod8253]

I'm so stupid 😭

[@VG__]

Nothing better than this animation for malaria🙏God bless you a trillion ❤️❤️

[@wahajuddin2323]

This video is really scary...❤

[@georgenotfloyd588]

This was kinda scary cause I got malaria once and when he said countless people have died I felt so lucky that I didn't

[@baileyellis5346]

Fun fact: Malaria protozoa hide in the liver and red blood cells, undetectable from our immune system due to the self-antigens on the red blood cells and the ever-changing strains which means that the phagocytes don't know what they're facing. It hides in your body for years. You likely still have it.

[@erickjuma7643]

I keep asking myself some very disturbing questions. They may sound silly but they disturb me non the less 1. How intelligent is the parasite that it knows our body and where exactly to go? 2. Inside the human body is a very dark place without even a photon of light, how does this parasite even know where it's going also given that the size of our body in relation to the parasite is quite a big place? 3. What is our natural defence system doing as this parasite just roams about searching for a convenient place? Does our body just watch helplessly? I find these questions a bit disturbing to say the least

[@tamminawar]

bruh if you think our body just watches helplessly then you wouldnt be writing this comment bcz theres millions of parasites around us and we still surviving

[@qornopiratu]

For 2: Blood passing through our body will sooner or later arrive at the liver, which has the task to "clean" blood. Therefore the parasite will almost always be able to reach the liver cells before its death and be able to perform its function.

[@samyakjain6795]

1. The parasites ain't intelligent it's just in a lot of numbers! WAY LOT OF THEM!! Like we are talking in millions and millions of it 2. The blood will diffenately pass through liver and when it does the parasite due to chemical reactions takes actions and infect the liver cells 3. Our body doesn't sit helplessly it does it's best to fight back but at some point the rate of reproduction of the parasites becomes more than our immune system can take care of, and then it becomes matter of who dies first! Either the parasite damages us more and kill us or the immune system damages our own cells trying to fight it! Both way we suffer There's one more thing, when the parasite leave the liver it gets itself covered in the dead cells of the liver cells much like a killing an animal and then wearing it skin to infiltrate therefore the immune system misses that too

[@waluigihentailover6926]

Yo, these are not stupid questions. These are the questions teachers want you to raise your hand for. That’s why they’re there.

[@waluigihentailover6926]

@@qornopiratu You mean one?

[@themelancholicguy139]

I watched a lot but it is pretty good rather than others.

[@glaciveestudios6170]

I am suffering from malaria right now, oh damn do I hate it

[@davidfalcon6550]

Malaria: *Wololo* Liver cells: *Now that's some good sh%t*

[@crazy2-1ilz18]

That's why I don't leave my house

[@driskomajdicku3448]

They came to your house

[@randomstuffs26]

And that's where they live.

[@worthless_nico]

O n l y epic gamers D o T h at

[@itsmyhobby1101]

Even the greatest people didn't survive to a mere parasite

[@nickfromm9492]

Wow, these graphics are top-tier, great video!

[@TusharSawant2]

Once I had Malaria and believe me it was the worst experience of my life.🤢

[@baileyellis5346]

Fun fact: Malaria protozoa hide in the liver and red blood cells, undetectable from our immune system due to the self-antigens on the red blood cells and the ever-changing strains which means that the phagocytes don't know what they're facing. It hides in your body for years. You likely still have it.

[@OfficialGOD]

i got this 3 times as a teenager, unbelievable

[@StudySavvyy]

Amazing animation and background sound.

[@swapniljoshi4104]

Awsome awsome......lovely 😘😘😘 vry good video ! Thanku so much it is helping in studies. ....n the animination is superab👌👌👌👌👌

[@aha3691]

Human

[@barsozuguler4744]

I wondering who the hell keeps give dislike this high quality videos

[@thokozanimakina9248]

How many hours/days does the schizonts stay in the liver and multiply before it ruptures???

[@Tyvior]

3

[@harshivpatel6238]

I thought it was 3-7 days...

[@meghaks6713]

Beautifully animated!

[@justinmatugas2588]

I never tried malaria bc if something softly touches me, I slap that spot directly

[@Soapduck_]

I felt my entire body while watching

[@rogelioyap4895]

Mosquito: Time for my blood meal. Nobody: Malaria parasite: *hippity hoppity this human is my property*

[@gayathripradeep1936]

Thank you😃

[@firefly7798]

This scared me more than all the horror movies that I've seen 💀

[@Chrysolite-kn3mz]

Thank you for the great illustration.

[@algireaux1364]

Beautifully animated.

[@ayeshamashiatisstudying]

The content was great, the sound effects felt like a zombie movie and created a kinda spooky vibe XD, LOVE ITTT

[@lalithakarthikeyan06]

316 malaria mosquitoes watched this video

[@SeaJay_Oceans]

excellent video. Is anyone studying the Mosquito immune system ? If Mosquito immunity can be boosted to Cure THEM of the disease, then they can not pass it on to humans.

[@auxegin7035]

Same goes a sbats, bats carry many viruses and bacteria that are lethal to human but meh... for them

[@jei9035]

No one: .. KZbin: Recommend Malaria Lifecycle videos that doesnt have any connection on what am i watching earlier.

[@nonamesaretaken5616]

No one: You: unoriginal meme

[@butterfly99899]

@@nonamesaretaken5616 Lame joke

[@nonamesaretaken5616]

Arpita Sahani sad you liked your own comment.

[@rahman1314]

Fun fact: mosquitoes actually feed on nectar, but when they are pregnant, they need proteins, which they can get from the blood so basically what's sucking you are pregnant mosquitoes 😭

[@chrisr03]

They said that

[@bablikitchen7485]

Best video ever saw👍👍 I shared it with everyone

[@trashyCorn.12]

I wish that mosquitoes never existed

[@ggsap]

Special force's clan So ur saying mosquito is good? Ur really stupid

[@SuzutakeJP]

Aarav Prasad it’s like saying someone that has and STD is bad

[@BlancoWilliams]

Aarav Prasad mosquitoes are good for the food chain

[@ggsap]

JoE MaMa P it wont make a difference if they are gone

[@BlancoWilliams]

Aarav Prasad it will lmao. They are important in the food chain

[@yazantopaji9467]

The way the body works is blood is the basic product of everything and it is found all around the body and when one part of this blood is contacted the whole body is

[@hzosailovazshnamte3342]

Very clear explanation Thank you so much

[@m.o.e._44]

As terrible as malaria is somehow seeing it was still in a weird way, dare I say beautiful? Not the destruction but just how detailed our bodies truly are

[@anwaraljnabi2143]

Thanks alot it was so clear for me .

[@joshuamcnab9605]

This was excellent animation.

[@EnsoLLC]

Had this when I was a kid in Vietnam, I was only in 2nd grade.

[@طيبةيونساحمدحسن]

wow ,awsome video its sooooo clear thank u alot its really heplful and make every thing clear

[@danthadon87]

Thanks for this awesome animation!

[@gozoom24]

Great animation ...

[@naazmacramearts2533]

please make video on entamoeba histolytica, its structure and life cycle

[@pukhrajmansion8445]

Good presentation PL translation in Hindi language

[@nothingbutbacon510]

Wow, we should really find something that can cure mosquitoes so it cannot be passed to us

[@aasthakumari4888]

wow awesome animation and explanation thank u

[@PremKumar-yg2hq]

It was both amazing and horrifying

[@mvenkateshnaik269]

Very nice

[@justonlyalta]

I'm watching this while recently diagnosed with malaria....

[@lk4543]

How can the parasite possibly know its reached the liver, amazing

[@cernugaming]

God created it like that. Smart efficient killer of babies.

[@patrickbateman6160]

The circumsporozoite proteins present on the surface of sporozoites bind to the receptors present on surface of hepatocyte facilitating the entry of sporozoites in liver... Normally it takes 30 min to enter liver after infection of sprozite

[@lk4543]

​@@patrickbateman6160It is a wonder to me how the parasite knows which direction to travel in order to reach the liver, unless it is a random but that would mean it is based on chance?

[@OnlyNo1Videos]

very well explained i recommend it to my all students Being teacher

[@Noeman2009]

Kina or Quinine is still effective medication against Malaria. Got contracted Malaria twice in Papua, but fully recovered and it never came back.

[@tharaniss]

Nice animation thank you

[@muhammadharis3938]

Great animation and work

[@fairytales1741]

why the back ground sound is so satisfying........😶😶

[@PYRAMIDHEAD1051]

Awesome animation.

[@chinchilla_fandoms9500]

OK thanks! I'm never going outside again but thanks!

[@RobertoCardadeiro]

Why I'm seeing this whole playlist at 1:00 am?

[@다정-t3t]

감사합니다 ♡

[@vijayakumarm1996]

The dislikes are from mosquitoes 😂

[@sharandsouza9898]

If mosquitoes are so necessary, then why don't I find any mosquitoes in developed countries. Melbourne City area does not have a single mosquitoe

[@terraxgaming4117]

It's actually terrifying how 2 small insignificant creatures can destroy our entire body

[@V1kram]

How are mosquitoes infected in the first place? Do they only get infected from other people or are there other sources?

[@WEHImovies]

Watch Part 2 of the animation: Malaria lifecycle in the mosquito kzbin.info/www/bejne/g6nMiKNuq9CFfKs

[@farmerkhmer2021]

Good lesson

[@riteshugale7953]

Awesome graphics 👍

[@غراماليمن]

Thanks for explain, we want a lot of vedio to take a lot of experience.

[@nataliyagabriele7561]

This is ao scary😞 its like a zombie apocalypse but its happening inside of your body😣

[@ravikumaryadav2155]

It is very nice video

[@SalvatoreEscoti]

Why did Malaria evolved such a COMPLICATED life Cycle, I mean so many diffrent stepps and changes of Hosts!!!

[@ajbiv]

Malaria parasites are related to common single celled algae found everywhere on Earth. Algae protist cells also have complicated lifecycles, with dramatic changes in morphology, behaviour, locomotion and habitat

[@abdelkarimalailou49]

Because the Creator of the universe sends a clear message to proud beings, that a common mosquito can make us succumb.

[@jaymz1999]

We have no evidence for any creators.

[@abdelkarimalailou49]

@@jaymz1999 Yet they are legion, constants for example

[@abdelkarimalailou49]

@@jaymz1999 The complexity of the eye observed by Newton

[@tomootomoo4871]

Just hearing buzz sound of mosquitoes that make me itchy 😌

[@ashpaksande1056]

Thanks for nice vedio

[@mairisberzins8677]

Sooo... if it goes to liver then what if i drink sum vodka? Will that kill the malaria parasite before it does anything to my liver?

[@emokaokwudili1674]

Very great animation i love it so much thank you 💕💕💯

[@Kritika_Goyal810]

Seriosly i am so afraid after watching this vedio and amazing understanding

[@DanielFenandes]

Nice ilustration

[@timothymwila7106]

very powerful doc

[@sandeepcreation3219]

What a wonderful explanation I like it 👍 much super duper jhakkas sir

[@sanjayprajapati7333]

Very clever explaining also animation

[@nagarajanpillai9290]

Amazing Video

[@Aliahmed-fv4gp]

At 2:01 what is immune system (neutrophils antigens etc)doing ?

[@rotanux]

Jerking off to anime girls prob

[@gjzztrrettmmggrrertzhgyena4950]

Goooood Sir.....💖💚💜❤💕🧡💔💋👄❤💚💓💛💙💗💌❣💟💞🌍🌎🌏💝💘💙💓💖💚💗💌❤💜💕💎❣🧡💔💞💟❣

[@EvilHermit674]

Kudos to the sound engineers.

[@shahdbts6225]

Is it possible T lymphocytes act against plasmodium once it's present inside of RBCs?

[@ColossalCake]

WOW!!! Very well done!!

[@chinmayeemurudkar7847]

Thank you!

[@WhoopDeDooz5250]

Why does this look like a horror movie for my body.