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Dr Breitbart (Memorial Sloan Kettering Cancer Center, New York, USA) talks to ecancertv at NCRI 2014 about psycho-oncology and the often overlooked importance of addressing issues surrounding meaning and purpose in cancer patients experiencing anxiety or depression. He suggests that looking at meaning as an alterative approach to anti-depressants may be more effective for those who are not clinically depressed but are, rather, experiencing "a profound loss of meaning".