Mediators of Inflammation: An Introduction

#immunology #inflammation #pathology
Microbes, necrotic cells or tissue injury could trigger the release of certain soluble factors, from inflammatory cells, endothelial cells or from plasma. These soluble factors, called mediators of inflammation, initiate and amplify the inflammatory response and determine the consequent clinical and pathologic manifestations.
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References and further reading:
💡Kumar V, Abbas AK, Fausto N, Aster JC. Robbins Basic Pathology. 10th ed. Elsevier; 2018.
💡Abbas AK, Litchman AH, Pillai S. Cellular and Molecular Immunology. 8th Edition. Saunders Elsevier; 2015.
💡Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and Cotran - Pathologic Basis of Disease. 8th Edition. Saunders Elsevier; 2010.
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[@susanahernandez6893]

It´s interesting how many mediators take part of inflammation. So the magnitude of the mediators might tell us, how important are the process in order to get the goal, destroy the stimulus. For me Histamine, is the one that orchestrates all the changes that comes below, and then, everything is conected.

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1st signal from cell damage can be transferred by what Signal? Pls reply

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Whether cytokines produced by damaged cells or leukocytes??

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TNF-alpha and IL-1beta mainly

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thank you for sharing knowledge !! i am very confuse with word "Mediator", what does mediator mean in medical ? what mediator do ?

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Does the mast cell typically die after degranulation?

[@HackDentistry]

Good question. No they don't. In fact after degranulation, mast cells resynthesize the mediators and repopulate granules. Here's an article you could read with regards to your question -> Mast Cell: A Multi-Functional Master Cell - www.ncbi.nlm.nih.gov/pmc/articles/PMC4701915/

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