Medical Animation explaining Coronavirus Mechanism of Action - How Coronavirus attacks a human body

our latest video- • Coronavirus outbreak (...
While the exact mechanism of action for the 2019 Novel Coronavirus is still unknown, the 3D structure has been published; This structure shows that the virus is very similar to other coronaviruses and so we show the mechanism of action of how coronavirus gains cell entry, coopts the human cell into producing copies of itself, and causes apoptosis or cell death.
For more info on the biology, the spread and the response to 2019 nCoV see our microsite:
coronavirus.sci...
The 3D ribbon structure was taken from Innophore who have created the structure based on the genome sequencing data published by Chinese researchers. You can find it here:
innophore.com/...

[@survivalofthefittest8043]

how you make these animated videos ...please reply

[@vrfacts7158]

Is this no copyright

[@-KillaWatt-]

Those receptors that allow the virus in. What is their mechanism for, What would it be letting in to begin with? You would think such a doorway would alway remain shut so to speak.

[@GirishKhera]

for example , receptors are used as a security system to judge between foreign bodies (antigens) and known ones. An example is an immunes system molecule giving antibody information to a cell so that it can produce antibodies. another example is to bring in nutrients to the cell.

[@soylentgreenb]

For SARS and 2019-ncov the target receptor of the virus is the ACE2 receptor that is part of the renin-angiotensin system that controls blood pressure, aldosterone and sodium retention. Cells are not these dead things that just sit there and don't move. Things constantly go into and out of them. They have a cyto-skeleton to allow them to move, deform (e.g. immune system cells need to chase and engulf things) and divide. They are sort of very trusting and not very smart; they have all this machinery for making proteins and they don't care or understand what they make. If a virus sticks a piece of malicious RNA in there the cell will make the proteins it codes for just like it will for mRNA that the body produces from the genome to make its own proteins. This virus RNA can code for parts of a new virus capsid as in this case, which can then bud from the cell surface and take a layer of human cell membrane with it as an envelope around the capsid, or it can be things like an enzymes for reverse-transcribing viral RNA into DNA, transporting it to the nucleus and inserting the viral DNA into the host cells genome (a provirus), so that the cell will make new viral particles if/when that provirus is expressed and transcribed. The provirus cannot be detected by the immune system when the cell is not making viral particles and it will be transfered during cell division so that both cells get a copy of the provirus. Such retro-viruses can make it into germline cells, become defective and remain as part of the genome past down many generations; effectively becoming "junk" DNA. Several percent of your DNA is old deffective RNA-viruses (so called endogenous retroviruses). Viruses that create chronic infections like HIV, HTLV and various herpes viruses also often hijack the cyto-skeleton and other systems to create viral synapses between cells that allow direct cell-to-cell transfer of viruses without giving the immune system much chance of detection. These synapses are controlled by the virus by making the cells produce signaling substances that promote the formation of synapses between cells; e.g. a T-cell can be made to "hug" another T-cell, make a junction that efficiently transfers the virus and the viral particles can then move along the cyto-skeleton so they concentrate where they need to be to infect the other cell. In HIV the viral particle count in the blood can be very low, and CD4 T-cells are still passing the virus along to each other direct cell-to-cell even though there are very few free virus particles.

[@diouranke]

I've always wondered that too

[@soylentgreenb]

@@diouranke There are things going into an out of cells all the time and cells have receptors that only allow in things which fit into the receptors so they just don't allow anything in. The ACE2 receptor that this virus and the SARS virus used is for angiotensin converting enzyme 2. It's an essential regulator for heart function and blood pressure.

[@neroknight1234]

Take a biology class

[@keithsimmonds1629]

I think when those fibroblast receptors is approaching the host cell it reads what the host cell does not want to do and then it appears like it don't want to do that that why it does not seem like a threat by the fibroblast receptors stimulating the cell to accept it.

[@iak7116]

plz give me a subtitles ㅜㅜㅜ I'm korean studying coronavirus acting mechanism. Video speed is so fast..ㅜㅜ

[@alexmercer1578]

hello im deaf, can someone add subtitle to this video?

[@poktya1920]

It looks so cute in animation

[@BasicsofEverything]

😂

[@hydrob_1048]

Foo wtf

[@ummulvara6852]

Yahi cuteness ne to logo ki jaan leli😂

[@shootsandhuts2809]

first you positive and see cuteness

[@babeena_gt_3645]

If they can explain the virus then they can find a cure

[@hydrob_1048]

Not necessarily

[@emileponcelet3439]

Are u stupid? There isnt a cure for viruses only your body can fight it by establishing anti bodies.

[@CellRus]

It is possible but not necessarily true. Finding a target does not mean easy medicine making. It requires a lot of optimisation to be able to produce some molecules that can bind to the target with enough affinity to produce biological effects. This can take months and years. Sometimes, the molecule is not specific enough or bind not tight enough and cannot be optimised, then it will have to be thrown away, and a new target will need to be discovered. This doesn't take into account the whole clinical trial in human, which can take months (in the case of emergency) or years (in normal cases). So it is not a straightforward process.

[@babeena_gt_3645]

@@CellRus good point, I never thought of it this way. Well none the less, I really do hope the find a resolution for this virus. Much to many innocent lives being lost 😔

[@SuperStupidmovies]

You must have no idea how science works. At least you're here though, attempting to educate yourself, better then most people!

[@MCGamer-tj9nr]

Pov: trump gets a little hurgry

[@lucreziagiangrande5138]

ciao

[@fayiksuleymanov7834]

He

[@mtx303]

Fail