Amyloidosis, Causes, Signs and Symptoms, Diagnosis and Treatment.

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Chapters
0:00 Introduction
1:06 Types and Causes of Amyloidosis
3:15 Symptoms of Amyloidosis
4:04 Diagnosis of Amyloidosis
4:26 Treatment of Amyloidosis
Amyloidosis is a group of diseases in which abnormal proteins, known as amyloid fibrils, build up in tissue.[4] There are several non-specific and vague signs and symptoms associated with amyloidosis.[5] These include: fatigue, peripheral edema, weight loss, shortness of breath, palpitations, and feeling faint with standing.[5] In AL amyloidosis, specific symptoms can include enlargement of the tongue and periorbital purpura.[5] In wild-type ATTR amyloidosis, non-cardiac symptoms include: bilateral carpal tunnel syndrome, lumbar spinal stenosis, bicep tendon rupture, small fiber neuropathy, and autonomic dysfunction.[5]
There are about 36 different types of amyloidosis, each due to a specific protein misfolding.[6] Within these 36 proteins, 19 are grouped into localized forms, 14 are grouped as systemic forms, and 3 proteins can identify as either.[6] These proteins can become irregular due to genetic effects, as well as through acquired environmental factors.[6] The four most common types of systemic amyloidosis are light chain (AL), inflammation (AA), dialysis-related (Aβ2M), and hereditary and old age (ATTR and familial amyloid polyneuropathy[7]).[2]
Diagnosis may be suspected when protein is found in the urine, organ enlargement is present, or problems are found with multiple peripheral nerves and it is unclear why.[2] Diagnosis is confirmed by tissue biopsy.[2] Due to the variable presentation, a diagnosis can often take some time to reach.[3]
Treatment is geared towards decreasing the amount of the involved protein.[2] This may sometimes be achieved by determining and treating the underlying cause.[2] AL amyloidosis occurs in about 3-13 per million people per year and AA amyloidosis in about 2 per million people per year.[2] The usual age of onset of these two types is 55 to 60 years old.[2] Without treatment, life expectancy is between six months and four years.[2] In the developed world about 1 per 1,000 people die annually from amyloidosis.[3] Amyloidosis has been described since at least 1639.[2]

[@RyanGMcElroy]

My mother passed away in March 2016 due to Amyloidosis. She was having fatigue issues for about the last six months of her life. She first expressed concern around July of the previous year. Doctors did not diagnose her until Jan 2016. She started having this problem where her legs would secrete water. She would get so embarrassed when she would wake up in the morning with the bed looking like she had gone to the bathroom on it. She was in good health up to this point. No smoking, physically fit, etc. She died after she got into the back seat of the car. Literally mid-sentence. I immediately called 911 and tried to save her myself in the meantime. It was so hard to get her out of the car. I failed. I had to tell her brother that she died in my arms. The whole situation plays back in my head daily.

[@MedicalCentric]

Sorry about the experience, May her soul Rest in Peace.

[@starflyer3219]

Very traumatic to have to go through. You did everything you could though.

[@hamayedres1904]

Hi bro do you have wattsap ???

[@Fennywaterwinkle]

I’m so sorry for your loss.

[@Zincink]

So sorry to hear about your Mother passing away. You did the best you could do. Wishing you peace in your life.

[@grillo591]

Thank you so much..I have RA and Lupus.. everything mentioned here fits me to the T

[@athisneha1165]

Very useful. Thank u so much.

[@gnanarajdaniel206]

Information 👍

[@MrGODINTHEMAKING]

Damn think im going though this now.

[@waqarjaved9277]

Thank u 😊

[@MedicalCentric]

You are welcome.

[@bettydandash580]

Hello, can the patient with amyloidosis return to his normal life? Knowing that he has the following symptoms : weakness, diarrhea, weight loss, less appetite and swelling of the feet and hand

[@zahidashaikh591]

The 5 to the the TT

[@vijaivarghese5417]

My mother have same issue. Now she is at CCU ans the stage is very critical

[@MedicalCentric]

I hope she gets well soon.

[@hamayedres1904]

My father😢😢😢😢😢

[@MaddyCakes-fx2pl]

To funny weird woman I dated when I was desperate had all symptoms. And name was Amy. I care for people but she was a pawn