Multiple Myeloma - Malignancy of Plasma Cells - Bone marrow - Hematology & Oncology

[@MedicosisPerfectionalis]

🦠Antibiotics Lectures: www.medicosisperfectionalis.com/ 📝 Download Notes: www.medicosisperfectionalis.com/

[@kshitizbhandari4740]

I can definitely say this is the best series on hematology in the entire Universe. THANK YOU VERY MUCH. Love from Nepal.❤

[@MedicosisPerfectionalis]

Wow! That’s an extraordinary complement 😊

[@sncnutrition7118]

@@MedicosisPerfectionalis can u do a video if someone's cbc w diff and CMP is all normal. ... yet their NRBC is 1 ... normal is 0 so its considered HIGH. your thoughts...? Thanks

[@hyori106]

1. Bone pain 2. Bacterial infection 3. Uti and pneumonia 4. Staph, strep, ecoli, klebsiella 5. Ecoli staph? 6. Normal 7. High anion gap? Thank you so much!!!

[@Leoantonio13]

I guess normal AG, because it causes RTA (a normal serum AG acidosis).

[@aymenkamal9488]

Anion Gap is decreased.

[@MedicosisPerfectionalis]

Anion gap is usually low in multiple myeloma

[@carolweaver3269]

Thank you for placing this in order.

[@lafurselfsik]

"In addition to displacement of sodium-containing water from serum by large amounts of non-sodium-containing paraproteins, some paraproteins (eg, IgG in multiple myeloma) can have a net positive charge at physiological pH. This leads to an increase in unmeasured cations and a low anion gap"

[@riyasingh8862]

1. Due to hypercalcemia fatigue,weakness including bone pain 2. Infection mostly bacterial 3. Pneumonia ,uti, pharyngities etc 4. Ecoli,staph,step,kleb 5. Ecoli 6. Normal bec no osteoblast activation 7. Due to acidosis anion gap is low

[@anandsuresh6]

Found the perfect page for hematology. Waiting for more subjects.

[@MedicosisPerfectionalis]

Coming soon...Thank you!

[@katyabergstrom5742]

You are easily one of the most talented and brainy teacher with a superb sense of humor. Thank you so much for putting out such excellent quality content. I literally wake up with a lighter heart knowing that you may have a video on any of the topic that has been kicking me. Kindly keep sharing your knowledge . One request though is to absolutely ignore the peabrains who whine about your voice or accent or whatever else that their insecure nitpicky anti social personalities want to water drip on. You keep doing you. We want more vieeos whenever time allows for you! Thank you with all my gratitude.

[@MedicosisPerfectionalis]

Best comment ever...Thank you, dear...I truly appreciate all of your kind words. Can you-please-share my videos with others? It really helps me :)

[@manarsmaan2624]

the most powerful lecture about multiple myeloma on youtube platform

[@MedicosisPerfectionalis]

Thank you 🙏

[@MedicosisPerfectionalis]

📝 Download my handwritten notes: www.medicosisperfectionalis.com/

[@user-qb2be6ug5g]

i want to thank you for making this video. i had a project on multiple myeloma and i kept reading and reading facts about it from multiple and different resources and i was a bit confused with how the one info connects with the other, but your video helped me understand the whole thing! again thank you so much! bless your soul

[@MedicosisPerfectionalis]

My pleasure 😇 Good luck 🍀 Can you please help me by sharing?

[@MedicosisPerfectionalis]

🩸 Hematology Playlist: kzbin.info/aero/PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU&si=tomFsUjAgOKhOJVq

[@alangarfias6075]

There is simply no better way to explain things, such a great job!

[@MedicosisPerfectionalis]

Thank you 😊

[@cris95v]

I swear to god I learned soooo much from you compared with what i learned from classes (med student here) thank you for doing this!!!!

[@MedicosisPerfectionalis]

Thank you so much! I am honored. There are 600+ medical videos on my channel...I hope you’ll enjoy them.

[@MilkySandwich]

This channel is seriously underrated and below the radar. Dude, you are going to outrun more famous channels if you continue like this ;)

[@MedicosisPerfectionalis]

Thank you so much 😊 I really appreciate it! Can you please help me by sharing?

[@Tarteel97]

When he said “buy you have the memory span of a fish”😭😭😭 you’re absolutely right I do

[@MedicosisPerfectionalis]

😊😊

[@srikantascandh9859]

Birds with feathers flock together Stacked rbcs quickly sink together 👏😂awesome,Thank you so much for these wonderful videos.Your humour is simply superb

[@MedicosisPerfectionalis]

My pleasure 😇

[@hb7017]

I’m watching the videos as I prepare for my nursing exam which includes Hematology. I loved it!🙏

[@MedicosisPerfectionalis]

Best of luck!

[@roshnikaveera649]

I could never forget about multiple myeloma, its really perfectly presented crystal clear concept which makes us understand logically and conceptually .thank you so much medicosis perfectionalis ❤

[@MedicosisPerfectionalis]

You’re very welcome!

[@jobinafaizal3249]

Thanks professor.Such an awesome presentation..Very clear,detailed and good visuals.It motivated me to learn more..(Nurse working in hematology department).Also going to help so many patients since it gave explanation in an excellent way.God bless you Sir.

[@MedicosisPerfectionalis]

God bless you too!

[@amaypaulsingh1894]

Hands down best medical channel, pure quality man, really appreciate the effort 💯

[@MedicosisPerfectionalis]

Thank you!

[@robinsalem8201]

You are crazy talented!!!! I had so much fun watching this video! Made learning soooooo easy and fun 💯💯👏🏼

[@MedicosisPerfectionalis]

Thanks a ton, bro All the best! Can you please help me by sharing?

[@JOYB0YY244]

I wish i could travel back in time and tell my past self about this channel 😅 Loving all of your videos its a shame that my 2nd year is ending now but I'll still watch your videos nevertheless ❤❤

[@MedicosisPerfectionalis]

I appreciate you!

[@abdulrahaman0157]

Dude imma about to cry! May Allah protect you and bless you

[@MedicosisPerfectionalis]

Thank you 😊 You too!

[@mokeiramokuamm]

Finally medical videos that are not boring lectures. Thank you!

[@MedicosisPerfectionalis]

My pleasure 😇 I am honored! Can you please help me by sharing?

[@mokeiramokuamm]

@@MedicosisPerfectionalis Definitely

[@monicapadurariu1997]

Thank you a lot for your videos! 🙂 In my opinion, your videos are the best! You help me to take my specialist exam in Hematology! 🎉✨I want to study every day and be a good doctor!

[@MedicosisPerfectionalis]

Awesome 👏 You can do it 👍 When you have time, please help me by sharing!

[@princevegeta5968]

My only regret is finding about this channel, quite late😅😅... You've changed my perspective of medicine. Massive respect bro!!

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@jayj7227]

These videos are really so helpful, they are so easy to understand. The information really sticks.

[@MedicosisPerfectionalis]

Awesome 👏 Can you please help me by sharing?

[@thinkagain99]

I first skipped the video because it was 28 mins long but I ended up watching the whole lecture. Amazing lecture 👍

[@MedicosisPerfectionalis]

Wow! Thank you so much 😊

[@drhumzaashrafsial6500]

The most complicated topic blood... No one can master it its so confusing but medcios u r boss really gem toward medical field......u do a lot of hard work to make the topic easy.... So much happy for u.... I think u deserve the Oscar ❤️🇵🇰 love from Pakistan.

[@MedicosisPerfectionalis]

Thank you!

[@doctormombaby4319]

OmG. I'm in soooo much love with the way u teach 🤩🤩🤩🤩🤩🤩 Keep upload more videos for medicine docs pls.. Thanks a lot. I appreciate ur work. May u stay healthy

[@MedicosisPerfectionalis]

My pleasure 😇 Thanks for your kind words! Please help me by sharing my videos with others!

[@romalouis6825]

Such a great video u made the topic digestible , thanks and keep doing this :)

[@MedicosisPerfectionalis]

Thank you! Will do!

[@faamsalih]

What a hell of easy learning! Fab!

[@MedicosisPerfectionalis]

Thank you ☺️

[@jojo-hj3ji]

YOU ARE THE BEST TEACHER EVER !!! many many thanks

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@hardik7942]

1. Bone pain 2. Infections 3. Bacterial infections ( Staph, E Coli, Klebsiella) 4. Staphylococcus Aureus 🤔 5. UTI - e.coli 6. Increased

[@MedicosisPerfectionalis]

The answers are posted in the next video in the series.

[@hardik7942]

@@MedicosisPerfectionalis gotcha

[@MedicosisPerfectionalis]

👍👍

[@roufaidabragdi6437]

Thank youuu @Medicosis perfctionalis you saved me From Algeria 💙

[@MedicosisPerfectionalis]

I appreciate you!

[@DrMassilia]

1. Bone fracture 2. renal problems ? 3. bacteria infections as pneumonia 4. staph ; strepto .... 6. ALP = normal 7. anion gap = is decreased

[@madhukardeshpande563]

Nice explanation of Multiple Myeloma, Thanks sir

[@MedicosisPerfectionalis]

You’re welcome 😉

[@KomalSharma-de2rr]

U r such a great teacher, making things so easy, thanku so much sir, u r great .... Love uuu sir😍😍 keep uplaoding such great videos and increase ur knowledge...

[@MedicosisPerfectionalis]

Thank you!

[@sarahahmad4147]

So amazong explanation .

[@MedicosisPerfectionalis]

Thank you 😊

[@hadjerjo2690]

Thank you for your videos, your channel is very helpful !

[@MedicosisPerfectionalis]

My pleasure 😇

[@Livinggud]

Your instruction is superb!

[@MedicosisPerfectionalis]

Thank you 🙏

[@Livinggud]

@@MedicosisPerfectionalis chiropractic student here BTW! You really made all the information finally *click* into place for me!

[@MedicosisPerfectionalis]

I am honored!

[@savagedan3474]

I have an exam i’ll make sure to update you about my answers since you helped me alot 💜💜💜💜

[@MedicosisPerfectionalis]

Good luck 🍀

[@ZainbAlshakhuri]

oh my... astonishing!

[@MedicosisPerfectionalis]

Thank you 😊

[@HamzaMahmoud-d9j]

I love you man !

[@MedicosisPerfectionalis]

Thank you!

[@sinaasviin4139]

Thank You from Iran

[@MedicosisPerfectionalis]

My pleasure 😇

[@Fr3doskin]

Not to be confused with Pajamas… riiight. Definitely what I was thinking thinking BJ stands for

[@meriembenta1663]

thank you

[@MedicosisPerfectionalis]

My pleasure 😇

[@srikanthmungara610]

Thanks alot medicosis for ur grt wrk in hematology

[@MedicosisPerfectionalis]

My pleasure :) Please help me by sharing!

[@royaltyfreeksrmusic9715]

Excellent .much interesting and valuble to all of ..

[@MedicosisPerfectionalis]

Thanks!

[@yarasafina1]

You are extremely amazing! Thank you soooo much♥

[@MedicosisPerfectionalis]

My pleasure 😇

[@richardho8283]

Many thanks, good teacher. In fact, excellent teacher.

[@MedicosisPerfectionalis]

The pleasure is mine :)

[@ФилипАтакер]

thank you so much

[@MedicosisPerfectionalis]

My pleasure 😇 Would you please help me by sharing?

[@ФилипАтакер]

sure

[@xDomglmao]

Why the Rouleaux formation? The incr. ESR is because Ab are proteins and thus (like RBC membranes) negatively charged? Also I don't quite get the amyloid part: Malignant plasma cells produce non-functional antibodies (Ab); antibodies consist out of heavy and light chains. If the light chains get into the urine they are called "Bence-Jones protein" (BJ); but the light chains can also transform into amyloid. So the difference between BJ and amyloid is that BJ lacks this transformation? However, they both damage the kidney? 26:46 You wanted to leave a link (type of fractures) in the description :D

[@MedicosisPerfectionalis]

To answer your question about rouleaux formation...Please Watch my video on ESR kzbin.info/www/bejne/laqUdHt7rtmNqJI

[@MedicosisPerfectionalis]

Types of fracture orthoinfo.aaos.org/en/diseases--conditions/fractures-broken-bones/

[@MedicosisPerfectionalis]

Regarding the amyloidosis...Let’s forget about amyloidosis for a second and talk about a toxin that damages the kidney (lead for example)...Lead will damage many organs including the kidney...Some lead will be excreted in urine and therefore detected in the lab (high urine lead level)...Now let’s remove lead and replace it with “amyloidosis” and let’s remove “urine lead level” and replace it with “Bence-Jones protein”...Make sense? 😉🤔💡

[@xDomglmao]

@@MedicosisPerfectionalis So light chains = synonym to amyloid; and BJ = synonym to amyloid in urine? Thank you!

[@MedicosisPerfectionalis]

You got it...It’s a simplistic approach, of course...but, you get the idea.

[@kalpanakarunakaran7033]

Best teacher.

[@MedicosisPerfectionalis]

Thank you!

[@kalpanakarunakaran7033]

Awesooome amAzing lecture..so thankyouuuu to you...😍😍👏👏👏👏👏

[@MedicosisPerfectionalis]

My pleasure!

[@harikagunnam4716]

Tqqqqqq so muchhhh sir

[@MedicosisPerfectionalis]

Most welcome!

[@kashifmuneer5490]

plz upload more pathology videos ur the best ♡♡♡

[@MedicosisPerfectionalis]

I sure will ❤️

[@aysecavdar9418]

perfect!!! thanks for everything you r excellent

[@MedicosisPerfectionalis]

My pleasure 😇...I am glad you liked my videos!

[@shailjashspandey4512]

I have a question that why only light chain get excreted not the heavy chain bcozz of bigger size?? Plzz tell

[@yousefashmeh1468]

Dude you're amazing! Very thanks!

[@MedicosisPerfectionalis]

I appreciate you!

[@mohitzambare]

When we talked about B cell Lymphomas/Leukemias why the increased number of B Cell does not cause Inc. in Plasma cells. Is it Because they are immature cells?

[@MedicosisPerfectionalis]

Yes! If you remember immunology, B-cells need to mature first (with the help of T-helper cells) in order to change to plasma cells and memory B cells. Good point 👍

[@Thesakeable]

Great video - is it normal I get ads every 3 minutes? I understand you want to run ads on this awesome content but I found it a bit excessive...

[@crystalss8354]

U r amazing ! Thank you 🙏🏻 ♥️

[@MedicosisPerfectionalis]

My pleasure!

[@hadiyounes8883]

Awesome and very funny teacher ! Thankful! Can't seem to find the answers to the questions at the end tho :(

[@sarahzoubair8895]

bone pain infections bacterial infections S.Aerus/E.coli... E coli Normal ?

[@alaaamein5931]

very helpful thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@funnnkyk1d]

thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@jasmincompr1355]

Does bence jones detecte heavy chains G too ?

[@drpepper7801]

Great video as always, my boy never disappoints. I have a question though you said we get proteinaceous tubular casts which may consist of albumin in the cast in urine but then in the bullet point u said glomerular function is nearly normal thus no albuminuria. care to explain?

[@mundiamachima7036]

" You have a memory span of a fish." ME: Goes on to LEAVE A LIKE AND SUBCRIBES... 😂😂😂😂 Such a great Video!!!!!

[@MedicosisPerfectionalis]

Thank you so much, Mundia! I appreciate you! Would you please help me by sharing?

[@p.asreeparvathi6190]

Tq for this elaborate lecture...

[@MedicosisPerfectionalis]

My pleasure 😇

[@shawnpinn9177]

Thank you bro that was so helpfull

[@MedicosisPerfectionalis]

My pleasure!

[@prankrishnanath5080]

I have already watched lots of your videos. Thank you so much. Love 💚 from Guwahati, India.

[@MedicosisPerfectionalis]

Thanks 😊

[@savagedan3474]

I have a quesion what sources do you use for your videos ? Im

[@MedicosisPerfectionalis]

📚 Recommended Books: www.amazon.com/shop/medicosisperfectionalis/

[@shuvarana5466]

Thank you for putting up such a good lecture videos. Your videos are really informative, where do you gather your resources from? Whats your references? Is it Harrison and Wintrobe or something else. If you could share your references would be really grateful.

[@MedicosisPerfectionalis]

Thank you so much 😊 I use Harrison’s, Davidson’s, Goldman-Cecil, Goljan and Medstudy.

[@saurabhdhabeknight]

Bone pain Infection Uti, rti, pneumonia Ecoli staph pneumo ecoli Normal ?? Don't know please help Also you rock, thank you very much 🙏🤣

[@napyaninja]

VERYYYY NICE 😁 LOVED IT

[@MedicosisPerfectionalis]

Thanks 🙏

[@beyzaylmaz1346]

AWESOME.....

[@MedicosisPerfectionalis]

Thanks!

[@sjrigatti]

It's "birds of a feather" - but honestly I like your version better.

[@MedicosisPerfectionalis]

😁

[@mouniraboug2027]

Finally I got this lesson even if eng is not my native language x) but with pics I understood everything But still have a one qst x), why urine stips don't detect light chains of IG isn't globine a protein too 🤔 And thank you in advance ☺

[@MedicosisPerfectionalis]

Because it’s hard for urine strips to detect the light chains in the urine.

[@mouniraboug2027]

@@MedicosisPerfectionalis🥰 okkkkey thank youu

[@rayayalmaz9403]

Dr Medicosis🤔thanks for this beautiful explanation, it helps a lot but i have a little question: I did not understand why hypercalcemia makes lethargy, confusion and weakness?

[@MedicosisPerfectionalis]

There’s an inverse correlation between Ca and nerve excitability.

[@rayayalmaz9403]

@@MedicosisPerfectionalis thank you sooooo much 🤩🤩🤩🤩

[@MedicosisPerfectionalis]

My pleasure 😇

[@saniyanarain]

if i pass haematology it is bc of this man alone

[@MedicosisPerfectionalis]

Thank you ☺️ Good luck 🍀

[@rosilyantony6261]

how does the plasma cell enters blood

[@shadia-z1w]

) Which of the following cytokines is intermediate in the pathogenesis of MM ? IL6 OR IL1? I HAVE Exam please reply?

[@Ham-os2wk]

Best teacher 🙏🙏🙏🙏

[@MedicosisPerfectionalis]

Thank you 😊

[@zainab-jg9vl]

Good job sir 🫡🤍

[@MedicosisPerfectionalis]

Thanks!

[@mitchellmbah6741]

Not to be confused with my pyjamas 😂🤣🤣... Beautiful lecture 💗💗

[@MedicosisPerfectionalis]

Thank you ☺️

[@samyan_saleem4252]

Thanks :)

[@MedicosisPerfectionalis]

My pleasure 😇

[@shanzehsharifkhan2002]

strts at 5:42

[@rameshwarsonawane6059]

Relatiom of ALP and ostoblast ??? Pls?

[@MedicosisPerfectionalis]

Described clearly in this video: RANK and RANK-Ligand kzbin.info/www/bejne/bJKvcnSZbs14sMk

[@AbhaySingh-nk6fi]

Thnku so much bro

[@MedicosisPerfectionalis]

My pleasure 😇

[@radiamohamed4531]

My father just died ،his death was to múltiple myeloma

[@MedicosisPerfectionalis]

I am so sorry for your loss. My condolences!

[@rovoB]

Thankyou

[@MedicosisPerfectionalis]

My pleasure!

[@CompBioQuest]

Fish actually have a great memory. =\

[@docmak-1256]

I. love. you.

[@MedicosisPerfectionalis]

Thank you so much!

[@Mariah-ge5be]

Thankful❤

[@MedicosisPerfectionalis]

My pleasure 😇

[@1st.marvelvsdc]

Thanks man I appreciate it

[@MedicosisPerfectionalis]

My pleasure 😇

[@mariyamkhan5399]

Amazing💖

[@MedicosisPerfectionalis]

Thanks 🙏

[@castic9848]

These unchanged batteries give me multiple gamotopathy

[@drteatrex2719]

i thought i had multiple myeloma, after you told me i dont, i was very relived. And now im getting paliative treatment for MM

[@MedicosisPerfectionalis]

I am very sorry to hear that. But, I have never told you that you don’t have multiple myeloma. I’ve never diagnosed anyone over the internet...This is for educational purposes only. I wish you the best!

[@xyzsjsmcks]

@@MedicosisPerfectionalis he is joking dude, you do explain perfect. Keep going :)

[@sarahwilliams2656]

I really hope you've changed the battery in your smoke detector by now 🙏🏻

[@MedicosisPerfectionalis]

Done ✅