Platelet Plug - Primary Hemostasis - How The Clot Forms!

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Primary hemostasis is balanced on the dynamic harmonious antagonism between the smooth endothelium (that prefers laminar blood flow) and thrombocytes (which favor clotting and thrombosis).
Platelets are called thrombocytes "cells of thrombus".
The smooth endothelium is squamous epithelium that lines the blood and lymphatic vessels from the inside.
When platelets roll over the smooth endothelium, nothing happens.
But, once there is an injured endothelium, platelets adhere, activate and aggregate to form a temporary platelet plug (primary hemostasis).
Then, the coagulation factors are stimulated "thanks to subendothelial collagen, tissue thromboplastin and platelet factor 3), coagulation cascade ensues until fibrinogen is converted into fibrin fibers trapping the RBCs and forming a stronger thrombus (secondary hemostasis).
After that, fibrinolysis occur (thanks to tissue plasminogen activator or tPA) to destroy the clot and restore function and flow.
Hemostasis is defined as “cessation of blood bleeding”.
There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets).
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).
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To be able to answer exam questions, Try to think of primary hemostasis and secondary hemostasis as two separate entities. 1ry hemostasis involves platelets and 2ry hemostasis involves the coagulation cascade. If you like my videos, please consider leaving a tip at www.paypal.me/perfectionalis/
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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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I Love watching your videos. They are way better than Pathoma videos and more interesting. I just had a small question, at <a href="#" class="seekto" data-time="347">5:47</a> you wrote GP1b and while showing the process of hemostasis you wrote GP1a, so which one is correct? Thank you. Forever your fan.

[@MedicosisPerfectionalis]

Thank you so much for your kind words...and yes, I made a mistake...The correct fact is that it’s GP1b

[@MedicosisPerfectionalis]

Please tell me anytime you have a question 😊

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Just FYI @ <a href="#" class="seekto" data-time="658">10:58</a> the receptor changed from GP1a to GP1b. Thanks a lot for making this video. :)

[@indiabiologyexplains5013]

I did some research and I think GP1a doesnt exist lol. I think the're both supposed to be GP1B

[@BMOfficial1114]

@@indiabiologyexplains5013 I agree that in the video it probably should have been GP-1b but GP-1a does exist :) its a receptor that allows platelets to weakly bind to collagen directly without the need of vWF, platelet receptor GP-IV does the same thing

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@@BMOfficial1114 thank you. Do you know if it is the reason platelets spontaneously aggregate in a given test tube?

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[@MedicosisPerfectionalis]

Awesome 👏 Yes! I do! Please go to www.patreon.com/medicosis/ and subscribe to tier 4 , I will send you all the slides that are in all of my videos... Thanks in advance!

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So how fast would platelets seal a paper cut ? How fast in the process ?

[@MedicosisPerfectionalis]

It takes about 2-7 minutes

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Hehe 😉 I was joking 🙃

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I have a question VWF that take part in coagulation comes in plasma from endothelial cells or platelets?

[@MedicosisPerfectionalis]

Both

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Sure!

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<a href="#" class="seekto" data-time="265">4:25</a> is when I stopped the video liked it and subscribed haha

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Thank you so much for supporting my channel! Please email me at: [e-mail]

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Fibrinogen it convert to fibren by thrombine will break down polypeptide of fibrinogen

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<a href="#" class="seekto" data-time="260">4:20</a> i spat out my drink haha thats one way to make learning memorable!!

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Talk to your doctor to assess your risk factors!

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