Anti-double Stranded DNA (Anti-dsDNA) Antibodies - Systemic Lupus Erythematosus (SLE)

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Anti-cyclic citrullinated peptide (anti-CCP) are autoantibodies that are present in the serum of most patients of rheumatoid arthritis...These anti-CCP antibodies are not sensitive, but they are very specific.
Citrullination is a method of post-translational modification (PTM) in molecular biology...Modifying arginine into citrulline via deimination (not to be confused with deamination).
Rheumatoid factor (RF) is an IgM autoantibody against the Fc portion of IgG. "an antibody against an antibody".
Rheumatoid factor (RF) is present in 80% of patients with rheumatoid arthritis (RA), which makes this test 80% sensitive.
Rheumatoid factor (RF) is not specific, because it can be seropositive in many diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), sjögren syndrome, interstitial pulmonary fibrosis, hepatitis B infection, essential mixed cryoglobulinemia, infective endocarditis (subacute bacterial endocarditis or SABE), tuberculosis, infectious mononucleosis (mono) and hematological malignancies...This, by definition, is non-specific.
Anti-neutrophilic cytoplasmic antibodies (ANCA) are IgG autoantibodies against the cytoplasm of the neutrophils and monocytes.
This is different from antinuclear antibodies (ANA) which are antibodies against the nucleus.
Anti-neutrophilic cytoplasmic antibodies (ANCA) have several patterns; the most important two being the cytoplasmic ANCA (c-ANCA) and the perinuclear ANCA (p-ANCA).
Anti-neutrophilic cytoplasmic antibodies (ANCA) are associated with vasculitis, such as granulomatosis with polyangiitis (Wegener granulomatosis), microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss), rapidly-progressive glomerulonephritis (RPGN), anti-glomerular basement membrane antibodies (ant-GBM or Goodpasture's syndrome), as well as inflammatory bowel disease-associated. vasculitis.
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In brief, Rheumatoid factor (RF) is more sensitive, whereas anti-CCP is more specific for rheumatoid arthritis If you like my videos, please consider leaving a tip at www.paypal.me/...
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[@MedicosisPerfectionalis]

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[@brk0093]

Really useful one..plzz do make tutorials on nervous system

[@MedicosisPerfectionalis]

Ok 👌

[@Sam-jw8mq]

Patient with RA can become anti-dsDNA + when treated with TNFα inhibitors :) Thank you for these valuable videos

[@MedicosisPerfectionalis]

You're very welcome!

[@ThatsWhy-]

Is it because that, if TNFà is inhibited , anti-dsDNA will be increasing? Then, give the patient balilumab to knock down the nasty antibody!!!! Right?

[@adrianlorenzosalvador9824]

It is when patients with RA taking TNF-alpha inhibitors because intake of TNF-alpha inhibitors may show as positive Anti-dsDNA. Just started watching medicosis perfevtionalis and it really helps me study. thank you so much

[@nwabuezeozuzu6370]

Your videos have helped me understand rheumatology a lot better now. Thank you!

[@MedicosisPerfectionalis]

I am honored!

[@siddhipatil5172]

You are truly a Godsend🙏🏻 thank you for helping a lot of students. I watched Rheumatoid Arthritis on your channel and it has still stuck with me as the best teaching I have ever received.

[@MedicosisPerfectionalis]

I am honored!

[@ItsMe-jr6kd]

im just wondering why some ppl dislike these amazing videos !

[@lucylou9030]

This man is a genius. No messing.

[@MedicosisPerfectionalis]

Thank you 😊

[@whachamacallitis]

What else besides Lupus can cause high DS DNA antibody widespread pain and fatigue?

[@grantgoldberg1663]

That's a mouthful.

[@anomalyp8584]

6:20 you mean less specific? Since normal individuals can have a + dsDNA test (false positive result) that would lower the specificity, not the sensitivity (which suffers under false negatives).

[@carolavila3590]

Thank you for the information and your humor :)

[@MedicosisPerfectionalis]

You’re always welcome, dear ☺️

[@gamaltaher9714]

Thanks

[@fokorali6739]

Thanks from Iraq

[@MedicosisPerfectionalis]

You’re welcome 😊

[@paws4life928]

How can it be a very specific test if normal individuals can have positive anti dsDNA?

[@puddincakes1005]

So let’s say a patient has a low pos ANA, but normal CBC labs and such. If a patient has a pos anti-dsDNA ELISA, but then a negative anti-dsDNA CLIFT, would it be considered a positive if they seem to have symptoms? I get the difference between the test types (one is more sensitive and one is more specific), but not sure what one pos over the other would suggest…

[@user-el2jf5oo3u]

How can someone have negative ana and antidsdna if it’s part of ana? I’m the rare one sadly. I have cutaneous lupus and consistently positive antidsdna so they diagnosed me with lupus-like disease. I also have a malar rash. They are now checking me for neurolupus because my symptoms are rare and atypical.

[@yanbingzhu2550]

Hi medicosis, I purchased the entire SLE video from your website. I got a link after I paid for it. However, now I cannot find the link any longer. Could you help me please?

[@MedicosisPerfectionalis]

Please email me: [e-mail]

[@b7san7san95]

RA pt show +ve anti dsDNA when he Rx with anti tnf.. And Thank you!

[@bhawanabudha2512]

very helpful thankuu so much

[@MedicosisPerfectionalis]

My pleasure!

[@bhawanabudha2512]

@@MedicosisPerfectionalis can you please make video on anti phospholipid antibodies or just tell me right now

[@fredpasini5537]

Yeah pt with RA can develop high level of Anti dsDNA if he or she treated with a-TNF 😇

[@ThatsWhy-]

Why? Or what do you mean?

[@clarysgianne2591]

Thank you for your information. It is very helpful and i like the way you explain it. I want to ask about borderline anti dsDNA in a lab test. What does that mean?

[@mirelleinisrael]

Did you find out?

[@mah5688]

Thanks you so much

[@MedicosisPerfectionalis]

My pleasure 😇

[@alaakhdir6672]

thank you for your great Videos they HELP so much, and for the answer: Because That patient who has RA may be on treatment with TNF-alpha like infliximab so if a patient is recieving TNF-alpha for any reason they may show positive Anti-dsDNA?

[@felixdakatt6995]

Hi, question. Right away you state, never repeat ana test. If repesting other tests is recommended why not ana. You not cover detail. Can anyone answer? Thanks . great info!👁👁

[@lucylou9030]

I'm not a medic but I think it's because changes in ana don't reflect disease activity.

[@ThatsWhy-]

Is lupus nephritis is vasculitis-wise? So, what about nephrotic and good-pasture syndrome "GBM" ? Please clarify it to me

[@noorhamed4690]

Amazing video👍

[@MedicosisPerfectionalis]

Thanks 🙏

[@prachisharma3600]

Thank you so much:)

[@elbert5208]

nice content

[@MedicosisPerfectionalis]

Thank you for your continuous support!

[@kitchenvalley7793]

Anti DNA injection kokhon dea hoi baby r heartbit asar age nki pore?

[@priyaashishful]

TNF ALPHA INHIBITORS USAGE

[@leroyanthony1208]

How antibodies enter cells and cell's nucleus ?

[@MedicosisPerfectionalis]

Antibodies are proteins (i.e. water soluble). Water soluble molecules are still capable of diffusing through the membrane (especially if they are tiny particles), but very slowly. Another possibility (this one, I am not 100% sure about), if a cell has antibodies on its interior, then during cell division, it’s possible that the new cell will borrow some of the antibodies.

[@leroyanthony1208]

@@MedicosisPerfectionalis I read this afternoon some articles about my question, and actually it's complex. Even in 2020 the mechanisms are not completely understood. I have found a new concept called the TransmAbs ( monoclonal antibodies ) which is very interesting, and other things.

[@hermionegranger1861]

In Robbins Basic Pathology they say that there is no evidence for Anti nuclear antibodies(ANAs) which are involved in immune complex formation entering intact cells. What happens is defective apoptosis leads to exposure of nuclear materials where then ANAs can bind.

[@Exodiaright]

Totally helpful

[@MedicosisPerfectionalis]

Thanks 🙏

[@adwaithshanmugan9413]

lupus infected person can join for civil service course .any problem. plss answer

[@MedicosisPerfectionalis]

I don’t know 🤷‍♂️

[@hananbasheer7720]

wow amazing videos/ tutor/channel---> thanks , may god bless u

[@MedicosisPerfectionalis]

Thank you so much!

[@Anon.G]

My antidsna is so high it's out of the range :(

[@AllysaLoweMusic]

I just scored equivocal (5) on the Anti-dsDNA test. Does anyone know what this means? Additional info: Negative ANA and complement C3 serum is 101. My kidneys "look fine." Have high LDL which is bizarre for a young, active, whole-foods Mediterranean-style diet person.

[@BizzyIzzy87]

Got the antibodies haven’t been diagnosed with lupus, it’s been ruled out.

[@MedicosisPerfectionalis]

Awesome 👏

[@wanderingdoc5075]

I was also tested positive for it, and I'm freaking out.

[@BizzyIzzy87]

@@MedicosisPerfectionalis well the thing is i been feeling “off” for years

[@AshishRanjan-tx5tc]

I have anti CCP negative, RA negative but anti dsDNA is postive, and ANCA&PNCA is negative then , is it Autoimmune disease please reply

[@zyprexa5mg]

Did you find your answer? Do you have any autoimmune diseases? I have anti ccp negative, RA negative but anti dsDNA positive too. :(( Please answer me.

[@irfanirfi7227]

Is there any symptoms? Joint pain? Rash? Skin problem? Hair loss?

[@emanuele2398]

🤠🤠🤠🤠

[@stephenprice3357]

talk too fast

[@MedicosisPerfectionalis]

Thank you for your honest feedback!

[@bharathir330]

Still i hear him at 2x😅

[@Anon.G]

I watch at 2x

[@codrut913]