Meet the biohacker using CRISPR to teach everyone gene editing

Meet the biohacker who wants to teach everyone how to edit genes
Josiah Zayner is a biohacker who thinks everyone should be able to change their DNA with biotechnology called CRISPR. That’s why he founded a company called The ODIN, which sells do-it-yourself biotech kits that teach people how to genetically modify bacteria and frogs. It's DIY gene therapy.
His company has sold tens of thousands of experiments using CRISPR, an inexpensive and precise gene-editing technology that has revolutionized the field.
Find more on CRISPR at Quartz
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[@Qznews]

We have the full field guide to Crispr at Quartz qz.com/guide/gene-editing-biologys-gold-rush/?

[@calvincertainrubaya4288]

Hi how can I get Crispa case 9

[@lucagheoc7485]

A

[@adeelmehmood7439]

@@calvincertainrubaya4288 same my question

[@HermitKing731]

do you know if crispr will be able to change a persons sexual orientation some day? i was born an asexual freak and am hoping some day to be able to get rid of this mental illnes and be normal.

[@petergunn9603]

Could CRISPR be used to scramble not repairing the mitochondrial DNA of cancer cells to cure cancer? Essentially starving the cancer cell.

[@John-un3lj]

I'll take one Spider-Man-Conversion-Kit please.

[@thetestdumby2981]

John SAME!!!

[@rauld9738]

That’s exactly what came to mind when first seeing this

[@patrichausammann]

I'm going for a Deathpool kit, but please without cancer.

[@Nyarlathotep_Flagg]

Sounds cool, except for when he turns into giant spider-monster. Personally, I'd be more into the parts that focus on true rejuvenation. Which is basically the hack that stops aging, cancer, genetic diseases, the whole package.

[@SeaJay_Oceans]

Woops, turns your white blood cells into venom sacs... you died. (no posthumous refunds)

[@realestateinvestordiyer8149]

This man is the perfect example of a mad scientist

[@ExistenceRoblox]

Thats what i was thinking!!3oekosjfl2ospwododh268382jehhcysge

[@fouadmas5413]

Many people around the world have been injected with gene editing technology due to the Pandemic

[@SoFloEnzo]

Me looking this up so I can create myself a superhuman with super memory and super fast stamina aswell as muscle

[@DontTrustGlitch]

@@SoFloEnzo nah you're finna die trying

[@EMlNENCJA]

We don’t yet have it narrowed down which genes are connected to greater IQ, but I guess we could take some samples from mensa community and some from the test group to check for significant corellations. Also, we already have it narrowed down that there are certain hemoglobin modifications that increace stamina and also there is an athletics gene, so I guess, if not for the controversy, Your request could actually one day become realistic for our grandchildren. 😁

[@richardshane456]

Are there any laws on the planet that will prevent or forbid me from creating a million frog army? Solely for my protection .

[@i_cant_fucking_find_a_good1938]

I hope not I want an army of ferrets

[@dontcheckmyprofilepicture1126]

I want an army of catgirls so I can be the ultimate simp.

[@caylya7869]

@@dontcheckmyprofilepicture1126 you virgin weeb

[@aleeburitz7310]

@@caylya7869 Aww daaaamn 🤣!

[@MrSeth166]

I can't imagine just to keep alive one million frogs per say

[@nyfries]

it been a couple years since he started experimenting with gene editing to increase his muscle. Doesn't look like he has gain anything. But his mentality of making this technology available to the mass is still interesting. Tinkering has always been the origin that world changing discovery

[@johnporter9034]

Well there is a possibility of it not being his genetics at fault but the amount of protien in his diet to build muscles. This his editing could of work but his diet is just not supporting the muscle increase. It often little overlooked things that cause hiccups.

[@caseycrawford6538]

He did one injection. It would take daily injections for months to be enough to saturate the muscle cells to the point of growth.

[@spidey5385]

Nope you can use uv light to activate dendrimers with a lentivirus that creates a chain reaction turning on and off certain genes 🧬 creating the perfect body more on this later but to do this you need a weakened immune system which is possible for this I will say the subject has been eating a lot of fast food and not been eating healthy and then a 2nd injection of dendrimers (no specific order) that carries important vitamins and minerals like vitamin c vitamin c and parathyroid hormone testosterone (now back to “first “ injection) mutation of the acvr2b gene allows proteins such as myostatin to be suppressed while increasing production of follistatin leading to to growth in muscle mass allows proteins such as myostatin contractile proteins like actin and myosin need to be significantly heightened enhancing strength a higher expression of the actn3 which encodes a member of thalpha binding protein line increases the volume of fast twitch muscle fibers. the lrp5 gene 🧬 is changed resulting in denser bone formation without sacrificing functionality this gives him incredible strength estimation that he can lift 3 tons easily The body produces protein chains mainly consisting of glycine and alanine blocks weaved through his skin muscle and organs giving him superhuman durability in addition his body makes excess of mg53 proteins giving him super healing peters cardiovascular system is overhauled with genes altered for higher production of blood for better hydration and higher concentration of oxygen automatic metabolic responses that regulate body temp and higher mitochondrial count all of this increases his stamina and endurance genes changed for higher production of glial cells And a mutation of the rutabaga 🧬 allowing for improved neural pathways to store memories longer and a general neural plasticity improvement greater strategic thinking and instantaneously calculate and the dec2 gene is altered allowing the subject to function on fewer hours of sleep. And switching off the p21 gene to slow aging. What do you think?

[@RoboPutinPresidentinCE]

@@spidey5385 daaamn where i can I learn more about the genes or the field where should I go /what should I look up

[@gotaro69]

@@spidey5385 what is your major:3?

[@curlyhairdudeify]

He should go full cosmetic industry; eye color, hair color, height, skin tone..... He would be making BILLIONS of dollars.

[@CommandoMaster]

Impossible to do those things at this point. Doctors cant even grow skin yet.

[@nathanialdodd]

Commando Master yes they can

[@curlyhairdudeify]

@@CommandoMaster That should be extremely easy to do. You are dealing with melanin, and melanin levels. The perfect example is vitiligo, and as for growing (height) create a way to make the body release more growth hormones during puberty.

[@namedyukinne4398]

@@nathanialdodd but have they fully succeeded???

[@DTheCritical]

Don't forget about body hair removal (alopecia specially designed)

[@aa235]

It’s more dangerous and intimidating if the tech is only controlled by certain small groups of ppl no matter who they are

[@starship3812]

Best self gene editing techniques is carrying uranium in pockets. Aur witnessing atomic explosion so that you gene modify and these modified trait can be passed to your children.

[@thegovtdoesntcareaboutyou]

Cr

[@thegovtdoesntcareaboutyou]

Fr

[@abel3557]

The tech can be done by anyone.

[@mattheww797]

we need to edit human children dna to be better prepared for the future. Combine with other animals like octopus or bird dna

[@cycleTheHike]

First of all what he said completely makes sense and he's not promoting causing damage, he's promoting sharing knowledge and learning. I see a lot of people aren't listening to what he's saying, but are either assuming things when they know nothing about the person in the video or talking about dangers of missuse. People die from staircases as well but he's trying to learn us how to use it whereas the institutions are telling you to stay at your place and call them whenever you need to use the stairs and pay for the help crazy sums of money so they can learn more and you just stay locked inside the whole time.

[@starship3812]

Best self gene editing techniques is carrying uranium in pockets. Aur witnessing atomic explosion so that you gene modify and these modified trait can be passed to your children.

[@johnlopez2028]

Exactly, not his fault if some people don’t follow precautions and just have poor common sense.

[@Hth478]

If people werent reckless in the past, we wouldn't have the tech we do today. Keep it up, dont be silenced

[@starship3812]

But self gene editing techniques made the effect's like carrying uranium in pockets. And like witnessing atomic explosion so that your's gene gets modified(or gets destroyed) and these modified(or destroyed) trait can be passed to your children if it's get happened to somatic cells

[@daguys7695]

@@starship3812 wtf ?

[@anonamemous6865]

Ehh not until hitler gets reckless

[@cosmicrider5898]

has anyone heard anything on those Chinese twins whose embryo was altered with crispr.

[@Qznews]

Quartz has more CRISPR coverage here: qz.com/guide/gene-editing-biologys-gold-rush/?

[@april8940]

Just did a paper on it. Nothing new since December that I could find.

[@user-zo8hs4yh2h]

He got 3 years sentence to jail

[@bodyofhope]

@@user-zo8hs4yh2h seriously? 😯

[@user-zo8hs4yh2h]

@@bodyofhope yes, Google it

[@JustinAndCars]

What amazes me is that they literally are still learning more about our cells and CNS every year and we just think changing millions of years of DNA is not going to have huge effects?

[@autosneak1618]

U knows what a GREAT idea? Give that to the average joe, might kill himself or ruin his genetic baton, but he might achieve a breakthrough!

[@KushWings]

You’re acting like that DNA hasn’t changed in millions of years. You realize that it’s only been 2,000 generations since humans left Africa? That’s only 2,000 levels of ancestors that separated every group, race, ethnicity in the world. All with specific adaptations to their local populations

[@G33K177]

Can't trust anyone with frosted tips

[@alprazolam1446]

He probably changed the genetic melanin level of his lips

[@Legalisenuclearclams]

Don't disrespect guy fiery like that

[@ktolwal]

he looks hi af

[@enigmafairy]

y’all really out here forgetting Albert Einstein’s hair looked like that..

[@thedutchman8793]

So you're saying you can't trust anyone who has an opinion that differs from your own?

[@markfrellips5633]

Listened to the podcast highlighting this from Quartz earlier in the year. The video is clearly more impactful. The issue and subject is very interesting and presents a conundrum. Thank you for the reporting.

[@Qznews]

Thank you for watching!

[@dboyatl285]

@@Qznews can this delete hsv2

[@Lima547]

I was born with PKD, a genetic disease, and 4 weeks ago I had my kidneys removed. So, for me, science is the only way I survive today (dialysis) and that will enable me to survive tomorrow and keep loving my family!

[@DerekFolan]

I think he just wants to sell kits

[@DerekFolan]

I mean what has anyone done with crispr, its been years now , Has anyone crispr'd any new drugs for super intelligence or super happiness ? Apart from injections HAS anything happened?

[@nsof9147]

@@DerekFolan Look up CAR-T cells (chimeric antigen receptor T cells). They are T cells genetically modified using CRISPR to fight cancer. Patients with ALL (Acute lymphocytic leukemia) and other types of Immune cell cancers are basically cured with this tech. This is just in the field of oncology but it's permeating in almost every cell based industry (medicine, agriculture, research etc.).

[@karebu2]

For 30 bucks? Cmon he's a PhD.

[@optopianlabs9435]

@@DerekFolan 1.someone just used it to make twin babies hiv resistant 2.a virus in the banana genome was just destroyed with crispr 3.its currently being used to develop better antibiotics(super bugs will be a problem)

[@optopianlabs9435]

@@DerekFolan science as you may know moves slower than most things due to ethics ,government and just the 1000s of test you have to run and billions of dollars you have to spend but make no mistake crispr has made some strides in the very short time it's been around it just takes a little while to hit the consumer market

[@cd8467]

bro this sounds like the plot to a sci-fi horror movie

[@MistakenMystery]

It is and it's happening right now with this covid vaccine

[@dtpgameing5096]

@@MistakenMystery a covid vaccine is chemicals not genetic spliceing

[@MistakenMystery]

@@dtpgameing5096 it's chemicals and cell manipulation. Everything is chemicals.

[@dtpgameing5096]

@@MistakenMystery no its chemistery and this is about geneticly spliceing cells are just apart of an organism bro

[@ArcticZombie]

@@MistakenMystery Stfu

[@dalechester2904]

In my opinion I believe genetic engineering should be available for anyone who seeks to make improvements in their bodies

[@dalechester2904]

@Ante D 🤣🤣🤣 it comes with age

[@dalechester2904]

@@xdarthpool6463 thats no good man, see a doctor and think about gene therapy

[@Ken19700]

He comes across as someone who shouldn't have been able to get his Ph.D.

[@smiley8106]

l l some people surprised you

[@enigmafairy]

l l ok boomer

[@lightbeareradonis]

Exactly.

[@michaelearthshipman5717]

Keep working on your GED you'll get it.

[@holymoly7118]

Didn't realize there were still people out there so cartoonish that they expect everyone to fit into their two-dimensional pigeonhole.

[@jonnupe1645]

If I can make myself glow in the dark, then I'll be happy

[@Qznews]

We wish you luck with your bioluminescent aspirations

[@jonnupe1645]

@@Qznews thank you 😊

[@jonnupe1645]

@kgb not fbi Maybe, animal testing is out the question, so they're little options left

[@johnporter9034]

@@jonnupe1645 plant testing? Yea not going to be that accurate unless you thinking of things like glowing in the dark.

[@StofStuiver]

Already been done on animals. Luciferase

[@fakeapplestore4710]

Damn. PhD in biophysics. Goals

[@april8940]

This guy has just watched too much Rick and Morty

[@Qznews]

Interesting feedback!

[@alessandropinelli2927]

THIS GUY comes from NASA

[@viratverma7518]

Or maybe you did resident evil

[@pffft8073]

As a Biology student, I can't agree with this guy, you can't just give people with no education on lab safety and such to do this, they might hurt themselves

[@spacesoup6797]

lol calm down stalin if i want to hurt myself i will

[@daguys7695]

@@spacesoup6797 exactly 😂

[@mrthugamer7603]

You can introduce diseases that could show up inmediately, or after a couple of years, but you don't know what it will cause. Giving random people the power to alter DNA, without any constrictions or security measures.

[@colonagray2454]

Certain genes can be passed on too. I think that should definitely be a line we dont cross. Who knows what havac that might cause for future generations.

[@GiRR007]

@@colonagray2454 We can just fix it later.

[@Draven.G]

​@@colonagray2454only with germinal cells not somatic ones

[@orca._.]

I’m a loyal customer from Odin. It’s an amazing company! To be able to genetically engineer as a high schooler, it’s led me to enable my dream to be an entrepreneur and fighter against climate change.

[@hunter21331]

Did he lost his eyebrow on crisper?

[@onesandzeroes]

I think his ear grew a row of earrings.

[@dgr8flav]

@@onesandzeroes Like Wolverine grew claws.

[@tarruvi]

Arguably, it’s better having more people interested and able to participate in any scientific field. A lot of scientific, and life saving discoveries were made by accident, and by people willing to take risks. Shake things up, maybe the next grand scientific discovery will be by someone who loves running experiments in their garage. The scientific field isn’t a private club, it’s something everyone can get their hands on if they apply themselves and everything we know to get results. (Results may vary, of course)

[@yiannimigias4024]

With a degree in Molecular Bio, I think the idea is great but the execution is bad. I like people like Josiah that push the boundaries of science and ethics. In large, the ethical component to research hinders the progress of humanity. So this approach breaks down those walls. But it's unsafe to allow people with little to no knowledge to inject themselves. Also, Crispr isn't perfect, so there is a risk of causing severe genetic damage that could inadvertently be passed on to future generations

[@denisdenak]

"The ethical component hinders progress", duh, that's the whole point of ethics. Last time we let go of ethics we ended up with 80 million dead.

[@tbotwest]

People thinking that they can edit their DNA at home. Well this will definitely teach them about natural selection.

[@snackers7]

And the best part is he doesnt denied it!

[@addie6400]

I randomly got recommended this today, but what's funny is I just ordered an ODIN kit a few days ago. Cool to see the people behind it

[@pflh2391]

99% of them already know what they're going into. they even already know that those experiments might be their death sentence in case of things going wrong. i would rather die because i've overcome my fear & chase what is important to me instead of living long enough to die with regrets

[@anjaninator]

"R.I.P to Jim, who would rather die than live the rest of his days with a 1 incher"

[@redone9553]

Changing eye colors is not something worthwhile to die for

[@Alexander-gx4cu]

"the majority of the people, you know, won't kill them, but thats the majority" Also him: "It's not something to be afriad of"

[@MichaelHayesagent]

Yea the world isnt black and white. Its 50 shades of gray and is nuanced. You wont get very far if you cant hold opposing ideas in your thought process.

[@symphonyinrose]

Yeah, I caught that too. He sounds insane and reckless with statements like that. You'd have to be a fool to inject yourself with whatever he's selling.

[@luiser370]

I wanna do this when im older! When i do i wanna call my company Umbrella ^^

[@another90daystochangethis34]

I'll be the last wild type man living in the forest while everyone is a walking GMO.

[@onesandzeroes]

Congrats. I'd rather modify myself because I'm fucked up.

[@RobertMorgan]

Walking? That's so late 2020s. Everyone uses their wings now, boomer.

[@dgr8flav]

All living organisms are products of genetic modification. Just look at yourself in the mirror and then look at your mom and dad.

[@jimboone6405]

Hlith Skjalf have fun getting nuked by the Samson option

[@yeetman4953]

@@jimboone6405 lol what?

[@mya262626]

The thing is in the beginning, people always freak out about new technology, but you have to get over that and see what this mean for us, this should be views as positive thing not negative. Can you imagine if we decided only few people can learn computer program in order to prevent hackers . Look where we are now , pretty much anyone can build apps, we wouldn’t have all this gadget, apps if it wasn’t for computer language available to everyone.

[@_anthrax101_5]

I don't really like the negative connotation toward his work in this video. This guy literally exposed a new scientific field to the public in a remarkably easy way. Good on him!

[@tellingfoxtales]

I'm reminded of a recent biohacker who died testing drugs on himself. I don't disagree with decentralisation, but people have to remember this stuff is hella dangerous.

[@RobertMorgan]

Have you looked recently at the millions who die from tested, 'safe', approved pharmaceuticals....

[@snackers7]

@@RobertMorgan Weird argumentation. Its kind a we dont need privacy at all because everybody is spyied nowadays...

[@martinjimenez7392]

You referring to Aaron Trewick?

[@GodsSparrowSpeaks]

Interesting because the kid who had CRISPER for sickle cell anemia - $2 million PER treatment…

[@crazeeborg]

If you edit the lettuce gene it can make it CRISPR.

[@agiff8690]

crazeeborg shut up lmao

[@crazyformyself9773]

lmao stfu😂

[@Metternich_Enjoyer]

Lmao 😂

[@_anthrax101_5]

lmfao shut up crazeeborg

[@atti1120]

Nice.

[@kamilmikowski8575]

Biotech improvements - YES For everyones use? - What a stupid idea?!?

[@faze0ne844]

well they created the covid shots based on this tech .. , did it help ? no .. everybody that had the boosters almost all have generic cancers now

[@CommentRodent]

I'm learning about this in school and it's really really interesting going into depth in the CRISPR topic and studies.

[@BrittBrattBossLady]

What class are you learning about it in?

[@CommentRodent]

@@BrittBrattBossLady I go to an alternative school and I learned about it on living Earth... That's all I'll say.

[@blackdagger7332]

I want to be his student.

[@cejasdeatol]

He is the perfect definition of a pioneer. Exploring unknown forbidden lands that no one’s wants to, because is forbidden, and you need to go agains public opinion to do that.

[@ishmilky6287]

“This will give me muscles” yeaaaaaa I don’t see anything ;-;

[@onesandzeroes]

It's the same with all those gurus. All talk, but no proof.

[@RobertMorgan]

Even those with all the genetic predisposition in the world won't be jacked without work and effort. That's why it's called POTENTIAL. Potentially your genes could make you intelligent, strong, smart, so on, but not on their own. A foundation is not a house.

[@bobbyhill4118]

Robert Morgan exactly! I’ve been building muscle for long enough to understand that. A year ago I couldn’t even deadlift 120lbs, now I can do close to 300. Still getting better too. And I can curl 50lbs with one arm and do 80lb weighted pull-ups.

[@carso1500]

@@bobbyhill4118 well now imaginé if you genetically modify your body so that your potential was even bigger

[@bobbyhill4118]

carso1500 I don’t think so. There’s a big potential for it to screw me up or give me cancer. I think I’ll just train my natural body further. I’ve already benched over 200lbs and I’m really close to a 400lb deadlift with my last personal record being at 315. I can leg press 400 easily though. I’m still only 16 years old so my potential is still bigger.

[@biohackshq4072]

Biohacking can be described as citizen or do-it-yourself biology. For many “biohackers,” this consists of making small, incremental diet or lifestyle changes to make small improvements in your health and well-being.

[@slader-hl1kk]

I agree with him anyone should be able to buy the kits and anyone should be able to do anything they want to themselves its there body. also i think that it is really good to have millions of people being able to experiment in there homes, I guarantee it will jumpstart the world into gene modification and will help science move forward at an amazing speed compared to before when only scientists and big labs could expirement like this now anyone can and it will cause the human race to excel in bio-engeneering, and gene modification. It could also help save the lives of animals that are going extinct due to pollution or anything else we could modify there genes to help them survive, same for people with genetic anomalies crisper could solve every problem on this entire planet. Not only animals and people but it could also help with pollution, if we could modify more bacteria to eat what we want them to like plastic, yes i already know we made a bacteria that eats plastic but we need to make them better and be able to programe curtain things to eat what we want them to eat there is just so much good this could do.

[@Callummullans]

I also agree we should be allowed to make our own decisions that ensure our own survival and longevity, especially when it is not at anyone else’s expense. If this knowledge was banned or outlawed it would be like telling people only the select few deserve to eat organic food so there will no longer be the option at the stores.

[@babyfox205]

I agree it can cause a zombie apocalypse

[@christopherorosz795]

Would it be possible to genetically modify a tree to increase its rate of converting carbon dioxide into oxygen? Would it be possible to genetically modify a organism to convert carbon into oxygen at a fast rate by inserting genes of another organism that does so on the planet?

[@autosneak1618]

That's the correct use of crispr

[@f-man3274]

As a man with some medical background, I can say that sensibilization and all other consequences can occure, especially if you keep in mind that this stuff is not FDA or other control organization approved and that it can't be purified properly and sold for such amount of money. Also if you want real changes, you should extract the right type of cells (stem ones, usual won't work in 99%), purify, transfect them (add the CRISPR-Cas9 system inside, it is actually very complicated to perform even in a lab), then pick the successfully transfected ones and after deliver to your body (even this is VERY simplified explanation of the process). But why to think about all dat egghead stuff if you can just order some strange substance from biophysician (I don't even know if his education allows to do such things, it is area of molecular biology/medicine) and then inject it into your abdomen, thinking that this will prevent HIV?

[@joedart1465]

Well here's a question. Should the FDA be allowed to slow things down until life saving medications get stalled in the pipeline and people die as a consequence of their not being made available? Take a look at how long it took for the current rabies shots to be approved in this country. It was decades after it was being used in Britain. The Pharma/academic/FDA research complex needs a complete revision because medical progress is far too slow as it stands. Every time an administration says they are going to focus on solving some medical condition (like cancer) the whole things grinds to a halt when it goes into the approval "system." That needs to be changed because it is killing people. One way to change it is to create a new group of biological researchers who augment the current system. That is what I believe we are talking about here. It's a new concept that needs time to work itself out, but don't crush it before it blossoms.

[@f-man3274]

@@joedart1465 man, I know how the things work and I kinda agree that they can sometimes be slow. But you should better leave the expeiments with such things at least to some competent researchers, because such biohacking in non-lab conditions just won't be effective, though dangerous anyway

[@HermitKing731]

i know this sint related to what you said but do you think crispr could one day change a persons sexual orientation? im asexual and am really hating it.

[@Lorant1984]

I would not underestimate the speed at which technology improves nowadays.

[@jacobzimmerman3492]

The kits are mostly to do things like make a plant with red leaves, none of them are at all intended for human or animal use

[@krupali607]

I kind of wish there was a project that lists all possible molecules and genes that lists all the different variations in molecules in terms of it’s result and usefulness and likeability as well as genes in terms of its result and usefulness and likeability

[@arafchowdhury3634]

2:29 that's a very complicated way of saying steroids

[@threes5031]

Rather than testosterone manipulation, if he inhibited his myostatin genes, which are responsible for limiting muscle growth, he could grow muscle by just doing his normal routines. This is potentially dangerous though, as cases of low or no myostatin are often detrimental rather than advantageous.

[@gregorymalchuk272]

@@threes5031 Another guy did a conceptually similar modification to mice that actually increased their lifespans by 14%.

[@MikeSmith-zo6eu]

Just learned about this, very cool. Cas9 endonucleous and guided RNA. Cool part is you can potentially use it to remove tumor genes, or mutated inherited genes replaced with normal ones. **this is not meant for fun/outside use. Very rarely used clinically

[@faze0ne844]

but it was used for the covid shots ..

[@ianerixon]

i can't wait for the 'i'm gonna inject myself with mineral oil to get ripped' crowd to discover this stuff

[@Spartaix]

Keep going we need people like yourselves and not these big pharmaceutical company’s init for the money ... Shame on them.

[@nirajgupta9257]

I can clearly see the effects of his experiments on him😂😂😂

[@bryanrodriguezx13]

This could be revolutionary, the more its in the hands of people the better the product can grow and genetic studies can be made, THIS IS GENIUS!

[@christineking8183]

There’s one thing that concerns me, does gene editing genetically change your unique personality? Because my fear is that if people try that, their personality might change.

[@LuxuryLenoxLuditoryLuthorLob]

@golden maknae this will likely cause the masses to obsess over changing they appearance

[@ThatGuyYouArent2]

No.

[@sdmdrums9275]

“Joey grew an eye on the back of his head and a foot on his stomach because he took CRISPR, but worst of all, he’s not as nice as he used to be.”

[@MrFoxGuy]

@@sdmdrums9275 he never says bless you after someone sneezes anymore

[@GiRR007]

I mean it can if the genes you are altering have something to do with your brain matter. For example if someone changed a gene that made them prone to depression into one that didnt. That might end up changing their personality.

[@raphlvlogs271]

genetic modification can be an effective way to minimise physical sufferings.

[@autosneak1618]

If don e right by professionals in a lab environment, not some crackhead wanting to genetically dye his hair

[@larrends8297]

Its dangerous as we dont yet know the side effects.

[@KDZ_Prime]

I've taken a deep interest in this field, so I'll be studying biophysics and hey, maybe I'll join him in his lab. Fun times. 😁

[@kennethr6403]

This guy is clearly insane if he doesn't understand the repercussions

[@JustinAndCars]

Millions of years of tweaking cells by trial and error and we think we can just change that without nothing going wrong lol

[@twerkinalisha7346]

This is the type of people we need, these are the types that will help us cure cancer.

[@dickjones9207]

CRIPSR editing can cause cancer

[@twerkinalisha7346]

@@dickjones9207 yes, but regardless, cancer is going to happen to millions. We need to start breaking down the bureaucracy to getting research and development done. Look how fast we got COVID vaccines to market after we broke down barriers. I dont support just throwing treatments at people. Obviously doing dudillgence and studying the gene being edited would have to happen first. But if we can identify specific mutation and know which gene needs to be replaced, that's where this technology fits in. There are multiple companies working on cancer mutation genome mapping in mice. Where they can create the exact mutation we see in human cancers in mice using CRISPR (like you said, it can create cancer too). Now they're learning how to treat those cancers. Before they couldnt replicate in mice the same cancer we see in humans. Thats why there was never much validity in the mice experiments because it would never transpire to humans.

[@dickjones9207]

​@@twerkinalisha7346 my bad, I should've said people like this and home kits will cause cancer .i'd argue that a re-evaluation of the currnet medical system (that pushes out new and experimental techniques and drugs, regardless of CRIPSR), is inherently, needing a huge amount of monetary investment (around 4b I think for a new drug to be /created/) to release a drug onto market. Getting dipshits like this that are goign to give you cancer is the problem, medicicne and scientific research shound't be decentralised, leave it to government regulation (this includes fundings of studies to stop companies from coercing researches into fudging studies to prove a certain hypothesis) leave that to bit-coin and bit-torrent, things that actually benefit from being free.

[@vf84tcat1]

Your video still did not explain crispr and how it's actually doing anything for anybody. What is it actually doing? Think about that before you make another video

[@jonathanwilson7724]

Thank you! I still don't understand what these people are trying to accomplish. What does the product actually do!?

[@republic-ld3hq]

Jonathan Wilson they are trying to make money the things this guy is selling is useless.

[@chr_isx1953]

vf84tcat1 They way he uses Crispr is just by changing his own body, he doesn't explain that it can be used to get rid of genetically passed diseases, HIV, Colorblindness, etc. Yes, the video did seem vague and made it scarier than it actually is. They could've have gone in depth about how it works and how it can change the whole world.

[@CommandoMaster]

Injects into ur body and modify genes.

[@Noobrobloz]

So basically, they have this cas9 protein complex, which is guided by an RNA (protein?). Scientists try to see the genome sequence (TCAAGAATCCG...). and see which strand is causing a problem: the RNA protein then guides the cas9 protein to that specific strand, and cuts it out.

[@wyomii]

Strong "HI EVERYBODY"vibes with this one.

[@jjmc00]

Yeah... injecting yourself with CRISPR, even if you designed it to insert a gene to 'increase muscle mass' (of which I don't think there is one gene for this) without a proper viral vector that can bypass your immune system will absolutely not work and will absolutely not help your muscle growth. Your immune system will just eat it up. Honestly this guy seems borderline similar to those people who sell Himalayan rock healing crystals He's just appealing to people's fantasies about superheroes getting radioactive spider bites and stuff. This stuff is hard enough to get to work in a lab

[@RoboPutinPresidentinCE]

The guy above this comment named more than a few genes that could enhance your body. You don't seem to be familiar enough with genes or gene editing to just claim that there isn't a gene to enhance muscle growth.

[@atomicash2475]

@@RoboPutinPresidentinCE less enhance then remove some of the limiter on muscle growth

[@peters7278]

I would compare CRISPR to cars. At first, everyone was afraid of cars. Then, only the rich could afford one. But shortly they started being mass produced, became a huge industry and an economical driver (no pun intended), and currently even in poor countries people can have one.

[@ManosTheOne]

Those "biohackers" have fallen to the deepest canyon of the Dunning-Kruger effect.

[@disturbiathruosmosis]

He seems psychotic to me and I think he is a good guy and I am very proud of him for the great thing he does for me and I

[@FinlayDaG33k]

As with everything, it's a double-edged sword. I love that he wants to be able to help people but I also know that it can go *horribly* wrong if done by incompetent people. I'm not really concerned with biological warfare because those that want to do that can probably already do that if they wanted...

[@GiRR007]

The consequences would more than likely be limited to individuals so i dont see it being that much of a problem.

[@william_8844]

Thanks for promoting him

[@mangarific1]

He's doing this out of self interest. Malevolent people with the right knowledge and background can use this in terrible ways. Bio-terrorism and ecological disasters, the consequences of a decentralized or unregulated gene editing technology are catastrophic to say the least. The internet, and software are mostly confined, or many degrees away from the natural world, it cannot be compared to open source code. These kind of technologies have a direct impact on physical reality if misused.

[@parsajavanshiri1079]

u mortal humans couldn't understand the knowledge behind this. this is inevitable work. this is PERFECTION.

[@kysmik8214]

He has my respect, can't wait till he gives us a gene edit to cure baldness and the world will be at his feet!

[@lukerutherford1174]

FOR REAL

[@snackers7]

He wants to be experimental rabbit? Why not. But we must protect from influence of his stupitidy.

[@ZubinB]

Progesterone is the cure for baldness.

[@hauntologicalwittgensteini2542]

@@snackers7 ok coward

[@bruh6828]

I couldve spared myself the whole netflix doc and watched this

[@nagihangot6133]

Such a company would allow the every day man to be able to create his own laboratory and make research without having to get a PhD and be employed by institutions. Ah, shame the future isn't here already.

[@thomasciarlariello]

In of high school I had ambitions of being a genetic engineer only to later able to teach a neighbor boy how make an electroporator transfection machine powered by 9 volt batteries to insert DNA genes.

[@melchizedekpsj]

It doesn't work that way. So stupid and dangerous.

[@casey-gt8nl]

Melchizedek Phuah Siow Jin explain.

[@terrysuk5077]

@@casey-gt8nl well CRISPR/Cas9 has only 1 function - to cut DNA. To target a specific gene you would at minimum need a synthesized piece of RNA for Cas9 to use to recognize a gene to cut it. Therefore two pieces are required for CRISPR to simply cut, but you cannot just inject Cas9 you need an entry system such as a plasmid to express the Cas9 AND the RNA for cutting. Let's just say he has this stuff if he injects it into his muscle the DNA will not likely pass through the cell membrane and nothing will happen. IF it is able to (by some miracle) and it does make it into the cell it will simply cut the targeted gene and the cell will continuously try to fix itself until the gene becomes mutated which could have deleterious effects such as increasing risk of cancer. If you wanted to actually edit genes you would need to additionally synthesize a piece of DNA to use as a template to be edited in which is an extremely rare occurrence in general let alone trying to do it on a human. And at best case scenario this would only happen to a few cells at the injection site and not the whole body as that is a current limitation in science is being able to target EVERY cell in the human body which is required for this to work properly (even if it was possible our current knowledge of CRISPR only allows for a 1/10000 chance of editing without mutations). So realistically all this man is doing when injecting himself is making himself susceptible to infection from the injection.

[@thunderaptor9094]

@@terrysuk5077 I don't like this guy, it makes me cringe. Like, oh let me just alter all my cells dna hahaha

[@terrysuk5077]

@@thunderaptor9094 exactly, like he has a PhD in biophysics he should be able to research and comprehend how CRISPR works, so it just seems clear it's all for attention

[@thr2648]

Big Chungus it doesn't. You don't inject it

[@takumithao1992XD]

Correct me if I'm wrong but I don't think genetic modifications work well on a cellular mature subject; I mean if anything the changes wouldn't be showing until after several months or years. The virus would need time to spread and then the GMO cell would then take time as well to fully proliferate & replace the body as a whole and then maybe the desired traits would start manifesting itself. I think that's the reason why most geneticists works with bacteria/single cell organisms because the results are almost instantaneous due to them being single cell,therefore observable by their next cell cycle. Other larger organisms/specimens were either insinuated at birth or during fetal development to give proper proliferation of the desired GM cell. So if I were to inject myself with a myostatin inhibiting gene for massive muscle growth, I don't think I'll be reaping the benefits anytime soon but my descendants probably will because they were born with it; but that's a maybe...

[@SuperAnimecity]

That frog at the beginning was screaming from the needle. Poor thing.

[@pathumihettiarachchi2184]

I hate the girl who roasting him inside the video started watching it thinking it would be supporting his idea but no what's the point of this video even. For everything, he is saying you're telling its bs and you can see the outcome in this comment section

[@quanmack6332]

If I want a tail and gills and live in the ocean then I feel like I should be able to

[@memecritic5539]

U might be but u might regret how you look :-:

[@slimeinabox]

Can I have one the boost metabolism by about 3%? Increase my idle calorie usage without cooking my internal organs or brain.

[@krish224488]

i wouldnt trust anyone selling me scientific stuffs with that hairstyle..

[@onesandzeroes]

@bangmeister2012 That's cartoons.

[@bellumxyz1421]

bangmeister2012 Nikola Tesla looks pretty stylish to me

[@enigmafairy]

Karthik Mahesh ok boomer

[@bobbyhill4118]

I think there still needs to be numerous trials on species related to humans to see how it could affect people, of all different genetics to know for sure how it could screw up later on for those animals with the things their cells do.

[@Ferenczi69Aron]

00:45 - 01:09 , risk 1: genetic engineering hurting people vs. risk 2: not having equal access to engineering in a world where others are doing it. This is a fallacious comparison as risk 1 is inherent in the situation where risk 2 can occur ie. when people are doing it (required for risk 2) there is also the inherent risk of it hurting people (risk 1). The comparison being given is risk 1 vs. risk 2 + risk 1.....and he argues for taking the 'risk 2 + risk 1', worse yet, it guides his thoughts and actions? So it's true what they say. 'Make something idiot-proof, and the universe will design a better idiot.' The 'Find New Antibiotics at home kit' sounds like a good product though, that's worth decentralising. 04:32-04:44 "Sometimes I still am afraid...it's more a fear that like, you can't control it" Well ***** if you would only control yourself... At the end of the day, it's someone who just does whatever the **** they want in a world where anyone can do whatever the **** they want, so where do we go from here?

[@chrismunns3480]

How can you undo it? Will anything we eat or take make it nul and void like we never had crisper?

[@mirramurthygiridhar2510]

I think he this the Frankenstein doctor

[@goncalopinho4606]

The scary part of this is that this dude is actually graduated...he holds a MSc degree in Cellular and Molecular Biology and a PhD in Biophysics. I would except this kinda of ideas coming from those crackheads who read conspiracy stuff on shady websites, but not from someone with actual knowledge on the field. Anyone with the minimal understanding on how CRISPR works + is mentally healthy, knows how dangerous this dude's idea is...CRISPR is not, at all, a 100% error-free technique...the first CRISPR human clinical trial has started in august 2019...it is still uncertain it's efficacy in human organisms....plus, for sure it must be handled by someone who really knows how the procedure works...not some brunette girl who is tired of her hair color and wants to change it to blond...or by some guy who wants to change his eye's colour.

[@autosneak1618]

Couldn't have said it better

[@iamgreat8181]

This dude is just asking to be wiped out lol

[@aeeevTHEBESTYOUTUBERXDDD]

im waiting for you to say that in english

[@juanvivero4021]

aeeev420 low iq

[@jimmyspillpinchproductions6523]

@@aeeevTHEBESTKZbinRXDDD im waiting for you to get a dictionary lol

[@fazeone1212]

he got promoted by bill gates .. im pretty sure that idiot modified an exonome to create covid19 ..

[@SeaJay_Oceans]

So at what point do the white vans and black helicopters show up ? Do governments even know kids are whipping up bioweapons in their mom's kitchen ?

[@deecyp64]

How do I learn it? I want to learn the whole process from deciding which Gene I want to Transfer to isolating it to putting it into the animals Genome. I know the theoretical process but how do I do it

[@ImmDirtyDan11]

Hey man, I was extremely curious about your channel. I have msfd and I'm beyond curious about gene editing and the crispr kit as to how it could be used to cure human deficiencies. I'd love to learn more and interest in your work. Love to take to you more in depth. Brandon Hamilton

[@Show0Me0The0Evidence]

I didn't know Dr Curt Connors had such humble beginnings.

[@Jesker_MRG]

well did he get bigger muscles? asking for a friend

[@hithere9755]

The one and only safe and trustable advice forever : Everyone find their own planet and stay safe. Because always the unexpected happens. Seriously trust me. Don't worry enough planets are there.

[@pratik7456]

🌚wtf

[@Donkeydoodoo42]

is that heath hussar's brother

[@Donkeydoodoo42]

Right

[@bhangrafan4480]

When genetic engineering was first invented in its earliest form, all the scientists got together and volunteered to have moratorium on all such work, pending a public debate and studies on safety. A few years later, responsible people started to apply these techniques to serious projects which had a worthwhile benefit to them. I think they would all be horrified to see the genetic modification of organisms, which is at the best of times ethically questionable, become a fashionable toy for people who have little idea what they are doing. I mean what sort of modifications do they want to make, and how do they think they will actually make them? It is like giving a tool box to someone with no skills and no materials to work with. Gene editing is a means to an end not an end in itself.

[@abhaysharma9317]

We have done so much progress in computer technology but we are still so primitive in Biotech, But I think that things are catching pace and it wouldn't be a surprise in future in one of in ten big fortune 500 companies there would be a Biotech Giant.

[@Qznews]

That is an interesting prospect @Abhay Sharma

[@themesozoicworld6586]

So basically this guy has given everyone the power to be bio-wizards

[@thomasciarlariello]

Science is not magic since your icon ignores how megafauna by Cube Sqaure could have only existed aboard spacecraft so are you Eric Von Daiken of Shaggy God stories?

[@themesozoicworld6586]

@@thomasciarlariello ???

[@Ndo01]

Yeah I don't think he's thought enough about the consequences

[@ho7092]

Natural selection. Let it be.

[@steveng4140]

Just because you’re intelligent doesn’t mean you possess common sense

[@WeirdPros]

Quartz: This man is revolutionizing how Gene Editting is taught and making it more accessible to the Public Everyone: HEY ISNT THAT THE SHIT PILL GUY?!

[@DTheCritical]

Everyone talks about hair loss prevention but no one talks about a way to make all body hair (at least from the neck down) fall out with gene editting

[@domenico4533]

I think same