Melatonin KILLS Cancer: REVERSES Warburg Effect & INHIBITS Glucose

[@DrCaseyPeavler]

Melatonin is a must for whatever paradigm of treatment you decide to employ for cancer. Is that fairly clear at this point?

[@przemkowaliszewski3290]

What is the sufficient dose of melatonin? We take 0.5 mg to facilitate sleep. But in the case of manipulation with cancer cell metabolism?

[@SlotstheMetaphysicalwa]

​@@przemkowaliszewski3290exactly... im sure it's just the normal dose tho😮😮😮

[@drskidzo]

Well, I guess considered the amount of studies that point out at least 7 different mechanism through which melatonin act on cancer celles directly and indirectly, the answer is yes. This being said, I still struggle with the massive dosage that many healhcare influencers recommend for this (180 - 300 mg daily).... I understand that studies shows that there seems to have a benefit at any doses without signifiant side effects, the benefit being higher at higher doses ,,,, very cool indeed and sounds like a major potential breakthrough... but man ... sounds a bit like the far west at this point in time from a clinical perspective as the long term effect of high doses are not known ... This being said , sounds like a very little risk compared to cycling chemo, radio, immuno ...

[@liberty8424]

So how about quoting Dr. Reiter in San Antonio, who's studied Melantonin for over 30 yrs, & who is going to logically tell the public just how much Melantonin stops the Warburg effect?? Y'all are talking in circles, with No shared mg amount of a suggested dose?? After all isn't that the point???

[@raykinney9907]

@@drskidzo Yah, sure seems that way.

[@MFR03]

the crazy part for me after having agressive and non agressive non hodgkin lymphomia (with really bad chemo experiance) plus stemcell transplantation. no oncologist i faced was referring to a glutamin glycolosis pathway...even when i asked them about the metabolism impact they rejected that idea... thanks for that additional insight which keeps my still existing cancer under controll due to metabolic intervention (which they still reject as a working path!)

[@DrCaseyPeavler]

I am sorry for your experiences with Lymphoma, chemotherapy, and conventional oncology. I am glad you decided to take your health back by taking responsibility and control.

[@judwatkins9478]

You are the most knowledgeable and articulate respondant I've ever read on KZbin. I'm praying for your full recovery.

[@sharonkende4774]

I met one doctor that wants to know how on earth i kept my stage 4 cancer from killing me a 8 months after no chemo/immunotherapy. I got one dose of immunotherapy, took egcg and metformin (to block glutamine and glucose) and the immunotherapy I got (keytruda) obliterated the cancer in my liver. This was all under the supervision of an oncologist that sayed it was all nonsense. My new oncologist, thank the lord, wants to know how this happened. I also credit my use of probitiotics. Lately, though, despite my supplements, metastasis is getting a bit worse so now time for melatonin. thank you so much for your help

[@TimothyFreeman-iy8xl]

I’ve always said , the cure for cancer is 2.95$ and they will never tell us . They will be sitting on the corner with a tin cup.

[@stellarblur]

❤

[@mbrochh82]

Here's a ChatGPT summary: - Melatonin can reverse the Warburg effect, a metabolic process used by cancer cells for rapid ATP production, by redirecting glucose oxidation to the mitochondria. - Melatonin inhibits cancer cell growth by downregulating pyruvate dehydrogenase kinase, which is crucial for converting pyruvate to acetyl-CoA in mitochondria. - Melatonin's ability to switch glucose oxidation from the cytosol to the mitochondria can resensitize tumors resistant to conventional chemotherapies. - Melatonin can convert disease cells from aerobic glycolysis to mitochondrial oxidative phosphorylation, reducing cancer cell proliferation and metastasis. - Melatonin production is crucial at night, and its suppression by light exposure can lead to continuous cancer cell growth. - Exogenous melatonin supplementation is recommended in cancer cases where endogenous production is impaired. - Melatonin reduces cell motility and viability in hepatocellular carcinoma by modulating lactate dehydrogenase activity and reducing glucose uptake. - Melatonin blocks glucose uptake and lactate production, disrupting the Warburg effect and promoting normal cell metabolism. - Melatonin inhibits HIF1 alpha stabilization, a key driver of the Warburg effect, and blocks multiple cancer growth pathways. - Melatonin synergizes with conventional cancer therapies, enhancing their effectiveness. - Urinary melatonin levels can be measured to assess melatonin production and its impact on disease prevention and treatment. - Main message: Melatonin plays a crucial role in inhibiting cancer cell metabolism and growth by reversing the Warburg effect and enhancing the effectiveness of cancer therapies.

[@DrCaseyPeavler]

Thanks chatGPT, soon we will all be out of a job!

[@mbrochh82]

@@DrCaseyPeavler nah, I don't think so, but we will all be much better informed, despite the information overload, and have more time to spend with our children :)

[@DrCaseyPeavler]

I can’t help but think of Terminator Judgment Day and Skynet haha

[@LaaraCopley-Smith]

​@DrCaseyPeavler great information and really gives aspects missing from the amazing Dr.Seyfreid protocol. In addition to the D l am still not clear on the amount of Melanin recommended. That's achievable cost wise, high doses may be prohibited for some. Thank you.

[@karimayoubi74]

@@DrCaseyPeavler tbh at times you were speaking a bit too quickly for me to keep up, and the ChatGPT summary was very helpful!

[@BQ900]

Many studies are backing up this hypothesis that melatonin may benefit a whole range of patients!

[@DrCaseyPeavler]

Yup! Evidence is overwhelming

[@johnc.8298]

How much dosage?

[@audreyfischer8662]

I have tremendous respect for Professor Russel J Reiter and his research. I’ve been following his lifesaving research for 15 years. Met him only once when he was the keynote speaker. He is a very kind and considerate gentleman. A true national treasure.

[@DrCaseyPeavler]

He seems like a very humble and friendly person. I would like to meet him in person.

[@jonnyde]

@@DrCaseyPeavler I suggest you get to Austin soon to do that ... he is already close to 90 .. kzbin.info/www/bejne/pHutf2aZabJofJY

[@stanley9794]

You should make the effort to meet dr. Reiter while he is still with us

[@stanley9794]

I meant, respectfully, you as a young medical person, bridging the gap from Dr. Reiters incredible body of work of over 50 years, to now, where this work is re

[@chasethehorizonx]

I love your straightforward delivery. It is so refreshing. No nonsense, just the data. Subbed.

[@DrCaseyPeavler]

I appreciate your straightforward supportive answer. Very encouraging for me. Thank you!

[@chrismacdonald4570]

Me too. Same reason.

[@DrCaseyPeavler]

I appreciate your kindness!

[@martinfinn674]

Dr, Peavler, thank you for bringing this to public knowledge.

[@DrCaseyPeavler]

You are very welcome!

[@ShufflePetro]

00:03 - Melatonin reverses the Warburg effect, reducing cancer cell proliferation and metastasis. 02:12 - Melatonin influences cancer metabolism by reversing the Warburg effect. 04:16 - Melatonin promotes healthier cellular metabolism, inhibiting cancer growth. 06:39 - Melatonin may reverse cancer metabolism by supplementing levels in patients with low endogenous production. 08:54 - Melatonin inhibits lactate production, reversing the Warburg effect in cancer cells. 10:55 - Melatonin inhibits cancer metabolism by blocking lactate production and glucose uptake. 12:57 - Melatonin disrupts cancer metabolism by inhibiting glucose uptake and lactate production. 15:06 - Melatonin enhances cancer treatment by blocking harmful metabolic pathways. 17:24 - Melatonin inhibits cancer growth and aids in treatment management. 19:14 - Melatonin offers significant benefits beyond its common perception.

[@DrCaseyPeavler]

Thank you!

[@WolfmanMack]

I READ THE CHATGTP SUMMARY IN THE COMMENTS SECTION AND AM BLOWN AWAY. THIS DOC IS BRILLIANT. THIS IS A GIANT LEAP IN THE CANCER FIGHT. THANK YOU DOCTOR.

[@DrCaseyPeavler]

Thank you for your kindness and support!

[@NomNomm6063]

There is a cure. Search the documentary “Cancer is serious business”. Blow your mind.

[@Peterslane1]

Dr. Casey Peavler, you are an incredible human being. This material and the way you have laid the ground work and have instructed and informed on every detail of such important information is of great service to mankind. You truly care about the health and wellness of others. Bravo! These presentations are so far beyond the quality anyone would find in medical school. You have a great talent in presenting difficult biochemistry and making it interesting and easy to understand. Thank you for ALL you do. It is so appreciated and hopefully your passion and service causes an awakening in patients and their doctors.

[@donaldkraft7371]

Well said

[@DrCaseyPeavler]

Wow that is very kind of you to say. I am a bit at a loss for words but I appreciate your support. I really hate seeing sick people. I know it’s hard to maybe fathom for a hospitalist/internist to say that, but considering what I have learned at this point, the majority of pain and suffering I have to see daily, I believe is preventable in many cases. If there is some tidbit of a lecture that helps prevent even 1% of that, it is totally worth it. Thank you again.

[@liberty8424]

Dr. Reiter in San Antonio has been researching Melantonin over 30 yrs; this Dr.'s basically repeating Dr. Reiter's work. I do appreciate the repeat of any info, but don't understand why this isn't more widely known..???

[@raykinney9907]

@@DrCaseyPeavler Yah, sure seems that logically, society should be throwing a huge % of medical funding into all the research it can for prevention! First line of defense. Then looking pointedly at root causation!, treatment could follow that in the priorities. Without prevention and root causation knowledge, there is just too much guess work in drug development, often with wrong results...... except the rich get richer. IMHO

[@raykinney9907]

@@liberty8424 Profit margin not high enough?!?

[@jayfigueroa2728]

Thank you doctor Casey for all the incredible work and information that you share.

[@DrCaseyPeavler]

You are very welcome! It’s my honor to share it with you all!

[@patiakreles]

My mannnn!! I see a huge improvement on your talking pace!! Not so fast, varying from time to time. You are also editing your videos and focusing on some things that are really important. Great work!!

[@DrCaseyPeavler]

Thank you for noticing. I am working hard to talk at a more reasonable pace. I talk fast all the time in real life so it’s a real challenge. Thanks for the encouragement!

[@patiakreles]

@@DrCaseyPeavler same bro, same... I talk so fast that my bf tells me that I don't talk, I rap. The struggle is real!!

[@DrCaseyPeavler]

Haha, I don’t rap but the struggle is real!

[@judexacosta686]

In my case when i was a kid i talked too fast bec I think my brain was faster😅😅

[@DrCaseyPeavler]

Haha I’m not going to claim that…

[@clintcarter]

Not all heroes wear capes! Thanks doc!

[@DrCaseyPeavler]

You are very welcome!

[@westcoastswingmusic]

Awesome content and delivery! I'm sharing this with others. 🎉

[@DrCaseyPeavler]

Awesome! I am glad you enjoy it. I hope to use KZbin as a megaphone to get this important info out. You sharing helps me amplify the message, thank you!

[@Rob-w5p]

Truly lifesaving content, can't speak highly enough of this content, ty Casey ✨👌

[@DrCaseyPeavler]

You are very welcome! It is my honor and pleasure to share this information with you all!

[@sharonkende4774]

Also, i like that you show the science behind this. It moves fast but great information. Will watch again to understand in more detail

[@DrCaseyPeavler]

I appreciate your feedback. The series builds on itself. It may be useful to start from earlier in the series if not the beginning for max retention.

[@daveobrien8210]

Go to settings… it allows you to play it back at slower speeds.

[@davidf9630]

Thank you for this series of VERY interesting and informative discussions. I am going in for CT scans on Thursday morning and immediately after I have an appointment with my oncologist. We’re definitely going to fill the appointment to capacity with a Q and A session.

[@DrCaseyPeavler]

I pray it goes well and you get some good answers to your important questions!

[@kimberlybegonia2869]

Oncologists are usually only able to promote the chemotherapy to keep the office money flowing. They might act like it’s ok to supplement but will always push big pharma on you.

[@NomNomm6063]

Thank you! I wish the medical guys that I have met had the time and the heart to break it down like this. I am alone. I appreciate your work very much, doctor. 🙏

[@DrCaseyPeavler]

You are never alone. Even when it maybe feels or seems like that. I am trying to build a community so you don’t feel that way. Many people on here comment regularly and are extremely supportive and bright!

[@fatimabonte-go3vy]

Courage dear you not alone

[@DrCaseyPeavler]

Let us know how we can best support you!

[@abdelilahbenahmed4350]

Watching this exciting video while taking a 10 mg melatonin capsule one hour before bed. I am on it just 5 days and I see the difference.Would be great if more videos are created on the impact of melatonin on diseases and pathologies other than cancer.

[@DrCaseyPeavler]

That’s awesome! Prevention or for some other reason? 10mg isn’t much either.

[@abdelilahbenahmed4350]

@@DrCaseyPeavler Hopefully it 's helpful for prevention and also as an anti-aging tool. Already I noticed the fast clearance of the swelling of my righy parathyroid gland and the increased energy and good mood I have at 76 yrs. Maybe I would in the future even take the maximum I can easily find in the market , which is 60 mg.

[@sabincioflec8413]

Why is 10mg not much? It seems like the body produces under 0.5mg and from other anecdotes ( and my own ) anything over 0.5 can mess up sleep too

[@DrCaseyPeavler]

Context is everything. Some people in this very community are taking 100s and 1000s of mgs per day. I’m not for or against that. It may have its place depending on the clinical situation. So when someone says I’m seeing benefit at 10mg, it seems like not much, which to me is exciting. Hope that clarifies.

[@rhb30001]

It’s dangerous to take it orally according to Jack Kruse

[@Lavasalsa1]

Thank you reading/citing/summarizing the studies and not dumbing-down the biochemistry. I subscribed!

[@DrCaseyPeavler]

I am glad you like the biochemistry!

[@AscensionSeries]

Cherries contain a lot of Melatonin and usually the whole food version of any fruit or vegetable contains other nutrients that help uptake. I'd look into combining Grapefruit with it, maybe chocolate if you can remove the L-Tyrosine (apparently Tyrosine helps feed cancer) both are known to be a hyper absorber, I'm sure there are others.

[@anthonymunafo8653]

Outstanding presentation

[@DrCaseyPeavler]

Thank you for your support! I am glad you enjoyed it!

[@itmaslanka]

In January 2020 I got cv bad for 3 weeks , 70 yo, lost 20#. I took 90 mg a day of Melatonin . 3-4 days I kicked it !

[@DrCaseyPeavler]

💪🙏 thank God

[@pamelabaker3029]

What’s cv

[@itmaslanka]

@@pamelabaker3029 Covid 19

[@WolfmanMack]

YOU ARE AWESOME DOC. PRICELESS INFO U GIVE. REALLY, WHAT OTHER DOC POSTS REPLIES (WITH ANSWERS) TO COMMENTS. NO ONE ELSE. MILLIONS OF THANKS TO YOU. COMMENTS

[@DrCaseyPeavler]

You are very welcome. It is truly my honor to be on this journey with you all.

[@1111andrewjackson]

That was an awesome presentation

[@DrCaseyPeavler]

I am really happy to hear that you liked it!

[@AmitChau81]

Admiration for the depth of your research!

[@DrCaseyPeavler]

Thank you for your kindness and support!

[@mitsurunishiuwatoko7149]

Thank you Dr. Casey. You are an angel.

[@DrCaseyPeavler]

No angel but I am glad you like it!

[@sonkefh]

Absolutely awesome Video ! Thank you !

[@DrCaseyPeavler]

I am glad you enjoyed it!

[@Herbert_Knavs]

You are a rock star. 😃 Thank you. ❤

[@DrCaseyPeavler]

You are too kind! Thank you for your support!

[@ea6051]

i wonder how much of this played a part of the sunlight therapy in the late 1800's, early 1900's ?

[@DrCaseyPeavler]

My guess, HUGELY

[@geviert]

Me too

[@raykinney9907]

Yes, and WHY did we move away from understanding this??? A false accounting of benefits, to bring more 'profit at any cost'????

[@raykinney9907]

AND, now we live in fear of daylight, as a rule, and poison ourselves as society bathed in isolated 'blue light', that our brains see as white light.

[@geviert]

@@raykinney9907 yes (disclaimer: my personal opinion)

[@cristianopalumbo4948]

I remember Di Bella's terapy . He was an italian strange scientist.... He introduced , in his terapies , the MELATONINA

[@DrCaseyPeavler]

Powerful!

[@paultraynorbsc627]

which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed “the Warburg effect.”

[@DrCaseyPeavler]

True.

[@egg399.]

@@paultraynorbsc627 Aerobic Glycolysis isn’t a very good name for the layman. We have to remember no oxygen is involved. It should be called “anaerobic glycolysis”

[@DrCaseyPeavler]

I understand the terminology is confusing. I didn’t invent it I promise haha.

[@F8Tributo]

​@@egg399.How about using the term: "Substrate Phosflorylation"?

[@DrCaseyPeavler]

Dr. Seyfried uses that at times “substrate level phosphorylation”.

[@RashidMalik-LabVIEW]

So all these; antioxidant properties, blockage of lactate production, inhibition of glucose uptake, inhibition of mTOR etc seems to indicate that melatonin supplementation might interfere with exercise benefits like muscle hypertrophy. So it might be better to restrict melatonin supplementation to nights away from exercise time.

[@DrCaseyPeavler]

I would not supplement with it at all unless you have cancer. That is where risk vs benefit comes in. I do not believe it will damage your exercise personally. If you have noticed during this series, melatonin has opposite effects in normal cells vs cancer cells when it comes to ROS, autophagy and mitophagy at least. My gut tells me its further reaching than that.

[@RashidMalik-LabVIEW]

" I do not believe it will damage your exercise personally. If you have noticed during this series, melatonin has opposite effects in normal cells vs cancer cells when it comes to ROS, autophagy, and mitophagy at least. My gut tells me it's further reaching than that." Okay, that puts doubts to rest. Since the Melatonin series has come to an end (I hope for the present only, that is, until something else is brought to light) whats next on the agenda, NAC, Niacin, something else?

[@DrCaseyPeavler]

Oh I have the next at least 45 video planned. Cancer, all cancer, and metabolic strategies to kill it…

[@RashidMalik-LabVIEW]

Awesome! Looking forward to the learning experience.

[@DrCaseyPeavler]

Me too. It’s just as exciting for me to be on the other end. Even though my framework is complete before every lecture I brush up on the material, find new discoveries to share. I learn along side you all.

[@fatimabonte-go3vy]

Thank you doctor keep up the good work

[@DrCaseyPeavler]

Thank you, I will!

[@DCGreenZone]

Excellent presentation Casey, in the future, please do a video on the synergy between Curcumin and EGCG vs Leukemia, the synergy between Resveratrol and Quercetin, (Trans Resveratrol is better, as is Quercetin Phytosomes imho) and the complete elimination of Ascorbic Acid due to the leukemic state. Standard is good, Liposomal is far far better. Intechopen has the literature.

[@DrCaseyPeavler]

I have the next 45 videos planned out, and all of those substances will be covered and many many more

[@ReefGeoscience]

Dude, most Docs have no idea about melatonin, so it would be helpful if you could do a standard of care video to help them

[@DrCaseyPeavler]

What do you think would be helpful for them in addition to what I have laid out today?

[@raykinney9907]

@@DrCaseyPeavler Gently, try to remind them of their oaths? Or, take a hint from Jack's abrasiveness, and confront them with their laziness in figuring it all out better to help far more people?

[@DrCaseyPeavler]

I don’t think I have it in me to be as abrasive as Dr Kruse lol

[@raykinney9907]

@@DrCaseyPeavler Well, me neither, but I'm worried that I may need more that direction, as time is short!

[@DrCaseyPeavler]

He definitely makes people feel they better get their stuff together. Fast. lol

[@ZionistWorldOrder]

i shared your video, great work!

[@DrCaseyPeavler]

Thank you so much!

[@SimonBuseman-uo1nj]

R-ALA + B vitamins (esp. thiamine) + magnesium work similiar. Also DCA has been long known to help the warburg effect.

[@DrCaseyPeavler]

The Amazing Link Between Thiamine And Fighting Cancer kzbin.info/www/bejne/pamnmYKdgaeCfpY

[@DrCaseyPeavler]

Yup you are right for the PDH side of things, I’m not aware of ALA having an effect on PDK, but thiamine and DCA does, as well as vitamin D, quercetin and others..

[@MrFrancishidalgo]

Thank you so much, I'm adding MELATONIN SUPPLEMENTS to my diet.

[@DrCaseyPeavler]

Make sure to maximize endogenous production first!

[@MrFrancishidalgo]

@@DrCaseyPeavler Ok, since I don't r know how, I'll look it up on Google... Thanks again.

[@MrFrancishidalgo]

@@DrCaseyPeavler okay, I found a nice list of easy ways to increase my endogenous melatonin.

[@MrFrancishidalgo]

@@DrCaseyPeavler thanks again, I appreciate your information very much 👍

[@DrCaseyPeavler]

BOOST Your Melatonin NATURALLY Without Pills! kzbin.info/www/bejne/hJ-zmp53mrKIjqs

[@gerrym-cat7119]

Isn’t melatonin also considered by some health experts to be the most powerful antioxidant in the body? On par with glutathione perhaps.

[@melvillejayathissa7415]

Fyi, my naturally produced antioxidant Astaxanthin 10-12 mg daily (in divided doses, preferably) extracted from the natural microAlgae Haematococcus Pluvialis for its numerous health benefits (including against cancers) according to updated research. Take enough of your naturally occurring Astaxanthin 10-12 mg as above with food & a tablespoonful of Coconut Oil for the best absorption! Thanks. Melville Jayathissa research from sunny Malaysia

[@melvillejayathissa7415]

Avoid the synthetic Astaxanthin supplements made from petroleum.

[@DrCaseyPeavler]

I believe it is far more powerful. Not only because of melatonin's and melatonin metabolites' direct antioxidant effects, but also because it up-regulates the endogenous antioxidant response elements (NRF2 and Klotho).

[@hodlwise2470]

Melatonin is actually an immunomodulator (like VitD) as well as an extremely powerful antioxidant (in high doses). It's best to take as a suppository (200mg) vs taking orally which has poor abortion due to first pass metabolism. It also protects against radiation (in high doses) and helps with oxidative stress/excess ROS involved with heavy metals and NPs/MPs (nanoplastics/microplastics), among a litany of other benefits.

[@DrCaseyPeavler]

That route of administration may be a hard sell for people but you aren’t wrong. Melatonin and Vitamin D are from what I see the 2 guardians against disease in all forms. Neglect them, and it will bite you.

[@mbrochh82]

Is there possibly a case to be made here that late night smartphone browsing maybe not CAUSES cancer, but due to melatonin disruption allows some cancers (caused by whatever) to grow and become a threat??

[@DrCaseyPeavler]

I’ve seen data that artificial light at night (ALAN) can cause cancer. It definitely leads to uncontrolled growth.

[@paultraynorbsc627]

Thanks for Sharing about

[@postscript5549]

I only understood some of what you're saying. I have almost zero medical knowledge. However, this is stunning news. First time listener.

[@DrCaseyPeavler]

Welcome first time listener! I could understand your overwhelm if your first exposure to the channel was this video. If you start from the beginning of the series, things build on each other over time. That is what would be the easiest to get to a point where this video makes more sense. It is dense material, I do give you that.

[@riumudamc4686]

Thanks again Dr. Peavler. Would you expect sunnier climates to have less incidence of cancer, and do you know of any evidence to support the possibility? It would be very interesting if such evidence exists.

[@DrCaseyPeavler]

My video on sun exposure and disease lays this out very well. And it is well documented. kzbin.info/www/bejne/laW8inx7isSrgposi=nNG00Df3x0eW_5Wv

[@Houster1000]

I'm doing the Seifried press pulse, which relies on the inability of the cancer cell to process ketones because its mitochondria is damaged. Wouldnt the return to OXPHOS orchestrated by the melatonin save the cancer cell from Seifried press pluse or from keto diet in general?

[@DrCaseyPeavler]

Fantastic question. No actually. What happens when you restore pyruvate to get converted to acetyl coA in damaged mitochondria? You restore the loss of control of apoptosis! This enhances metabolic therapy, as does high dose thiamine and DCA.

[@scottdavies6636]

Oh boy, a lot packed into this talk. The one thing that stood out that so many don’t talk about and therefore know, is antioxidants affect on cancer cells. Antioxidants are great for healthy cell protection but once you have cancer, antioxidants actually keep cancer alive because of its very aggressive cell division and thus large amounts of oxidative stress that require antioxidants to survive This is actually its weakness or one of, and antioxidants help it survive this which is why you much not supplement which antioxidants or elevate glutathione naturally

[@DrCaseyPeavler]

Very little know piece of information. And since people have an all good or all bad mentality, it’s a tough topic to teach and for people to accept.

[@scottdavies6636]

@@DrCaseyPeavler it seems pretty simple to me but I realize for others it’s challenging to understand. It’s complex if you don’t have a broader understanding of some of the mechanisms of oxidation and methylation for example

[@DrCaseyPeavler]

It requires the ability to see nuance and not be in black or white thinking

[@mustseevideos7777]

Can you direct us to the dosing guidance for colon- rectal cancer?

[@DrCaseyPeavler]

First off I am sorry you or someone you love is dealing with colorectal cancer. That would be a conversation between you and your like minded local healthcare provider. Aside from the supplements, would heavily look into maximizing endogenous melatonin production first and foremost.

[@riumudamc4686]

Dr. Peavler, Do you personally get sun exposure as a preventive measure, and if so, what do you recommend (amounts, time of day, etc.) Thank you for your work!

[@DrCaseyPeavler]

I get A LOT of sun, and I live here in Miami at 25th latitude North. I really like using the d-minder app. Once you have it on your phone, you will plug in your skin type, it will geolocate you, then you plug in skin exposure and cloud cover. It will help guide you. For me, and my skin type and melanin level (solar callus), I am usually out for 30-60 minutes daily of direct sun exposure. I try to get out several times in the morning, afternoon, and evening for circadian and infrared purposes.

[@anitaitisanita8549]

@@DrCaseyPeavler and do you wait hours after before showering as D is only made on the skin? Thank you Dr.

[@DrCaseyPeavler]

No need. You cannot shower off Vitamin D or melatonin

[@anitaitisanita8549]

@@DrCaseyPeavler I must have mis-worded my question . With sun exposure the skin makes vitamin D, and not instantly, so poor idea to swim, shower. My question was how long does it take for the skin to make vit D please? I do understand once its made you cannot wash it off.

[@DrCaseyPeavler]

I appreciate you rephrasing. Why is it not instantly? Its a chemical reaction that is catalyzed by UV light exposure. I would have to imagine it is instant and constant until exposure is removed. I am still not understanding why it would be a poor idea to swim or shower. The conversion is happening in the more superficial and deeper layers of the skin. The skin has many layers of dead skin cells that provide water proofing. Those cells wouldn't make D because they are dead. Does that help?

[@englishclass9782]

I pray you are right,am gonna buy them as am fighting leiomyosarcoma

[@DrCaseyPeavler]

Remember first things are first you need to maximize endogenous production before considering any supplements. The foundation of metabolic therapy is a therapeutic ketogenic diet with exogenous ketones as described by Dr. Seyfried. But should likely be heavily integrated into recommendations from Dr Jack Kruse. God bless your fight

[@drskidzo]

My understanding is that Some cancer cells may develop resistance to the effects of melatonin, either by downregulating melatonin receptors or adapting their metabolism. Thus, even if melatonin is increased in the microenvironment of a tumor cell through NIR stimulation for instance , it may not significantly affect some cancer cells. What is your opinion on that Doc ?

[@DrCaseyPeavler]

Remember cancer cells cannot make melatonin due to Warburg metabolism, lack of Acetyl-CoA to synthesize it. The down regulated receptors I am not sure about. But melatonin has both MT receptor dependent and independent mechanisms so that would not nullify its functions.

[@drskidzo]

@@DrCaseyPeavler fair enough :)

[@DrCaseyPeavler]

I appreciate the question and the though exercise!

[@raykinney9907]

Good night moon, good night community, may you sleep even better!

[@DrCaseyPeavler]

Take care Ray!

[@raykinney9907]

Speaking of sleep, I just listened once again to Jack on Cameron Borg, and realized how Stasha Gominak teaching about paralysis depth in slow wave sleep is so important, and now Jack talking with Cameron at one point brings this whole points up again in a quantum sense about the purpose of sleep. And, how darkness and quiet is so very functional to allowing the biophoton communication and energy driving physiology. And, the disruptions of NIR starvation, LED light, and non native EMF pollution is so devastating. Melanin, melatonin, NIR, and coherent domain water w/o deuterium in mitochondria needs the deuterium presence in blood for vast flow of light energy within physiology.

[@DrCaseyPeavler]

It’s a light show as Jack says. Some of that light show is absorbed from solar exposure and through non-linear optics transferred to the body systems for utilization. Jack talks about holding that energy and information in water networks and electron excitation. The darkness and quiet at night allows for the next phase of the light show to begin from within. Beautiful.

[@raykinney9907]

@@DrCaseyPeavler Mind boggling!

[@DrCaseyPeavler]

Truly.

[@Roberto-cg2gr]

Does it mean that you need sunlight to increase melatonin? Near Infrared and infrared lights? Low blood glucose levels and sunlight?

[@pterakau]

Yes,but for a teatment itis better to use 40mg/d

[@p_peja]

Cancer cells could have disrupted melatonin production.

[@p_peja]

@@pterakau my mom tried, started with 5mg at evening and could not stay awake next day. She stopped.

[@raykinney9907]

@@p_peja Early morning (first two hours after dawn), is a great time to get near infrared light (outside in the LIGHT) for a half hour. this helps turn off the pineal gland melatonin production that tends toward sleepiness, and the early morning NIR starts up the mitochondrial production through the whole body (and does not induce sleepiness). This syncs up the whole hormonal process to be TIMMED right! If your mom avoids LED light in the evening, and sleeps in total darkness, goes out each morning to catch the first daylight, she will probably not even need to try to induce sleepiness with taking any melatonin a all, because her pineal-derived melatonin would be enough IMHO.Someone with cancer issues might however benefit greatly by higher doses, as SO WELL suggested by all of these research papers.

[@DrCaseyPeavler]

To answer the first question, I think that better describes prevention. Healthy weight, healthy diet w/ preserved insulin sensitivity, active lifestyle, perfect circadian rhythm, as much natural light as possible both direct and indirect. When you have disease you need all the above with even more urgency and as alluded to in the video, likely endogenous melatonin because cancer cells loose their ability to produce melatonin which is really good for them but bad for us.

[@ws7001]

How about a 500 watt halogen lamp especially for the cancer region? It’s NIR spectrum seems appropriate and only $18

[@DrCaseyPeavler]

Sun first and foremost. But I think I would do a Sauna Space Bulb, RubyLux or TheraBulb instead or you could do Photobiomodulation Red/NIR panel.

[@ws7001]

@@DrCaseyPeavler well, I’m trying to find one at 3300-3400K but the 500 watt halogens only seem to reach 2800K, which provides mostly far infrared. Incandescents have shorter life at higher temperatures without some halogen to keep the tungsten surface clean from oxidation. Nothing is easy.

[@monnoo8221]

@@ws7001 a precise and optimized wave length composition is only possible through LED ... physics tells us

[@Gary65437]

@@ws7001 I just looked up that sauna bulb, $595....I'd have to get a job to buy that and hope it doesn't break in the mail. Can you imagine? lol In the mean time I'll use the $12 infrared 250W chick warming bulb I got at Tractor Supply. Better than nothing and I read that cancer can't stand the heat, and it does get the area mighty hot.

[@geviert]

@@ws7001 Look into infrared panels, devices and lamps. There are a lot on the market at different price levels.

[@camwells9726]

So the person that takes fairly high doses to help him sleep , will at least get a positive side effect of reducing cancer risk ?

[@DrCaseyPeavler]

Likely yes, but it would be probably better to figure out why you need help with sleep…

[@kimberlybegonia2869]

@@DrCaseyPeavlerinterrupted sleep from arthritis pain and post menopausal

[@darbylettick3008]

Great compilation and explanation for me... thank you. Kudos

[@DrCaseyPeavler]

Glad it was helpful!

[@r.davidyoung7242]

Thank you.

[@DrCaseyPeavler]

You're very welcome!

[@raykinney9907]

Casey, WOW!

[@DrCaseyPeavler]

I know Ray lol, it’s unbelievable

[@tedmed7349]

So how many people here are cured by taking melatonin ? Let's get a list of successes.

[@CJWass09]

300mcg seems to be the maximum effective dose that does not shut down endogenous production.

[@DrCaseyPeavler]

Russel Reiter who is the world’s expert in melatonin says there is no known negative feedback loop. But for non cancer patients I think it makes WAY more sense to maximize endogenous production. For cancer patients benefits of supplementation seem to outweigh risk. Always a discussion to be had between you and your healthcare provider.

[@CJWass09]

@DrCaseyPeavler i looked up a '97 study just now to verify what you claimed to be true. I guess it does not act like insulin negative feedback or sex steroid negative feedback.

[@DrCaseyPeavler]

Almost all hormones have feedback loops. I still am skeptical about melatonin. But as of now it looks like there is no negative feedback.

[@hocheefatt2974]

Dr Casey, does sleeping in complete darkness ( by double covering your window curtains) increase melatonin production by the pineal gland?

[@DrCaseyPeavler]

Absolutely. Humanity has a nocturnal darkness deficiency.

[@wcg7555]

What’s the daily dosage

[@DrCaseyPeavler]

Thank you for watching and your question. Those are the kind of question best between you and your doctor. I will say this, if you don’t have cancer then maximize endogenous production. If you have cancer, maximize endogenous production and then supplement.

[@nonarcsense]

Hello Dr. Peavier, Would you be able to cover Oregano Oil as a tremendous resource for fighting Cancer. Thanks for all you do. 🙏

[@DrCaseyPeavler]

I will absolutely be covering it in the future

[@FuzzyBearYT]

So, what sort of dosage of Melatonin are we talking? 1mg? 10mg? 100mg? 500mg? Some suggest we should be taking in the hundreds of mg to get the REAL benefit of melatonin from an anti--aging point of view. The sleep aspect becomes almost irrelevant.

[@DrCaseyPeavler]

Context is king. For non-cancer patients, likely not needed. What is needed is radical changes to your light and dark environment. For cancer, that is its own thing, the dosages regimens are vast depending on integrative doctor and the discussion would ultimately be between a patient and his or her doctor.

[@Always-xl9db]

As I understood from this video - in high doses it can be pro-oxidative, not antioxidant, correct? What would be unsafe amounts of melatonin to take, upper limit? Approximately. Also, I saw somewhere else that blood levels of melatonin (which u can increase thru supplementation) is not necessarily a direct representation of intra-cellular levels of melatonin, which is what important. Can you please explain what is correspondence between blood levels and cellular uptake.

[@DrCaseyPeavler]

I do not believe it takes high doses. It literally seems to have antioxdant effects in normal cells and pro-oxidant effects in diseased cells. Also has pro-autophagy/mitophagy in normal cells, and blocks autophagy/mitophagy in cancer cells. Its impossibly to clinically differentiate intracellular and serum melatonin production and excretion. We just dont have the tools. Serum melatonin can interact with cell surface MT receptors, can be internalized and act upon organelles such as mitochondria and interact and signal directly in the nucleus.

[@jamesthompson7282]

@DrCaseyPeavler That's sort-of helpful, but dodges the question. What kind of dose are we talking about? Supplements offer 3-5 mg typically. Are you thinking that would suffice, or are you thinking one or two orders of magnitude more?

[@DrCaseyPeavler]

I cannot give specific doses online as this could come off as medical advice or practicing medicine over the internet. What I would say is that the specific discussions about dosing would completely depend on context. Context of patient's health, disease risk and burden. This is best suitable for a discussion between a patient/client and a like minded well read healthcare professional. Discuss risk vs benefit of any intervention proposed and implemented. Follow up and monitoring. My main goal here is to raise awareness, provide scientific backing for these important modalities. I hope that brings context to my at times vague answers.

[@LifeIsThePrayer]

I took a 10 mg sublingual tablet of melatonin last night. It dissolves under your tongue so you can absorb all of it and it doesn’t have to travel through the high acid environment of your stomach. Slept longer than usual and still felt like a zombie for most of the morning. Not ready to give up though. Going to get a lower dose sublingual tablet, maybe 2 or 3 mg and see if I can work my way up to higher doses. Maybe a 2 mg a couple times a day.

[@raykinney9907]

If you watch dawn break, with the near infrared-rich early morning light, if does some reduction of melatonin from the pineal gland to turn off the groggy effects, yet greatly increases the mitochondrial melatonin. The mitochondrial 95% of the melatonin in the body does not seem to increase sleepiness at all. And, it does loads of energizing the cells in the body IMHO.

[@LifeIsThePrayer]

@@raykinney9907 That’s pretty cool isn’t it? I’m going to have to start setting an alarm for sunrise….and sunset to get in the habit of being outside at those times. Thank you!

[@vicpso1]

I do 3 20 mg tablets.. a little groggy before coffee .. but fine afterwards.. but I am 65

[@DOCKent-3339]

​@vicpso1 i just doubled mine to 20mg. Might get some sleep tonight. May have to boost it to your dosage. TY

[@just_Freedom_Peace.]

How much mg you would recommend to supplement to kill cancer cells and Tumors in body. Should someone will benefit if he take Vitamin D3 in Daylight and in the Evenings Melatonin. Thank you very much.

[@DrCaseyPeavler]

The exact dosing, timing, and schedule would be a discussion between a patient and their physician. I have seen a wide variety of dosing and scheduling from various integrative oncologist.

[@geviert]

@@just_Freedom_Peace. Thats exactly what I do. My husband and kids (young adults) as well.

[@just_Freedom_Peace.]

@DrCaseyPeavler Is it shown in clinical studies or similar that Melatonin kill cancer cells and Tumors? Can high Dose of Melatonin (like 100mg) be toxic for someone.

[@DrCaseyPeavler]

So the last 2 videos are on exactly that. How powerful melatonin is against cancer and by what mechanisms it works upon. There is no know toxic dose, but anything is toxic in general at a certain point. If nothing else risk exceeds benefits. The use for cancer would definitely be between a patient and a doctor.

[@DH-oi4kr]

Dr Casey. Much respect to you but no oncologist is going to recommend anything but standard therapies. They scoff at alternative treatments. Mine did

[@SandyLee-xt7js]

What dosages are you recommending?

[@DrCaseyPeavler]

Great question. It would depend on the patient and condition which is why I always say talk about this with you like minded healthcare provider. That being said, everyone including cancer patients taking the supplement, should perfect their circadian rhythm release of melatonin and get maximum tolerable sun/infrared to make their own intra-mitochondrial melatonin

[@SandyLee-xt7js]

Finding a likeminded Dr is almost impossible. Give us general ranges colon cancer anywhere from 10mg to 40 mg a day in divided doses or single dose, for auto immune say MS what would a range be, what is a dangerous dose, etc

[@Corteum]

Hi Doc Casey. Are there any other dietary supplements or nutraceuticals or minerals etc that can be taken alongside melatonin to increase its positive benefits or even catalyze other kinds of benefits that would not be produced by taking melatonin alone? 🙏👍

[@DrCaseyPeavler]

Hmmm 🤔 I would have to think about that. My gut answer is yes. But it’s a pretty vague question. Any particular action or condition you are interested in?

[@warrengayman2716]

Re: The melatonin that's available over the counter at the health food store ... are all melatonin products made the same?

[@DrCaseyPeavler]

Biochemically should be the same yes. But what fillers does each brand use? What is the absorption? That is where the difference lies.

[@warrengayman2716]

@@DrCaseyPeavler Many companies of the manufactures provide little to none in the way absorption data and/fillers Would a time release capsule improve absortion?

[@DrCaseyPeavler]

What are your health goals and where do you live?

[@warrengayman2716]

@@DrCaseyPeavler Toronto , Ontario, Canada. I am currently using "Tagrisso".

[@DrCaseyPeavler]

Lung cancer?

[@bertcollard6619]

Inspiring information

[@DrCaseyPeavler]

I am glad you like it!

[@sophiagertz1083]

Are the gummies ok to take if you have cancer? 10 mg? It helps me sleep for sure but don’t want the cancer to grow from sugar

[@DrCaseyPeavler]

I cannot give medical advice here unfortunately. You would need to discuss that with a like minded local doctor. I will tell you that the doses used by integrative oncologists are very high.

[@sophiagertz1083]

@@DrCaseyPeavler ok. I will try to find one in my area. Or go to a health food store to get capsules and double or triple up perhaps.

[@sophiagertz1083]

@ In a handful of completed clinical trials in patients with primary brain tumors, colorectal cancer, non-small-cell lung cancer, breast cancer, and brain metastasis, researchers found that melatonin, in doses up to 40 mg daily, worked well with conventional treatments

[@DrCaseyPeavler]

I will tell you that 40mg is low compared to what I have heard being used in clinical practice…

[@sophiagertz1083]

@ wow!! Thank you. I’ve was dx’d with breast cancer 6 years ago. No surgery, radiation or chemo. I’m trying Phen Phen now. Ran out of Rx for Ivermectin. You know doctors won’t prescribe it but you can get Phen Phen and Artemisisin. So I’ll add Melatonin to all the supplements. Thanks

[@brendagratza6210]

Where is the best place to buy melatonin and how much do I need to take a day? I have -3 breast cancer.

[@DrCaseyPeavler]

I cannot provide medical advice on KZbin. Those would be questions between you and your local licensed healthcare provider. Melatonin can be very synergistic in a metabolic approach that being said.

[@WilliamKelly-ou2nm]

Thank you so very much.

[@DrCaseyPeavler]

You are very welcome!

[@odenspieler]

Thank you very much for this hint to investgate Melatonin as a possible additiona treatment for breast cancer oof my wife. Are there any restrictions ? Does Melatonin work in even each type of breast cancer? Even in Er+ Pr- Her2- ? I apologise for each answer.

[@DrCaseyPeavler]

The Warburg effect and aberrant metabolism is conserved across all know human cancers. So the basics of metabolic therapy should work. Melatonin does a lot of amazing things but in particular its actions on the glucose side of things, PDK inhibition, as well as HIF1a means it is very operational in breast cancer. But don’t stop there, there are many many things she can do besides melatonin…

[@spitfirekid1]

Is the Warburg effect at play in adenocarcinoma?

[@DrCaseyPeavler]

Absolutely!

[@williambuckley6128]

Dr. Casey, do those studies say how melatonin should be delivered to create this environment? IV, under the tongue, mix in the fat of your meal.

[@DrCaseyPeavler]

I would have to dig into the methods but I would bet it’s all oral administration.

[@kelleywatt4167]

@@DrCaseyPeavlerthanks for answering

[@DrCaseyPeavler]

You are very welcome!

[@williambuckley6128]

@DrCaseyPeavler Dr. Cho says 4 g/day under the tongue. She is a leading melatonin researcher.

[@DrCaseyPeavler]

4 grams?! Lol that is a lot! For treating a certain condition or for preventing illness?

[@trisht7003]

I was diagnosed with ER+, PR+, HER2- breast cancer three and a half years ago. I had a lumpectomy, radiation,take letrozole daily and luckily there is no evidence of disease now. I’m constantly worried that the cancer may metastasise at some point so I’m not sure if you’d consider me as a cancer or non cancer person when thinking about taking melatonin.

[@DrCaseyPeavler]

I am sorry you are dealing with that. You should not have to worry. But that is how the medical paradigm keeps you. Thinking it was just dumb luck and it could happen again and there is nothing you can do but watch and wait. COULD NOT BE FURTHER FROM THE TRUTH. Find every single thing that could be causing hypoxia or pseudohypoxia in your body. Then fix it.

[@DrCaseyPeavler]

Would also say you need a perfect circadian rhythm, no light after sunset. And as much natural light during the day as possible (not behind glass or sunglasses). Where do you live in the world?

[@trisht7003]

@@DrCaseyPeavler I live an hour west of Melbourne Australia. Since my diagnosis I’ve started raising my own cows for beef and growing vegetables without any chemicals. I try to buy organic foods when possible. I hate to admit it but after giving up smoking six years ago I started vaping nicotine and that’s something I need to address.

[@DrCaseyPeavler]

Had to google this but that is 37S. I have to imagine it’s fairly temperate there? Do you have winter? Diabetes, overweight, vitamin D deficiency, sleep problems/light at night? Get ahold of a young Australian doctor named Max Gulhane. Good guy and is on the right track.

[@joanneclark8256]

​@DrCaseyPeavler l have that what to do? Also is melontoin bad to take with no cancer

[@enricodilorenzo4453]

Have you looked into Zimmerman’s research into subcelular production of melatonin triggered by NIIR? It seems like you touched on it at the end if your video. However your focused seem to be pineal and exogenous melatonin

[@DrCaseyPeavler]

Did a whole video on it: BOOST Your Melatonin NATURALLY Without Pills! kzbin.info/www/bejne/hJ-zmp53mrKIjqs

[@enricodilorenzo4453]

@@DrCaseyPeavler Oh good. I will check it out.

[@DrCaseyPeavler]

Please do!

[@chrisdavies6473]

Dear Dr Peavler, It is quite difficult ,as a non scientists, to follow all of your talk. I still dont really know how to increase melatonin. Would it be possible for you to do a written summary of your research and how to access the melatonin. Thank you

[@DrCaseyPeavler]

Good morning! Thank you for watching! This is the final melatonin video in a whole series of videos on melatonin. I would recommend you start at the beginning to better answer your questions! Harness The POWER Of UV Light: MAKE Your Own Vitamin D kzbin.info/www/bejne/Z2ixYWudeZadpac

[@RussRasmussen]

The sun my friend the pineal can't spell sorry gland in the brain only produces only 10% of the melatonin the rest comes from the sun and can be absorbed through your clothes

[@DrCaseyPeavler]

Yes you are correct. But why create a barrier that doesn’t need to be there. Skin exposure directly by light seems ideal.

[@Roberto-cg2gr]

How to you get melatonin? Sun light from sun rise to sunset whole day?

[@DrCaseyPeavler]

That would be the best way. And don’t forget the other critical element: darkness at night.

[@wcg7555]

I heard you must sleep in complete darkness with no visible lights

[@nancienordwick4169]

How is it determined which cancers have the Warherg effect present. Is it by cancer type, or does a biopsy sample need tested?

[@DrCaseyPeavler]

All cancers utilize the Warburg effect to my understanding. The PET scan works based on this fact.

[@nancienordwick4169]

@DrCaseyPeavler ok. It's just I've had other docs tell me that ketogenic/ low carb diets don't help, and if cancers are obligated glucose metabolizing for energy, one would think it would be helpful...

[@DrCaseyPeavler]

It makes sense to anyone with half a brain. Too bad doctors seem to be lacking..sad.

[@nancienordwick4169]

@DrCaseyPeavler be careful with generalizations. I get that you are frustrated but that comment is not constructive. Maybe we just need to do more clinical studies to convince others if all cancers are truly obligate glucose metabolizers.

[@DrCaseyPeavler]

I agree with you. We always need more studies. But people are suffering and dying now. No one can walk through the hallways of a hospital or an ER and believe we are successful as a healthcare system. We need immediate changes.

[@ola-fq4hv]

Woow this is very interesting thanks. So sleep much should be good then?

[@DrCaseyPeavler]

I’m not exactly sure what you mean. But just being in bed asleep would not be enough no. Melatonin is based on light and dark cycles, in particular exposure to sunlight during the day and lack of light at night. Especially blue light.

[@brendagratza6210]

Where is the best place to buy melatonin and how much do I need to take a day?

[@DrCaseyPeavler]

Context is everything. Do you have cancer?

[@brendagratza6210]

Yes negative 3 breast cancer

[@brendagratza6210]

They removed the two lumps and gave me chemotherapy for treatments and told me that had any problems to come on back. And they said most of the time this kind of cancer comes back in 16 months and it goes to your liver or brain! I tried to ask him is there any alternative medicines I can take and he said no

[@DrCaseyPeavler]

Do you mean triple negative breast cancer or stage 3 breast cancer?

[@DrCaseyPeavler]

Yes most conventional doctors are extremely closed minded to alternatives. To the point that they will tell you no or yes to things they have no idea about. It’s pretty sad.

[@rjsongwriter]

Great info! I just wish my brain could keep up with your words. 🙂

[@DrCaseyPeavler]

You can! Just take it slow (not easy with my speaking speed) and know that repetition is your friend! I am glad you enjoy the information!

[@rjsongwriter]

@@DrCaseyPeavler I've been using melatonin for a couple of years for sleep. I'm glad to learn it may have other benefits as well.

[@DrCaseyPeavler]

Many! But likely better to figure out how to maximize your own endogenous production than pills…

[@lulabelle4760]

Video and comments truely fasinating...even tho i didnt understand everything🤣🤣🤣

[@DrCaseyPeavler]

Repetition helps, but also watching the series in order. Every video builds on the prior video! I’m glad you find it interesting!

[@raykinney9907]

@@DrCaseyPeavler Yes, such good advice to ideally follow through the videos series in order they were produced!

[@DrCaseyPeavler]

I find it hard to communicate this message to everyone. Perhaps explaining it in the comments?

[@raykinney9907]

@@DrCaseyPeavler Perhaps a very short statement at the start of each video?

[@raykinney9907]

And, remember, NONE of us understand everything in these whole series of videos Casey is offering to us! Anything we might be able to gain personally, is a great bonus, a gift for humanity. Our physiology, affected by physics, is an extremely complex system o try to understand, mistakes will be made frequently, with opportunity to learn more from correcting mistakes. Which really IS the scientific method trying to correct mistaken understanding, one step at a time... with curiosity!

[@icnow2097]

How much a day though

[@DrCaseyPeavler]

Case by case basis to be discussed with your doctor. That being said, you should first and foremost learn to maximize your endogenous production using light and dark.

[@leonaiki]

so what is your recommendation in terms of dosage and iming? (night/day) thank you :)

[@DrCaseyPeavler]

I hope you enjoyed the video! I cannot give that over the internet. It would be considered giving medical advice over the internet. My goal with the channel to raise awareness and empower you. But medications, supplements, diets, dosing, timing, scheduling should be in a discussion between a patient and a healthcare provider.

[@leonaiki]

@@DrCaseyPeavler I do enjoy your channel, I learn a lot :) thanks keep going please.

[@DrCaseyPeavler]

You know it! I am glad you enjoy the channel. I still have A LOT to share

[@jiritichy6855]

The question is, what will happen, when you try to get off the Melatonin supplement and normalize your body. Your body got used to the supplement and thus suppressed it's own production and it might be very difficult to bring the body's production back up to normal level. Similar thing happens to body builders. When they get off the supplement (because they cannot continue for the reason of damaging side effects or for financial reason, because these things are costly) they "shrink" like unplugged balloon. So the second question is: does the prolonged use of supplemental Melatonin have adverse effect on the human body? Does it shut off body's own production only temporary or permanently. Is the cancer patient going to need to use the drug for rest of the life. What if it is found later that there are indeed damaging side effect and patient cannot continue (is there any study done about it?).

[@DrCaseyPeavler]

First off, fantastic questions and concerns. They are concerns that my mentor Dr. Jack Kruse and myself share. Most hormones have feedback loops. According to Dr. Russel Reiter, melatonin does not. Therefore you do not shut down endogenous production by taking exogenous melatonin. I think taking melatonin under any other circumstance than cancer is not the smart play. No cancer, maximize melatonin production and release by mastering your solar exposure and darkness at night. With cancer, risk vs benefit, as with all things discussion between you and your doctor.

[@rossanajoubert4881]

BrilLIANT ! THANK YOU

[@DrCaseyPeavler]

Thank you for your support! I am glad you enjoyed it!

[@frugalgardener7921]

Thank you thank you

[@DrCaseyPeavler]

You are very welcome! My pleasure!

[@marshallsaltzman9924]

Would this apply to metformin as well?

[@DrCaseyPeavler]

We will talk about metformin and yes it does also antagonize the Warburg metabolism through several mechanisms. I personally would not take it for prevention because it damages mitochondria. For cancer, risk vs benefit discussion between you and your doctor.

[@marshallsaltzman9924]

@@DrCaseyPeavlerthank you for clarifying, I am looking forward to any and all future content 🙏

[@DrCaseyPeavler]

Oh it’s coming! I’ve got the next 45 videos planned out at least.

[@raykinney9907]

@@DrCaseyPeavler I hope you have a few GOOD breaks planned in too! When do you sleep? Maybe you need a little more melatonin and D3?

[@DrCaseyPeavler]

I live in Miami so it’s good nearly all year round. My full time job is in the way of me getting more sun and doing more videos lol!

[@DCGreenZone]

First author, Russell J. Reiter. No surprise there. ❤

[@DrCaseyPeavler]

Nope! He is the melatonin man…

[@DCGreenZone]

@@DrCaseyPeavler I watched a few of Dr. Chris Knobbe's videos, where he explains that excess omega 6s in the diet creates leakage in the electron transport chain in mitochondria.

[@DrCaseyPeavler]

Fascinating, one of your fellow mitochondriacs just referred me to that person in particular and I’m watching one of his lectures as I type…

[@richieheetebrij8189]

You are awesome Dr. How much melatonin and when should it be taken?

[@DrCaseyPeavler]

Thank you for your kindness and support. Ideally you first and foremost maximize endogenous production. The oral doses for example in cancer treatment would be a discussion between you and your healthcare provider.

[@p_peja]

What about vitamin K2?

[@DrCaseyPeavler]

What are you interested in knowing about K2?

[@p_peja]

@@DrCaseyPeavler cancer related topics

[@DrCaseyPeavler]

I will see if I can add that on the list of topics to discuss and investigate its mechanisms of action in relation to cancer

[@DrCaseyPeavler]

Thank you for the suggestion!

[@brendagratza6210]

So what can we do to heal our cancer?

[@DrCaseyPeavler]

A ton!

[@sharonkende4774]

Thank you for this. I never knew cancer cells could be fixed. Is that what you are saying? Mitochondria that were ghost mitochondria and non functional can now use pyruvate and perform oxidative phosphorylation with pyruvate as the start compound?

[@DrCaseyPeavler]

There is a continuum of mitochondrial damage but in general mitochondrial are nearly irreparably damaged in cancer. If they can be salvaged, melatonin can do it, but if not, then melatonin will induce apoptosis, programmed cell death.

[@jonnyde]

@@DrCaseyPeavler Please do not neglect to include Methylene Blue to help repair mitochondria! Personally I have felt the difference when using it but I am not sure of possible counter indications of use with supplements. Your thoughts would be appreciated.

[@DrCaseyPeavler]

Methylene blue in combination with PBMT = photodynamic therapy. I am a fan…

[@jonnyde]

@@DrCaseyPeavler sadly there is no OTC light sensitizing agent available (that I know of)😥

[@DrCaseyPeavler]

You can find IV Methylene blue at some iv therapy clinics and services. You will have to do some research

[@davewallace5008]

...and where does one procure this 'melatonin'?

[@DrCaseyPeavler]

Ideally inside of your mitochondria and pineal gland first and foremost. Supplemental melatonin is widely available although dosing would be between you and your healthcare provider

[@eb4452]

@@DrCaseyPeavler I've read 20-50 mg/day is the effective anti-cancer dose. I've tried melatonin - at 5 mg/day it completely knocks me out. How can one tolerate 20 mg?

[@riumudamc4686]

Thanks Dr. How can people get sun exposure and avoid skin cancer?

[@DrCaseyPeavler]

Simply don’t burn. Chronic sun exposure is associated with a roughly 15% decrease chance of developing melanoma (the most deadly skin cancer) and an almost negligible increase risk of basal cell and squamous cell skin cancer. When you look at the epidemiological data for cancer deaths those 3 combined make up WAY less than 1%. What people are actually dying from Breast, Colon, Lung, are all decimated by sun exposure. Just take it slow but get out there as much as you can.

[@geviert]

@@riumudamc4686 Use sunlight in the mornings and evenings when the infrared part of sunlight that reaches your body is higher. Also look into Methylene Blue for UV damage protection.

[@DrCaseyPeavler]

Thank you for the feedback, building solar callus slowly is the key.

[@kingsxkids]

What’s the dosage? Which form, or derivation? Where do we get it? Please help us. Stage four and we still we don’t have this information.

[@DrCaseyPeavler]

I am so sorry for your stage 4 cancer diagnosis. But I cannot be providing medical advice on this platform. This highlights the importance of working with a local, qualified, like minded healthcare provider.

[@kingsxkids]

@ I’m not looking for you to write a prescription for anyone. But with a mind numbing variety of this stuff, it seems you should be able to say: “Here are a few good bioavailabile versions. Made by such and such reputable companies ” Thank you Casey, I have an amazing number of high-quality folks praying for me . As well as anti-parasitics, homeopathy, and experimenting with a Rife frequency generator. 🙂

[@DrCaseyPeavler]

Hmmm 🤔 that is a good idea. I’ve never thought about talking about which brands I like…I guess I’m just fearful of them saying I am practicing medicine over the internet. I cannot put my license at risk. Just sharing this information is probably going to put some degree of a target on my back. The channel is mostly to raise awareness and educate. Add one more person praying for you! God bless

[@Bouboutv89]

30 mg

[@Bouboutv89]

30 mg

[@drskidzo]

What are the modalities of the press pulse that can damage the mitochondria besides metformin ? does HBOT do the same for healthy cells ?

[@DrCaseyPeavler]

That is a great question. I mean I guess what all does press pulse entail? There are many different ideas of what it could look like. But if you use strictly Dr. Seyfried’s framework, then metfromin would be the only obvious one. HBOT likely does cause a mild oxidative stress to normal cells also. But this may act as a hormetic stressor and overall boost health in process. I personally would not use HBOT unless I had cancer.

[@drskidzo]

@@DrCaseyPeavler thanks for this. it helps

[@DrCaseyPeavler]

You are very welcome man!

[@robertwood9984]

Are there any studies showing that Exogenous Melatonin is beneficial? It would seem so, but just asking. Thanks!

[@DrCaseyPeavler]

If you mean like large human trials of high dose melatonin, not that I am aware of. Unfortunately the cost of a study like that would be millions and no one would likely ever fund it. Sadly.

[@showbread9366]

@@DrCaseyPeavlerjust millions? That’s a drop in the bucket for cancer research. I wonder how much money goes into cancer research annually & nobody is any closer. Blows my mind. They’re still using methods from the 60s. What a sham. At least Ukraine is getting paid 🤷‍♂️

[@DrCaseyPeavler]

lol gotta keep that war machine rollin…I shouldn’t laugh it’s terrible.