Metabolism of Tryptophan By Dr Pooja For MBBS 1st Proff

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Metabolism of Tryptophan 🌟 -
Tryptophan, an essential amino acid, is vital for protein synthesis and serves as a precursor for several important biomolecules, including serotonin and melatonin. 🧠💤
Initially, tryptophan undergoes transamination to form kynurenine via the action of the enzyme tryptophan 2,3-dioxygenase.
Kynurenine can then be converted into various metabolites, such as kynurenic acid and quinolinic acid, which play roles in neuroprotection and neurotoxicity, respectively. 🌈
Subsequently, quinolinic acid contributes to the synthesis of nicotinamide adenine dinucleotide (NAD+), a crucial cofactor in cellular metabolism. 🔄
Another significant pathway involves the conversion of tryptophan to serotonin through the action of the enzyme tryptophan hydroxylase. Serotonin is a neurotransmitter that regulates mood, sleep, and appetite. When serotonin is further metabolized, it produces melatonin, a hormone that regulates circadian rhythms and sleep-wake cycles. 🌙✨
This intricate interplay illustrates the importance of tryptophan metabolism in maintaining mental health and overall well-being. Imbalances in tryptophan metabolism can lead to various disorders, such as depression, anxiety, and sleep disturbances, underscoring its role in human physiology. ⚖️
Understanding the metabolism of tryptophan not only sheds light on essential biochemical pathways but also emphasizes the need for adequate dietary intake of this amino acid to support these critical functions. 🍽️🥦
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