Methylation | The Top 4 Supplements & How To Use Them.

[@jimbarrack]

Finally, the KZbin algo gave me something worth watching. I subbed automatically, and, definitely will be binge watching. "You had me at methylation"

[@dr.robinlewis]

I’m glad you feel that way! Hopefully it doesn’t disappoint

[@jasonbarretto3806]

This is very accurate and informative. Thank you it took me years of stumbling through my health to figure some of this out. You provided an extensive knowledge of helpful information in one video.

[@dr.robinlewis]

Thank you!!

[@adhipmitra]

In life everything is balance, neither too little nor too much.

[@dr.robinlewis]

💯

[@donnagarner6007]

"All things in moderation."

[@jakec5618]

Question regarding Sam-e, there was a recent paper Excess S-adenosylmethionine inhibits methylation via catabolism to adenine, published in nature, they state, "Here, using biological rhythms to assess the effects of exogenous S-adenosylmethionine, we reveal that excess S-adenosylmethionine disrupts rhythms and, rather than promoting methylation, is catabolized to adenine and methylthioadenosine, toxic methylation inhibitors. These findings further our understanding of methyl metabolism and question the safety of S-adenosylmethionine as a supplement." I was wondering your thoughts on the paper and their conclusions. Some of it goes above my head. Thank you

[@chrismyers9951]

@@jakec5618 Don't take samE take TMG - Trimethylglycine instead. Also methyl B12 under tongue (sublingual) also active form B vitamins.

[@inheaps]

Wow, divine timing with your video coming out! Your series on this has been extremely helpful. Thank you!

[@dr.robinlewis]

I’m so glad you found help in it!! 🙂

[@user-zq9pt8nx3w]

I was diagnosed with homogeneous MTHFR, thankfully my NP was educated on this subject ( 28 years ago!). This information is so valuable and yes, you can feel better. Take out the darn processed foods. 😊

[@dr.robinlewis]

Thank you for the helpful comment! Yes, we would all be better without our processed food!

[@asherasator]

It's not a gene mutation, but the reality that some ancestors were not consuming a lot of methionine foods that result in high homocysteine byproducts. This has been understood in science for quite some time. [Pre 2003 MTHFR symptoms were understood by Homocystinuria]: (1) Geigy Scientific Tables, 7th edition, page 449; Inborn Metabolic Errors and their treatment, 'Homocystinuria' the treatment is 'Diet low in methionine, but higher in cysteine and pyridoxine [vitamin B6].' Which B6 is naturally found in fruits, veggies and grains. (2) Enzymatic Reaction Mechanisms, pages 846-850; 'Cobalt coenzymes with FADH enzymes attacking SAM [S-adenoslymethionine] creating methyl-CoB12, which then turned homocysteine back into methionine.' Normally SAM would create methyl-CoB12 by the enzyme NADPH, with a "defect" and lower ability to metabolize the Cobalt enzymes with FADH can also do the job. But the next pages 851-863 show that methyl-CoB12 '... appears to function secondary methylation category... methylates mercury, palladium, lead, platinum, gold, tin, arsenic, selenium, and chromium' in the environment creating toxic chemicals. High doses of methyl-CoB12 is well known to increase oxidative stress and has many other toxic reactions. So lowering methionine with focus on natural foods with cysteine, B2 and B6 [from diet] seems to be a better route and dealing with homosistinuria [MTHFR] for over 50+ years. Methionine is carcinogenic and involved in angiogenesis that creates blood vessels to tumors. The common ideas of methionine being "essential" is overrated because even with no MTHFR "defects" the toxic effects of methionine to homocysteine recycling can affect anyone. From my point of view it is irrelevant if B fortified foods are a source, what is important is to lower methionine which is the starting point of the cycle.

[@jmorgan6218]

Hi! Any supplements you take to feel better??

[@lauragray5696]

Where Is your dr. So many have no clue about this. I need someone who gets it.

[@suzysandiego6478]

Hi Doctor, Just wanted to mention that I learned (by way of Dr Walsh, methylation guru) that people with SERT gene, low serotonin, problems should not take folate in any form except food. B9 made me very depressed due to this. Thanks!

[@dr.robinlewis]

Thanks for sharing. I’ll check Dr Walsh out.

[@THaughton]

Great video. Very informative. I'm taking a supplement that has helped me immensely but I'm concerned about the level of Folate: 15mg L Methylfolate from 18.75 L-5 methylfolate, calcium salt) which is indicated on the amount per serving on the bottle as 25 mg DFE and 6250% Daily Value. Fortunately also coupled with B12 as methylcobalamin 1000 mcg or 41666% Daily Value. Seems extremely high to me as well. Not sure whether to take it sparingly or daily or what.

[@dr.robinlewis]

For many people you need to trail and error to see what dosing schedule makes you feel best 😊

[@THaughton]

@dr.robinlewis Thanks. So far I feel great taking that stuff but again Wow that's a heavy dosage. I'd rather not end up with side effects. I am thinking of cutting back to once a week to see how that feels.

[@Jmka-q3h]

Yaah. Same thought. Anyhow the good news is that B vitamins are water solable and anything beyond body need is taken out of the body

[@THaughton]

@@Jmka-q3h Thanks for the info. That's what I've heard from my providers as well. I'm always suspicious of mega doses of anything. Glad it's safe.

[@carlor.s.4742]

Thanks for Pts 1& 2, I learned a lot! I'm an older man & I take a B vitamin complex, which I imagine is the inactivated forms of B9 & B12. What about nutritional yeast? Does it have B9 & 12? You mentioned Betaine. I take Apple Cider Vinegar before I break my fast & eat at about 11 AM. But sometimes if we are having a "heavy" meal, like steak or pasta I will take Betaine Hydrochloride to increase stomach acid. How is that different from Betaine?

[@dr.robinlewis]

Nutritional yeast is good source of B12. The betaine HCL is the same betaine but you take that more for the HCl and it would be hard to achieve the therapeutic doses getting it through that combination. I would try it on its own so you don’t end up overdoing hydrochloric acid in the meantime. I hope that helps 🙂

[@thunderthumbz3293]

The best supplement dose ive found is one rolled habano Nicaraguan leaf, along with fermented corn or rye drink

[@dr.robinlewis]

Very interesting! I haven’t heard of that one!

[@thunderthumbz3293]

@@dr.robinlewis cigar and bourbon 😅😅😅

[@dr.robinlewis]

@@thunderthumbz3293 HAHA! I clearly didn't get the joke 🥴

[@stargazer17]

Excellent video, thanks for explaining it so well. Where can I find a list of your top picks as far as brands for these supps? Thank you!

[@Future2024]

B12 injectable only works because of missing transcobalamine factor..take with folinic acid..activated..and P5P active B6..because forms of anemia are present so get a bloodvsmear,CBC,b12 may test high,folate may test high,though they are not functioning ..also have thyroid T3 T4 TSH and Liver Enzyme Test for differtial on fatigue...abd a good life style factor like exercise is great and avoiding too much partying with your spouse

[@pramuanchutham7355]

In older age, above 60, Pernicious Anemia stems from autoimmune causing lack of protein in the stomach to carry B12 from digested food. Sublingual B12, under the tongue until fully dissolved and absorbed into the veins under the tongue, is a simpler remedy than iv B12. See Kirkland's 5000mcg sublingual B12...works very well at 10cents.

[@trucobarentos4538]

Bless you for sharing this educational information for all of us so that we can improve our lives. Thank you

[@dr.robinlewis]

You’re very welcome!

[@ShayVidz]

❤ this channel is awesome please do more videos, very informative, no distractions, simple and straightforward

[@dr.robinlewis]

Thank you so much for the kind words 😊

[@MrYoubet]

you are are a great speaker and very detailed , i learned so much from your videos,,thank you so much for your great work

[@dr.robinlewis]

You’re welcome, thanks for the kind words 🙂

[@GhostOfRT300]

What a brilliant presentation, thank you. 🙏🏼

[@dr.robinlewis]

You’re welcome! Thank you for the kind words 🙂

[@karronlaneNOLA]

yes.

[@tomlwallace]

Really well presented. Just wanted to say thank you!

[@dr.robinlewis]

Thank you!!

[@mwbobo1]

Hi, I have the MTHFR mutation. I have tried supplementing with a b complex and methylfolate, and with just methylfolate by itself. Every time I get too stimulated and my preexisting sleep issues gets way worse. What can i do about this? Not taking these supps currently.

[@dr.robinlewis]

There isn’t a simple answer here. Sometimes the B vitamins are worsening a preexisting mold issue due to their manufacturing. Sometimes you didn’t preload with enough B12. Sometimes it’s kicking you into a detox reaction and you need to ease into it more slowly. I wish I could give you a direct solution but ultimately when people react poorly it’s typically because something else is going on health wise.

[@peacefulruler1]

Never take B vitamins late in the day. There’s a reason they put them in energy drinks.

[@danieldaniels5034]

​@dr.robinlewis hi, i have 677 heterogeneous and once i use liposomal methylated b complex i have severe palpitations. Any advice please?

[@mikecolwill]

Sometimes, as you activate methylation, you can have a surplus of some neurotransmitters, especially if you have the COMT or maoa snips as well. Try much much smaller doses. B2 MG support methylation here at those bottlenecks

[@asherasator]

It's not a gene mutation, but the reality that some ancestors were not consuming a lot of methionine foods that result in high homocysteine byproducts. This has been understood in science for quite some time. [Pre 2003 MTHFR symptoms were understood by Homocystinuria]: (1) Geigy Scientific Tables, 7th edition, page 449; Inborn Metabolic Errors and their treatment, 'Homocystinuria' the treatment is 'Diet low in methionine, but higher in cysteine and pyridoxine [vitamin B6].' Which B6 is naturally found in fruits, veggies and grains. (2) Enzymatic Reaction Mechanisms, pages 846-850; 'Cobalt coenzymes [B12] with FADH enzymes [B2 based] attacking SAM [S-adenoslymethionine] creating methyl-CoB12, which then turned homocysteine back into methionine.' Normally SAM would create methyl-CoB12 by the enzyme NADPH, with a "defect" and lower ability to metabolize the Cobalt enzymes [B12] with FADH [B2 based] can also do the job. But the next pages 851-863 show that methyl-CoB12 '... appears to function secondary methylation category... methylates mercury, palladium, lead, platinum, gold, tin, arsenic, selenium, and chromium' in the environment creating toxic chemicals. High doses of methyl-CoB12 is well known to increase oxidative stress and has many other toxic reactions. So lowering methionine with focus on natural foods with cysteine, B2 and B6 [from diet] seems to be a better route and dealing with homosistinuria [MTHFR] for over 50+ years. Methionine is carcinogenic and involved in angiogenesis that creates blood vessels to tumors. The common ideas of methionine being "essential" is overrated because even with no MTHFR "defects" the toxic effects of methionine to homocysteine recycling can affect anyone. From my point of view it is irrelevant if B2, B6 fortified foods are a source, what is important is to lower methionine which is the starting point of the cycle.

[@bobkatc9368]

Is there any supplement that combines all these?

[@jamieclarke321]

Very helpful walk through the cycle

[@dr.robinlewis]

Thank you!

[@robcolvin8574]

Do you have any supplement recommendations for B9, B12,TMG and Sam-e that are within the recommended ranges you discussed in the video? All I seem to find are mega doses of these supplements.

[@asherasator]

The high dose supplements can produce toxic effects. "MTHFR defect" is not a gene mutation, but the reality that some ancestors were not consuming a lot of methionine foods that result in high homocysteine byproducts. This has been understood in science for quite some time. [Pre 2003 MTHFR symptoms were understood by Homocystinuria]: (1) Geigy Scientific Tables, 7th edition, page 449; Inborn Metabolic Errors and their treatment, 'Homocystinuria' the treatment is 'Diet low in methionine, but higher in cysteine and pyridoxine [vitamin B6].' Which B6 is naturally found in fruits, veggies and grains. (2) Enzymatic Reaction Mechanisms, pages 846-850; 'Cobalt coenzymes with FADH enzymes attacking SAM [S-adenoslymethionine] creating methyl-CoB12, which then turned homocysteine back into methionine.' Normally SAM would create methyl-CoB12 by the enzyme NADPH, with a "defect" and lower ability to metabolize the Cobalt enzymes with FADH can also do the job. But the next pages 851-863 show that methyl-CoB12 '... appears to function secondary methylation category... methylates mercury, palladium, lead, platinum, gold, tin, arsenic, selenium, and chromium' in the environment creating toxic chemicals. High doses of methyl-CoB12 is well known to increase oxidative stress and has many other toxic reactions. So lowering methionine with focus on natural foods with cysteine, B2 and B6 [from diet] seems to be a better route and dealing with homosistinuria [MTHFR] for over 50+ years. Methionine is carcinogenic and involved in angiogenesis that creates blood vessels to tumors. The common ideas of methionine being "essential" is overrated because even with no MTHFR "defects" the toxic effects of methionine to homocysteine recycling can affect anyone. From my point of view it is irrelevant if B fortified foods are a source, what is important is to lower methionine which is the starting point of the cycle.

[@chrismyers9951]

@@robcolvin8574 Don't use SAMe.

[@mianshahmirali1607]

Dr. Lewis, thanks a lot for the amazing video. I really like them. I've come across a few videos in which Doctors claim that Goat/Bovine Colostrum might cause Prostate Cancer since it contains growth factors not recognized by the human body. Others claim that Colostrum heals Leaky gut. I'm really confused. Please comment

[@dr.robinlewis]

Hi, I haven’t heard of the claim around cancer but I use it often in clinic and have had good success with it.

[@meenakothari7841]

Thankyou for the clarity . Very well explained.❤

[@dr.robinlewis]

You’re welcome!

[@cedarcabinsociety]

Thank you! Really informative episode. 🙌🏻

[@dr.robinlewis]

You’re welcome!

[@inittiela4934]

Why you didnt mention creatine? Its literally the best and the biggest methylation supporter.

[@dr.robinlewis]

From my understanding methylation helps make creatine and not the other way around but if there is some research you have I would love to learn more 🙂

[@inittiela4934]

​@@dr.robinlewis by getting end product of methylation in this case creatine which is 40 up to 70% of all methylation in body you highly increase availability of methl donors for other reactions and its especially usefull for people that have problem with recycling homocysteine to methionine(mthfr mutation or bhmt) in which case it may help them a lot and those methyl donors that you mentioned serves as cofactors for remethylation homocysteine to methionine so in other words you can get that effect without increasing those nutrients simply by using creatine. I hope it make sense for you, if you have any doubts then ask

[@dr.robinlewis]

@@inittiela4934 I see what you mean now. Yes, that makes tons of sense. These episodes are never comprehensive enough but I do appreciate the helpful addition :)

[@sjars1393]

Hello love the video. I have high blood pressure, not taking a supper high dose just 4mg. It still stays around 136/80 I’d like to get the top number down. I have read TMG is good for high blood pressure, would this be good to supplement with and potentially get of my blood pressure med.

[@dr.robinlewis]

I’m glad you enjoyed it! It can help some people but not everyone! It’s fairly safe and worth trying.

[@tinaholbrook9719]

We are using Thorne's "Methyl-Guard" supplement (my daughter has 2 bad genes, so she's limited in function of her MTHFR gene by 70-80%. She gets migraines as a symptom). The Methyl-Guard supplement says that it contains as written "folate (1.2 mg as L-5-methyltetrahydrafolate from L-5-methyltetrahydrofolic acid, glucosamine salt)" Is this the same as methylfolate? The folic acid part is throwing me off. We are being very intentional with her (and the rest of my family's) diet. We have elimated all folic acid and have upped folate rich foods (broccoli sprouts, beef liver, pasture raised eggs ect). I do not want her taking a supplement with folic acid. Can you help me figure out if this supplement contains folic acid?

[@dr.robinlewis]

These are essentially the same and that is a good supplement!

[@tinaholbrook9719]

Thank you so much! Your videos are so helpful and easy to follow! Thank you for the work you put into them ☺ ​@@dr.robinlewis

[@dr.robinlewis]

@@tinaholbrook9719 You're very welcome! I am so glad you're getting value out of them.

[@dramondellis5214]

Good afternoon, I read your comment. Most are misunderstanding something. The MTHFR scare is that people are deficient in riboflavin. Also the headache she is getting is because she does not have the energy to use the methylfolate. NAD in the energy cycle is “Riboflavin” AKA vitamin B2. You need riboflavin(Vitamin B2) for the methylation cycle to work correctly. Also folate(methylfolate) needs b12 break down the homocysteine that’s produced in the methylation cycle. All b vitamins are needed for the body to function appropriately but for the methylation cycle mainly Riboflavin(B2), Folate”(B9), and pyridoxine(B6). Just don’t overdo with b6. The methylfolate with B12 and added riboflavin will remove the headaches. I’m an adult so use small doses or see what your child’s body responds to. I had the same issue with the headaches until I realized most b supplements give small doses of Riboflavin, Folate but synthetic(folic acid) and low dose b12. I’ve taken all at high doses with the exception of B6 and most issues have been corrected. You can see Chris Masterjohn PHD for the info on the Riboflavin deficiency as the culprit regarding the mthfr gene mutation. There isn’t one… people are just deficient in riboflavin(B2). There are 11 B vitamins total. Inositol, Choline,PABA, folate, thiamin, niacin, riboflavin, pyridoxine, panthothenic acid,biotin and methylcobalamin

[@asherasator]

@@dramondellis5214 You are correct. It's not a gene mutation, but the reality that some ancestors were not consuming a lot of methionine foods that result in high homocysteine byproducts. This has been understood in science for quite some time. [Pre 2003 MTHFR symptoms were understood by Homocystinuria]: (1) Geigy Scientific Tables, 7th edition, page 449; Inborn Metabolic Errors and their treatment, 'Homocystinuria' the treatment is 'Diet low in methionine, but higher in cysteine and pyridoxine [vitamin B6].' Which B6 is naturally found in fruits, veggies and grains. (2) Enzymatic Reaction Mechanisms, pages 846-850; 'Cobalt coenzymes [B12] with FADH enzymes [B2 based] attacking SAM [S-adenoslymethionine] creating methyl-CoB12, which then turned homocysteine back into methionine.' Normally SAM would create methyl-CoB12 by the enzyme NADPH, with a "defect" and lower ability to metabolize the Cobalt enzymes with FADH [B2 based] can also do the job. But the next pages 851-863 show that methyl-CoB12 '... appears to function secondary methylation category... methylates mercury, palladium, lead, platinum, gold, tin, arsenic, selenium, and chromium' in the environment creating toxic chemicals. High doses of methyl-CoB12 is well known to increase oxidative stress and has many other toxic reactions. So lowering methionine with focus on natural foods with cysteine, B2 and B6 [from diet] seems to be a better route and dealing with homosistinuria [MTHFR] for over 50+ years. Methionine is carcinogenic and involved in angiogenesis that creates blood vessels to tumors. The common ideas of methionine being "essential" is overrated because even with no MTHFR "defects" the toxic effects of methionine to homocysteine recycling can affect anyone. From my point of view it is irrelevant if B2, B6 fortified foods are a source, what is important is to lower methionine which is the starting point of the cycle.

[@marcrabbat]

I have the Mthfr c667t homozygous mutation. What would you recommend I start with and in what doses? Thanks a lot for this informative video.

[@johngamman9698]

This is so helpful, thank you! I have C677T/A1298 mutations. Was taking 15 mg L-methylated folate, had severe anxiety. Switched to 1 capsule/day Methyl-Guard+. Anxiety much lower, energy levels still a bit low. B12 at 1100, MMA 70. Thinking of adding Glutathione or SAMe. Your thoughts would be much appreciated.

[@chrismyers9951]

@@johngamman9698 Don't add SAMe. Add NAC instead of glutathione. 15 mg was waaaay to much.

[@dianafobert6402]

Does ppi's ( acid reducers) block b9 or b12 to be absorbed(Methylated in the body)

[@dr.robinlewis]

Yes it can, especially B12.

[@honkeykong752]

Do you have any recommendations, such as a multivitamin or brand to lean towards ?

[@dr.robinlewis]

Not just one but the brands I use are professional grade because they hold themselves to higher standards. Ie AOR, Cytomatrix, designs for health, etc.

[@honkeykong752]

@@dr.robinlewis thank you!

[@user-zq9pt8nx3w]

So, you can take a SamE, methionine, and the others we lack? Good to know. 😊

[@sourcehealing82]

I have multiple copies of this gene. My latest blood work, b12 was 4000! I’ve never taken b9 before. I just wonder how to balance that with my high b12 at the moment.

[@dr.robinlewis]

Were you taking a B vitamins or something containing b12 at the time of the test? 9/10 times elevated b12 is simply because you took b12 too close to the time of the blood draw.

[@sourcehealing82]

Yes I was! I stopped taking it because I was scared of that high number. I need to get my homecystine levels tested. Thanks for the video.

[@dr.robinlewis]

You’re welcome! If that’s the case then you likely don’t actually have elevated B12. I’d suggest retesting when you go in for the homocysteine but make sure to stop the B12 3 days beforehand. That way you will get an accurate reflection of your true B12 stores :)

[@willjays1]

@dr.robinlewis Hi, I got gene tests done and it confirmed I have MTHFR gene variants. So I took a very small amount of methylfolate about 4 days ago and have been suffering with anxiety and insomnia since. Should I have taken B12 prior then as you suggested? And can you take it after methylfolate or does it have to be prior? FYI I did not continue to take methylfolate after the reaction 4 days ago.

[@dr.robinlewis]

You would take the B12 alone for at least a week and then you can try them together 🙂

[@willjays1]

@@dr.robinlewis thanks for your reply. I will try this.

[@perthgirl1012]

​@@willjays1I had this problem, methyl is the problem. I now take a methyl free b from seeking health and no more anxiety. 😊

[@HawaiiLimey]

If you have suffered lifelong non-responsive gut dysbiosis then you might be a FUT2 non-secretor (identifiable with a genetic test). This is synonymous with B12 deficiency as well as multiple other symptoms/conditions. If you are a non-secretor your body will not be able to absorb methylcobalamin and your blood serum B12 will read high, you will need to administer regular intramuscular hydroxocobalamin injections to increase intracellular B12 levels.

[@dr.robinlewis]

Thank you for the helpful contribution. 🙌❤️

[@susanmack4450]

Where do you find out who can give you the gene test to find out if you need methylation vitamins?

[@dr.robinlewis]

Typically it’s done by functional medicine doctors or naturopathic doctors. The only way to know is call local doctors in this category and ask

[@inittiela4934]

Active form of folate is most overrated suplement in case of methylation and i will explain you why. Your body converts folate to different forms like dhf, thf and mthf all day long and suplement that you take will be converted back to this other forms really quickly and then it again needs to be converted using mthfr enzyme so it wont save you, if you ask then what can i do do actually improve my health without mega dosing folate which wont do you anything good in long term then i will tell you that you need to do 2 things, first of all make sure that you have good b2 status becaue this vitamin speeds up mthfr enzyme and second of all suplement with creatine which will lower your body demand for methylation which will lower homocysteine production and by that lower your demand for methylfolate and also betaine.

[@dr.robinlewis]

👍

[@Jmka-q3h]

What you say is making sense since I didn't find any benefit by consuming methylated B9 even when I increased the dosage to around 4mg / day. However, I had better feeling by Methylated B12 only. Also, I have generic better feelings when I take the B complex, which unfortunately contains B UNmethylated B9+12, but include all others from B1 till B6

[@stevemarx6204]

Hey beautiful doctor what does it mean when somebody does very bad with vitamins and supplements including vit D?Thanks !

[@dr.robinlewis]

It often means your liver has issues running certain pathways, sometimes genetics can also give a bit of insight into.

[@Mrssohasalama]

What about if homocysteine is low , not high? In this case , is it wise to use methylated forms , Im dealing with Autism case

[@MrYoubet]

in one of your videos you said vancouver was moist,was an understatement, i lived in port alberni up until i was 35 and there is only one worst place, is ocean falls, i wonder why it was called that? i live in ventura ca. high and dry ,love my lemon tree and my tomato plants don't shrink when i transplant them outside

[@dr.robinlewis]

😂 so you can relate! I’m glad you found drier climate!

[@nolamayer4101]

Any suggestions on Methylated B vitamins supplements to take as I have great trouble taking them ? Many thanks 🌻🌻

[@dr.robinlewis]

To be fair many are similar but I like the brands Thorne, AOR, NFH and DFH!

[@nolamayer4101]

@@dr.robinlewis thank you Robin, I was able to get some from a compounding chemist which make to suit the individual 🌈

[@gardengirl9099]

I’m taking Why Not Natural from amazon B vitamins complex and I think it’s pretty good. Sublingual orange flavor.

[@carmeneblen3556]

What about sulphoraphane? Does that in any way aid in methylation?

[@dr.robinlewis]

No but it does help with detoxification which is something that methylation also helps.

[@Lolaa11]

My over-methylation is so severe that I have to take Betaine-HCL for my low stomach acid and even from that I get severe anxiety. What can I do in this case?

[@dr.robinlewis]

That’s not a simple answer but you may want to look into niacin

[@Lolaa11]

@@dr.robinlewis Thank you! ♥️

[@noneofyourbusiness5433]

You need sodium for your stomach acid

[@Lolaa11]

@ yes i take half a teaspoon of salt every morning for a while now

[@rredding]

I learned from DNA testing that I have an issue with MTRR enzyme. Homocysteine elevated to 14. My functional doctor prescribed Riboflavine (B2). I supplement with B3 and I take Betaine (TMG) with it.

[@asherasator]

It's not a gene mutation, but the reality that some ancestors were not consuming a lot of methionine foods that result in high homocysteine byproducts. This has been understood in science for quite some time. [Pre 2003 MTHFR symptoms were understood by Homocystinuria]: (1) Geigy Scientific Tables, 7th edition, page 449; Inborn Metabolic Errors and their treatment, 'Homocystinuria' the treatment is 'Diet low in methionine, but higher in cysteine and pyridoxine [vitamin B6].' Which B6 is naturally found in fruits, veggies and grains. (2) Enzymatic Reaction Mechanisms, pages 846-850; 'Cobalt coenzymes with FADH enzymes attacking SAM [S-adenoslymethionine] creating methyl-CoB12, which then turned homocysteine back into methionine.' Normally SAM would create methyl-CoB12 by the enzyme NADPH, with a "defect" and lower ability to metabolize the Cobalt enzymes with FADH can also do the job. But the next pages 851-863 show that methyl-CoB12 '... appears to function secondary methylation category... methylates mercury, palladium, lead, platinum, gold, tin, arsenic, selenium, and chromium' in the environment creating toxic chemicals. High doses of methyl-CoB12 is well known to increase oxidative stress and has many other toxic reactions. So lowering methionine with focus on natural foods with cysteine, B2 and B6 [from diet] seems to be a better route and dealing with homosistinuria [MTHFR] for over 50+ years. Methionine is carcinogenic and involved in angiogenesis that creates blood vessels to tumors. The common ideas of methionine being "essential" is overrated because even with no MTHFR "defects" the toxic effects of methionine to homocysteine recycling can affect anyone. From my point of view it is irrelevant if B fortified foods are a source, what is important is to lower methionine which is the starting point of the cycle.

[@joydomain]

‘Loading up’ on B12 before methylated B9 BUT still have increased anxiety I can obviously drop my daily dose of B9 but is it a case of just ‘riding thru’ these symptoms…should they diminish in time? Thank you for your video 😊

[@dr.robinlewis]

I would typically just lower the dose and ease more slowly into it. :)

[@johnrdunbar]

How do Redox Signaling Molecules affect this?

[@phatan555]

I had been low on b 12 and then started supplementing. It got corrected... Recently I tested for folate it turned low as defined by range... I had been very anxious and moody though out my life.. Now 35... Now it has been a week taking folate 300 mcg.... And let's what comes the result.. Any further suggestion you would put in plz

[@dr.robinlewis]

I’m glad you’re finally figuring it out! The moodiness could be cause by a lot of things but starting one thing at a time is a good idea. You could always explore hormones and dopamine next if that doesn’t help, but ultimately there are a lot of causes!

[@keylanoslokj1806]

Would you recommend a methylated B complex or its kinda imbalanced often? Are 2-3 B vitamins safer than 5+ in the same product?

[@dr.robinlewis]

I do methylated B complex all the time! Some are better than others but it’s a great way to cover your bases.

[@keylanoslokj1806]

@@dr.robinlewis i mean fot mhtfr mutation people

[@dr.robinlewis]

@@keylanoslokj1806 I would say the same thing for people with that mutation. You can try both. Meaning, either just supplement with 5-MTHF and methylcobalamin OR a B complex with more B vitamins but just make sure they are all in their active forms.

[@rogerdupont8348]

Hello Is taking only one working (like TMG) or should we take MB12 MB9 and Sam-e as well ? Thanks a lot

[@dr.robinlewis]

It totally depends on which methylation genes are affected.

[@rogerdupont8348]

@@dr.robinlewis Thanks. Could you give us a breakdown please ? Does it work to take it all "just in case" ^^" ?

[@michawill6599]

​@@rogerdupont8348read her response above...depends

[@joydomain]

Is B12 & B9 when found in food already methylated?

[@dr.robinlewis]

It’s a mix, some foods have the active forms like methylcobalamin and others don’t.

[@HANZELVANDERLAAY]

​@@dr.robinlewishi.. perhaps a brief list..of these would be lovely..thanks

[@davidflorez1196]

​​@@dr.robinlewisWould you be so kind to give us a list of the top methylated foods, one should take for B9 & B12.

[@MAGA_AMERICA]

Add a grounding blanket to this regimen.

[@dr.robinlewis]

Love it

[@shawnfallahi5616]

NMN with TMG (an hour later) I hear is a good combo

[@dr.robinlewis]

I haven’t heard of that combo but both great supplements! Thanks for sharing 🙂

[@shawnfallahi5616]

@@dr.robinlewis NAC is another good one combined with Glycine. I believe the TMG 'completes/donates' the methylation of the NMN, something to that degree. Also, if you have not, check out TUDCA (and getting your stomach acidic beforehand with apple cider vinegar.) Thank you for the reply!

[@shawnfallahi5616]

@@dr.robinlewis found this: Trimethylglycine (TMG) is a supplement that may help make NMN more effective by restoring methyl groups that NMN needs to function correctly

[@shawnfallahi5616]

@@dr.robinlewis more: NAD+ boosters such as NMN can end up draining the pool of methyl groups in the body, and TMG helps prevent this

[@loveKG26]

Iv had seizures does this have any connection to this methylation? I want gene testing to find out anything.

[@dr.robinlewis]

Not that I am aware of but it’s possible.

[@richieheetebrij8189]

I believe I have this gene mutation as I have the symptoms of poor methylation, my homocysteine is high and my some of my B status is low based on my metabolic text however when I take SAMe or methylmax, I feel like garbage. I took b12 sub con and got a painful purple bruise that last about a week. Thoughts ?

[@dr.robinlewis]

I would get tested properly to know for sure and then go from there. None of those products are blood thinners so they shouldn’t cause easier bruising but if it keeps happening get it checked out.

[@mystrength5640]

Hi Doctor I read that B12., May read High.. Because it may build up in the Fat Tissues! Is this true please? ? I take 10 000 D3.. and my D3 blood level with this is normal.. Been Taking 5mg of K2 M7 .( Natto) could not Tolerate more.. The dizzy sensation. Light headed feeling is debilitating.. Although., it gives one a feeling.. of having more energy.. but Do Struggle to fall asleep with this K2… Do you know if Vitamin K2 M 4 will have this same problem?Too much Caffeine feeling please? ?? Tnx kindly 🎊

[@dr.robinlewis]

The body doesn’t tend to store excess amounts of B12 and the main stores are in the liver so I don’t believe that’s true. K2 is not generally considered stimulating but the only way to know would be to try taking it away from bed and see how you get on. I hope that helps.

[@mystrength5640]

⁠​⁠@@dr.robinlewisThank you. Soo kindly I’ve Stopped taking the Vit K2 m7. Anxiety gone away .. 5mg Due to it Being SOY and With Hashimotis .. Just started a Vitamin K2 M4 5mg with my D3.. . 10 000 daily. Taking 1333 Mg methyl Folate in my Mutli B. Take 2 two Glycogenics Metagenics And have added B12 as extra. 3000mg adeno B12 sublingual Need to have homocysteine and Copper Checked in time. Take from 30-Mg - 45 Mg Zinc at night get too sleepy In morning from Zinc . Have a C p450 .. And add Boron and SELENIUM Nocte. With 600 Mg Magnesium. Being Citrate and Biglycinate.. added recently a 100 mg Betaine hcl with Breakfast.. ( digestive enzyme) helps my digestion. A lot in a few days .. But it just started to hurts Knees. 🤣🥲 Is this too much Hcl please. It has 10mg Tumeric too. ? Plus I take 3 g Tumeric per Day.. cooked .. Tnx kindly.. 🎉💐🩷🩵💛

[@janineclemons746]

I take my stimulating supplements in the morning. I find B vitamins are stimulating. I take regenerative supplements in the evening D (if I didn't get sun), K2/MK7 and nattokinase. I take a lot more supplements, but that is how I group them. Also B vitamins and vitamin C are water soluble and your body should eliminate excess in your pee.

[@robertmarking817]

Great job!!! 👏😊

[@dr.robinlewis]

Thank you!

[@charlesfuchs]

WOW!! TMG CHANGED MY LIFE!!! :)

[@AlexCozens]

how so?

[@wnose]

Same here.

[@davidflorez1196]

How so?

[@davidflorez1196]

​@wnose can you share how?

[@wnose]

@@davidflorez1196 more energy, less depression

[@JATIN-s6q]

doc my b12 is 190 may i go for basic b complex or b12 jarrow or thorne?

[@dr.robinlewis]

I can’t give direct medical advice but if b12 is below the reference range I will typically do B12 alone in a supplement or as muscle injections to boost the levels quickly and then maintain with a B complex.

[@rebeccagarner2576]

The under the tongue B12 drops worked for me… I was taking supplements but I wasn’t absorbing it. The drops saved my life.

[@feelinghealingfrequences7179]

methylcobalamine dots or liquid sublingual

[@bananaana04]

I have been overmethykated after taking a methylated b12 3 months ago. I stopped taking the supplements but still having symptoms and they are debilitating. Do you have info on how to help with overmethylation

[@dr.robinlewis]

It could be many things but some literature suggests that niacin may be helpful for over methylation.

[@arrepuess]

is it OK for people that might not have this genetic mutation to take the methylated forms instead of the non methylated forms if already taking folic acid & b12? Im asking for a friend. Because i took the test and actually do have 2 variants. I suspect he may have it too, but I doubt he will be taking test.

[@dr.robinlewis]

Absolutely, I always recommend my b vitamins in their active or methylated forms! Not everyone does the test

[@arrepuess]

@@dr.robinlewisthank you ! Followed

[@l.c838]

Good video, Thank you 🙏

[@dr.robinlewis]

You’re welcome!

[@dfinite1111]

Are the side effects always from not taking enough b12? Because I think I get a lot of b12, and of the right form. I think I just can’t tolerate the methylation? It’s been really rough…Only a few online medical “experts” seem to understand that it can be a lot more complicated, and many C6777T people can’t actually the methylated bs. Might it not work for those of us?

[@keylanoslokj1806]

Who knows

[@asherasator]

It's not a gene mutation, but the reality that some ancestors were not consuming a lot of methionine foods that result in high homocysteine byproducts. This has been understood in science for quite some time. [Pre 2003 MTHFR symptoms were understood by Homocystinuria]: (1) Geigy Scientific Tables, 7th edition, page 449; Inborn Metabolic Errors and their treatment, 'Homocystinuria' the treatment is 'Diet low in methionine, but higher in cysteine and pyridoxine [vitamin B6].' Which B6 is naturally found in fruits, veggies and grains. (2) Enzymatic Reaction Mechanisms, pages 846-850; 'Cobalt coenzymes [B12] with FADH enzymes [B2 based] attacking SAM [S-adenoslymethionine] creating methyl-CoB12, which then turned homocysteine back into methionine.' Normally SAM would create methyl-CoB12 by the enzyme NADPH, with a "defect" and lower ability to metabolize the Cobalt enzymes with FADH [B2 based] can also do the job. But the next pages 851-863 show that methyl-CoB12 '... appears to function secondary methylation category... methylates mercury, palladium, lead, platinum, gold, tin, arsenic, selenium, and chromium' in the environment creating toxic chemicals. High doses of methyl-CoB12 is well known to increase oxidative stress and has many other toxic reactions. So lowering methionine with focus on natural foods with cysteine, B2 and B6 [from diet] seems to be a better route and dealing with homosistinuria [MTHFR] for over 50+ years. Methionine is carcinogenic and involved in angiogenesis that creates blood vessels to tumors. The common ideas of methionine being "essential" is overrated because even with no MTHFR "defects" the toxic effects of methionine to homocysteine recycling can affect anyone. From my point of view it is irrelevant if B2, B6 fortified foods are a source, what is important is to lower methionine which is the starting point of the cycle.

[@mickmarkwick2263]

Thank you! for the vidoe it was good here!

[@dr.robinlewis]

You’re welcome!

[@Dolphin_457]

It's a great educational video Dr. Lewis. Thank you. 😊

[@dr.robinlewis]

You’re very welcome!!

[@anastasiavarianichenko9026]

Can l give TMG t a 9 year Child? Thank you

[@dr.robinlewis]

With children you have to adjust the dose based on their weight but otherwise it’s generally safe.

[@melissadevaux8700]

My doctor has never even heard of this and disregarded anything I said about it.

[@dr.robinlewis]

Unfortunately this isn’t routinely taught in medical school. Although, I’m sorry your doctor disregarded you. That should never happen.

[@ourlittlesouthernhomestead4154]

THANKS

[@dr.robinlewis]

You’re welcome!

[@KatinaLifeCoach4444]

New to the channel thank you new subscriber shared and liked❤❤❤❤

[@shawnshawn7477]

Nothing is more attractive than a beautiful woman who is smart.

[@dr.robinlewis]

🙂🙂

[@me67226]

I still don't understand what methylation is.

[@jonash226]

The more I watch this stuff the more I don’t know what’s safe anymore totally confused.

[@AnythingGodamnit]

This was super useful - thanks!

[@dr.robinlewis]

You’re very welcome!!

[@iamindigamer]

i am having frequent renal stones issues . i did 2 lazer surgery and frustrated . any test how to solve this isssue?

[@samirnarvekar8488]

Magnesium citrate is used to reduce recurrence of renal stones. I have had stones four times one in bladder (large one- 26 mm) for which I did lazer surgery but three renal stones I passed with Ayurvedic herbs within month. I am from India. After I started Mg Citrate I have not had kidney stone.

[@joelsombroek]

Didn't you hear which element / substance these stones contained ? For oxaletes you can change your diet, no more spinach and such. For calcium maybe extra vitamin K2 can help, because it channels the calcium in the blood into where it belongs: the bones. If I remember well, your blood/urine PH also plays a role, you could eat more acidic food or take applecider vinegar pills or so. Check these suggestions online to see if I'm correct :$ I guess drinking more water is also a good idea in general.

[@samirnarvekar8488]

@@joelsombroek calcium oxalate.

[@samirnarvekar8488]

@@joelsombroek If your reply is directed at me I don't have renal stone issue anymore as I said earlier after supplementing with Mg Citrate. (I am already on K2 as I take Vitamin D3- combination) Just for info to viewers : Citrate combines with Calcium reducing formation of Calcium oxalate crystals. Also Magnesium has antagonistic effect on Calcium throughout the body. Hence in cardiology it's called natural Calcium channel blocker. CCB are drugs used for hypertension etc.

[@mreudeco]

Beautiful 🙏

[@Butterflylovely5]

Except we need methyl folate not folic acid or any other form of folate.

[@dr.robinlewis]

Yup!

[@calebbuchanan3267]

❤

[@TechnoCogito]

Your name is not Dr Robin Lewis, eventually it is Robin Lewis and you are a doctor.

[@dr.robinlewis]

Thank you.

[@rangerdoc1029]

Caution: MTHFR, but Methylfolate caused severe anxiety & depression

[@dr.robinlewis]

Thanks 😊

[@mikecolwill]

Check your comt and maoa status

[@carriea479]

​I have the COMT mutation, what would need to be done differently?

[@perthgirl1012]

I had this problem, now I take Methyl free b by seeking health. No more anxiety. 😊

[@agrinewsnet3569]

Your mix of supplements is not completed- you need to do a real test on a real device- PHARMa is so use to Symptoms- the coarse never exist- Quanlim Life

[@dr.robinlewis]

I’m not sure what you’re trying to say but I go over testing in part 1.

[@johnl477]

I don’t see a ring on that finger 😉 what a lovely woman

[@jennajade4388]

great video, so much valuable information i learned alot. thank you for explaining it in such a simple way for us people that are just starting to learn about methylation. absolutely the best , to the point video ive seen. also i live in vancouver bc so always nice to subscribe to a fellow neighbour :)

[@dr.robinlewis]

Thank you so much and hey there neighbour 🙂

[@the-beneficiary1809]

Sound like a fraud

[@dr.robinlewis]

Interesting take on the subject material

[@the-beneficiary1809]

@@dr.robinlewis So sorry I am all out of troll food. Grumble.....Grumble........

[@asherasator]

It can seem like that because the online ideas focus on methyl-supplements. These companies and MDs turned a topic not well known publicly into an opportunity to sell unecessary products. I think some of the video content creators intend well, but don't have the proper overview and correct understanding, as their education is limited and/or current remedies formed by collegues and trends. The Reality of Actuality is much more simple. "MTHFR defect" is not a gene mutation, but the reality that some ancestors were not consuming a lot of methionine foods that result in high homocysteine byproducts. This has been understood in science for quite some time. [Pre 2003 MTHFR symptoms were understood by Homocystinuria]: (1) Geigy Scientific Tables, 7th edition, page 449; Inborn Metabolic Errors and their treatment, 'Homocystinuria' the treatment is 'Diet low in methionine, but higher in cysteine and pyridoxine [vitamin B6].' Which B6 is naturally found in fruits, veggies and grains. (2) Enzymatic Reaction Mechanisms, pages 846-850; 'Cobalt coenzymes [B12] with FADH enzymes [B2 based] attacking SAM [S-adenoslymethionine] creating methyl-CoB12, which then turned homocysteine back into methionine.' Normally [without supplements] SAM would create methyl-CoB12 by the enzyme NADPH, with a "defect" and lower ability to metabolize, the Cobalt enzymes [B12] with FADH [B2 based] can also do the job. But the next pages 851-863 show that methyl-CoB12 '... appears to function secondary methylation category... methylates mercury, palladium, lead, platinum, gold, tin, arsenic, selenium, and chromium' in the environment creating toxic chemicals. High doses of methyl-CoB12 is well known to increase oxidative stress and has many other toxic reactions. So lowering methionine with focus on natural foods with cysteine, B2 and B6 [from diet] seems to be a better route and dealing with Homosistinuria ["MTHFR defect" B2, B6, B12 deficiency] for over 50+ years. Methionine is carcinogenic and involved in angiogenesis that creates blood vessels to tumors. The common ideas of methionine being "essential" is overrated because even with no MTHFR "defects" the toxic effects of methionine to homocysteine recycling can affect anyone. From my point of view it is irrelevant and good if common simple B2, B6, B12 fortified foods are a source, what is important is to lower methionine which is the starting point of the cycle.

[@inheaps]

I am new to your channel, and wow, you're brilliant! Do you do online consultations? I'm located in FL, US. I am actively searching for a doctor willing to review my elaborate history, which has been challenging for years. Very long story short, I'm curious. on top of a slew of other issues, can this gene mutation cause estrogen metabolism problems? I know that MTHFR is involved in methylation, a key process that facilitates proper estrogen breakdown and excretion from the body and that the 677T mutations reduce MTHFR activity. With less active MTHFR, methylation capacity decreases over time. Can this slow the clearance of used estrogen from cells, allowing levels to build up?

[@dr.robinlewis]

Thank you! I can’t see patients formally outside of Canada which is why I wanted to make the channel! There are some amazing naturopathic doctors in the states though.

[@dr.robinlewis]

The issue with MTHFR variations is poor detox and that includes the excessive estrogen as well!