Methylene Blue: Biohacker's Delight, or Playing With Fire

[@richardmalone3172]

I have been taking MB 40mg per day for 4 months after listening to Dr.Francisco Gonzalez-Lima. Gradual improvements over that time have been, improved sleep quality and much improved cognitive function in the area of maintaining my attention on a task. I am 69 and work full time and my occupation requires my full and complete attention for extended periods. Prior to using MB, I was considering retirement but now I am back to working well with full attention.

[@HussRisingYT]

I’m currently taking 40mg per day and I noticed an increase in energy.

[@richardmalone3172]

@@HussRisingYT yes, I should also mention increased energy. My gym workouts are testament to that. The fact that Dr. Francisco Gonzalez-Lima has been researching this for many years and he and his wife and children supplement with MB then it’s good enough for me.

[@ActivateMission2ThisTimeline]

​@@richardmalone3172thanks 😊

[@MasterofPlay7]

@@richardmalone3172 but i get more muscle pain (DOMS) after exercise when taking MB compare to before without MB, any thoughts?

[@skipskiperton4992]

thanks, I am in my 60s too, I am considering taking it

[@benniejohnson81]

Thank you for this great resource and also the helpful comments. I began experimenting with MB probably 6 months ago. For many weeks I took only 4-5 drops every day (64 yrs old/175lbs). That is a very low dose but it was enough to help me to begin to move forward from the grief of losing my lovely wife to cancer after 42 years of marriage and children. It seemed to help with my mental and emotional energy when engaging in conversation during social interactions. I also drive a lot in my work, and sometimes all day. I would take 4 drops just before a long drive and noticed that it helped me to remain more alert without the need for stimulants. For now, I don’t take it every day. But I’ve taken it twice during the past week just before some all day drives and still impressed with it. So glad to have found it. Hope this helps someone.

[@i-love-comountains3850]

I've been taking it in 3-4 drop dosages twice per day, for the last couple of days. I have struggled a LOT with quitting drinking, and I've struggled with substance use in the recent past, especially during extremely stressful times. Last night I found out we lost my uncle, with whom I connected more than most in my fairly large family. I've been worried that I'm going to have to fight my worst tendencies, but I haven't had nearly the strong cravings for substances and alcohol that I would have just a few weeks ago. Idk what it's worth, but it's very very surprising how well it is helping my stability in mentally stressful times. I'm looking forward to this MB journey.

[@js4325]

The alertness you get from MB is because it increases your blood pressure and heart rate. You might want to experiment by taking your BP when tired and then after taking the MB. It could cause you to stroke out if your BP gets too high, bad diet and multiple vax can be a major contraindication to taking MB. I wish you good health and healing after your loss❤

[@X4vi3RV]

Thank you. Excellent deep dive into the mechanisms of action. Those of you that complain about the length of the video, and quality of the sound, should be grateful that someone takes the time to share their knowledge to such a degree for your education. Keep up the great work.

[@ROSWITHAkr]

👌✌🌹

[@rs6588]

I would like to present my own version about MB. 1. Low dose is beneficial, high dose can be toxic. Start with 2 drops gradually increase to 10 -20 drops according to how your body reacts and your body weight. 2. Check long list of drugs that can cause side effects with MB before taking MB. 3. Consider enhancing energy production with MB plus near infrared light therapy. 4. Drop MB in some juice, chasing down with water to avoid blue stain and bad taste. 5. This is not a natural nutrient. Use it as needed. Take breaks from MB from time to time.

[@billw6903]

Thanks, i am about to try it, already using red light with great results. Probley will keep as a medicine for occasional 😊use

[@glenmonks1]

Can you provide any links for contraindicatory medicines 💊 for MB

[@joseykraemer9939]

Thank you!

[@lilyfield7634]

@@glenmonks1 I've studied MB for awhile. The contraindications are SSRI's (Serotonin uptake antidepressants) as MB increases Serotonin and Dopamine on it's own and can cause Serotonin syndrome, which can be deadly - but would have to take very high dose of MB for that to happen. Have read very low dose has been given along with SSRI's - but recommended to get off of them. It's easy to google drugs that are contrary to MB as many drugs can elevate your Serotonin. i.e. had no clue that things like Codeine (and other pain killers) elevated Serotonin. The other is a G6pd (Glucose-6-phosphate dehydrogenase) deficiency. This is an inherited condition where your body doesn't have enough of an enzyme called G6PD. This enzyme helps red blood cells work properly. A lack of this enzyme can cause hemolytic anemia. This is when the red blood cells break down faster than they are made. So, it is important to have this cheap blood test to see if you have it, as MB can heighten this situation. That's all the extremes I've read about, but I'm not a doctor, just a researcher.

[@jeffg7478]

@@glenmonks1contradictory meds come down to serotonin reuptake inhibitors. There is a small risk of developing serotonin syndrome with concurrent use with MB. But low dose MB combined with normal dose sris isn’t really going to pose a problem. But like they always say “check with your doctor”.

[@GoldenBlaisdale]

I started looking into methylene blue sometime ago. I was nervous to take it, and I ended up contacting Dr Gonzalez, who was very helpful. I have been taking it daily for months and months and see no particular downsides. It’s certainly has increased energy. And it seems to have helped a healing tooth abscess which was rather nastily infected. My mother suffers with cognitive impairment, and I’ve been microdosing her and it seems to be having quite a remarkable effect. Of course, these are just personal anecdotes. In my mother’s case, she doesn’t even know what I’m giving her so it can’t be Placebo.

[@LeapOfFaaaith]

I have had the same experience. Mom and Dad have experienced the same. My son did to. Same with my best friend.... And my son's PCA. But some who I shared it with didn't respond as well. This video explains why. I don't think Chris has direct experience treating with it. This removes some bias that I have. I'm not hearing him talk about low low doses, which most people I know that benefit are using. I'm talking 1 to 7.5mg, not the doses in the studies, which I think is too high for most people.

[@LeapOfFaaaith]

I would love to hear Chris talk to Dr Gonzales.

[@GoldenBlaisdale]

@@LeapOfFaaaith I’ve been doing it for so long that I couldn’t quite remember the milligram dosage to I tend to use so I checked. Mostly I take it once a day and recently I’m taking 15 mg 30 drops. You’ve made me think about it I’m going to half the dose today and see if I notice anything. I know it’s a completely different subject, but a friend of mine who has had issues surrounding a certain treatment given to everybody recently has been using a protocol that includes naltrexone. Specifically, low-dose naltrexone. It appears that this is not the therapeutic dose for which the drug was designed, but in this low dose has profound effects different from the full dose. All very interesting. I have to say I would need to go back and research again, but Chris asserts that methylene blue does not directly donate electrons into the electron transport chain. At least I think that’s what he said. I have no education in this field, I only understand it superficially. But I have listened to a lot of people who treat patients with this and researchers who assert that it definitely does improve the functionality of the electron transport chain at least if I have not misunderstood.

[@mackroscopik]

Just fyi, a person not knowing what you're giving doesn't rule out placebo. Generally they don't know when they are getting a sugar pill.

[@ald770]

I tried to find a way to reach Dr Gonzales. How do I contact him? Thank you

[@johnmurdock4229]

Thanks so much for this comprehensive presentation. You've saved all of us a great deal of time compiling this academic research. You must have spent hundreds of hours digging through countless journals and books to produce this video. Excellent work!

[@mychannelfornow]

I agree there is a sound quality issue. However, I learned more about MB's chemistry and it's associated impacts on the electron transport chain than in many previous hours of MB related viewing. I appreciate the time it took to organize all this. Thanks!

[@stillnessinmovement]

OK. been researching this, and doing some experimentation based on that. heres what I think is the best way to use methylene blue. 5 to 10 drops 2x a day in a glass of water in one of the doses, add 1 mg of ascorbic acid. freaking magic I tell you. basically methlyne blue upgrades mitochondria function and the vitamin C also does so. the C mixed w blue reacts to become anhydrous, which allows it to pass the blood/brain barrier. so it's getting a key antioxidant into a place that normally just does not get much. I saw significant lift in brain fog in 2 days of use. all sorts of good improvements. this is a long term supplementation type of use, not a medical intervention. trickle charge but keep it going, seems to be a superior way to really improve these things. i have been using home health treatments for several years to recover from colon cancer, and a host of other things. ive found some powerful recovery tools but this might be the most beneficial, just for what it's upgrading...

[@theozarksjourneytoself-suf5420]

Got a question: Is 1mg Ascorbic Acid correct? How would you measure such a low dose out? It usually comes in capsules no less than 500mg. Did you mean 1 gram?

[@Palaecro]

Good for you! Great info. Do you use DMSO at all or CDS? I've been using it for 2 years at 50-80 drops a day. I cycle off for a few weeks or so and go back on. I DEFINITELY notice a difference when I'm off for a couple weeks vs on it. I also have MANY metabolic genetic mutations, luckily not the one that would cause issues with Methylene Blue.

@@Palaecro whats CDS ?

[@Palaecro]

Chlorine dioxide

[@theozarksjourneytoself-suf5420]

@@Palaecro Do you have information about making CDS? I had links, but all of those links have not been removed........

[@heartsource]

20 mg methylene blue makes me calm and motivated. I use it occasionally, as a substitute for psychiatric medicine like bensodiazepine.

[@reidbounsall9098]

That's encouraging. I'm hoping it will help me with my anxiety issues as well.

[@rdallas81]

AWESOME

[@user-mn1ql6ky4x]

Thank you for your update. 8 months later how do you feel? I'm hoping MB can help my son.

[@heartsource]

@@user-mn1ql6ky4x Unfortunately it stopped giving me calmness. Maybe i need to up the dosage, but that makes me a bit exhausted, so i only take about 10 mg now for health. If you're searching for a healthy substitute for benzo there're many alternatives to try if mb doesn't work, eg: Kava, Nigella Sativa, Ashwagandha, Lithium Orotate, L-Teanine, Taurine, Inositol, Chamomille.

[@joanneurbanowicz4994]

Just started today hoping will help headaches depression lots of problems since covid shots

[@AZMYTHKAMINSKI]

The main reason there’s a contraindication with MB and SSRIs is because of a theoretical rat study of upwards of 8 mg per kilogram of body weight and higher which interacted with SSRIs and increased serotonin capable toxicity levels. MB is at low dosage a very safe alternative to the massively negative side effects causing pharmaceutical SSRIs of today. Great information overall dock. Well done being more comprehensive than anybody’s video I’ve seen on methylene blue! 👏👏👏

[@marial3231]

Please people if you’re on SSRIs do not take this stuff. It will not degrade serotonin as the enzyme is blocked and you might die from too much serotonin. And if not you will be extremely miserable.

[@KimLong-v4i]

Thank you. Because I am going to try anyway. And I take 150 mg of Efexxor daily . And I take Tramadol daily. I will. Start at a low dose..

[@AZMYTHKAMINSKI]

@@KimLong-v4i that’s the smart way to approach it. Start with one or two drops a day because even 2 drops a day we’ve seen assist with removing peoples brain fog within a week and a half.

[@caseyhartigan9]

​@@KimLong-v4ithere have been 14 cases of serotonin toxicity reported in humans from methylene blue and 1 fatality. The FDA put a warning out for this because it's used for things like CO poisoning and lymphatic dye. These were IV doses so probably more than you'll take but I would be very wearing since tramadol is also an ssri. Taper off the garbage pharma and hit the MB to help withdrawal after you're off

[@teresaring8049]

@@KimLong-v4iwondering how you’re doing? I take 75mg Effexor and wanted to try MB for my long covid symptoms…but the interaction with ssri’s makes me scared to try it.

[@edwardbryan5154]

An amazing marathon effort. Thanks, too, to the author for making this available as a PDF. Very grateful for the resource.

[@stefcat5331]

Using low dose oral MB has had unexpected benefits for me. It has eliminated a fungal condition that I could not take medication for, unexpectedly, as I was using MB for help with something else. Thanks for the detailed info.

[@rdallas81]

Well, what is the "something else"? You can't tell us the first part without telling us about the second part! So, how did you aquire your "dilemma" and what benefits did MBlue have on you?

[@glenmonks1]

Dosage? And body weight? I am managing a fungal infection.

[@user-mn1ql6ky4x]

That's awesome. Please keep us updated

[@TheSpecialJ11]

I take 1mg, not per kilogram, total, and am experiencing noticeable benefits. I almost certainly have mitochondrial damage that I need to work to heal, maybe from mold, maybe from SARS-CoV-2, maybe from both. I'm working on healing, but in the meantime, Methylene Blue has been a game changer for me.

[@RUMBLEGO1]

How long have you been taking it? I started with 2 drops and felt like falling asleep. The next day i tried 7 drops at 4pm. Felt really great but had a hard time falling asleep. I also experienced cold hands after the 7 drops. After reading about how it inhibits Nitric Oxide, which could inhibit blood flow, I have been nervous to keep taking it. I have been trying to keep a good blood flow profile at my age of 64, and this seem counterproductive. It did make me feel good in the brain though! Darn!

[@TrustInJesusChrist-John3.16]

​@RUMBLEGO1 Take it in morning in very small amounts if anticipating stress or if have a virus. Low doses shouldn't inhibit blood flow.

[@monnoo8221]

Completely agree. Beyond the age of 50 practically everyone has damaged mitos. And yes it should be very low dose. As kind of a reference: PQQ is dosed at around 20mg, given MBs role 5..50% of that seems feasible as a max, which would be 1..10mg, , which is roughly 2..20 drops

[@svetusik72]

@@RUMBLEGO1i had same reactions first two days. So then I skipped a day and started talking it again. I have occasional headaches and I don’t feel energetic per se but I feel like my body is working through some toxins (it detoxifies, right?). I take 7.5 mg in tablet with vitamin c included. I also take my other supplements fish oil, multivitamin and NR.

[@RUMBLEGO1]

@@svetusik72 Stopped taking it. Reason being is that I was feeling like I was experiencing some recall problems and became concerned about the purity of my MB. I purchased it off a so called reputable source with the documentation but it was off of Amazon and didn't want to mess around since the price seemed a little to good to be true. Seems that high purity MB is rather pricey. Didn't want to mess with my health in possibly consuming any heavy metals. Where have you sourced your MB from I am curious?

[@franceslock1662]

I have been taking MB 30 mg per day for over 6 months and am very senior in age. I experience increased energy, work capacity, and cognitive function. I work full time and study. I have just started C60 in extra virgin olive oil daily, and am getting out my near infra red light Wellbeam device again. I also take fisetin. I hope to have time to get back to the gym in the coming months.

[@brakeme1]

That's exactly what happened to me. I used it till I got better. I knew I was better because it flat out didn't feel good anymore.

[@Anne_Onymous]

Not feeling good = "better" lol

[@andrewrivera4029]

I was diagnosed with epiditimitus in February and was prescribed an antibiotic, it helped but felt like I had a low grade infection, was not at peak energy then started taking MB, FF 2 months and I feel completely cured, have crazy energy, just climbed a 14’er and was beating people 20 years younger that me to the top.

[@isaacroberts9089]

a 14 foot'er what?

[@andrewrivera4029]

@@isaacroberts9089 a14’er, 14,000+ft mountains in Colorado.

[@svetusik72]

How much you’re taking and your weight?

[@andrewrivera4029]

@ I was 220 lb at that time and I would do the tip of the dropper. 5 drops’ish. I’ve since also learned that excessive carb intake feed the bacteria so also cut the carbs, the lower the better. It will also help with so many other maladies.

[@maschoff69]

I am fighting candida and it is helping a lot. The sharing of electrons of the double bonds causes the conformational change which makes the molecule reflect all light. It reflects blue light otherwise.

[@betelgeuse68]

I would recommend you add BORON to what you're taking. Boron is crucial for fighting fungal infections and most people only get about half of what they should. In the United States, Boron levels along the Atlantic Coast and the Pacific Northwest and even worse. So any food grown in those areas will have even less BORON than average. My suggestion would be 6 milligrams/day. You do NOT want to go over 9 milligrams/day. ASIDE: BORON is important for FREE testosterone and iterating, people on average only get HALF of what they SHOULD. pubmed.ncbi.nlm.nih.gov/36156555/ "Conclusions: Boron is an inexpensive, non-antibiotic element with potential uses as an antifungal agent."

[@gl8715]

What brand / company do you get it from?

[@maschoff69]

I should mention that I did have a fall recently and my balance has been off lately. It was weird, I turned to walk down the stairs and twisted my ankle. I couldn't react, kinda like those mice that couldn't move/react. I am MAOA/COMT. I am 90 kg and dose at 50 drops per day. At .5 mg/ drop, that's 25 mg/day.

[@rdallas81]

Interesting

[@azsunburns]

I found the same thing with hidden candida. I've been no sugar, low carb or keto for 10 years. I started low dose mb for a head injury and had hidden candida die off on my chest. It was crazy.

[@avarielblackwing6613]

Closed Captions, please. Because you're a Professional. Or some sound editing. Or a better mic. The poor sound quality detracts from the educational effectiveness of your presentation. 🙂

[@chrismasterjohn]

The captions are generated on all videos soon after uploading.

[@rnkim2564]

at about 139:00 he explains that at properly functioning kreb cycle with healthy mitochondria and no defects- that the hIghest amount of ATP (ENERGY UNITS) are created already. MB goes around this normal functioning system which can save you during a defectively functioning kreb cycle, but its at a loss of ATP and at the risk of metabolites you must process... in vitro vs in vivo are discussed earlier and a good foundation of chemistry and physiology are really helpful to understand this most excellent presentation and synthesis of information on this video. youre welcome to all of you complaining its too long and hard to understand. he does an EXCELLENT job of explaining the history and studies and his conclusions for those of you who dont get it. this is the most complete and interesting delve into pretty much any subject matter ive seen here on youtube... im so impressed at the knowledge and organization it took to make this presenatation❤

[@alextomlinson]

So what’s the TLDR? If you’re kreb cycle is good then there’s no point taking it? But if it’s faulty then it’s useful but also depletes ATP? Can you summarise

[@freethoth]

You definitely made me feel I should proceed with caution. I had observed elevated blood pressure from it even before seeing your presentation. Others made it sound like a total godsend. Thank you.

[@rixgaming9989]

Microdosing this right now (one drop of 1%solution a day) and it helps a lot with the autism.

[@tommyortiz6623]

Wow I just want to learn more on your autism experience! My son has autism and he’s too young I think to put him on microdosing but when he’s older I am thinking of it.

[@rixgaming9989]

@@tommyortiz6623 yeah, it's not good for the stomack. If you ever use it use it watered down to the point where it's tasteless. I'd say it something for adults to use (18 and up). Until then give your son some sulphorophane (broccoli extract) and also try some healing mushrooms like coriolis, hericium and cordiceps. All those i felt did me good. Hope that helps.

[@rixgaming9989]

@@tommyortiz6623 also reducing intake of the pesticide glutein can help. This is mainly done by eleminating wheat products from the diet and replacing wheat with rice.

[@rixgaming9989]

@@tommyortiz6623 some voices suggest autism could be a chronic inflammation of the brain so looking into inflamation reducing diet could also help. This is also likely why MB works so well because it is such a strong antioxidant. For children there are natural antioxidants available like linseed and honey. Reducing inflamation causing foods in the diet is the number 1 step every autist should do to improve in my opitnion. It doesn't have to be 100% but just make sure you're not feeding vast amounts of white bread and noodles to the kid. Potatoes and rice are better.

[@tommyortiz6623]

@@rixgaming9989 thank you 🙏 yes I have been trying to do gluten free diet and he eats a ton of rice!

[@genesmith3582]

I screwed around with MB for a while because I have history of concussion and chronic insomnia. One of the interesting things I saw in regular bloodwork is, even in small dosing, it would consistently knock down my elevated creatinine and BUN.

[@lauraa2877]

Wow, that’s very interesting. I have the same issue and was afraid to take MB because maybe it would be bad for my kidneys.

[@reidbounsall9098]

Thanks for sharing that. I'm also hoping that it will lower my creatinine levels and also raise my eGFR - improving my overall kidney health!

[@genesmith3582]

@@lauraa2877 Just to clarify, I had those elevated markers but my kidneys appear to be in good order. There are warnings about MB and those with impaired kidney function. The source of MB is also crucial.

[@MasterofPlay7]

interesting, that's why I get more DOMS (muscles pain after exercise) with MB

[@isaacroberts9089]

Why would MB give you more DOMS?@@MasterofPlay7

[@martytheman6816]

NOS inhibitor .. helps my ADHD phenomenally. People with adhd have high levels of nitric oxide in the brain MB is supposed to block nitric oxide. Also a recent study in Israel directly links high nitric oxide levels in the brain with ASD .. so maybe worth looking into that connection .

[@M00nVine]

How does one test & determine brain levels of Nitric Oxide ? I know when I tried NO supps I got major headaches.. so genuinely curious

[@isaacroberts9089]

Does MB increase nitric oxide?

[@martytheman6816]

No - quite the opposite but I think people with ADHD produce too much@@isaacroberts9089 kzbin.info/www/bejne/gonCoJ5qid18obs

[@pamskaggs2788]

Would you mind stating your dose? Interested in this for a family member. Thanks

[@martytheman6816]

It's very low. dilution is 1g/100ml , I take 2-3ml a day sometimes twice a day sometimes not at all , I take vitamin C chewable straight after. Sometimes I take ( legal ) mushrooms as well like lions mane and that helps even more @@pamskaggs2788

[@crfogal67]

I appreciate the great detail of the subject. I note the Orthodox icon. This reassures me you have attention for historical details and truth. Thank you for your good efforts. 🙏🕯☦️❤️

[@DChristina]

Amen♥️🙏🏼☦️ Edit: enlarged the icon to see St Paisios 💓

[@mattwhisnant5926]

This is interesting. I think it’s fair to raise alarms and questions. However, I have seen many a very intelligent person explain (and publish) why this or that drug/supplement will do this or that for this or that chemical/biochemical reason. They are always highly intelligent and have good reasoning. However, the human body is an extraordinarily complex system. It specializes in defying understanding and expectations. This video is long on theory based in chemistry and short on evidence. So it’s interesting and worth noting, for sure. But nothing to take to the bank.

[@isaacroberts9089]

Why do you say it's short on evidence?

[@adespade119]

So if whether you feel better on it is not to be taken notice of, then what about all those millions of clinical trials out there on other drugs which use patient assessment in their analysis of efficacy of a drug. The human body is so unfathomably complex that sometimes, the best way to assess efficacy is to ask a patient, do you feel better.

[@paulluckey6997]

I do High Dose Melatonin Melatonin is a molecule that can affect the mitochondrial respiratory chain in several ways, including: Mitochondrial activity: Melatonin can increase mitochondrial activity by increasing the activity of respiratory complexes and ATP synthesis. Mitochondrial dynamics: Melatonin can regulate mitochondrial dynamics by reducing mitochondrial fission and increasing fusion. Mitochondrial oxidative stress: Melatonin can maintain mitochondrial oxidative stress by altering autophagy. Mitochondrial membrane potential: Melatonin can maintain the optimal mitochondrial membrane potential. Mitochondrial permeability transition pore: Melatonin can inhibit the mitochondrial permeability transition pore (MPTP). Mitochondrial uncoupling proteins: Melatonin can activate uncoupling proteins (UCPs). Mitochondrial redox state: Melatonin can modulate the redox state of the mitochondria. Mitochondrial sirtuins: Melatonin can influence the deacetylation of sirtuin 3 (SIRT3), which is located in the mitochondria and modulates the redox state of the mitochondria. The mitochondrial respiratory chain is made up of five enzyme complexes embedded in the inner mitochondrial membrane. The complexes include NADH CoQ reductase, Succinate CoQ reductase, and Ubiquinol cytochrome c reductase.

[@Novacasa88]

I've been dealing with long covid like CFS and POTS for a few years now and MB is one of the few thigns that consistently restores my energy levels to my pre-infection energy levels and brain clarity. I'm 35 and have no other health conditions. I take 50mg a day as a 220lb male. I appreciate your perspective on a drug that clearly has complex pharmacodynamics as well as the alternative ways to treat various conditions.

[@paulbarclay4114]

you need to take a LOT of probiotics, colostrum, fiber, kefir, and akkermansia

[@markoilic8375]

Mb is also antibacterial

[@maramclaine830]

RCCX Theory has answers for you. I have LTC19 HEDS, Tethered Spinal Cord, FMS misdiagnosed for 25 years. RCCX Theory it will change your understanding of your genetic codes mutations and reason WHY you

[@JoJo-cy4tb]

my friend, did you loser you taste/smell from cov? if so did MB bring it back thanks

[@michabrendancreedy6573]

Long COVID eh? How many jabs have you had?

[@gabyfridman7475]

Amazing job.Thank you for researching. You have done for us, your followers. You´re incredible.

[@Mo-yj3wf]

Was waiting for this one. Please continue with protocols you mentioned at the end. Thank you!

[@Sophiabosch11]

I have been doing a deep dive into methylene blue for a week now. I wish I had found this first. Thank you for such a thorough and unbiased explanation of the history and research.

[@misterETIO]

I am currently looking to buy methylene blue as a daily supplement. I am 34 and I always have been full of energy, for a couple of months I have been feeling tired and have noticed a significant decrease in my short and long-term memory (the other day couldn't remember the name of a colleague I had around for a year). I have been to the doctor and they did a blood test - they said that I have perfect health. Started to look for supplements and stumbled upon MB - I will definitely give it a shot. I understand the risks, from what I have read and I feel like it's worth giving a shot. regarding your explanation - you need to talk to an average Joe here on YT, not PhD graduate - I couldn't distill why exactly I shouldn't try it orally. In your example with rats - MB was injected in their brain, but how does it translate to humans taking it orally? Even in your comment section people are praising the MB. Maybe you could do another video where you explain this to less smart people - like me. =) Would truly appreciate that.

[@Partysize2]

I have heard it is available in some drug stores for other purposes. You might check me on that.@@Pumpychan

[@clammerify]

​@@Pumpychando you even have to ask? It is purposely not made available due to big pharma can't patent it it and profit off it. It solves a lot of health issues so who would buy their poison then?

[@creativegirl9710]

Those symptoms sound like mine in the beginning of Lyme disease. I suffered and suffered, went in circles with Drs. Was given the label "Fibromyalgia." What a joke. Then pain issues would come and go. Took years to get a diagnosis which then makes treatment really really difficult. Don't listen to just the first conventional Dr. Seek alternative NDs or Functional. We can always be functioning better not just be "average" on testing. There is science as to why we start to not feel right. Dig deeper.

[@magmasunburst9331]

I think you have something to say here that's not in a lot of the other videos but expecting the public to sit through two and a half hours of general history and every single study kind of avoids the main reason why people want to watch this via your title. You're trying to help people see that there might be certain people that should not take this. But then you're expecting people to Wade through two and a half hours of a fairly unprofessional presentation. Maybe you could sum up what you're really trying to help people with that's your unique analysis in a 10 minute video?

[@nolanj3578]

Yeah this is way too long. Understand your audience.

[@isaacroberts9089]

Also get a microphone!

[@AD_2178]

Thank this man for giving you 2 hours of his valuable time. Full explanation is important with this subject.

[@SteveSpencerProtouchRehab]

This is critical information! If you quit following the leader looking for a God to save you then you would take the time to listen and learn. Nature kills dummies.

[@che4840]

I still appreciated this

[@TheDesertBlizzard]

I'd posit that the increase in falls was directly related to an increase in activity. I can attest to the increase in activity. There is something to this molecule that warrants much more study.

[@simonjeppesen9484]

I love watching your videos you're excellent at explaining, but it would help the listener a lot if you could improve the audio quality

[@Lovescoffeeandtea]

I wish closed captions was on

[@SkedgySky]

We complained last time of his microphone, so he gives us even worse quality this time. 😂😂

[@chrismasterjohn]

Sorry I was experimenting with a new setup and apparently the audio sacrifice is too large for the video benefit.

[@chrismasterjohn]

Cut me some slack. Someone recommended this setup to me and it doesn’t work so I’ll return it.

[@chrismasterjohn]

This is in your settings. KZbin sometimes takes an hour or so to generate captions.

[@abutcherswiferecipes1875]

I have been using MB for 40 days to treat my hyper sensitive airborn nitrite reactions, where it cuts oxygen supply to my brain. 10 mg a day is giving me my life back after 20 years.

[@mrmeach1967]

28:17 Thanks for explaining the history behind the terms “oxidation” and “reduction.” No chemistry text book (or teacher) ever bothered to explain why gaining an electron is considered to be a reduction.

[@hosoiarchives4858]

I just think of it as “reduction in oxidation”, but most terminology in science is garbage because when they named things they barely understood them

[@paulbarclay4114]

@@hosoiarchives4858 they still barely understand them western medicine is pseudoscience

[@keithbyrd7566]

Excellent video. Thank you for the hard work that went into your presentation on a subject of great interest to me. Some of the information you shared is not readily available elsewhere on the Internet.

[@thebluedan]

But what is it???! Oh wait this is actually the first guy that I found that actually talks about what it is and how it’s made. 👍🏼

[@PrimalBodhi]

Thank you for making this video. Its a great resource for those wanting to know more about MB.

[@niemerow1953]

Thanks for putting the short answer at the beginning!!

[@glenmonks1]

This is the mark of a Master...Ancient sacred texts' give the total frame on paragraph 1 and then proceed to explicitly confirm their point for the lesser learned.

[@antoniodesimone4689]

Hey, Chris, what about taking both Methylene Blue and Nicotinamide riboside? are there any negative interactions between these two compounds?

[@patrickweber8284]

For the less patient people. In the last chapter at 2:33 you find a summarized answer to "Is MB biohackers delight or is it playing with fire" Thank you for the research and presenting it 🍀

[@garybonacci2031]

read your comment and try it for yourself. You're off by about 2.5 hours as written,

[@TheGeneticHouse]

Fantastic video my man! More in-depth information about methylene blue and the mitochondria energy transport chain and anywhere I've found thank you. I have a MTDNA mutation LHON at 11778 in the MTDNA causing complex one and loss of electrons creation of ROS leading to blindness so this was incredibly informative on how methylamine blue helps to bypass the messed up complexes and ensure electrons get to the end of the process :-) this could really help people with LHON

[@azsunburns]

I have head trauma & lipedema, I know my mitochondria has issues. MB and creatine were the two things that changed everything. I take maybe 5 drops in my morning water, 3 or 4 days a week. Game changer. My autistic son started adding just 3 drops to his morning routine and he noticed a definite thought improvement. That being said, I've consumed countless hours of medical talks on this subject & you've done a great job. I feel sorry for people who aren't willing to dive in & the sound quality is what it is, unimportant considering the content❤

[@isaacroberts9089]

Thanks for your comment! I have some questions: how long have you been taking that dose? Also, what is 5 drops? 2.5mg? That's way less than what the studies in question mention--less than even the recommended dose of 20 drops or 10mg from the ones you buy on amazon.

[@azsunburns]

@@isaacroberts9089 it's a 1% solution so .5 per drop. I decided to micro dose before going higher & I honestly don't feel the need to add more. There is quite a bit of info out there on the success of micro dosing. I was also not thrilled with the thought that high doses could truly disrupt the microbiome. We've been using it a few months now.

[@Partysize2]

Yes it is about 2.5 mg of a 1% solution of methylene blue. That solution is made by dissolving one gram of solid methylene blue in 100 milliliters of water. This assumes that the size of your drop is calibrated at 20 drops per ml. @@isaacroberts9089

[@user-mn1ql6ky4x]

Please keep us updated! Thank you. Trying to help son.

[@stephenalevesque2361]

very interesting. It seems less is more with this drug. I was wondering, when MB is circulating through a body, certain areas "need" fixing it helps, but for those other parts that did not need it and get harmed, does it stay degraded? Or once MB is discontinued (or expires in the system) do all benefits and harms revert back to how MB initially found them?

[@JennyJEllen]

I'm curious about your perspective on nootropics and whether there are any possible adverse effects to consider. Also, have you ever explored normotim?

[@micdargis]

Your position regarding the use of an unnatural compound is correct. that's why I use MB. in my case, I use MB 45 mg divided per day (15 and 3x10) in replacement of 10 mg of Adderall. this is the first time that I have found a replacement despite all my trials. Do you think overall I am reducing or worsening my addiction to unnatural compounds?

[@rdallas81]

Interesting

[@ernestodavilia364]

My nephew has ADHD and he also take 10mg of Aderall, has MB replaced the use of Aderall, my sister would love to take her son out of the stimulants. your answer will be very appreciated.

[@isaacroberts9089]

how long have you been on that dose? Today's my first dose of MB and it certainly feels like it could replace MB--I'm very skeptical though because anything that feels this good has almost definitely got some downsides. Like you, I am concerned about becoming addicted (or just habituated)

[@ernestodavilia364]

@@isaacroberts9089 hi. Are you saying that you are worried of getting habituated to MB? I have been using it for a month and there is no habituation to it, it is not a stimuant.. How much MB are you using for your ADHD, or what is your condition. It would be great to get more feedback from you.

[@pamskaggs2788]

Interested as well!

[@SkedgySky]

What about information on micro doses of it, the way nootropics users have always used it? 0.01mg/kg. That's how we biohackers all use it.

[@chrismasterjohn]

See my response to your other comment.

[@smarzig]

I enjoy his voice and audio not sure what everyone is complaining about

[@2017_K___Booth]

Me too. He did a great job! I'm thinking too many people watch TikToks and shorts then expect all videos to be short, no matter how much information is in it.

[@airmark02]

yes , lol... People are always complaining about stupid things ..whatever

[@TheGurumagoo]

The audio is giving me a headache. Very hard to get through 2.5 hours of slightly garbled audio. Harder on 2.5x speed. I’m only trying to push through because this level of detail is rare. But here I am with the video paused searching for summaries or salient points in the comments section.

[@defforadio6428]

So many great info about ETC! Ill watch this video at least twice!

[@area51sea]

I started using methylene blue after being on keto and carnivore diets for years and it gave me great energy better then any other supplements I ever took. When I started adding carbs to my diet I didn’t experience feel much benefits or energy like I did when I first started when on keto.

[@trippthree8842]

What dosage?

[@rdallas81]

Did it stop working after some time? What's the dosage/benefits plz?

[@area51sea]

@@rdallas81 came in dropper bottle I usually took about 5 to 10 drops which is about half milliliter per drop and gave good energy. I took it pretty regularly for about 6 months. The only thing I could compare it too was taking caffeine for the first time as time went on caffeine doesn’t have the same effect. But it wasn’t like a caffeine bump. If you have problems with some complex in your cellular metabolism you will feel the benefits. No supplement I ever took made me feel better. I take every now and then and don’t feel the effects as I did when I first took but I’m guessing my cellular metabolism was wrecked and mb helped fix it

[@area51sea]

@@rdallas81 i would say when take it now it’s more of mental clarity versus a full body energy. I recommend it . Take a few drops and see how you feel and studies shown people taking 50 plus which I don’t think you need

[@pointshealthcoaching8474]

Just wondering if MB could possibly make the liver's texture look different on an ultrasound??? My liver was homogeneous echotexure without any other pathology noted... the radiologist wasn't concerned... at same time he had no explanation as to why liver enzymes elevated... it's not NAFLD... I think it's secondary to the vax I got, b/c before the jab I had normal enzymes ... thx

[@frugalgardener7921]

While there is a great deal of information you mentioned a study in which "placebo" group took 8mg a day. Way to prove that MB not working. Except that I get result at 3mg a day. My placebo would be zero. In my "study" it works. How many of you actually understood my point? A

[@erwinrogers9470]

Methylene Blue, is food, for our mitochondria👍

[@TrustInJesusChrist-John3.16]

At the end of the day though it's foreign to our body and may not be good used continually. Red light therapy which does the same thing is a harmless alternative.

[@theosbass]

I’ve been taking it some. It really clears my brain fog and I’m hoping it helps with a bacterial infection I have that 4 rounds of dif antibiotic treatments haven’t touched.

[@sherrycushman9333]

I Have been taking MB for over a year for my MS to help damaged mitochondria. I just want to let you know if you take too much for your body a side effect is ringing in the ears. I can not take the full standard dose or I get the ringing in my ears.

[@xerse29]

I have a feeling this is the he type of video I was looking for for my question. Haven’t seen the video yet but my question was this, just because it helps the mitochondria with its electron flow, does that actually mean this is a long term sustainable product? Like everything I’ve heard is that it helps the mitochondria run more efficiently but , and I know it’s a weird question but, do we really want our mitochondria to run more efficiently? Like just because the mitochondria are able to run “better” does that really translate to better health? Does it actually hurt us in any ways? And by no means am I against Mitochondrial health, I’m actually a huge supporter of ketogenic diets, light, and exercise to help mitochondria run better and smoother but I ask myself very critical questions so that I can understand something before I actually do something, especially if it’s a man made chemical that is reported to help human health when humans haven’t evolved with this compound in our environment for the entirety of our existence. Not against it but I really need to understand the biochemistry with this compound before I ever put in me

[@binathere2574]

Yes if you want good energy and health.

[@alexanderohanlon8825]

Whats your thoughts on john lieurance? Only asking as he's down for balsting people with this and very high melatonin levels. I've not read his book yet (dont want to buy it truthfully as i feel he's a cherry picker like morely robins) so just wondering if my guts right or if I'm being to judgy!

[@chrismasterjohn]

Not familiar.

[@alexanderohanlon8825]

@@chrismasterjohn Fair answer, my gut says he's a money grabber but! Doris loh and dr russel reaitter are legit so high dose mel seems reasonable... If you could get her on your show you'd be in for a treat bro.

[@creativegirl9710]

His book is free. So go ahead and research it yourself.

[@creativegirl9710]

His book is free, it's a PDF. He is Lyme literate and had Lyme himself. @@chrismasterjohn

[@awestphal9602]

Most of the videos I have seen on KZbin are very positive about taking MB even those produced by people who I consider to be very responsible individuals. However, your video has caused me to rethink whether I need MB. I am already taking a number of helpful supplements and I do not want to take something that may have some benefits but at the same time be negatively interfering with the complex workings of the mitochondria.

[@lindaabernathy4876]

Have you communicated with Dr. Francisco Gonzalez-Lima? He seems to have done a lot of research and the last time I heard him summarize it, his take was, in general, a positive one for M. Blue.

[@chrismasterjohn]

I read and analyzed much of that research. I did not converse with him.

[@richardmalone3172]

Dr. Francisco Gonzalez-Lima also stated that he and his wife and children were supplementing MB daily.

[@-kristian]

As someone that has greatly benefited from Methylene Blue, I would genuinely encourage you to have a conversation with Dr. Francisco Gonzalez-Lima. I think certain statements in this video needlessly defames a compound that could help many, and the specific concerns raised with regards to MAO-A inhibition and the initial Alzheimer's trial failures have been accounted for by Dr. Francisco Gonzalez-Lima in several podcast appearances. Rhetorically, I could ask you why John Hopkins University continues to administer high dosages of Methylene Blue in surgery to patients on SSRI's? That's despite the FDA black box warning for serotonin syndrome, a warning which Canada for example does not have. Administering a drug in opposition to FDA guidelines is highly unusual considering the litigious prevalence within US healthcare. As you may know with Oxycontin, the FDA can make or break a drug based on black box statements that do not have scientific validity. I have personally taken up towards 1 gram daily for 2 weeks whist being on 30 miligrams of Vyvanse for severe fungal and bacterial infections without any issue. Ramping up to such a high dose, the MAO-A inhibitive effects cannot be mistaken, but only occurred with those dosages in the grams range. I can tell you for a fact that 100 mg's is not maxing out MAO-A inhibition, not even remotely, in fact there is a lull between the lower dosages that acts as mitochondrial enhancers and the MAO-A inhibitive effects that occur in extreme dosages only applicable to certain poisoning or viral, bacterial or fungal infections. This means that the lower dosage contributed more so to an internal glee then the majority of those high dosages in the several 100's of miligrams, probably indicative of the biphasic efficacy of Methylene Blue on mitochondrial function (due to its photosensitising effects), sugessting I was in the mitochondrial poisoning range until I had that unmistakable MAO-A inhibition at the grams threshold. With the regards to the trials conducted with Alzheimer's, I did not see mention of the fact that participants were using the current standard of care medications for neurodegenerative disease concomitantly, which are toxic and were even banned previously in the UK and reinstated for political reasons. Why did TauRx all of a sudden have a succesfull Phase 3 trial of 16 mg's daily off of a simple derivative of leucomethylene blue? Peculiar what can happen when you examine the effects of low dosages with a biphasic drug, without concomitant medical pollutants and with a novel patentable compound of all.

[@lindaabernathy4876]

@@chrismasterjohn I had only listened to 2 hours of your presentation when I replied. Should've waited until the end. Thanks for replying. I always enjoy your videos.

[@TheCatalyst999]

Great video! I recommend watching at 1.25 speed

[@jeffzacha9154]

This is above my head. Is MB safe and is it effective?

[@JaniceLBlake]

Yes, but keep to lower doses. To my understanding, one drop is 0.5mg or ml. So if someone says 0.2ml, that's 4 drops.

[@Mark4Jesus]

⁠@@JaniceLBlakeso 1 drop is 0.5 ml, but 4 drops is 0.2 ml?

[@Blaze23557]

@@Mark4Jesuslol

[@svetusik72]

@@JaniceLBlake4 drops would make it 2 mg

[@jeffmastin]

Thank you for catching me before i fell down that rabbit hole!

[@jondor654]

Thank you for such an undertaking. With introductory use of MB , where I did not easily discern any benefit , your explanations (as far as I grasp them) inform my view on M B. The hormetic aspect of MB seems to rule it out as a general support. The specified health indicators are a seperate category . Your argumentation on it's status vis a vis the provenance of natures chosen pathways is reasonable yet the future may be intriguing .

[@christopheraakre8369]

I noticed right away that my sense on smell increased dramatically. I think I take about 15ml. My weight is 208 however it’s dropped from 215 I a week. I have much better cognitive function, more connected to old memories and a sense of well-being, confidence and more energy. It’s been a miracle so far.

[@WaterspoutsOfTheDeep]

I have to say when I have a night where I never got enough sleep and feel run down the next morning, Taking a capsule full of MB and a capsule of rhodiola extract gives me either moderate or significant improvement to the point just 1-2 advil can totally nullify any remaining discomfort. Truly been life changing along with lemon balm for headache/stress/hyper mind. And same with ginger extract capsule for any digestive discomfort. They are all basically like drugs they work so well for me.

[@joeylodes]

Fantastic Doc, very informative. Thank you

[@cleancryptoverse9645]

Amazing how he spent so much time talking about tangent items that had little or no effect to help someone decide if MB is a good fit for them....

[@Frederer59]

Hi Dr, Chris. I'm an RMT and also provide professional-grade near-red/near-infrared photobiomoduation therapy (formally called cold or low-level laser therapy). As you well know this light therapy stimulates mitochondria ATP production. I've only just started listening but immediately I began to wonder if there's been any investigation into combining MB with photobiomoduation?

[@propellerhead2000]

Dr. Francisco Gonzalez-Lima is the man. "Protection against neurodegeneration with low-dose methylene blue and near-infrared light"

[@PatrickMcParlane]

There are many studies with combining MB and red light therapy. The benefits are exponentiated.

[@clammerify]

Absolutelly. CCOx 4th complex has specifically 4 red light receptors for this 620nm 680nm 760nm and 860nm

[@Coincidence_Theorist]

4:36 📕 Rockefeller + Petroleum = the AMA/Basis for our medicull cystem

[@dennismixon9028]

I like the long video, I feel I am much more educated from this video than any other video I have seen on MB. I do have a question. Do you take MB & where do you get supplies. Please list or make video of all supliments you personally take. Thank you for your time!

[@HellGod67]

Refreshing to hear someone being more objective than all the hype riders and actually being educated on the mechanisms WOAH!

[@2017_K___Booth]

I'm going to try putting it on my skin before using my red light. I added ascorbic acid until it turned clear and will add it to my lotion. I'm hoping and praying it will help my edema and plump up my skin. I've been drinking some this last week...2 drops but bumped it up to 6 drops. I'm starting low and slowly increasing it. I haven't noticed anything good or bad except greenish blue urine. If it raises my boood pressure, that will be okay. I usually have low blood pressure.

[@michellejoy6752]

Wow, I can’t seem to find my way through the weeds tangled maze of weeds here. This presentation is extremely chaotic.

[@vivvoveo384]

See, you need MB. This presentation is perfect . Maybe you have a attention span problem....

[@michellejoy6752]

@@vivvoveo384 lol, yeah maybe.

[@sarahcork5288]

Hmmmm 🤔sooo, is it good for me or not good for me??? 😬

[@gymratsunited8391]

This was extremely valuable from a research perspective. What's your thoughts from an exercise perspective, could methylene blue be used to augment hydrogen peroxide generation from moderate endurance exercise with proper dosing potentially allowing for a greater stimulus for less work. Given that hydrogen peroxide is already used as a signal for mitochondrial biogenesis. I think you should definitely make a shorter version though

[@Anton-vj7yx]

Thanks for the informative video. This is the best material I've seen. The main conclusion of the video is negative and it is very different from the opinion of many people who practically use MB (improvement in short-term and long-term memory is difficult to associate with antidepressant activity. It is also not clear why most people using red light phototherapy and MB together report increased positive changes, despite the increase prooxidant activity (superoxide, MB radical). Do you think it is possible that the combined use of hydrogen (water or inhalation) and MB (production of reduced Methylene White) can neutralize the pro-oxidant negative potential of MB and increase its reducing properties? Probably Methylene white may be a safer and more interesting compound, and besides, it will not stain the oral cavity (it can be easily obtained by reducing MB with hydrogen). Thanks again for your work!

[@Vegasflatout]

He spends 12mins talking forever about useless stuff then skips over the real story of how methylene blue was found to kill the malaria bug. I feel he doesn’t like methylene blue and is going to waste over 2 hours getting to that point.

[@Caleb-xf5yn]

I wonder if MB would be of any benefit if applied topically to a diabetic wound.

[@UserHandle0702]

I listened to this entire video, very grateful for your informed incite, I want to know what you eat or take and exercise in order to maintain you focus attention and drive on this topic ;)

[@manwithblackdog254]

Absolutely great. But what’s all that mean in lawman’s terms?

[@RobertSpiller]

So I'm guessing that for bladder cancer, this is not going to work...is that right?

[@dianneevans5492]

Thank you so much for this comprehensive coverage of MB! I've just come across this chemical and I appreciate hearing more than just the everyone should be using this and the understanding of why it works when it works so that I can make an informed decision.

[@trezinhadasilva7820]

Please fix the audio!!!!

[@lisafrequency55]

I have been taking 1-2 drops of MB 3-4 times per week for over a month. I notice my memory is better. I don't think I ever will take a higher dose. I may get a point where I only take it once a week or once a month. I am 69 years old and from my earliest memories I have paid careful attention to my body. I eat low on the food chain as much as possible. I stay as active as possible, and work to control negative thinking that's the hard one for me. When I introduce something new to my body I always take less than recommenced dose. I desolve most supplements in my mouth to see how quick they absorb if they do not absorb quickly I take it to mean that my body does not want it.

[@randallburgess6393]

Would methylene blue work if you applied at topically to toenail fungus, and to skin barnacles

[@TrustInJesusChrist-John3.16]

Hydrogen peroxide ointment or a few drops of Tea tree oil for toenail fungus ...3 times per day.

[@propellerhead2000]

Those dosages are insanely high. I take 0.025mg/kg once every two or three days.

[@Dippmip]

is that a drop?

[@propellerhead2000]

@@Dippmip It depends on the size of your drop and how much MB is in solution. The MB labeling should say how many mg per drop. If a 1% solution = 1 gram in 100 milliliters then 1ml should contain 10mg If one (1) drop (typical dropper) = 0.05ml then there are 20 drops per milliliter. So 10mg / 20 drops per ml = 0.5 milligrams per drop. Basically I consume the equivalent of two drops every other day or so. I judge the cycle based on the color of my urine. I wait until it runs straw yellow before dosing again.

[@gins8781]

@@propellerhead2000How long did you dose at .1 mg before it turned up in your urine? I just started 0.05.mg yesterday. No change in urine, so I thought the dose might be too low to have that affect.

[@frugalgardener7921]

3mg a day is a good amount.

[@theeprincess777]

Can you give a talk on berberine 🙏🏻

[@ThePythonicCow]

If I turn OFF KZbin's "Stable Volume" setting, that helps the audio sound of this video. With "Stable Volume" =ON=, the higher frequency distortions make this video very difficult to listen to. With "Stable Volume" =OFF=, the audio sound is still poor, but not so annoying.

[@personanongrata9289]

Thank you for posting all of this information. It is very helpful in determining the veracity of all the methylene blue hype. The sound quality made it a difficult listen, and i had to rely on the transcript a bit, but the content makes it worth the effort.

[@SymoneTrust]

Do you have any experience using methylene blue for people that have sickle cell anemia or sickle cell trait? It seems like this might be an issue for those with certain blood disorders

[@musimedmusi8736]

I appreciate that you give a summary up top. Looking forward to taking in the whole content.

[@FahlstromJohn]

Chris. great presentation thank you. I have heard from two users ...low dose liquid in water for ten days..reported feeling return to numb extremities plus clearing of sinus ...have you heard of similar outcomes? this was not mentioned in your meta analysis I believe

[@SubmitTheKraken]

I have sinusitis my doc says; take some salt spray (did that in the past didnt work)

[@smarzig]

Sinus issues solver with quercitin

[@edbehan1306]

New to MB. Taking 1 X 5mg capsule with my morning coffee. Empty stomach. But after first small meal of the day I feel sick. Nauseous with bloated stomach. Does this improve?.

[@ImmanentizeTheEschaton]

I'm a woman and MB has been almost a miracle for helping me with various chronic issues, ME/CFS, POTS, and others, but it has shifted my hormone production very quickly and now I am T dominant and my scalp hair is falling out. My Estrogen and Progesterone are way below reference range. I'm trying herbal remedies for this but wondering if something else can be done?

[@chrismasterjohn]

Figure out the root cause of your issues instead of throwing highly non-specific drugs into your system.

[@Protolamna]

I believe Dr Lima was talking about using methylene blue to raise testosterone?

[@mgyulai1417]

How long were you on mb before it started the hormonal issues?

[@cubensis7706]

look into DIM

[@clammerify]

Need to look into Leptin sensitivity. Master hormone, all other hormones downstream from Leptin. No Sense to try to balance each individual ones if Leptin sensitivity is gone. And yes DIM is a Test blocker as per above suggestion.

[@airgetmar1928]

So more or less DO NOT take C0Q10 while taking methylene blue??? and, should you supplement with Iron when taking Methylene Blue? I’m asking because after taking 20 mg’s of Methylene blue for like 30 days my ferritin levels were VERY low.

[@chrismasterjohn]

I didn’t say that. Those are possibilities.

[@Yoyo-kp8sf]

Why can’t you take it with coq10?

[@cpg7804]

Have you thought about the fact fact that Ferritin is meant to be the cells and not in the blood? Therefore if it is not in the blood - it is now, most-likely, in the correct place of ; in the cells ? Is that not common sense?

[@thomasl4298]

Awesome Breakdown!! Other than Genetic Defects, and exogenous compounds like Rotenone and Metformin, what diet, environment/lifestyle factors (that you know of) INHIBIT or BLOCK Mitochondrial Complex I?? Mitochondrial Complex II? For example, would it make more sense to take MB during a fasted state vs fed state (besides the impact of ADP buildup) to facilitate mitochondrial function? High fat diet? High iron diet? Etc. Any insights there??

[@chrismasterjohn]

Follow me on substack, I’ll be writing a lot about this: chrismasterjohnphd.substack.com/?

[@adriancampbell777]

Can they make available a clear version I understand how infrared light can interact with blue colour , Seems unnatural to me I’m using my methylene blue for weed spray indicator

[@FarazKhanYusufzai]

thanks Mr Masterjohn - a veritable tour de force , I had to listen to it in more than one session-