Рет қаралды 113,933
The development of the heart explained in a very simple way.
Watch Embryology of the Heart I before watching this video for a complete understanding. You can watch it here: • Embryology of the Hear...
If you are completely new to embryology and you want to understand it quickly, this should be the first video you watch: • Introduction to Embryo...
--------------------------------
Recommended Text
--------------------------------
Easy Embryology is a book that is dedicated to the simplification of embryology. It is available at drminass.com/product/easyembr.... Contact Dr. Minass for more information.
----------------------------------------
Interact With Dr. Minass!
----------------------------------------
Website - www.drminass.com
Email - info@drminass.com
Patreon - / drminass
Facebook - / m1na55
Instagram - @m1.nass
Post - Address to:
Minass
Parcel Locker 10106 04448
59 Penshurst Street
Willoughby, NSW
Australia 2068
Summary of the video for your notes:
1. The heart is developed from the splanchnic (lateral plate) mesoderm.
2. Atrioventricular endocardial cushions at anterior and posterior walls appear and proliferate until they fuse, turning a single lumen into two. The two canals are the right and left atrioventricular orifices.
3. Once fused, the AV orifices are surrounded by proliferations of mesenchymal tissue.
4. The bloodstream hollows out and thins tissue on the ventricular surface of these proliferations forming the valves and the muscular cords.
5. Muscular tissue in the cords degenerate and is replaced by dense connective tissue.
6. The valves are now connected to thick trabeculae (papillary muscles) by the chordae tendinae.
7. Development of the conotruncal ridges and closure of the interventricular foramen occur by proliferations of the right and left conus cushions, as well as the proliferation of the anterior endocardial cushion - this closes the interventricular foramen and form the membranous portion of the interventricular septum.
Clinical note: Abnormalities in endocardial cushion formation may cause cardiac malformations, including atrial and ventricular septal defects (VSDs) and defects involving the great vessels (for example, transposition of the great vessels, common truncus arteriosus, and tetralogy of Fallot).
Tetralogy of Fallot is one of the more common congenital disorders, classified as a cyanotic heart disorder. It is characterised by four heart defects: (1) pulmonary stenosis, (2) right ventricle hypertrophy, (3) ventricular septal defect, and (4) over-riding aorta (aorta overrides the septal defect).