I'm a biomedical researcher just working with a mitochondrial protein called IDH. IDH is involved is normally involved in the citric acid cycle (the pathway which eventually drives the production of ATP in mitochondria) but specific mutations inIDH are also frequently found in different cancer types. The reason is that mutated IDH can lead to the production of a harmful molecule which messes up a lot of proteins leading to the repression of genes which would normally protect against the development of cancer (I would love to make a video about that mechanism one day). After so many years of research, mitochondria still show fascinating new sites!
@mmmmmmmmmmm1114 жыл бұрын
just to save someone a google search, IDH = Isocitrate dehydrogenase. Also, looking out for your video!
@plutonium51834 жыл бұрын
Thanks a lot for the info 👏. Waiting for the video!
@reneulifeolshop35034 жыл бұрын
awesome,, looking forward that video
@joshuamirabal36174 жыл бұрын
Chinese Virus not very much unless you’re hired by a super rich private company like oscorp in spiderman. A lot of time is spent asking for money for their research so they can continue their stuff and also live and lots have another job like working at a university.
@BKScience8124 жыл бұрын
Hey! Long time no see. Fellow researcher here stalking the same corners of the web. Another thing I've been shocked about for a while since I began doing research with mitochondria is that the textbooks never accurately describe their structure. They form long networks in some cells that are constantly fissing and fusing. I never knew they formed such networks existed or that fissing and fusing was so important (especially to cancer) until I began looking into its mechanics.
@theseusswore4 жыл бұрын
Me : Sees Video Title Also me: *years of academy training wasted*
@theseusswore4 жыл бұрын
@@zack7122 hehe hi
@theseusswore4 жыл бұрын
@Christopher Damant it's a profile pic only some could get ;)
4 жыл бұрын
Excuj meee that your fault
@theseusswore4 жыл бұрын
@ r/woooosh
4 жыл бұрын
Excuj meee stfu your responses are lame and they are unoriginal
@HyruIia4 жыл бұрын
The cell is the power mitochondria of the house!
@abhis76764 жыл бұрын
The house is the power cell of the mitochondria!
@aljon59474 жыл бұрын
Power is the cell of the mitochondria house!
@naveenrajaelangovan46414 жыл бұрын
house of mitochondria is the cell power!
@francoiskaram4 жыл бұрын
Mitochondria house is the power of cell!
@abhis76764 жыл бұрын
I think that will be it guys 😂
@TheRealGuywithoutaMustache4 жыл бұрын
So the heart muscle cell has an average of 35 to 40% mitochondria per volume? That's amazing. It makes sense since it's still very active even when we sleep.
@blaqthrax4 жыл бұрын
And because the heart only runs the CAC
@nv_514 жыл бұрын
Ok I m also going to comment every video I see
@AST4EVER4 жыл бұрын
Just like our D!CK....
@yo-no98794 жыл бұрын
Once your muscles hit 100% mitochondria per volume, you have officially transcended.
@marc40104 жыл бұрын
I swear I saw u in boy in bands video abt school
@anonamuss16044 жыл бұрын
As a person with mitochondrial diseasr I'd like to say thank you for creating this video. It is one of the best I've seen on the topic.
@anonamuss16044 жыл бұрын
@@viracocha Huh?
@gmdrandom62873 жыл бұрын
@@viracocha he just said he had mitochondria disease
@Alexe8292 жыл бұрын
Hi, how are you now? I'm being currently tested. Any advice?
@anonamuss16042 жыл бұрын
@@Alexe829 As it's a degenerative condition I knew my health would deteriorate but in my case thats been reasonably slow and consistant. Unfortunately I got glandular fever and ended up with post viral Chronic Fatigue Syndrome, fibromyalgia, POTS, Mast cell ectivation syndrome etc which often seem to accompany each other. In spite of all that I've learned that it is possible to maintain a certain level of wellness, have a reasonable quality of life, and also contribute to society in a meaningful way. I don't generally give advice except that which I found most helpful at the beginning of my journey. 1. Listen to your body. Every peraons journey and symptoms can be quite different. 2. Join a supportive community. As there is no cure and treatment options are limited finding a helpful supportive community is essential as they can share tips and tricks for staying as healthy as possible and offer support when things get difficult. 3. Start low, go slow. If you ever try something recommended by others start very slowly and on low dose/setting as your body may not respond in the way you might expect. 3. Be honest about your symptoms, even the weird ones. Mitochondrial issues can cause all sorts of bizarre sensations and dysfunction. 4. Find a dr you trust not to make you feel stupid for bringing up things that might not make sense at the time, or that blames everything on your mental health. Though mental health issues should be addressed, gasslighting patients is unprofessional, appropriate and uncalled for. If a dr does that to you, don't waste your time with them. 5. If you don't end up being diagnosed with a mitochondrial disorder font give up searching for a diagnosis. Just because the nedical fraternity spent know what is causing your symptoms, doesn't mean that it's nothing. Don't give up, don't give in, you deserve a diagnosis however long that takes. I hope all is going well and that you find peace and confort in your life whatever form that takes.
@anonamuss16042 жыл бұрын
@@gmdrandom6287 I figured that if Viracocha actually knew me they'd know I wasnt lying. Trolls are gunna troll so I thought ignoring them was probably best. Thank you for your comnent though. :)
@gvbm4004 жыл бұрын
*Title* : Mitochondria is not just the powerhouse of the cell *Me and the boys* : Those Bastards Lied to us
@KillaD554 жыл бұрын
For years.
@jeong-ilkajokaya38494 жыл бұрын
Time to riot
@shivangisingh18993 жыл бұрын
Revenge time!
@AlMerrymBintImranaway Жыл бұрын
Lolz
@Vienna30804 жыл бұрын
Mine liege I would like to inform thee with great haste that thee mitochondrion produces significant energy to power thee cellular structure
@superitgel14 жыл бұрын
So Obiwan was talking about this and the force!
@photonicpizza14664 жыл бұрын
thy* mitochondrion/cellular structure "Thou" is the subject form, "thee" is the object form, and "thy" is the possessive adjective (and "thine" is the possessive pronoun, like "yours" or "ours")
@Christian988.4 жыл бұрын
That's just a fancy bulshit away to tell me mitochondria is the powerhouse of the cell just speak to me like a normal person instead of a fancy wanker and tell me mitochondria is the powerhouse of the cell
@klumaverik4 жыл бұрын
Surely you jest!
@camplays4874 жыл бұрын
Heart: *laughs in mitochondrial superiority*
@spacewolfcub4 жыл бұрын
Cam plays - You’re so funny.
@gamerbossharmon4 жыл бұрын
Lol
@haipabli76704 жыл бұрын
The real question is: What is the powerhouse of the mitrocondrion??🤔
@bradug4 жыл бұрын
thermodynamics
@haipabli76704 жыл бұрын
@@bradug Oh yeah. it has something to do with kinetic energy right??
@yourcommentmightnotworksop99874 жыл бұрын
quantum fusion charge
@caimacd4 жыл бұрын
lol
@caimacd4 жыл бұрын
he actually said it in the video. tacos. tacos are the powerhouse of everything
@BenRobson1234 жыл бұрын
Everyone: The mitochondria is the powerhouse of the cell Me: come on guys, really? Also Me: The mitochondria is the powerhouse of the cell
@fundemort4 жыл бұрын
Also Everyone: come on dude, really?
@BenRobson1234 жыл бұрын
Fundemort Grey Prime Defender of Truth and Justice Also Me: Yes really
@mannetjie37044 жыл бұрын
what powered the cell before symbiosis?
@balasubramanians79324 жыл бұрын
Star is the powerhouse of the solar system.
@bootblacking4 жыл бұрын
Big if true (It's true)
@Altraiid4 жыл бұрын
Which star? Or you mean Star from Cartoon Network?
@appletizer84153 жыл бұрын
@@Altraiid No he/she mean't the star from the more you know
@arnjain4 жыл бұрын
the mitochondria is the power house of the cell !
@Spacedog_424 жыл бұрын
NOTINMYARSE ! ThE mItOcHoNdRiA *aRe* ThE pOwErHoUsE oF tHe CeLl !
@arnjain4 жыл бұрын
@@Spacedog_42 ahhhhhhhhhh
@arnavjain75663 жыл бұрын
@@arnjain same name bro.
@ChristianWilliams-k9c Жыл бұрын
This is the most important video on health
@yasinmahmudchowdhury14124 жыл бұрын
Nobody : Schools: Hey did you know that *Mitochondria is the power house of cell.*
@louf71784 жыл бұрын
I think "Everybody:" is what is meant.
@WadcaWymiaru4 жыл бұрын
Me: Hey did you know that chloroplast is the power *plant* of plant cell? Seeker: ...
@ferce8894 жыл бұрын
@@louf7178 XDDD
@Corporis4 жыл бұрын
This was a fun episode to write, hope you guys like it ☺️
@rajesh_sagar_yt4 жыл бұрын
Editing this was fun too 😁
@jacquietarr7280 Жыл бұрын
Please remove the distracting music
@IntuitiveGanesh Жыл бұрын
There's an update available which you probably can't edit into the video, about which parent we inherit mitochondrial DNA from.
@vicariousgamer28714 жыл бұрын
Cool ! My college days ended in the late 90's. My favorite classes were A&P lecture and mostly lab. The cell structure, constituents, and function was my favorite point of study, primarily the Mitochondria. I was fascinated by this micro powerhouse. It seemed so surreal. I was wondering what new developments would arise in the future after further research was performed on this particular particle of wonder. So, once again... Cool ! I look forward to learning more about this subject matter.
@jessiep319 Жыл бұрын
Thank you for making this video. The pace, depth, and visuals are perfect for my students. You will be added to my lessons 😊
@user-ls9ff4cu9x4 жыл бұрын
*THE MITOCHODRIA IS THE POWER HOUSE OF THE CELL*
@jamrollz4 жыл бұрын
SCP 89 THE MITOCHONDRIA IS THE POWERHOUSE OF THE CELL
@oliverhees40764 жыл бұрын
are*; 'mitochondria' is plural (yes I watched the start of the video)
@trinado42604 жыл бұрын
Ah! There you are!
@andybryson49894 жыл бұрын
These Human versions of Seeker are truly awesome. I really enjoy them. Teaches me SOOoo much!!! Way to go. But dont stop the other regular Seeker videos. Luv watching all of them
@tammcd4 жыл бұрын
8:56 "making the mitochondria a warning signal that something bad is happening" .... which fits with the CENTRAL role of mitochondria in apoptosis (programmed cell death).
@ricardoansantos4 жыл бұрын
*pausing the video* Before watching the video I just wanna say one little thing... The cell is the power mitochondria of the house. That's it! Thank you! Let's continue watching. *resuming*
@Ostinat04 жыл бұрын
Not often that a video goes "but you may ask..." with what I was actually asking. So glad I don't have to sacrifice any sleep time to solve unanswered questions! Loving this series.
@MR-ub6sq Жыл бұрын
3.53 "Endosymbiosis theory suggests that eventually, one of those anaerobic single celled organisms consumed an aerobic purple Bacteria that survived being eaten and they kicked off a symbiotic relationship. That was the first mitochondria. That purple Bacteria could consume and metabolize oxygen, which provided energy for the host cell. And in return, the host cell protected the bacteria." Could someone please explain : ATP is a necessity for all life. So since an anaerobic cell had no source of energy before endosymbiosis, how did it survive and function until then?
@marvintherobot323 Жыл бұрын
I’m no expert but would it have anything to do with viruses being the first parasites on this planet and bacteria as its host?
@hugoapresname8 ай бұрын
There are other forms of energy: Please sit down before continue to read: *Focusing on Metabolism* Pressure Osmotic Pressure Thermal (Movement) Electric Charge Differentials Molecular Orientation and Charge of Atomic Hull Infrared Light 💡 (Thats why darkness is a Vitamin 🫥) Electric Current and therefore electromagnetic interaction where relativity theory is infolved. 🤯 Radiation ☢️ (local, regional and especially cosmic) the curvature of space Dont think just because the space is small there is no effect. You clean the outside of the house 🏡 with a garden fork, the toilet with a toilet brush and your ear with a Q-Tip. Small space but still some small effect. Small for You. Ask a Hydrogen Proton if the mass of a protein looks big 😳. The pull towards the sourrounding ‘gravity wells’ The changes in not directly involved molecular neighbourhood. Please continue the list…
@javierbaena70308 ай бұрын
Anaerobic cells can get energy from other methabolic pathways: the most known are fermentations, like alcoholic or lactic fermentation
@yourcommentmightnotworksop99874 жыл бұрын
Apart from the meme,i did learn something NEW MITOCHONDRIA is also the POWERHOUSE of our ANCESTORS.
@earthterra85464 жыл бұрын
Yeah
@karimmartin61254 жыл бұрын
the mitochondria is the powerhouse of the cell
@greenrace88544 жыл бұрын
Mitochondria is plural,hence,are should be used.
@BizAutomation4 жыл бұрын
Would love more about how Sirtuins and NAD play a role in the mechanism. As you know NAD boosters NR and NMN are a big part of the anti-aging right now (will look forward to the ATP video).
@nomanafzal28974 жыл бұрын
Patrick is doing a great job on seeker, i like very much his medical related videos
@pieter-bashoogsteen22834 жыл бұрын
He has his own channel. Called Corporis if you don’t know and really enjoy videos by him.
@eukaryotic07034 жыл бұрын
If you want to learn theories on how mitochondira evolved, Nick Lane wrote a book called "Vital question" goes in depth about endosymbiosis and Chemiosmotic coupling.
@userq.a31943 жыл бұрын
We believe in the Almighty
@berryberrykixx4 жыл бұрын
Last time I was this early, the mitochondria was still the powerhouse of a cell.
@ErenYeager-xk3cy4 жыл бұрын
Thumbnail - The most badass - High-tech - futuristic Mitochondria. Video - 6th grade drawing.🙂 Great knowledge though 🔥🔥🔥
@Stone_6244 жыл бұрын
"Has been firmly inserted into our Middle school textbooks for years" High School Biology : Am I a Joke to you?
@marilip51384 жыл бұрын
the title is misleading. It suggest mitochondria has some other major functions. But the video is mainly showing other aspects of mitochondria, its number, origin, etc. Kind of wasting time for a man that has that specific question in mind.
@thomasdean23734 жыл бұрын
Your Diet, Lifestyle Is Some Of The Most Important
@onajet14 жыл бұрын
I learn so much from these videos. I wish they would have taught like this is my High School.
@tooploopers7373 жыл бұрын
They won't
@tooploopers7373 жыл бұрын
School forever gonna be the same and boring machinic place
@doctortabby Жыл бұрын
To accept the endosymbiotic hypothesis is a huge step of faith.
@abel3557 Жыл бұрын
Endosymbiotic theory*
@doctortabby Жыл бұрын
@@abel3557 It doesn't fit the criteria of a theory.
@abel3557 Жыл бұрын
@@doctortabby It in all ways does. Present your peer reviewed study to back your argument.
@doctortabby Жыл бұрын
@@abel3557 The burden of proof is on those who would try to assert such an absurdity. The need to present peer reviewed material to discredit this nonsensical notion equates to the need to present peer reviewed material as to why 2+2 doesn't equal 5. It may be helpful to look at what a theory actually is.
@VIKINGOCATIRE4 жыл бұрын
my god, the hosts of this channel are just perfection in the way they narrate everything, How do they do it?
@MARIPILIPM5 ай бұрын
I just discovered you, EXCELLENT teaching skills👏🏻
@nicholashorton55664 жыл бұрын
Aaaah. Mitochondria. The powerhouse of the cell.
@superitgel14 жыл бұрын
The force? Obiwan was speaking the truth!
@laurab98676 ай бұрын
Thanks so much for this video. Great information.
@BusinessMadhouse4 жыл бұрын
I have been following you since the very beginning and have seen you grow. Your work and dedication has inspired me to start my own channel and put in a lot of effort Looking forward to your support and advice as always!
@jamesfletcher719611 ай бұрын
So we know what happened billions of years ago? Historians argue about some things that happened a hundred years ago.
@Jules-74010 ай бұрын
😂🤣 Great point!
@johnpaul36284 жыл бұрын
This is the "Mitochondria is the powerhouse of the cell." comment youre looking for.
@mindtherapy37534 жыл бұрын
Thank you for never disappointing brother! 💪🏿
@anonymbigfox4 жыл бұрын
What about other organels like lysosomes and ribosomes ? How did they become part of our cells ?
@cheliospanama97862 ай бұрын
Great Video! Thank you 🔥👏💪🫶
@LarlemMagic4 жыл бұрын
I wonder if "The mitochondria is the powerhouse of the cell" will become an eternal meme that is passed down in our culture for as long as children are taught biology.
@SauceMeGud4 жыл бұрын
My mitochondria are off the charts. Over twenty thousand!
@AngryKittens4 жыл бұрын
The Mitochondria is the powerhouse of the cell.
@greenrace88544 жыл бұрын
U did not add the exclamation mark (!) as shown in the video.
@greenrace88544 жыл бұрын
At the end.
@AngryKittens4 жыл бұрын
!
@greenrace88544 жыл бұрын
😒😒
@mpicar24 жыл бұрын
Awesome summary!
@dantheman29074 жыл бұрын
Midichlorians are the powerhouse of the force.
@Petrov34344 жыл бұрын
Outstanding - thank you !!
@popescucristian8978 Жыл бұрын
the mitochondrion is also responsible for weight loss as it's the only organelle that can burn fatty acids in the cell and tha allows us to use the energy stored in our body fat
@mengxiaozhang64964 жыл бұрын
Thanks. Very imformative
@Silverfirefly14 жыл бұрын
Mitochondria to each other: Remember guys, the cell is the powerhouse of the world domination.
@AlMerrymBintImranaway Жыл бұрын
I really appreciate the word organelles. Although powerhouse deserves a rank too for the record
@lolawchooawchoo4 жыл бұрын
Whenever I see Mitochondria I always think of the Parasite Eve game and it makes me miss it.
@mushi_k4 жыл бұрын
Great game, that one. Makes me wish i had mitochondrial powers too
@J_Lag4 жыл бұрын
Mitochondria are awesome organelles!
@PaulThronson4 жыл бұрын
Mitochondria are the powerhouse of the cell
@Alobas19843 жыл бұрын
So much termins used in here - I will go to bed confused again except for remembering that "Mitochondria is the Powerhouse of the Cell"!
@aaronstafford33894 жыл бұрын
Can you provide a link of fossil records or confirmation of a mitochondria that is not within a cell?
@insanitysreign61954 жыл бұрын
Hmm, that's interesting! Can't wait to learn more!
@woodzman9193 жыл бұрын
Teachers: wait that’s illegal
@ninjasiren4 жыл бұрын
Adenosine Triphosphate FTW! Thanks powerhouse of the cell!
@awm21awm214 жыл бұрын
Mitochondria's relationship to cancer is far stronger than you indicate. Please expand with a video on the Warburg Effect - a very recent area of research focus and something most people with cancer can take advantage of themselves to greatly increase the effectiveness of standard therapy.
@oirampeceda2409 Жыл бұрын
DCA
@ivanguthrie04204 жыл бұрын
Powerhouse of a factory or process plant is called cogen often. Referring to co generation. Co because it is connected to the Grid or a primary power generation plant. Cogen or Gen#. Was a industrial analytical device technician for long time.
@DailyFunFactsYt4 жыл бұрын
Fact of the day: Being alone for a long time is as bad for your health as smoking 15 cigarettes a day. - Daily Fun Facts
@hassanabdellatief52904 жыл бұрын
Not fun but ok
@Joyful_leo4 жыл бұрын
Oh ok
@alycias73454 жыл бұрын
may as well smoke?
@stefansauvageonwhat-a-twis13694 жыл бұрын
Probably smoke cause you’re stressed anyway
@alexi23694 жыл бұрын
And how do you prove it??
@Bannditbunny3 жыл бұрын
Thank you for the basic knowledge human that *the mitochondria is the powerhouse of the cell*
@foodslave29183 жыл бұрын
Thanks doc for this interesting and simplified video yet informative indeed
@himanshusingh66924 жыл бұрын
My only power move in the intellectual community rendered useless. Thanks for spoiling my quarantine SEEKER.
@Horizon__4 жыл бұрын
ThE POweR HouSe oF THe CELL
@cseonlineclassesmalayalam Жыл бұрын
Very interesting and informative 👍 thank you
@greenrace88544 жыл бұрын
The mitochondria is the powerhouse of the cell!
@giuseppesaccone11312 жыл бұрын
at minute 5.50, the description is a bit confusing: actually the recombination of chromosomes happened before fertilization, during gametigenesis and not in utero during embryos development...
@melchizedekpsj4 жыл бұрын
I was introduced to mitochondria when I first played Parasite Eve. Fascinating. Thanks for the video!
@liggerstuxin14 жыл бұрын
Melchizedek Phuah Siow Jin that’s such a cool video game. Still remember it’s gameplay and it’s story theme.
@melchizedekpsj4 жыл бұрын
@@liggerstuxin1 Right? I love the music too! The atmosphere created was intriguing.
@nicolawhatley46528 ай бұрын
I have had doxirubicen when I had Hodgkins lymphoma, post chemo I developed me/cfs. Which is suspected to be a dysfuntion of ATP and mitochondria. Along with EBV could this have a link to my illness? Curious to delve into this further 🤔
@julioequinones4 жыл бұрын
Look up parental mitochondrial DNA inheritance. I remember seeing developments that might put in question the maternal inheritance theory.
@momovaryacting8798 Жыл бұрын
That’s what I was wondering. I had thought it was passed to girls only & they carried the paternal line
@baze35413 жыл бұрын
Great, PERFECT, everything I knew from school gone now thank you
@sparshsrivastava83034 жыл бұрын
This is the third comment, "mitochondria is the powerhouse of the cell."
@greenrace88544 жыл бұрын
U did not add "The" at the start and exclamation mark(!) at the end as shown in the video.
@sparshsrivastava83034 жыл бұрын
@@greenrace8854 hahaha you got me!
@greenrace88544 жыл бұрын
😁😁
@101personal10 ай бұрын
Awesome. This information should open research on how fasting should allow cells to “clean themselves” during the fasting stage
@cojojacobs3538 Жыл бұрын
Great video! Filled in a lot of knowledge gaps for me.
@salomonarreguin37484 жыл бұрын
Millions of years ago, a mitochondrion walked into a bacteria and BAM! Science.
@sidneyibiom28673 жыл бұрын
Thank you so much You've answered all my questions
@satyamgautam1084 жыл бұрын
Sir, you said in matrix most of the ATP generated but other ATP generates where please tell
@KIKONUTINO4 жыл бұрын
*Tesla is the new mitochondria*
@CristalMediumBlue3 жыл бұрын
True
@fghelmke Жыл бұрын
Fascinating great information! So interesting! BTW, how did the information in the mitochondria get into our common African ancestor? Eve of Adam?
@lordadams57624 жыл бұрын
Mitochondrion for singular Mitochondria for plural. That's enough learning for today 😂
@STILLSTANDING2391323 күн бұрын
6:44 Wow I learned something new. Thank you moms!
@PoeticPoppa3 жыл бұрын
I'd always thought each cell had one mitochondrion 😳
@oirampeceda2409 Жыл бұрын
Chondroma is the name given for all of the mitochondria within one cell.
@alledzebu19754 жыл бұрын
Thanks seeker!
@rodylermglez4 жыл бұрын
I sometimes forget that we all have symbionts inside of us... Like Venom >:3
@clayronjonnacar62262 жыл бұрын
Proves the Intelligence of The One who created All
@SciFactsYT1184 жыл бұрын
Random fact: Butterflies have their skeletons on the outside of their bodies, this is known as the exoskeleton.
@ericdanielski48024 жыл бұрын
Interesting. Thank you.
@EntropyConcept4 жыл бұрын
As do alot of insects lol
@Xocrates2510 ай бұрын
You have a new subscriber!
@uss_044 жыл бұрын
Mitochondria also sets people on fire in Parasite Eve. Thanks 90s Squaresoft games!
@AlokKumar-ym8bl Жыл бұрын
❤excellent explanation 👌
@speedy012474 жыл бұрын
mitochondria are the pets to our cells. (imagine if one day if the mitochondria decided to rebel and kill us all)
@foodslave29183 жыл бұрын
I've seen a pitbull attacked its owners 😓
@lynshenstudio3 жыл бұрын
Such a great knowledge I learnt. It's help alot for me as a beauty consultant.
@Xpistos5104 жыл бұрын
And the Worker is the powerhouse of the Economy. *USSR National Anthem begins*
@serta57274 жыл бұрын
Exactly what I leaned in school.
@ZAvier80214 жыл бұрын
When I read this I thought it said midichlorian at first
@davids95224 жыл бұрын
Maybe George Lucas is trying to tell us something....
@prevengeix85512 жыл бұрын
2 1/2 years later....still the powerhouse of the cell!