Mitochondrial Dysfunction

[@knight24474]

00:15:41 your problem 00:20:08 the solution 00:27:26 food to avoid at all cost

[@templetreasures9514]

Thanks❤️

[@pgreen6840]

Thanks

[@doctorstotrust]

Great on most everything. Very clear and concise. I did not see the case against saturated fat--which do not oxidize like polyunsaturated oils do. You simply say that clog up the system. Where is the science on that?

[@gregsLyrics]

This lecture is the first to educate me on what is happening to my body and elevated blood sugar, and tremendous loss of energy. I am excited to learn from you how to build and restore my mitochondria. I am researching everything I can get my hands on and your wisdom is absolutely brilliant. Thank you, thank you, thank you for your time.

[@harryc2708]

Great, keep up the great teaching. I spent 45 years as s MD and wish they taught this in med school. Of course ,much of this is new knowledge. Even if I am now 80 , I wish to spread the information and live a healthier life.

[@jani7166]

Did you manage to find a solution for energy levels? I have mitochondrial disease. Exhaustion is unbelievable. No energy to exercise. Medication no help. Hope you improved greatly.

[@gregsLyrics]

@@jani7166 If you have a genetic MD disorder that this may not work. My solution is a stack of supplements to support the krebs cycle: Niacine-500mg first thing in morning, after late lunch CoQ10-200mg, PQQ-100mg, Vit-B2-100mg, Vit-B6-12mg, GTF Chromium-200mcg, Benfotiamine-300mg, B-12-1mg, and a prescription medication called low dose Naltrexone-6mg. This combination has restored me to the point where I can get out of bed and work again. Miracle to me. Best of everything to you.

[@shaolintraditionalmedicalq6976]

Thanks Doctor. This is the most comprehensive lecture I hear on insulin resistance, cause and effect.

[@johnbauman4005]

Doctor? What sort of doctor? She does not introduce herself as a doctor in this video, nor list any sort of training and education in her bio as far as I can see. Please clarify.

[@evawood438]

EXCELLENT......Best explanation I've run across yet....I FINALLY understood it. Thank you!!!!

[@Sy2023hk]

Thank You so much, it's really helped me understand mitochondria health at the core level. Gonna avoid eating so much and processed carbs, didn't know they cause this much damage, and explains my tiredness.

[@humptydumpty8984]

Beautifully explained. Even a layman can understand. I am already working on reversing my prediabetic condition and this knowledge shall definitely help a lot. Thank you Juliet Richards.

[@peanutnutter1]

Excellent. Also sunlight/infra red light has been found to stimulate the mitochondria to produce melatonin which is a powerful antioxidant that tackles ROS directly. So exercising outdoors is good advice.

[@vitrifiedvolcanicvent1500]

Aha yes, I suppose you might be aware of some paper - off the top of my head - that addresses the bound water of cytochrome c oxidase and its being the ultimate target for the infrared radiation leading to improved efficiency? I'll try to find it ... But that point that you raise is not emphasised enough, that melatonin is produced (I think it might be valid to frame it as recycling perhaps?) for use inside the mitochondria, with other familiar antioxidants not being inferior to melatonin, so much as never making it into the mitochondria - glutathione does go inside the cell, but no further, and vitamin C if I'm not mistaken doesn't go into the cell, let alone mitochondria. Melatonin is not merely a powerful, but the crucial intra-mitochondrial antioxidant.

[@peanutnutter1]

@@vitrifiedvolcanicvent1500 thanks for the info, it's a fascinating area of study that may be an important correlation or cause to the population scale decline in multiple health conditions.

[@pramujisinggihriyanto6901]

Thanks Juliet... I could easily understand your lecture. You are genius teacher. Pls make lecture on protein needs

[@erinMcL281]

Excellent video and clear explanation about mitochondrial function. I studied exercise physiology with a focus on metabolic flexibility and I wish this video had been around when I was in school!

[@johneubank8543]

Ben Bikman says the sat. fat you mention around 17:19 is not from exogenous sat. fat - not from consumed fat. It's made - and comes from carbs. It makes no sense to say that saturated fat consumption "causes insulin resistance" - if that's what you're saying - because thousands and thousands of people on keto diets and carnivore diets, eating LOTS of sat. fats, are going into diabetes remission, not getting diabetes - they're essentially curing their diabetes eating fat - including lots of saturated fats.

[@AZ1306AZ]

Thanks for all the work you put into this. It's very helpful.

[@Mr_Fission]

What is the research data saying that saturated fat is bad? I've heard again and again that it's not bad at all. The Masai have a diet of primarily animal meat, with 50% of their calories coming from saturated fat, and they're just fine. Would welcome any technical explanation, including exact metabolic processes, to explain why saturated fat is bad.

[@Breezeyogi]

Keep eating it until it clogs you get CAD. Go ahead.

[@Mr_Fission]

@@Breezeyogi Statin shill detected.

[@veganandlovingit]

And Massai life expectancy is 55 - 60 years...

[@Mr_Fission]

@@veganandlovingit Yeah because there are zero other differences between their lifestyle and the American lifestyle besides saturated fat intake. Your comment is irrelevant. The relevant fact is the Masai have no heart disease. Oh also, they live in a part of the world infested with malaria. That may have something to do with it.

[@StarvingMyselfToLIFE]

One of the best explanations on this topic I have hesrd and I have heard a lot. The illustrations was a great touch.😀

[@iamkirankumarkv]

i came across your channel very late, now I'm watching all your videos.. thanks for the detailed explanation without just wandering around the topic

[@hw9876]

Thank you so much for this. The explanation was very clear, and the diagrams and writing were tidy. Thank you.

[@alman3071]

Thank you for an amazing most detailed scientific explanation to what a very abused subject

[@user-sh9xd4ou1g]

This is a great summary.

[@fabienneonyema4748]

Thank you so much, I was really struggling to understand how they all interlink

[@abidfarid439]

Wonderful lecture

[@vickiwithers8563]

Best explanation I have seen. I feel empowered and motivated Thank you so much Keep up the great work

[@NelsonRazo]

Hi, Juliet. Nice work! You've got a mexican fan. I'm an applied nutritional sciences student trying to do exactly that: educate the population on the latest advances in chronic diseases reversal with lifestyle interventions.

[@NelsonRazo]

This is my KZbin channel: kzbin.info%C3%ADdateHoy

[@johnrhodes3350]

Someone should educated doctors, and more importantly incentivised them appropriately to deal with this earlier

[@camelcase811]

This is the best overall explanation I've been able to find so far - and I've seen quire a few!!

[@bigmac3006]

FANTASTIC EXPLANATION!

[@andreamcpherson6409]

Excellent presentation!! The mitochondria functioning is key!!

[@mutazalhussamy9043]

Great lecture. Beneficial information. Thank you.

[@coffeehouse44]

Hi Juliet, Just letting you know that I'm finding all you KZbin videos fascinating and the more i watch the better my understanding on how my body works increases. Would love if you could do one around fatty liver and the different levels of a fatty liver, plus how long it can take to repair and improve it or get back to a normal healthy liver.

[@rizwanwaseem207]

Though I know everything about mitochrodia dysfunction I still find your video very interesting. Thanks.

[@yasminlarmond2559]

Awesome presentation...very helpful

[@freethinker3131]

One of the best video on this topic in laid man term. Thanks!

[@firstlookrealty]

Very well explained, Excercise and eat sensibly....thank you!

[@jagodastefanska7697]

Finally, someone shared enough detail for me to know how to explore further and understand why certain processes occur within my body. Most videos on it are so vague... Thank you!

[@Annabelleese1]

superb explanation. thank you.

[@CJ-lj9fb]

I would be interested in what research actually implicates animal fats vs all of the industrial seed oils that are ubiquitous in processed foods and most kitchens, because when people committ to a carnivore diet thecreverse inflammatory diseases, type 2 diabetes, and many common chronic and autoimmune conditions.

[@ponzo1967]

Seed oils are toxic 🤢

[@Breezeyogi]

​@@ponzo1967Yes

[@veganandlovingit]

Forget seed oils. Extra virgin olive oil is the way to go.

[@Franco-on7yw]

Best video on this topic EVERRRR!!!! Thanks Juliet.

[@Dr.OmArToMa]

Thank U for this Video I have type 1 DM and have noticed tow groups fighting about the cause and pathogenesis of IR One group is the KETO ( high fat ) and the the other is VEGAN ( low fat ) Believe me the answer is in the middle and with Fasting and exercise. BUT thanks again for showing the wholemark of the problem

[@kriskozolanka2665]

Fantastic...Your sweet ...direct analysis on Nutritional intake; garden vegetables ...what we should eat in place processed foods, so interesting, and basic knowledge I had all this time. The Mitochondria cell was what I searched for initially, the power house cell. The delivery system of energy, I think I got that right. Can be over loaded with junk food. Exercise in moderation, you don't need to be an athlete, pressing too break world records. Just workout, walk to your destination. Promote fresh air into your lungs. Again, Brilliant, simplistic for a complicated system we are rapped in..

[@selvarajanmuthiah8180]

Fantastic and clear explanation easy to understand thanks so ..much and congratulation

[@miguel1974ification]

Thank you for your easy explanation about the subject. Very helpful to u derstand my diabetes and the that we are supposed to improve or reverse DM trough improvement in mytocondrial function. I would like you to do a explanation of omegas role in the mytocondia fx. Thanks

[@Lifeofaseriousdiva20]

Love the way you explained it, thank you.

[@maryal-humayani8761]

Thank you for your clear presentation.

[@neetirana4435]

Very informative. Thank you so much 👍

[@hk-not-to-know-or-try-to-know]

Simple but very informative. I subscribed. thanks.

[@kreedarudraaksh7089]

EXCELLENT EXCELLENT EXCELLENT..... the most simple and accurate description.... Subscribing your channel. You are sharing true knowledge ma'am in this maze of information bytes overload... God bless!

[@agustriprasetyo8320]

Thank you very much Julliet. God bless you.

[@lokeshsharan2003]

Helpful overview mam.. For starting my PhD in Diabetic neuropathy.. Thanks

[@honeysid1126]

Bhi plz send your number

[@honeysid1126]

I have daibates nuropathy

[@franzbuchel7295]

Excellent explanation! - Supplementation for mitochondria would be interesting.

[@jagodastefanska7697]

It's the lack of supplementation that's needed here 😁

[@GretaTurdeau]

Methylene Blue might be of interest to you.

[@simpernchong]

Thanks so much for the very clear explanation. Really appeciate your work.

[@julietrichards8747]

Glad it was helpful!

[@mauricebiron8773]

Good podcast. Thanks. Can’t get that info from my doctor.

[@dominicboileau]

Great video! I just don’t know what inshulin is

[@anissweb]

That was good work.

[@karreenco.beautyhealthwell9806]

Thank you for this information

[@oldskooldriver9379]

I over trained myself doing too much zone 5 work in the pool. This happened about a year ago. I still train, but less, and take longer to recover between workouts, and have generally a much lower amount of energy per day. I'm wondering if somehow I damaged my mitochondria through over use. My muscle tone and other health aspects all measure fine in annual checkup at the doctor. But something permanently changed from just a few months of over training.

[@swapnilsangle]

Thank you so much making this video ...🙏🙏🙏🙏🙏

[@333thelc]

Thanks, that was very easy to understand and I'm very much a layperson! I just wish I didn't have ME/CFS and the inability to exercise, but at least I can do these other things.

[@connerheermann4955]

So very helpful.. thank you, thank you, thank you!

[@Enigmalady]

First half is a good explanation, complies with what I have read in many books on mitochondrial health. But I am sceptic to the part in which you say that saturated fats comming from animals are bad for mitochondria. In ALL good books on this topic (including books written by doctors practitcing the mitochondrial medicine) they say that animal fats are the best fats for mitochondria as they are the best genetical fit for homo sapiens. On the contrary all the seed oils are said o contribute to inflamation, insulin resistance etc. So the question is what is the evidence for what you say about saturated fats? Maybe it is a research showing that fats combined with carbs are bad for mitochondria (that makes a huge difference and should not be used as evidence against animal fats.) Also if we talk about a build up of triglicerides or exidized LDL it also means they come from mainly from carbs and carbbs with trans fats and not from saturated animal fats.

[@dickschwanzstein1789]

Oh, well, you will inherently get some saturated fats from your diet. Your egg will contain some, your meat does most of the time, some nuts like cashews do, coconuts do. The question really is how much of it we need. We can’t go without fats and some fats like the omega 3s are very important for us to take in. I eat a great variety of food sources and therefore I get all sorts of fats into my body.

[@MM-qp4pd]

Typical pharmacy shill with her half truths

[@vecernicek2]

Great video, thanks!

[@johnrdunbar]

What do you think about Redox Signaling Molecules?

[@danielpincus221]

A key to reversing American Type 2 diabetes in many is to stop overloading the mitochondria with fructose. Right up front, she is clear that what the mitochondria convert to energy are glucose and fat. Fructose is not in that list. So, fructose should be consumed only moderately.

[@rosso9996]

Thanks, very helpful..

[@madhu_1489]

Wonderful explanation 👏 thank you so much

[@jaroslavvita]

good work

[@gloriaasaram2982]

Excellent

[@obioraonunkwo2228]

Thanks Dr Richards!

[@johnbauman4005]

What kind of doctor? She calls herself "Diabetes Educator." No info in bio. Physician? Nurse? Dietician? Self taught?

[@martinirving3824]

Interesting. I have a different interpretation of mitochondrial dysfunction. I see it as a gradual and increasing inability to oxidize fats for energy. The mitochondria become lazy and rely entirely on aerobic glycolysis (which takes less oxygen). Aerobic lipolysis takes more oxygen but ultimately provides more ATP with less CO2 as a byproduct. Yep, gotta keep those mitochondria happy, healthy and preferentially fat-burning.

[@Unsensitive]

Agreed. I believe lectures from Chris Knobbe kzbin.info/www/bejne/pnnRgZykjq5lj8U and Thomas Seyfried explain it well. kzbin.info/www/bejne/ZmfIXoOtndKGp5o Basically the only problem from fats, on mitochondrial dysfunction are the PUFA, which in excess lead to lipid peroxidation, causing structural problems in the mitochondria.

[@martinirving3824]

@@Unsensitive, Yeah, I gather there's more nuance to it than that. I was listening to Peter Attia's podcast with guest Inigo San Millan (or something). Ha, I have a new computer with Bing (used to have Firefox) and I don't know how to copy and paste a link with it. I'm just hopeless at computers. Anyway in untrained, overfed people, there is some factor whereby fat can build up inside the cell basically blocking fat metabolism and causing the mitochondria to rely on glucose burning. Highly-trained elite endurance athletes develop the same buildup (known as "athletes paradox") but with no dysfunction. I've always been skeptical of using elite athletes as a model for what regular people should do. Clearly the problem with the general low-trained population is overfeeding and being overfat. The solution is just to eat less frequently (with your preferred fasting protocol) and let the system clear itself out. Refined carbohydrates and industrial seed oils, PUFAs, further complicate the situation and should be minimized (ideally eliminated).

[@Unsensitive]

@@martinirving3824 I respect much of Peter's approach, using research & data, and have learned quite a lot from his discussions. My only qualm is he seems a bit biased and anchored to the status quo in a few areas. He a smarter guy, or maybe just better informed and researched, than myself, so I wouldn't say I'm sure he is incorrect.. but I disagree with his conclusions in a few areas. Time to go study more, till I can show myself, or him, incorrect.

[@martinirving3824]

@@Unsensitive , Agreed that Attia is a bit anchored in the status quo in a few areas but it's hardly surprising. He is a product of the medical establishment. For this reason, he carries some baggage with him and tends to be open to pharmaceutical interventions for biohacking and optimizing health. I'm a biohacking "purist" and not open to such things for healthy people. It seems to me, interventions are only helpful to people who are sick or metabolically compromised. It really does boil down to mitochondrial health. If they are healthy any pharmaceutical intervention tends to damage their performance. Attia is an incredibly smart and accomplished guy (very humbling) but arguably a little "elitist" for the general population. I'm interested in finding things that help regular people. I think the science clearly shows what those things are.. mitochondrial health through... 1. non-industrial food intake 2. preferred fasting option: 16:8 to omad, alternate day, 5:2 Mosely protocol. (and a host of others) 3. exercise: weights and/or HIIT 4. proper sleep in accordance with circadian rhythm 5. (consistent practice of the above) ...but it's very hard to get a clear and consistent message across through all the noise and competing interests (and the distractions of self-promotion and commercialism). It's very frustrating.

[@Unsensitive]

@@martinirving3824 I think there may be a place for pharmaceuticals, even in the healthy. We need to know more than we do in most areas, or have very good data, to ensure we're not mucking up the complex machinery of the human body, so I'd say we're clearly not there in moat respects, particularly on aging. Pretty much on the same page with everything else. I'm a big fan of daily 20/4, or 23/1(OMAD), but never did longer than 30hr fasting. Long work day today, so looks like I'll be doing a 24hr fast today 🤣.

[@vitrifiedvolcanicvent1500]

Interesting, high concentrations of mitochondria in the eyes, what do you know about ipRGCs and ultraviolet light's role in shaping the eyeballs? I notice lecturer is wearing glasses, interesting.

[@JavedKhan-vt2gj]

Omega 6 LA of process oil does most damage rather than saturated fat

[@at2step]

Good challenge

[@jameskelly6479]

Is that fatty acid long chain that is being stored?

[@thewrightoknow]

So helpful, thanks so much!

[@lasal134]

I hope you have updated your understanding of the value of saturated fat.

[@nirmaladrieskens4338]

Great video ❤️❤️❤️

[@julietrichards8747]

Thanks for watching

[@ShivaramKR]

Very nice video!

[@victorkh7]

Thank you Juliet! This was for me so far, the best explanation of this topic, around mitochondria and the metabolic conditions... Excellent!

[@EddieZak]

Thank you so much!

[@kc7339]

I agree. That a person suffering with mitochondria disease can not tolerate exercise. If your mito are not supplying the energy to my muscle the only thing that will happen to my muscles is pain. For days if I continue with the exercise. I'd really not want to do something that cause extra pain. Believe me I know first hand. Exercise is needed to keep your body moving. But when you have a disorder that pain affects your muscles. Do what you can. But all means do not go and sign up to an exercise program.

[@jamessang5027]

Can you do a video on what vitamins, minerals, molecules or polyphenols can inhibit reactive oxygen and nitrogen species? Good talk!

[@Star-Bright]

I’m watching all your videos. I hope you’ll make more. I wish I had this in school. Knowing how our body works makes it easier to understand how our health is the result of our choices.

[@dominicboileau]

You guys forget that lactate activates the glut-4 transporter thus helping glucose absorption into the cell (without the need of insulin!!) making exercise a key factor in glucose management.

[@johndorio4427]

Great video. Does Oxygen also help ease disfunction?

[@annetcell-ly4571]

Good job!

[@rpellicer]

A good explanation. However, she made one common mistake in stating saturated fats come from animal products only. We are also animals. ALL the fats which are made from excess glucose is saturated. After that, 60-70% are desaturated, leaving 30-40% saturated. Therefore, saturated fats can come from excess carbs as well. Also, not all saturated fats are the same. Stearate is known to increase the number of mitochondria. Butyrate is known to increase fatty acid oxidation in the liver. So, she was being a bit dogmatic in that respect.

[@nurlanmustafayev1901]

Do dental implants affect oxidation in cells as well given the rise of titanium in blood?

[@matteosforz]

Can You make another video about Mitocondrhia dysfunction in long Covid Syndrome

[@junesharp9649]

amazing

[@julietrichards8747]

Thank you! Cheers!

[@rgcamgb1452]

Perfect thank you. I am interested in it all , and particularly the bit at the end, as I understand it, that says the stressed and struggling mitochondria can damage the DNA which can initiate cancer. So how does this relate to increase in child cancers. So does the fasting kill off the malfunctioning cells to prevent cell messaging and inflammation signalling in metastasis throughout the body.

[@mrbigsdaddy]

Lady, people, protein and saturated fats in the diet are quite literally the solution to diabetes t2. High processed food, carb, and industrial PUFA in the diet cause diabetes.

[@WaltConway]

You're clumping healthy fat together with seed oils which hinder the mitochondria

[@WaltConway]

This is 3 years old time to start over from scatch as this is an important topic

[@joanneclark8256]

What kind if fats ..l am insulin resistance some are saying blk beans ... how much fat??

[@joanneclark8256]

What to do?? Healthy far and olive oil ok??

[@ursulahofbauer7668]

@@joanneclark8256you never fail with olive oil. But also fish and seafood = omega 3. I wouldn’t actually have too much fear of saturated animal fat as well. The reason for T2D is sugar, carbs and processed food. But if you are not convinced: everyone agrees on olive oil.

[@lancelaw5966]

Mitochondria the key to everything. Symbiosis at its best

[@matthewrogowski8526]

What about eliminating trans-fat which was shown to cause liver inflammation as well as vegetable oils (not more olive oil or other MUFAs) which is often loaded with aldehydes and free radicals, also damaging the liver?

[@jaym9846]

What regulates the flow of fat from blood into cells?

[@nalakaprasanna621]

Thanks a lot....

[@julietrichards8747]

Most welcome!

[@tomdavis9236]

So this vid is three years old , so young lady i hope you have learned about fatty acids and ROS in the three years since

[@WasenshiDo]

Exercise outside and eat healthy clean keto etc intermittent Fasting. Got it

[@dr.g6105]

This was wonderful. I learned so much. Thank you.

[@QCreyton]

No references 😭 useful info

[@derfalke90]

I have severe mitochondrial dysfunction what should I do?

[@susanbirch5705]

Overall not a bad explanation. Was a bit weak on the science around fatty acids and protein. The most nutrient dense foods are animal foods particularly organ meats. The poly unsaturated fats she recommends are a mitochondrial toxin whereas saturated fats are not and burn cleanly. However too much energy from carbs and fats does cause mitochondrial dysfunction. COQ10 is excellent to help the passing on of electrons from complex 1 to complex 3 and reducing the reactive oxygen species build up that occurs with too much energy. Protein doesn’t convert to fatty acids - excess protein is eliminated and it’s very difficult to consume due to its high satiety. Pretty good overall - shame about the inaccurate plant based message - not saying don’t eat plants - but not to replace animal proteins.

[@madhu_1489]

To much calories from carbs and red meat caused me a dysfunction in mitochondria, now if I eat dietary fats mean , I get dizzy ! Do you know why how to cure it !

[@susanbirch5705]

@@madhu_1489 how do you know it was too many calories from carbs and red meat? Meat doesn’t contribute a significant amount of energy. Protein does supply some glucose through gluconeogensis but it’s hard to overeat and most of the excess nitrogen is wasted. Do you think it’s calories from the fat in meat. Is it more a digestive - bile acid, digestive enzyme problem?

[@madhu_1489]

@@susanbirch5705 beacause everyday I used to eat bbq red meat at nigh of 400 grams and in the morning I used to eat carbs! So do you have any idea why currently fat causing me a dizzy or low blood sugar kind of feeling , and also recently fatigue diminished little by little . Can you share instgram Id, lpoks like you may have some idea on this. My life is living hell now

[@ibenlarsen3174]

When does it clogg up the kidneys?

[@oldskooldriver9379]

If fatty acids are so bad, why does a high protein, high fat, low carb diet (keto) work so well to regulate blood sugar in diabetics? I found papers and evidence on FAO disease, but not references to FAO problems in healthy individuals.

[@Marc-Vickers]

What is the most ancient human diet?