Understanding PHI and PSI Angles, Ramachandran Plots, & Newman Projections

This video was created using models, images, and inspiration from the Proteopedia page: The Ramachandran Principle Phi (φ) and Psi (ψ) Angles in Proteins
proteopedia.org/wiki/index.ph...
REFERENCES:
• Ramachandran, G.N.; Ramakrishnan, C.; Sasisekharan, V. (1963). "Stereochemistry of polypeptide chain configurations". Journal of Molecular Biology. 7: 95-9.
• Prilusky J, Hodis E, Canner D, Decatur W, Oberholser K, Martz E, Berchanski A, Harel M, Sussman JL. Proteopedia: A status report on the collaborative, 3D web-encyclopedia of proteins and other biomolecules. J Struct Biol. 2011 Apr 23. PMID:21536137 doi:10.1016/j.jsb.2011.04.011

[@_jeena]

There's no way I'd have grasped the concept of these torsion angles if it weren't for this video. I owe you my life, no jokes.

[@gg025]

im glad im not the only one

[@chakubanga1]

Hahahaha. NO Comments. Otherwise the list will get longer 😂😂😂😂

[@scruffymakaveli6870]

Criminally underrated video. You are awesome.

[@stellyd3752]

Dr G N Ramachandran would have been so delighted to see your video if he was still amidst us. He did an amazing discovery and I have tried reading Lehninger, Voet to truly grasp the concept of phi and psi and no book could have done more justice to his contribution than your animated video. Heartfelt thanks.

[@gyaneshshukla1946]

The best Ramachandran plot explaination on the internet.

[@Clockworkbio]

Oh you KNOW it's a good day when there's a new Molecular Memory tutorial!

[@goncalosoares8420]

been reading my ptts for more than an hour and understood more from these 10 minutes . . .

[@AmruMagdy]

I truly did not understand phi/psi angles and Ramachandran plots until watching this video. It was really helpful, thanks!

[@levydo8051]

This saved me from hours struggling understanding phi and psi angles

[@marahsaad9047]

Great job, this video allowed me to understand what I have been not understood for 3 years now.

[@dmajumdar2059]

This is the best video on dihedral angles out there!

[@astrobiojoe7283]

This is the best video on dihedral angles!

[@trixstandflipped]

Fantastic video with awesome visualizations. Thanks!

[@ogunoluwamayowa4749]

You always have a way of explaining things in an awesome way

[@yazzydrazzy]

What an amazing video!!! Thank you so much

[@rajatkumarparida4542]

thanks a lot for the amazing visualization, and this is helpful to me......

[@adhoccerswings]

VERY clear video, thanks! You'd think "basic" stuff like phi and psi would be difficult to forget but apparently not. My mnemonic; "NCC phi psi"; phi N-CC, psi NC-C. Middle C being the alpha carbon, of course - kinda intuitive and easy to remember since N -> C and "phi psi" is in alphabetical order (h before s; phi before psi)

[@MolecularMemory]

Thanks for sharing your mnemonic!

[@adwaitdighe4342]

cool!...h before s 🤣🤣

[@sathyamurthys9855]

THANK YOU FOR THE VIDEO MAKER AND THE PROTEOPEDIA FOR PROVING SUCH DETAILED EXPLANATION

[@mathiasverbeke9817]

A great visualization, thanks!

[@divyanshdixit933]

Thank you for this, I'll be forever grateful 💓

[@jhankargarg7327]

Both the video and the link provided in description is very helpful Thank you for making my concept clear. It was so confusing earlier

[@SherKhan0122]

Brilliant video. Thanks!

[@rehabalsaleh166]

Amazing! Thanks a lot! This definitely helped.

[@sudippattanayek6760]

You have done an excellent presentation.

[@tamilbiology5078]

Dr Gn Ramachandran is from my state tamilnadu , India

[@Ash-vl5ph]

Amazing video!!

[@jdmccool1]

You do such a great job at visualization that it would be awesome if you could make a video series around group theory. Symmetry is so hard to visualize and I feel you would do an awesome job!

[@gabrielqin9687]

Hi, is there any recommendation for group theory? I am a math-beginner for a biology major, but currently I need to deal with Euclidean group in molecular symmetry.

[@ishakashyap6974]

So so thankful to you...

[@ericmartz9100]

Really well done!

[@jessicalv6442]

AMAZING!!!!! Thanks!!!

[@doctorumar1700]

excellent PLEASE KEEP THIS CONTINUE

[@johnman1626]

Really really osum explanation great work

[@herrmanselcher1632]

Beautiful, thank you

[@simonlo2532]

Great video!!!!

[@Theabok853]

Excellent video and explanation

[@jacktietjen]

Fantastic!!!

[@sayanghosh123]

Great explanation, Thank Youuu

[@felixbaez9439]

Excelent video!

[@anirbanbhowmik1416]

Thank you very much for this video! I might have never figured out what these dihedral angles phi and psi actually mean from those textbook descriptions. You know, they should really suggest something like a student should refer to a good KZbin video for a better understanding, sometimes. And, I don't think not many people understand this concept clearly (even those who've been teaching this). Thank you very much! ❤️✨

[@franklinpulikkottil7826]

Amazing! Concise and understandable ☺️ Thanks a lot. And for the proteiopedia link

[@syedjamal3262]

Great job

[@VenusAndMoon]

this video saved my life, thxxxx ❤❤❤❤❤

[@Thinker-gd8ck]

Thanks for sharing!

[@jamesbean9396]

So damn clear! appreciate

[@marioncaramel2415]

THANK YOU SO MUCH !

[@jkg6491]

From a native speaker, his name is pronounced " Rama-Chunn-Drun/Dran". Also thank you, great video yet again

[@Hyumifu]

thank you so much!!!!!

[@thex5772]

Thank you soooo much. I subbed

[@tanushri4236]

Wowww 😍

[@mahvishathar6483]

Thank you .

[@infinightsky53]

Thank you so much

[@divyarana3637]

lovely

[@rimplekour3882]

Well done

[@asiakhatoon954]

Thank you

[@shujahat_8c]

Why do we study this

[@tandelchandni1273]

yeah thank you

[@kgranalysis1052]

Good video and

[@HydroZxZInferno]

I wonder if you would be interested in speaking at an event my university is going to hold in connection with the UK Biochemical Society for the students. I have always found your pymol videos to be extremely well explained and clear! please reply if this is something you'd be interested in. Best, Will

[@aswinikumar8503]

❤️

[@hansenyang4014]

Hello I am learning this outside of the textbook for research. Can I ask why the substituents on the nitrogen are 180 degrees to each other? Shouldn't the nitrogen atom also have a lone pair so the substituents have to be 120 degrees or less apart? If this is a convention in some textbooks can someone explain the logic? Thanks very much. Edit: I think I just figured it out. Since the nitrogen is in resonance with the carbonyl, it does not have a lone pair and the N atom is essentially planar with only two substituents. It looks very cursed to have two groups 180 to each other in a Newman projection.

[@siddheshshewade7063]

we are saying that at particular values of phi and psi we have to look down in ramchandran plot and we will get an idea of its secondary structure but the plot u displayed is for alanine so if there is a peptide solely made up of alanine only then it can be true but if we are having variety of other amino acids in our peptide then how can we surely say that at those values corresponding will be the secondary structure. I mean the plot would have to change in that case

[@mimosveta]

we people are collectively insane...

[@meghashreeguha99]

03:15

[@namy7506]

It's Raaaaama-'cha'-ndran, cha as in cherish. Not Sharon. Raamachandran Great video tho❤

[@rabrojonel]

I truly did not understand phi/psi angles and Ramachandran plots until watching this video. It was really helpful, thanks!

[@mimosveta]

I don't think those who wrote my book understood them either. like, at no point did they clarify that 6 atoms were co-planar, which to me seems kinda crucial...

[@soumyaartz8912]

Thank you