Monoclonal B-cell lymphocytosis is on the road to CLL: always?

Lydia Scarfò, MD, Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Milan, Italy, discusses the identification of monoclonal B-cell lymphocytosis. Monoclonal B-cell lymphocytosis has the presence of chronic lymphocytic leukemia (CLL) like cells, however, they are below the threshold to fulfill the criteria for diagnosis. In a study observing the concentration of monoclonal B-cells in healthy individuals, they were present in 12% of the general population. However, it is unknown what the risk is of development to CLL. Out of those who seek medical attention due to lymphocytosis, 1-2% develop CLL. Therefore, patients with a high monoclonal B-cell count should be monitored over time. This interview took place during the European Research Initiative on CLL (ERIC) International Virtual Meeting 2020.