MPN Progression: What We Know and What We Hope to Learn

[@steve3944]

I very much appreciate the discussion and information. Living with an MPN, you address many of the issues/concerns/questions we all think (and feel) on a daily basis.

[@MsSpriggle]

Thank you very much for such an informative discussion! I am a PMF patient that enjoys watching any and all information that helps to educate me on this MPN cancer. I appreciate all that this foundation does to advocate for more data on behalf of patients.

[@gjjakobsen]

CXCL4, anti-SLAMF7-abs, alarmins, PI3k, etc. It's hard to keep up with all the advances, not only with the agents currently in phase 3 trials, but all the novel targets. It really fills me with hope to see so much work being done. Hopefully we'll see meaningful, enduring molecular responses and reduced VAFs in the years ahead. Until then, we pray for stability until a cure comes. Thank you for your efforts on our behalf.

[@henriettbodnar9468]

I really appreciate for this informative discussion! My question is having Calr+ type 1 (deletion) Pre MF was dx 8 years ago watch&wait and i have noticed that my Ldh number is getting higher, is that progression? My Plt number however is declining...is that time to start Pegasys?

[@sirwayne8498]

IF you want a broad patient input from patients, it seems like a standardized non onerus check sheet (for the doctors) which shows how a patient has changed over time would work.

[@jabu003]

Which are the interactions between Acalabrutinib and Ruxolitinib .....any experience on this ? I have both CLL & MF ( CALR type II) and might be put on Ruxo

[@karanmaheshwari260]

My father is also suffering from MPN, i want some help and guidance 🙏