Multiple Myeloma - Malignancy of Plasma Cells - Bone marrow - Hematology & Oncology

Multiple Myeloma - Malignancy of Plasma Cells - Bone marrow - Hematology & Oncology
😍🖼Animated Mnemonics (Picmonic): www.picmonic.com/viphookup/me...
- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
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►👨‍🏫💊Antibiotics Lectures: www.medicosisperfectionalis.c... ... Check out my brand new "Electrolytes" course at www.medicosisperfectionalis.c... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Multiple myeloma is a plasma cell dyscrasia.
Multiple myeloma (MM) is characterized by the overproduction of plasma cells.
Bone marrow fibroblasts, as well as myeloma cells, produce interleukin-6 (IL-6) which stimulates osteoclasts to break down bones, that's why bone pain is the most common symptom in multiple myeloma.
Since osteoblasts were not stimulated:-
1) Nuclear bone scans are useless to diagnose multiple myeloma.
2) Alkaline phosphatase (ALP) will NOT be elevated.
The anemia in multiple myeloma is normocytic normochromic (normal mean corpuscular volume "MCV").
Neurological symptoms include neuropathy​ as well as radiculopathy.
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Disclaimer 1: The medical information contained herein is intended for educational purposes only, and are not intended for diagnosis of any illness. If you think you may be suffering from any medical condition, you should consult your physician or seek immediate medical attention.
I am NOT a licensed physician…Talk to your doctor.
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As always…Be safe, Stay happy and Study hard!
MEDICOSIS PERFECTIONALIS
In brief, multiple myeloma is a plasma cell dyscrasia characterized by overproduction of plasma cells. If you like my videos, please consider leaving a tip at www.paypal.me/perfectionalis/
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@@MedicosisPerfectionalis can u do a video if someone's cbc w diff and CMP is all normal. ... yet their NRBC is 1 ... normal is 0 so its considered HIGH. your thoughts...? Thanks

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[@hyori106]

1. Bone pain 2. Bacterial infection 3. Uti and pneumonia 4. Staph, strep, ecoli, klebsiella 5. Ecoli staph? 6. Normal 7. High anion gap? Thank you so much!!!

[@Leoantonio13]

I guess normal AG, because it causes RTA (a normal serum AG acidosis).

[@aymenkamal9488]

Anion Gap is decreased.

[@MedicosisPerfectionalis]

Anion gap is usually low in multiple myeloma

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Thank you for placing this in order.

[@lafurselfsik]

"In addition to displacement of sodium-containing water from serum by large amounts of non-sodium-containing paraproteins, some paraproteins (eg, IgG in multiple myeloma) can have a net positive charge at physiological pH. This leads to an increase in unmeasured cations and a low anion gap"

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the most powerful lecture about multiple myeloma on youtube platform

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Coming soon...Thank you!

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[@MedicosisPerfectionalis]

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[@user-qb2be6ug5g]

i want to thank you for making this video. i had a project on multiple myeloma and i kept reading and reading facts about it from multiple and different resources and i was a bit confused with how the one info connects with the other, but your video helped me understand the whole thing! again thank you so much! bless your soul

[@MedicosisPerfectionalis]

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[@riyasingh8862]

1. Due to hypercalcemia fatigue,weakness including bone pain 2. Infection mostly bacterial 3. Pneumonia ,uti, pharyngities etc 4. Ecoli,staph,step,kleb 5. Ecoli 6. Normal bec no osteoblast activation 7. Due to acidosis anion gap is low

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I was admitted 4 days ago to the hospital. Diagnosis Multiple Myeloms. Tuesday my bone marrow biopsy test will provide more information. I watched the entire video, will watch every video in your library related. Im am so grateful for your documentation.

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

My pleasure 😇 Thanks for your kind words! Please help me by sharing my videos with others!

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[@MedicosisPerfectionalis]

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My pleasure 😇...I am glad you liked my videos!

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The answers are posted in the next video in the series.

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[@MedicosisPerfectionalis]

My pleasure 😇....Welcome to Medicosis.

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My videos are on KZbin, but the illustrations that are used for them are available on www.patreon.com/medicosis/ organized in pdf forms...I would be happy to give them to you 😊...Thanks!

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Thanks 😊

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I'm glad I found your channel. Thank you for your videos. Can you make a video about myoma? Thank you in advance

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Thank you so much!

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Thank you 🙏

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Thank you 🙏

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Great video as always, my boy never disappoints. I have a question though you said we get proteinaceous tubular casts which may consist of albumin in the cast in urine but then in the bullet point u said glomerular function is nearly normal thus no albuminuria. care to explain?

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@medicosis perfectionalis Great lecture!! but isnt viruses reactivation are related to B-cell and antibody immunity? @7:17

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Thank you very much

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Thank u so much.

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

Thank you 😊

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Thank you for putting up such a good lecture videos. Your videos are really informative, where do you gather your resources from? Whats your references? Is it Harrison and Wintrobe or something else. If you could share your references would be really grateful.

[@MedicosisPerfectionalis]

Thank you so much 😊 I use Harrison’s, Davidson’s, Goldman-Cecil, Goljan and Medstudy.

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My pleasure 😇

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24:22 why are you calling me out like that XD. awesome vids btw.

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hi, can you elaborate more why ALP is unaffected in MM?

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Thanx from earth to the moon 😁

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The distance is variable, but I get the idea 😉

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