Myology - Skeletal Muscle (Sarcomere, Myosin and Actin)

[@armandohasudungan]

📌MAKE THIS LECTURE STICK: FREE PRACTICE QUESTIONS HERE! 🎓 youmakr.ai/test-playground/questionnaire/673d5236859b9c170836f28b

[@amphylayola9869]

I was here 4 years ago when I started vet school, here I am now watching this again as I prepare of my licensure exam.

[@Therian183]

same, for RPN and now for RN

[@muhammadali.2755]

It must feel nostalgic

[@Someonebutnoone10]

Here for DPT. Figure I’ll be back for the licensure exam as well

[@brandonbardin5810]

Here now studying for a physiology exam while also working on VMCAS :')

[@ranyha6956]

Good luck!

[@ZaraKaku01]

You are the reason m getting good grade in biology, m a veterinary doctor and currently pursuing master degree, i have read many notes from different sources but the most simplified form of understanding came from ur lecture sir. Thank you

[@courtneycook1977]

The calcium that binds to Troponin-C comes from the Ryanadine receptor (Ca Release Channel) which is located on the Sarcoplasmic Reticulum (Ca is stored in the Terminal Cisternae of the SR).

[@teresaswift7419]

I think you might have the role of ATP slightly wrong, ATP is required to release the myosin-actin cross bridge. Like rigor mortis - upon death Ca2+ flows into cells which allows the myosin-actin binding, however since there's no ATP muscles remain tense. Other than that though it was a good video.

[@sarahmueller335]

Nope, you are confusing two total different situations: rigor mortise and voluntary muscle contractions.

[@liademchenko6767]

She's actually correct, check any physiology textbook. In a muscle contraction it is a very very brief stage of the tight attachment, then ATP binds and myosin is able to release the actin. In rigor mortis, as there is no ATP, it remains attached, hence the rigor. @@sarahmueller335

[@比特币摆渡人]

@@sarahmueller335 She is correct, ATP is used to release myosin head from actin, not to bind

[@juliakercsmar6587]

you became a part of the curriculum! :D my Anatomy teacher makes us take notes of two of your videos. :D

[@bobbojibbs]

Great job explaining. Best one I've seen yet. Keep it up man you're gonna help a lot of people get A's on those Anat/Phys tests. Especially the muscular unit exam I have tomorrow morning...

[@imrnp]

what grade did u get

[@muslimsister924]

You have just saved me from days of avoiding revising this because the text books are so confusing. Thank you so much!!!!!!!!! You're so brilliant at explaining with your talent!!!!

[@Slimshady50182]

Can't thank you enough for speeding up the drawing! Helps me make connections without losing my train of thought from watching someone draw a picture for 30 seconds at a time

[@haleyellis1093]

I Just want to let you know your Video has basically saved me on my anatomy final! thank you so much for putting this in "Layman's Terms" this is so wonderful and I'm so incredibly thankful!!!!!

[@Cristine401]

My teacher introduced me to your videos and I love them. Thank you so much for helping me understand anatomy better.

[@YasOOsha]

Cristine401 this is not anatomy lol

[@patrickmata27]

I know these videos are a little older, but they have been a great help to understand my A&P class better. Thank you

[@KJKP]

Great video, Armando. And I'm not being sacrastic.

[@eldrienadsilva3385]

KnowJesusKnowPeace Good one.

[@aaronrodriguez110]

So looking forward to the "Sliding Filament Theory"!! Bless you,@armandohasudungan- you're an amazing human being both for your artistic style and your simplified prose. look forward to the SFT

[@abdelrahmanomara4984]

where is the link for sliding filament theory ??

[@imsunny3416]

This is the sliding filament theory

[@biglosergiraffe]

Want to thank you very much for your time and effort into not only editing and making this video, but drawing everything out and explaining it. Really do appreciate it. Personally. Thank you.

[@pricilliacaldwell525]

Shoutout to your actin and myosin drawing for these amazing videos

[@katwill9276]

sARCOmere... its killing me Best videos though, thank you!

[@martingaens2073]

why? i don't get it

[@martingaens2073]

oh, i see, he says the whole time sacromere...

[@tahiyyakhan3189]

Thanks for wonder video. A sarcomere (Greek σάρξ sarx "flesh", μέρος meros "part") is the smallest functional unit of striated muscle tissue.

[@Xycopixie]

This is soooo helpful! My professor gave the same lecture today but you are far more clear and concise.

[@shuante05]

Helps a lot to actually watch it being explained than just reading it from the textbook. Thanks

[@booya4ah]

I am mindblown over how good this actually was! U my man, are THA bomb!

[@Corntraitor]

Wow, bravo on your skeletal muscle contraction video! We totally needed to hear about calcium binding to troponin about 47 times - because, you know, once just wouldn’t cut it for our poor, struggling brains. Your relentless repetition really hammered home the point that troponin moves tropomyosin, as if we were auditioning for a role in "Dumb and Dumber: Anatomy Edition." Maybe next time, try explaining it in Morse code or interpretive dance, just to keep it fresh. Thanks for the overkill - you truly have a gift for turning a simple concept into a marathon of monotony.

[@hunger4jsutice]

Great videos and combination of fantastic artwork and clear explanations. I will be using these throughout nursing school. Thank you so much for making these.

[@rickeymohammed9123]

Amazing the creativity of drawing and explaining makes your work so much easier to understand. Honestly i learn more on this channel than i do in school.......and im a medical student. So thank you. P.S new subscriber :)

[@yusrahassan2363]

thank you so much. you have no idea how clear this topic is now

[@benparker5775]

bro you are a genius! they say if you cant explain something simply then you dont understand it enough! this goes for 90% of people teaching physiology and 90% of the you tube videos! all your videos so far have been incredible best source i have seen yet!!!! please make more of these brillant clips as i (and many others) are keen to learn! (ps can u do the sliding filament theory one b4 next thursday as i have an exam lol cheers!)

[@haider8590]

I was here 6 years ago when I started Dental School and am again preparing for my licensure.

[@danis3160]

Wow! This video is great! What I didn't learn in an hour in class I learned in a 6:15min video. Thanks!

[@BlinkJoe182]

I have an anatomy exam in two days. thank you for saving my life with these videos!

[@jijoegal8058]

This video is soo amazing!What took me months to understand was summarized in 6 minutes! Thank you soo much :)

[@jaidenreddy7473]

you are amazing at this way better than any of the famous stuff even better than khan academy! You should start your own thing like that

[@rachitap1401]

He is a doctor

[@katiekusterministries]

it is explained very well!!!

[@Islammagomedov]

Armando, thank you for these videos! It's interesting so much to see it! You are very talanted!

[@msurya1004]

this is the most amazing way u in which can serve youngsters do better and learn better .. ! i m in love with the way u work ! thanku so much sir :)

[@MK-jh7mv]

THANK YOU SO MUCH !! this made skeletal muscle physiology much easier for me .

[@sofiamehr9768]

Just wanted to thank you. You were my time saver during my DAT studying period. Thanks! :)

[@Bahar1370]

how did your DAT go? i have my MCAT in 4 days :(

[@sofiamehr9768]

I haven't done it yet! Its near!!! :(

[@Bahar1370]

.

[@Shaggyslounge]

Omg please tell me you have a video about how the smooth muscle works, not just the introduction to it! Eeek! You are AMAZING by the way and once I found your videos I shared them with my entire phys and anatomy class :)

[@hiwarduski7959]

I have never seen any one to explain in this amazing way and unforgettable. ..well done wish you success

[@NIDHIMUDIT]

excellent explanation and awesome diagrams!

[@meera-m7734]

Omggg thank uuu so muchh for thiss,my teacher literally explained this in 2 hours

[@karnapriya4568]

just a small correction idk if i am correct or not but the ATP at the end (5:13) should be ADP plus a seperated phosphate group because the muscles need ADP for the power stroke and for contracting the muscle but need ATP to relax the muscle and disassociate myosin from actin.

[@Dbestskills]

+Karna priya yes you're right. BTW ATP is not needed for muscle contraction, Ca is and in smooth muscle the addition of phosphate. ATP only causes the myosin to unbind from the actin aka relaxation. This is what causes rigor mortis, the lack of ATP.

[@Dbestskills]

+Ishwar Raghu Thanks for the troll, btw I agreed with him and gave the clarification in case anyone needed it; however maybe you've been using google translate because you did exactly what I did. Without ATP the muscle will stay contracted until the muscle fibers deteriorate. Thanks for adding nothing to this conversation

[@Dbestskills]

+Ishwar Raghu I said ATP only cause myosin to unbind from the actin aka relaxation. This is what cuases rigo mortis, the lack of ATP...therefore the muscle is always tight because it cannot relax no ATP. Whatever I don't care any more. As for your question, myosin after it is relaxed hydrolyzes the ATP and returns to its cocked or excited state. That means that once Ca binds to tropinin C to move tropomycin out the way mysin can bind to actin and pull. Think of it like cocking your arm back before you through a ball. Myosin bound to ADP and Pi is waiting to bind and have that power stroke or throw the ball. I hope that makes sense

[@biologyworkout693]

thanx

[@becky4957]

Amazing. Beautiful illustrations make the concepts very clear.

[@emilyspooner801]

Thank goodness for Armando. !!!

[@evileye1]

Sliding filament theory was basically explained. Calcium comes from an action potential ie. nerve conduction on to muscle. Hope that helps x

[@IvyRoseLuna]

This makes so much sense, I am so happy I found these video’s before my exam!

[@kanikagoyal4422]

same here siso

[@kevinc5086]

Your videos on skeletal muscle contraction are very well done. Thanks for helping me study!

[@elsalarissa7563]

if I may add, actin is a dimer. We called it "fake helix". It's not a monomer that combine together to become a double helix. It's different. You can do more research for your video about "actin formation". And you'll find out.

[@cherian9679]

Thank you so so so much for your time and contribution for doing this excellent video for us!

[@jamesduffin3990]

Thank you! You've made that sooo much easier than reading a text book!

[@UltraPvnk]

Thank you for existing man!

[@akhilaa2134]

nice u cleared all my confusions abt this theory .ur diagrams are so neat and clear

[@ashtonbrown119]

you are wonderful, I'm so glad I came across your videos. A&P is kicking my butt!

[@alicee171]

wow, i have never heard a better explanation of this process. thank you!

[@alanmckenzie3228]

Thank you very much. Universities should give you an Honorary Doctorates Degree for your work!

[@zannatul23]

thank you, one of the best video on the net

[@gustavoadolfocardozo96]

dude this is very helpful! I've seen this video 3 times. Thanks a lot

[@廖-h6b]

Your videos are the best for understanding the details. Thank you

[@Crazyfor2PM]

I LOVE U MAN SRSLY!!! 2 HOURS OF LECTURE EXPLAINED IN 6 MINUTES!!

[@jjarrell1010]

Brilliant videos! You make the tough stuff much easier to tolerate.

[@barkatullah4590]

Wonderful method and diagram I never saw a method like this Keep it up sir 💕💕💕💕💕

[@armandohasudungan]

Sorry bro, havent made one yet, hopefully soon

[@karthickshanmugam5841]

I love it .. please upload cardiac muscle and smooth muscle full description

[@IkechukwuIheanacho143]

Excellent video and straight to the point

[@akudoemmanuel6950]

Big bros

[@mahmoudobeidat4741]

thanks, you always make things so easy to understand

[@manahilsarfraz3496]

Sir your way of explaining with diagrams is amazing 👍please Keep it up

[@ΑλεξάνδραΠιπέρου]

Congratulations!!!Your amazing explanation helped me a lot .

[@ptkid8]

you are the greatest man ..much love

[@FCA440]

this is outstanding explanation of SLIDING FILAMENT THEORY..Amazing..

[@SushiBabieL4D]

You're so awesome!! thanks for sharing! It was a great idea to draw it out and explain it. I was able to understand it.

[@andreavargas7474]

Very helpful. Thank you! Studying for my PT Recert and NASM doesn't quite go into depth like this.

[@zannatul23]

honestly i have to comment again, the video is excellent thank you g

[@DamZFXBeats]

just for you guys to know, i think the atp binding site of myosin is the same as the nucleotide binding site, since my textbook calls it that!

[@uncleladdi]

ATP is a nucleotide. it;s generic name is nicleotide.

[@Holubiac]

GREAT!!!!!!! Keep doing that, because you are doing an extraordinary job!

[@adamwright7887]

such a clear and well explained video. extremely helpful.

[@CatherineAnneMoreau]

Nice video, but unfortunately the role of ATP is stated a little differently than what research is saying at the moment. ATP is needed to RELEASE the myosin from the actin and it has to be ADP+Pi to be able to extend to bind again in the next round.

[@omarikhlef9152]

So useful thanks Armando

[@Loniburger]

You are my favorite teacher!

[@bodegalal6834]

realy

[@sujanawahid4076]

May peace be upon you ❤️

[@kimkeeley6156]

Hi. Great video. I cannot find your sliding filament theory video. Can you please direct me to it? Thank you in advance.

[@yazeedal-dossare2851]

OMG !!!! ,, This is the most outstanding teaching performance that I've ever witnessed in my entire Fucking life. thank you so much and you are a true hero indeed.

[@MsCowsiecow123]

DANG IT :( Studying for my finals and your videos were helping so much and one on the sliding filament theory would have been so amazing! But thank you. You're so great at explaining.

[@RedemptiveIRage]

Truly great stuff. Keep it up, man! I'm sure you've saved many students from the arduous task of learning this from a badly worded textbook ;)

[@melvinpeters807]

Excellent video!

[@MohdGhm247]

You're amazing man thanks A LOT

[@farismoinudheen1477]

Amazing work bro ... Keep it coming ❤️

[@WhyIGorroBeAnonymous]

Your drawings are so good!

[@erinstephens5135]

You're amazing! I love your lectures. thank you!!!

[@GUIDE_Nico]

dude, Youd made an excellent video about the parts of a muscle and the contraction of the muscle. Bro, would you make a video about the sliding filament theory soon?

[@kaitlynnn2]

SO helpful. Thank you!!

[@HighHell99]

Extremely helpful. Well done! 👍

[@shakiba7860]

Amazing videos! Thanks for making it so much easier

[@medunimontes6813]

u r an artist

[@bishoysid9495]

Informative and clear explanations !

[@muhammadazlaan481]

you are amazing ....cleared everypoint in few minutes...great!!!!

[@futoonbinsaleh2220]

your videos are helping me a lot!!! thank you thank you thank you !!

[@ojashvi6226]

Oh my god !! Your drawing skills are dope Thankyou sir☺

[@chetorasti209]

Awesome video, thanks!!

[@dr.aneesahfarrisdc-chiropr2368]

Amazing your helping me through chiropractic boards !!!! THANK YOU

[@pranayuttam9043]

This is great! Thank you so much

[@Lakshmi235Lakshmi]

Thank you so much 🙏🙏🙏