NAC (& Glutathione) Crucial New Research

[@DrBradStanfield]

Update: I plan on taking NAC from age 45, not serine 💊 MicroVitamin (multivitamin & mineral that I take): drstanfield.com/products/microvitamin 📜 Roadmap - how to look young & feel strong: drstanfield.com/pages/roadmap • Join Patreon For Early Video Access & Discord Chat: www.patreon.com/bradstanfieldmd

[@nomebear]

Eighteen months ago, suffering from brain fog, muscle pain, dodgy eye sight, and other physical symptoms from long haul COVID-19, I started taking NAC, Quercetin, Zinc that helped bring relief from many of the symptoms. I'm 72. Yesterday, I hiked 14 miles, not bad for someone who was making his funeral arrangements a year ago.

[@arckanum332]

That's fantastic! glad to hear you have recovered and feeling good!

[@vickydittfield9822]

Hopeful News- and just at the right time 4 Me ❣️🎉💝👍👏

[@lelawilkerson4299]

Congrats!!! May i ask what brand or where you got the Quercetin? Thanks!🙏

[@HillHyker]

Scientifically we still can't know if NAC Or Quercetin and Zinc or Exercise caused the funeral to be cancelled. I won't take any chances, I'll take my health remedies, my exercise, diet good sleep my relaxation program. Just to be on the safe side. And for extra caution, I'll keep clear of all new gene therapies. I would like every chance to die healthy.

[@schesche69]

Read my answer above! Add this and never get post viral conditions again!!

[@tom79013]

Taking NAC about two weeks now. Huge improvement in my breathing and lung capacity

[@amieljaven6794]

What brand are you taking? And where do you buy it from?

[@crusader1563]

Life extension eBay 🥺

[@HealthyLife4Me]

I use Orthomolecular

[@DrBradStanfield]

Glad you've noticed such a positive difference

[@karimghrab6634]

could you please tell us about the dosage and age if you don't mind

[@865style]

I disagree with the part of what you said about our brain not needing more glutathione. In this study they checked old people and young people to see a difference in levels. But glutathione is very important to brain health because the brain consumes 20% of our total oxygen so it's loaded with oxidative stress markers. Meaning it demands more antioxidants to offset these free radicals. My point is that why test different ages for glutathione in regards to aging. In my opinion they should of tested young and older people with a current or history of past mental illness issues. Such as depression, anxiety, ptsd, seizures, Parkinson's, alzheimers etc. I just think that they were testing the wrong subjects for the wrong reasons. They should of tested people with mental health issues because of how toxic free radicals can be in a environment filled with them which will demand a lot of antioxidants, especially glutathione.

[@Aryankingz]

good point

[@Coco762011]

NAC helps improve the Heath of people suffering from dementia and Parkinson’s disease.

[@865style]

@@Coco762011 yes along with other diseases involving the brain. Which is why I said a study that test young people and old people that have not suffered or dont currently suffer from mental illness issues is downright dumb. Again the brain uses up 20% of the body's oxygen. The brain absolutely needs antioxidants the most because it is packed with free radicals as a result of the oxygen demands. Of course glutathione levels wont drop in the young or the elderly without mental issues because the brain is probably the last place that can afford a excess amounts of free radicals. I just believe how he said that oh glutathione is not needed in the brain because it doesn't get depleted or something to that extent is a poor use of words. Well of course it wont be depleted because they aren't suffering from mental illness issues. Their is a reason that a lot of antioxidants cross the blood brain barrier.

[@865style]

Alpha lipoic acid, vitamin e, polyphenols, vitamin c, Astaxanthin all cross the blood brain barrier along with other antioxidants. The blood brain barrier is very selective as to what it allows in. Only what is needed gets allowed in.

[@thor4164]

Studies aren't worth the paper they're written on

[@scorpioman1964]

I used ALA, Q10(ubiquinol) and NAC for half a year. I didn't notice any relief with my neuropathy. Started 2 months ago with only broccoli sprouts regime daily, a week ago I noticed 50% less numbness, uncomfortable feeling etc in my hands and feet. Hopefully it will turn out even better. I also heat the broccoli sprouts for 10 minutes in 70C water, that will increase the sulforaphane in the sprouts about 2/3 times as much Thanks Brad for your info. No doctor has ever helped me that much. Also nice to look at too 😍😍😍

[@Antiguanian]

I was taki g 600mg of NAC for asthma for 12 years. Woeked ok. As good as inhaler. But i looked it up a few months ago and saw it worked for CV19 symptoms and for anxiety and deptession and Alzheiners. So i upped mty daily divided dose to 2400. In 3 days i gave up naps. And i started to garden again. And began other projects. My facial wribles half disappeared! Im 67 and drive a motorcycle in Antigua Guatemala. I feel 50!

[@browneyedgirlFL67]

How did you know to increase your daily dose? Are you still taking the same amount?

[@YourGypsyJoker]

What are wrinkles? Did u mean wrinkles?

[@hwaynes]

@Taiwo Omotosho He doesn't take naps during the day anymore...

[@farhanbaig678]

I wonder if I can take 2 in the morning 1.2g and 2 in the night 1.2g as someone who loves working out but feeling way tired now.

[@cinystarr4657]

I'm new to this chan but what I appreciate about your information is that you don't seem to represent big pharma and have helped me keep from wasting my money on useless Supplement purchase or using it wrongly. Thank you

[@DrBradStanfield]

Thanks for the support

[@jamesthomas1628]

Now I understand why the FDA recently decided to regulate NAC, they saw the study inferring 1.5 grams of NAC twice a day is good to go and said WOOHA and NAC became a regulated drug.

[@bridgepoc]

It was to push people away from alternative treatments to Covid vaccination.

[@joycewright5386]

But I still buy it online from a company called Wellevate.

[@privatecitizenguy2640]

If your government wanted to kill you, they’d poison your beer.

[@razzledazdazzle]

@@kingston163 yep, and that way they can make money at the same time, ain’t any money in poisoning your beer

[@hollyphelps5755]

You can still find it online and at most health food stores

[@robertalberts2636]

I (55 years) have already been taking glynac for 3 months now. 600 mg nac and 3 grams glycine before bed. It really makes me feel better (relaxed and more energy). Additional benefit is that glycine also promotes better sleep. So if you’re lacking energy and/or have sleeping troubles try it. Best to add vitamin c and magnesium as it is also used in the same biochemistry pathway. I can really confirm the findings that this helps a lot. Glycine and nac are cheap and it is well worth a try.

[@cinystarr4657]

What brands do you use?

[@robertalberts2636]

@@cinystarr4657 NAC from Pro Natural. Glycine bulk 1.1 kg bag from vit4ever. Both ordered from Amazon. NAC is still available on Amazon outside USA.

[@cinystarr4657]

@@robertalberts2636 Oh ok, ya I'm in USA so I can't get that :( I'll still look it up and see about adding that glycine in my order today or tomorrow. Thanks so much!

[@robertalberts2636]

@@cinystarr4657 Maybe you can get from Ali express still. They sell it too. Don't know if it will pass customs at your end though....

[@carebear8146]

Just remember glycine can lower cortisol, which is good for some people and not for others. My cortisol runs low so I avoid glycine:)

[@stepananokhin693]

Quality and value of your videos increased dramatically during the last year! Thanks a lot for your work!

[@crusader1563]

I take 1.2 grams per day and I been smoking forever. I noticed and incredible increase in breathing and much deeper sleep. I am 61 years old 😁. Your channel is excellent thank you. ☕

[@darcy5823]

I've been a supplement and bio-hacking junkie before it was called that, since my 20s in the 1990s. My supplement budget keeps growing the more videos of yours that I watch!

[@willnitschke]

Well at least you haven't poisoned yourself yet...

[@FayCreative]

Ha me too!! Before there was any internet, I had books on supplements and loved trying different free form amino acids!! I love supplements! Lol

[@ThiagoDVaz]

Got to love Medical Medium tips, denatured organic whey Peptides helps to boost the conversion process of your own glutathione

[@leelunk8235]

DARCY+ HEARD OF CARDAMOM?

[@TheRimtautas]

As we age, glycin levels decline more than twice. It is estimated, that we need around 10g of glycin per day, 1 g comes from diet, 1 g is produced by body, and we miss a lot- 8 grams. I'm a bit skeptic about using serine as glycine precuror, since if we need 8 g, 1.5g of serine is nowhere close to required amount. I take NAC + 10g glycine, glycine is safe up to 50g and is proved by ITP to extend longevity. Serine effects are less known. As bonus, glycine helps to clear out from body methionine- most anti longevity amino acid. Great video, thanks.

[@mxm9167]

Wow interesting!! Thanks, I use glycine to sweeten my drinks, two benefits in one!

[@tayfunkorkut1757]

I agree ıt is also one of the factors of the aging along side Elovl2 gene-Ascorbic Acid 2 phopshate.... Glutahitone is health-anti cancer ındıcator ıt is the speed of the aging telomarese the other side you have elov2 and c1orf132 genes when you have micronutttirnts healty lifepan walking sleeping drink water natural outdoor activities you have more borader picture....

[@AcesGaruda]

10 grams of glycine per day is expensive

[@jameslester6785]

I have been taking glycine for several years to counteract the methionine which comes from my red meat heavy diet.

[@MsJayski]

Nice! What brands and what dosage of NAC please?

[@TheronGBurrough]

I plan to take the NAC when I can afford it again, and try to learn more from fellows like you. (Thanks!) What I really found important in this video was that you view liposomal glutathione as dangerous or potentially so. It wasn't on my shopping list but if I'd come across it, I wouldn't know of your concerns had you not published them.

[@Joe_Blo]

It's only $5 per 30 day supply.

[@devonr7497]

I was about to say, you cant afford $4 USD/month?

[@TheronGBurrough]

@@devonr7497 Good point. However, NAC is one of many things I wanted at the time. So the total cost of shopping was the obstacle.

[@drydz8670]

Glutathione is popular in Southeast Asia, even for the younger people. It is not used for anti aging, it is used for its side effect-for skin lightening. As is the high demand for whitening creams and related products, it makes sense that glutathione supplements will also follow the same trend.

[@SawmillerSmith]

I have lots of supplements and NAC is one of them. I'm 73 and I think I'm healthy for my age since I have nothing to complain about.

[@MrBeckala]

So am I

[@ConflictedYouth]

Which brand ?

[@SawmillerSmith]

@@ConflictedYouth NOW brand but I see the FDA has banned it. I can't get it from Amazon anymore.

[@JonasAnandaKristiansson]

@@SawmillerSmith Yeah corrupted motherfuckers ruled by psychopaths.

[@lelawilkerson4299]

@@JonasAnandaKristiansson TRUTH!!!🤜🤜

[@elitefitness341]

What a great video about NAC! I agree that about 3 grams a day is right. Here is what I have found. I have done a little experiment for myself. On nights I drank, I tried no NAC, 600mg. of NAc, 1,200 mg (1.2g) of NAC, 2,000 mg. (2g) of NAC, and 3 grams of NAC. At 0-600mg. I felt no effect the next day. At 1,200 I felt some effect the next day, at both 2 and 3 grams of NAC, I felt as if I had zero drinks the night before. Therefore, I use 2-3 grams of NAC daily now. It is important to note, as you stated, the absorption through oral means, or bioavailability isn't great. NAC should, like other amino acids, be consumed on an empty stomach to help aid in absorption.

[@jameskringlee8974]

with time and true understanding - proper diet will be the major part of meaningful life extension

[@SuperJaimeMendoza]

Dr. Brad did not say how high levels of glutathione are toxic to the body. He says that high levels of glutathione are dangerous. How? Where's the data about it?

[@eaappell]

I agree, I'd like to see research that shows liposomal glutathione is dangerous. Also, I just found research that shows brain glutathione drops in old age, opposite of the research Dr. Brad provided. I would like to understand which is actually a better path (and most affordable), liposomal glutathione or glutathione precursors (eg. Glycine/serine + NAC).

[@emulan5887]

He replied to another comment and he said he has no data to back up that claim. From my own research, pretty much every study said it’s fine as long as you are not on chemo, or have kidney issue. Apparently it can help cancer cells replicate themselves and mess with your kidneys if you take an extremely high dose but it seems to be in rare cases, some people are taking extremely high doses for skin lightening in the Philippines but this is around 3000-5000mg, so taking the normal dose of 500mg seems to be safe to take. In all honesty oral medication is only absorbed by 60-70% anyway so you will be fine.

[@joesophie90]

I have read that NAC, which is an amino acid, may also be helpful for: *healing the neurotoxic damage associated with cocaine and amphetamine use, as well as improving several mental disorders* It is recommended that it's taken on an empty stomach or at least 2 hours after food. From what I have read, NAC doesn't absorb well, so the ideal time to take it is on rising in a morning, at least 30 mins before eating. It can also disturb sleep, so taking it prior to bed is not recommended, according to what I have read.

[@jacks4705]

mdma included (an amphetamine)👍🏻

[@adilchaudhry3272]

But you need food to better absorb medicines, vitamins etc absorption otherwise you urinate most of it out? Isn't it recommend to take NAC with a protein meal?

[@itsagoodday2165]

I read the opposite. NAC should be taken at night.

[@Fil0u07]

Don't misinform yourself. Check your doctor and he says after a meal and not at night before sleep

[@itsagoodday2165]

@@adilchaudhry3272 Not all medicine work well with food, certain work better on an empty stomach.

[@Hapkat800]

Dr Stanfield, I’ve been taking NAC for about a year & I believe it gives me a different body odor . It’s not terrible & it wont stop me from taking it. Has anyone else noticed this? I’m 77 and taking 600 mg a day.

[@Joe_Blo]

Do you smell like a dog?

[@leelunk8235]

KATH+ TAKE A SHOWER, IT WOULD HELP

[@niellalien]

Some people say it gives them BO and bad breath. Are you still experiencing this? What is your BO like?

[@laurieparis2203]

Thx for your research, appreciated as always! Sad to learn NAC is being removed from the marketplace, especially at a time when it is so needed.

[@fu2174]

In France?

[@laurieparis2203]

@@fu2174 No, here in the States. FDA decided that since it's been used as a drug in hospitals since I think the sixties? and has proven effect (helps detoxify Tylenol overdose,is used as a mucolytic), it can no longer be classified or sold as a supplement.

[@doniphan72ify]

@@laurieparis2203 ... Yes it can. Amazon stopped selling it, but there are hundreds of websites that still sell it. The FDA did not label it as a medicine. That's just propaganda. As a matter of fact, I just bought some the other day. If you want to know the company I bought it from, just ask me. Lol, I don't work for the company or get any compensation from them, but I like their product. There are plenty of other companies to get it from tho.

[@laurieparis2203]

@@doniphan72ify Thx! I already have some. I use it whenever I have nasal congestion. But I appreciate your help!

[@doniphan72ify]

@@laurieparis2203 ... Hey no problem. Glad I could help. Do you mind if I ask you how much you take ? Or how often ? I take a 600 milligram product. I was taking it multiple times a day, but my stomach started hurting pretty bad, so I cut down to just one a day. I would like to take more if I can, as it is amazing at opening up the bronchial tubes to take nice deep breaths, and also cut down on phlegm.

[@jarichards99utube]

EXCELLENT Overview. I'm over 70 and have recently begun taking 600mg NAC ONCE a day.. Since the science on this is new, my judgement is it's Better to 'risk' Too LITTLE than TOO much.. I will look into serine supplementation.. Thanks...

[@HealthyLife4Me]

I had some respiratory issues that doctors diagnosed as exercised induced asthma. I treated myself with NAC and it cleared it up…I use NAC by Orthomolecular daily

[@amperage8032]

How much is there’s? Do they sell to the public?

[@anthonyhopper7830]

Thank you for taking the time to create these videos and post them to KZbin.

[@billb5732]

Very excellent presentation about an important (and current) topic. Let's hope that the FDA does not successfully shut down all NAC sources in the USA. (I know; not your problem, but they shut down Amazon, which is disconcerting.) ;) Side note: This struck me as your best presentation to date. No repeated filler material; just straight to the point, with relevant details clearly presented. If you have been grooming your presentation skills, it is working.

[@DrBradStanfield]

Thanks Bill :-)

[@DezentKeck]

i bought a kilo due to that...just uin case

[@ExplodingPsyche]

Do you know what their excuse is for not allowing it? I noticed I also couldn't get vinpocetine from Amazon.

[@billb5732]

​@@ExplodingPsyche Define "their". Amazon is not selling NAC because the FDA sent out warning letters to many vendors telling them not to. If you mean the FDA, they say it is not a legal supplement because it was first approved as a medicine. There are multiple groups trying to oppose the FDA's position. My personal take: NAC is a potent defense against severe Covid, which conflicts with Big Pharma's desire to sell anti-Covid meds at hugely inflated prices. Same as Ivermectin.

[@ExplodingPsyche]

@@billb5732 "Let's hope that the FDA does not successfully shut down all NAC sources in the USA." Do I really need to define "their?" thanks for your answer.

[@Mamarita3333]

Thank you Dr. Brad for all you do, for your valuable time and information which helps us so much. You are a beautiful human being. May God our Father bless you always!

[@willnitschke]

I ran this experiment with my partner for 4 weeks. 1g of NAC and 3g of Glycine. We are in our mid 50's. Nothing noticeable for the first 2 weeks, then the development of mouth blisters in both of us. (I was the worst.) My blood glucose levels also turned to shit. Went off it and a week or so later, my blood glucose levels were back to their usual level. As we're both fit and have good BMI's I think the lesson here is don't assume there is automatic benefit. Maybe for elderly people who are more metabolically damaged, but for us we went backwards. (We still take 1g of glycine daily with no ill effects.)

[@ahefner33]

Opposite happens for me. So much I have to self limit my own foundings. Not sure. Lots of things going to play. Medication, diet, supplements, body inflammation (naturally) or from extra energy expediture.

[@WideAwakeHuman]

It's like any other supplement... They're only beneficial if you happen to be deficient and not everyone is deficient. Good to point it out tho, lots of people just take everything without stopping to think if they actually have any symptoms of deficiency

[@willnitschke]

@@WideAwakeHuman Depends what the supplement is. Huge numbers of people don't get enough D. I found out the hard way I wasn't getting the A I needed. Almost nobody gets enough K2 or magnesium... Although I suspect if you include plenty of meat in your diet the benefits of amino acids are going to be marginal, so I agree with you there.

[@ahefner33]

@@willnitschke yeah magnesium was huge for me. I ate a balanced diet and doctors told me that I was getting enough magnesium but from all the workouts years prior I started developing a bunch of premature beats to a point where I could barely even do anything around the house. Had my magnesium checked the wrong way which is in the blood and it was normal but I took 300 to 400 magnesium glycinate night for a while and those skipped beats stopped according to a linq recorder. My vitamin d is also low so now I'm on that with K2. Found out it runs in our family.

[@glend5990]

Now foods makes the best NAC because of the two add things they use which are essential... However we all have different metabolisms

[@esteemedenergy]

I just bought 25 bottles of NAC before it gets banned.

[@dutchhustler187]

HAHA 👍

[@journeytoself8067]

WOW lol

[@SLUMP317]

I’m 24 years old and I been taking 600 mg of nac daily. It’s help my inflammation with my psoriasis and it reduces many of my used to be side effects. Such as fatigue and heart beat problems. My teeth are like super duper white now too it’s amazing lol

[@niellalien]

That's really cool! How and when do you take it? Do you pair it with anything? What brand?

[@b3u3g3g3y]

What about the data that NAC accelerates lung cancer in mice?

[@Hail2MasterChief]

Thanks Dr Brad! I really appreciate your fact-based approach! I have added this to my routine, but only 600 mg per day. Got to add the glycine now!

[@leelunk8235]

GLYCINE IS IN THE FOOD, YOU DON'T NEED SUPPLEMENTS FOR IT

[@Sfedtd]

@leelunk8235 like which foods?

[@reinerheiner1148]

It makes no sense to use serine to increase glycine if you can just take in glycine instead. It is cheap, virtually free from side effects, and even has a slightly sweet taste. Glycine is not only needed for glutathione synthesis but also plays a role in methionine metabolism and is hugely important in collagen synthesis amongst other things. The more methionine(basically especially any animal protein source) you take in, the more glycine you need. Virtually anything that depends on collagen synthesis is basically rate limited by glycine,which includes the skin, cartilage, and other connective tissue, and cartilage you really want to support as much as you can because of its very very slow regenerative capacity. Going the serine way you will eventually rate limited by its conversion to glycine and you will probably need more serine than if you would supplement glycine directly.

[@darrenmedmonds4603]

Silymarin has been shown to increase glutathione levels and prevent depletion.

[@ahefner33]

Love milk thistle

[@starfishw7138]

What I'm going to do is place nac & glutathione in drug bin at pharmacy, as I'm on blood thinner. Thank you for keeping us public so well informed!

[@levondarratt787]

what the heck is a drug bin! English ..dude!

[@joses5356]

I was given some Acetyl glutathione 500 mg a day for detoxing heavy metals after a test . After 30 days I took a blood test to see what was happening. My AST and ALT were a little higher than usual 34/36 but under the 46 limit. I figured it was the detoxing caused by the glutathione raising this. Im 58 years old so I plan on using it long term hoping it will keep my system functioning properly.

[@cosmichealth3907]

You can.....just add 200 mg nac ,vit c 500 , and milk thistle to gsh

[@lawrencelawkc]

I have been taking NAC and glycine for a few months now. The body feels like 10 years younger in vitality. I am in my early 50s. NAC - 600mg once a day Glycine - 1g, twice a day. NAC dosage has room to increase.

[@browneyedgirlFL67]

What difference did you notice when you started glycine?

[@lawrencelawkc]

@@browneyedgirlFL67 I cannot quantify the benefits because I took it shortly after starting NAC.

[@ktkktlzubi]

in my whey protein I use ,is glycine and cysteine , I am closing in on 50 and I am looking at NAC for a while I will probably start with a small dose to see how I react to it, great Video 👍

[@xavierbotteri1950]

Some mouse studies show that NAC supplementation can lead to cancer onset. The question is whether glutathione levels go down after a certain age because the body can’t cope with too much glutathione in the presence of many senescent cells. Same problem than with NAD+ precursors.

[@willnitschke]

or maybe oxidants have anti-cancer effects.

[@Korvxx]

I started eating more protein and beefliver as often as possible (40g 7x a week If I can but usually 5x a week, If I feel like I dont want it some days) I feel way better now, liver is natures multivitamin and very inexpensive today.

[@niellalien]

Instead of NAC? What are your other sources of protein?

[@richb1917]

Great information in this video! Can you do a video on which liposomal supplements would you recommend for longevity? Alive By Science has so many liposomal options now and I was wondering which would be the most benefical to take. Seems like some could be harmful after watching this video. Thanks!

[@MadMax300173]

Thanks dr Brad for sharing selflessly all this good information. I had taken lyposomal gluthathion a year ago, and it expired on the shelf luckily, only twice i had taken it. I do use nac 600mg day since many years with breaks in between, it helps clean up my lungs, and makes me feel somewhat more lucid.

[@doniphan72ify]

How long are your breaks ?

[@MadMax300173]

@@doniphan72ify 5 months on 1 month off

[@doniphan72ify]

@@MadMax300173 ... O wow. Okay thanks. Do you notice anything when you take a month off ?

[@drednac]

The thing about aging and intervention is that what we want is sort of a prevention strategy rather then symptom management. So what we can do to offset the problem while we are younger?

[@MixtrisUFOimages]

Thanks. I Take NAC With Collagen and TMG daily. Plus nicotinic acid (Niacin) Supercharged with vit C from citrus source

[@ivanandreevich8568]

I feel "down" when taking 1200 mg of NAC. I feel fine with 600 mg. I find this strange since NAC is actually anti depressive. Not sure what's going on there.

[@mreverybody1150]

You probably just don't need that much.

[@donnavermeulen9206]

Are you taking 2 capsules at the same time? Or 1 AM one PM

[@alidorgan1529]

Might be related to your gut NAC can be an issue for some people with SIBO symptoms , if you have any SIBO maybe deal with that first then look at in increasing NAC

[@niellalien]

@@donnavermeulen9206 Does it matter? I've been taking two a day at the same time and I think maybe the same is happening to me.

[@niellalien]

@@alidorgan1529 Where do you go to be tested for SIBO?

[@deuss001]

Thanks for the info, I’m knocking on the door of 60 and I wasn’t sure if taking just NAC would be enough…

[@Jill_SmokeandMirrors]

Sigh. I'm nostalgic for the old days two years ago when I'd just heard about David Sinclair and believed that some NR and a spot of resveratrol and maybe some olive oil and fasting in addition to a healthy lifestyle were going to fix everything. That seemed manageable.

[@karimghrab6634]

same sentiment here. I am losing my mind over the overwhelming new data coming our way.

[@Jill_SmokeandMirrors]

@@karimghrab6634 I spent a fortune on a massive supplement stack including hydrolysed marine collagen, niacin, berberine, sulphurophane, TMG, apigenin, alpha lipoic acid, ashwaganda, hyaluronic acid, MSM and a multivit that includes vits K2 and d3 and to be fair I haven't had a migraine in a year and my anxiety seems much better but now my head is spinning and I am very poor!

[@user-wv5gv3dw5u]

@@Jill_SmokeandMirrors A huge problem is the inability for supplements to be regulated/prescribed. Nationalizing aspects of the pharmaceuticals/healthcare would alleviate this and cause rapid progress on this side of medicine. And to be fair the things you mentioned about fasting, olive oil, ARE a huge factor.

[@marinusmourik9494]

@@Jill_SmokeandMirrors hahaha,that's a good one, for me it seems that with all these vitamins etc who are recommended by the so said "internet" doctors, people are only supporting the pharmaceutical industry...... they are the ones who are causing all these troubles ! Including the new "hype" Covid ! Why are people in the so said 2 and 3th world getting mostly healthy old ? Because they don't have access to all these vitamins,minerals etc. Try to eat,drink and live healthy and you will hearty "need" all these extras. I think that it can be tricky to listen and follow these "doctors" . Use common sense.

[@mreverybody1150]

@@Jill_SmokeandMirrors I hardly use any of those and am healthy as can be. But I do supplement with iodine, nac, camu camu powder, D3 and a form of collagen that includes multiple types (Natures Plus). If your iodine levels are no good, you open yourself up to all kinds of issues.

[@BeauBody]

Great video. I cannot take NAC because it makes me nauseous after some time. Instead, I go to an IV bar to receive a direct blood infusion of glutathione about every other month, along with other nutrients. It seems to work for me, no unpleasant side effects.

[@Booklivre]

Did the Gluta IV brighten / lighten / whiten your skin !?!

[@willnitschke]

Maybe if you have a bad reaction to NAC it would be really dumb to main line it, just saying...

[@tomasnielsen5132]

Not sure what is new here. It has been around for some years. I take NAC and Glycine as there are a lot of studies showing benefit from that. Never heard of a study saying anything about serine, maybe that is the new thing? Also taking B-vitamins (all the numbers) help to increase glutathione.

[@markrobertdevison1227]

I am over 50 and I found a couple companies on Dr Gundry channel that sell a glutathione supplement. I trust it because Dr Gundry would not have had them on his podcast if he didn't trust them.

[@Booklivre]

What are their names ( brands ) !?!

[@markrobertdevison1227]

@@Booklivre kzbin.info/www/bejne/i6SYpKejq9iphtk

[@levondarratt787]

dude you sound like 12 years old, trying to market a product....just say the facts!

[@Booklivre]

@@levondarratt787 Did did not harm anyone

[@ysohot223]

Started NAC 3 WEEKS AGO.about 2 days ago I started to clean flegm from my lungs I didnt know I had .lungs also present better and breath better since I have been diagnosed with hypotropic cardiomiophathy/myocardatis

[@browneyedgirlFL67]

How much are you taking?

[@ysohot223]

@@browneyedgirlFL67 there is 900 mg capsules .i just only take 1 tablet

[@brightmeadow820]

Really well presented thank you-clear and concise.

[@HaMashiachSaves]

I’ve taken 600-1000mg per day for years. I scoop the battery acid straight into my mouth 🤪

[@chasingshangrila]

I’m closing in on 50 so I’m starting already. 1200 NAC daily with 20 g of Collagen peptides that already has glycine. Thanks for all the fantastic info on your channel Dr.

[@MrAbi123]

I'd say stick to 1200-1400 mg and split the dose to take in morning and 2 hours before dinner

[@chasingshangrila]

@@MrAbi123 thanks

[@Andrew-0815]

I'm almost 40 and started to take 800 mg per day. I think I'm fine with that.

[@user-pv3vp1cw7g]

same here

[@notsogreen]

Bought a big bottle of liposomal glutathione for a Xmas gift for someone, haven't seen them yet so still have it. Then today I saw this. Oh boy. Bought a smaller bottle for myself weeks ago, been taking it. Back to NAC and glycine. Shucks. I was hesitant to watch this didn't want to hear anything negative about glutathione.

[@kevinscott4938]

Would it not be just as useful to take Whey Protein? As It has a decent level of Cystine vs other proteins, plus the addition of the Leucine for triggering muscle protein synthesis could be useful for older people? Couple with some light resistance training?

[@mreverybody1150]

Excellent question. I found this video because of it: kzbin.info/www/bejne/jaWwYYOuibigqNU

[@terrydevaney8601]

@@mreverybody1150 nac probably better on its own..best on an empty stomach

[@billsemenoff]

I found a paper to the effect that cysteine and methionine are balanced via a mechanism involving homocysteine, and that the mechanism depends in good vitamin C. I can dig up the reference...that one is a bit older but not recently referenced...and it would seem to be at odds with the idea of simply increasing NAC intake having any ultimate effect without regard to the bodies ability to interconvert certain aminos

[@elephantandcat]

Hi Robert, I would love to get the reference of the article you mention. I am wondering indeed if taking NAC supplement can be safe for people dealing with high levels of homocysteine..

[@matzefritz]

Is there any evidence so far, that by taking NAC or liposomal glutathione that this intake will automatically increase glutathione levels in the brain? Or does it automatically go to the areas where it is needed? I understand that you claim that taking such supplements this will increase Glutathione levels in the brain automatically. Are there any studies out there that this is the case? How much Glutathione induces toxicity and what are the effects of glutathione toxicity in the brain?

[@JonathanOvnat]

Good questions.

[@anguslean4058]

The thing about liposomal is that its short lived NAC is better because it causes your body to produce glutathione NAC needs to be taken with selenium.

[@levondarratt787]

@@anguslean4058 But what if it doesnt make it. isn't Liposomal tested and shown to work? Is NAC tested? What if we take both?

[@anguslean4058]

@@levondarratt787 like everything else if you take the liposomal your body will soon detect it and stop making its own That’s why the NAC is better because it promotes the production of your own glutathione I’ve never heard of anyone not making any glutathione as apposed to production just decreasing with age or illness.

[@DoritoWorldOrder]

Liposomal formulations of glutathione, or any compound, taken orally, do not bypass the body's regulatory mechanisms or get ferried directly into cells. They just increase absorption by removing the need for the compounds to be modified for uptake at the enterocyte. The liposomes are broken down just like the naturally occurring liposomes present in common foods, such as milk. Liposomes are ubiquitous in biology and organic chemistry anywhere phospholipids are present; phospholipids spontaneously form into liposomes on their own in an aqueous environment (such as the digestive tract), which is part of why the absorption of certain vitamins taken on an empty stomach is enhanced if they are co-administered with a phospholipid such as phospatidylcholine or lecithin - the phospholipids form liposomes naturally once hydrated and end up trapping a small portion of the vitamin molecules inside them. Lab-made liposomal formulations just allow this to be done at a higher efficiency and with a wider array of compounds.

[@maryhall3722]

Thank you for this shortcut through the research. I used NAC very successfully when I had covid 2 months ago. I use glycine as a sweetener in coffee. As the NAC powder tasted awful, I sweetened it in solution with glycine, knowing glycine was one of the 3 components of glutathione. NAC did give me heartburn/stomach ache, it was so bitter, so I washed it down with milk. Problem solved. In relation to oxidant/antioxidant balance, could you also discuss the problem of NAC halting apoptosis/autophagy? These processes are equally important in aging and staving off cancer. It was mentioned in a very long article that I found on pubMed. Many thanks 😊

[@actuitivevisrl1014]

It's fascinating that NAC can hinder autophagy! If you find the name of the paper please let us know!

[@waynewalleye8458]

I WOULD LIKE TO SEE A VIDEO ON HOW TO CHOOSE A SUPPLEMENT AND INGREDIENTS TO AVOID

[@pottymouthstarseed6315]

Yes

[@pottymouthstarseed6315]

Yes

[@pottymouthstarseed6315]

Yes

[@SlamminGraham]

EVERYTHING falls after 45. You need a lot more causal information than this to draw strong correlations.

[@ThePedro247]

Thank you for the update!

[@kimdavis7812]

Thank you Brad …. So do i as a newly 60 yr old extremely healthy post menopausal female take both NAC & glutathione ? Thank you

[@barringtonallaby3637]

I began taking NAC but, then, I stopped taking NAC because I read an article on the ScienceDaily website about a study done in 2007 The source of the study was the University of Virginia Health System where it was determined that NAC can form a red blood cell-derived molecule which makes blood vessels think that they aren't getting enough oxygen. I haven't found any more recent information regarding this study.

[@Elaba_]

Yes, I have found information about the study you are referring to. It was published in the journal Circulation in 2007 and conducted by researchers from the University of Virginia. The study showed that N-acetylcysteine (NAC), a commonly used antioxidant supplement, can increase the production of a molecule called "S-nitrosoglutathione" (GSNO), which can cause blood vessels to narrow and reduce blood flow. This can lead to an increased risk of heart attacks and strokes. However, it is important to note that since then, much research has been done on NAC, and there are also studies showing that it can have a positive effect on cardiovascular health. It is always best to consult with your doctor before taking supplements or medications, especially if you have a history of cardiovascular disease.

[@brucebird55]

As NAC cannot be sourced on Amazon where would you purchase your NAC from?

[@user-pv3vp1cw7g]

sunavit

[@ymeski56]

I order mine from Life Extension.

[@michaeldomansky8497]

67 years old ….. Two months now taking 1800mg NAC twice a day, 800mg Benfotiamine twice daily, 3ml Ivermectin once daily, all inflammation has vanished and I no longer need ANY pain meds of any kind!

[@algo545454]

with all due respect, what about Sulforaphane which you recommended that will increase glutathione in one of your video. I do appreciate you videos and kindly advise.

[@cinystarr4657]

I would love to hear about this too, I've never heard of it

[@chuckbecker8735]

Yes, a few months ago he said he would switch to Broccomax from Jarrow to derive sulforaphane to engender Glut.. Maybe he discovered Jarrow allegedly ruined Broccomax and deleted the second of the pair of molecules which must pair up to render sulforaphane.

[@rayvortex8663]

I think taking sulforaphane or eats broccoli sprouts is a longer way. Same like taking milk thistle or whey protein to build GSH.

[@MrSurferglobal]

Following, I have been taking broccomax after Brad did a video that it was superior to NAC, now NAC is all sold out on the iherb site, is it true it's been banned because it can help cure covid?

[@SteveFrench_420]

@@MrSurferglobal that's my understanding. Our gov't, including the CDC and FDA, has been captured by Big Pharma, esp the FDA. Their vaccine "department" gets 65% of it's funding from Pharma. That's why the "media" spreads propaganda whenever a cheap alternative to the "vaccines" & the new pills is discovered. Take Pfizer's new pill. (Developed using tax dollars and $17 to make but charging $700 for a 5 day treatment). It is a protease inhibitor. It blocks 3CL Protease. Do you know what else blocks 3CL Protease? Ivermectin. As for NAC, it thins mucous, helping your lungs clear out any foreign substances. Also it's my understanding that NAC helps the lungs produce glutathione.

[@lennylenoir]

I am surprised you disregarded the main indication for NAC which is to loosen mucus in the lungs, specially in asthmatics. You did not mention the lungs in your video.

[@cosmichealth3907]

That's what it's meant for

[@chuckbecker8735]

Few months ago, you felt we should switch from NAC to BroccoMax from Jarrow to derive sulforaphane to engender Glut.. Maybe you heard Jarrow allegedly ruined BroccoMax and deleted the second of the pair of molecules which must pair up to render any sulforaphane.

[@jerrywon1226]

Have any link or source on this? Thanks

[@SLUMP317]

I’ve had a severe psoriasis breakouts during Covid I was taking NAC with psoriasis still present I noticed a huge difference in the side effects of psoriasis on NAC versus not having any NAC and I will say with supplementing 600 mg every day has took out almost every single internal side effect I used to experience I do not know why or how but it’s like a miracle supplement for me my fatigue is gone brain fog and numerous other things that I used to have problems with or wiped away because of this in nac. I’m 24 years old

[@strokertoo]

I've been taking NAC on and off for years. But I'm curious about the combining with serine/glycine. Aren't Serine and Glycine both vital for tumour growth in cancers? Could you weigh in on this? I really like your channel!!

[@LITTLEROCK2517]

yo

[@Jozehv]

oxygen too!

[@caseyw1050]

I would love a video explaining Substance P and how to control high levels 🙂

[@patrickburgermeister7940]

Thanks Brad, good research and well balanced information as always. Small correction: the landmark paper mentioned at 02:30 was published in 2013 (not 2009).

[@raindrops7044]

So I cannot take 1500 mg NAC twice a day because I'm on blood-thinner? Please confirm.

[@lucasvlox]

I used to drink my NAC for years, since I read about the benefits about 7 years ago. I also believe it's the best chemical out there against hangovers. During outdoor-trips I force all my friends to drink some for breakfast, so noone gets sick - So far it worked, but most of them don't like the taste :D

[@MudMotorsMax]

Just mix it with OJ man

[@tuliplemay6136]

I loved this video. Unfortunately, my doctor has never heard of NAC. She looked at me like I was crazy. I showed her the video and she said she didn’t understand it. Uggh:(

[@anonymissed3611]

They're trained on drugs and protocols for symptoms. Almost zero on nutrition

[@laurieparis2203]

That's cute! You actually thought your doctor was going to learn something from a KZbin video. 😆

[@levondarratt787]

doubt your doctor would allow you to play a 30 minute video without cutting you off. Their time is valuable... hey'll watch 3 minutes of it at best, and after that will be upset with you....

[@laurieparis2203]

@@levondarratt787 exactly. But on the other hand, if you heard just a percentage of the absolute madness patients tell their doctors, doctor's reluctance to listen is understandable. Meanwhile they have a backlog of patients waiting....

[@SBecktacular]

NOT surprised 😂

[@barbarahughes620]

I am 61 and recently diagnosed with stage 1 adenocarcinoma lung cancer, can NAC advance or slow this?

[@lizzymoore54]

I’m 67 and take NAC and Alpha Lipoic Acid but not daily. Is this doing me any good at all?

[@seanj8878]

Excellent overview on the subject. Thanks I'm 72, use to take both Glysine and NAC; recently learned serine converted to glysine, so dropped glysine and moved to serine.

[@samatoid]

Another tour-de-force review. I am older than 50 and have been taking both serine (2g) and NAC (600mg) for about 6 months. No side effects. Thinking of increasing the NAC to 1.2g based upon this review.

[@nickjacques6087]

Will NAC increase or decrease cancer risk? And would cycling NAC be safer?

[@willnitschke]

It could do both depending on your specific situation. I.e., how much or little inflammation is already in your body because it's all about balancing oxidants and anti-oxidant levels. This is mainly theoretical because there is not a lot of solid research out there.

[@cosmichealth3907]

ffda removed it from the shelves ,bet it cannot cause cancer

[@blackbart5803]

Wonderful, useful information Dr. Stanfield.

[@julieableschapin3178]

Very good info! Thank you! I have taken NAC but it’s increasingly hard to find now. Amazon stopped selling it and it’s often sold out at the stores near me where I shop. I have not taken Serine or Glycine before so will look for those. I try to get as much through my diet as possible, without supplementation. If you can talk more about specific foods that contain some of these, that would be interesting too…I am guessing it’s going to be lots of veggies! Very few of us are eating the amount of these we need. I think our body metabolizes foods much better than supplements but I agree supplements DO have their role.

[@cinystarr4657]

You can use a search engine, foods with NAC etc =)

[@donaldfarmer8421]

The Vitamin Shoppe sells it - that's where I get mine.

[@tom79013]

Life extension. I use life extension Europe but they are an American company

[@mysongzz1521]

Order it on Walmart app online

[@terrydevaney8601]

Vitamin shoppe..Nac

[@MrEtc31265]

Great website. I was going to send you an email asking you to add research / supplements you are watching or thinking about. I went back and found your "Molecules I’ll Add In As I Age". Thank you for your channel.

[@raymondspagnuolo8222]

Could you comment on s-acetyl glutathione?

[@terrydevaney8601]

Taking Glutathione straight up body doesn't absorb well..Nac is the s**t

[@deb5425]

I use to take D-Serine for OCD and it was helpful in maintaining stress. It became difficult to find so my doctor suggested NAC. I have been taking it for awhile and it helps but not as good as D-Serine but then I may not be taking enough I only take one pill a day. Most recently I also started taking Liposomal Glutathione per my doctor's recommendation because I'm 63 and have a family history of cancer and heart disease. I watched your video to determine if the Liposomal Glutathione should be taken with NAC and I appreciate your insight about the two products.

[@tohopes]

you could take (sodium) benzoate, perhaps 2g per day. it is an inhibitor of D-amino acid oxidase, which breaks down D-serine. so benzoate preserves D-serine in the brain. they give it to schizophrenics who have NMDA dysfunction.

[@deb5425]

@@tohopes Thank you!

[@FrankPloegman]

Thanks for this great video. I'm increasingly interested in NAC after slowly learning what a powerhouse this is. See also the fantastic video 'Coronavirus Pandemic Update 69: "NAC" Supplementation and COVID-19 (N-Acetylcysteine)' by YT channel MedCram. NAC is mucolytic (thins mucus), antiviral, anti-oxidant, and a great blood thinner. Not only does it prevent clots from forming, but it dissolves clots that have already formed (thrombolysis). MedCramVideos hit the nail on the head, already in May of 2020.

[@sarafarid8952]

NAC with selenium and Molybdenum okay?

[@reubengermain9771]

Once you reach 50? You might benefit from it earlier, depending on how your methylation cycle runs and what SNPs you have.

[@ronpower7790]

Why most people ignore S-Acethyleglutathione?

[@missmarryanne937]

Exactly, I take it 3 months and now I almost do not know what is a hang over... it is not the main reason why I take it however it shows me that it works in my body (liver) :)

[@amperage8032]

I’ve taken NAC for years, I’ve not heard of this one. Thanks for suggesting it. Do you feel it’s comparable or better?

[@missmarryanne937]

@@amperage8032 unfortunately I don't know - I use SAG few months and NAC just few weeks - my filosofy is to take s-acetyl-l-glutathione (which gives pure glutathione to your body) when I am sick, under stress or when I will celebrate and drink a bit more and NAC on the other days - because it is harder for body to get the glutathione from it but it is also cheeper. However I am not a doctor

[@robertdankanin]

It is much more expensive ;-)

[@ronpower7790]

@@robertdankanin yes, but at least is has to be mentioned as an option.

[@KyleValet]

ty for ur time and educating us...i have a question..Is there a test for all of the nutrients discussed in each of your videos? Im 52 and would like a list of the missing chemical components for longevity in my body?

[@markveen1373]

Or instead of popping pills again. Eat foods high in Cysteine and Glycine. Also keep chronic stress and anxiety to a minimum. Because that really eats up your Glutathione supply. Meditation raises it.

[@heidiharrison9245]

What foods are high in glycine?

[@markveen1373]

@@heidiharrison9245 My favorite sources are buckwheat, amaranth, sardines and pumpkin seeds. Besides Glycine you're getting whole lot more for your dollar.

[@heidiharrison9245]

@@markveen1373 The glycine receptors do not function in the presence of glyphosate btw, so important to eat organic.

[@willnitschke]

@@heidiharrison9245 Meat.

[@marilou2207]

I have been taking Glutathione for years. It helps me stay healthy and I recovered faster from TBI. My Neuro told me that it will take a long time to recover since I am over 60. My Neuro was surprised to that I recovered quite amazingly fast.

[@Jjoevme]

Hey Dr Brad. I have been taking NAC from Now Foods before bed since a couple weeks. I generally sleep 8 hours without a problem and never wake up. For whatever reason with taking this supplement before bed i wake up around 2 am every night and im wide awake, which is about after 4 hours of sleep. The supplement from Now Foods has 600mg NAC, 25mcg Selenium, 50mcg Molybdenum. Do you have any idea why i wake up and why i'm wide awake with this supplement. I tried to look everywhere to find any information about this but with no avail. When i stopped taking the supplement my sleeping went back to normal within 3-4 days i think.

[@cinystarr4657]

This is odd, that's my basic sleep cycle but I'm not taking any NAC at all - I do take vitamins before bed. Trying to take D, C, CoQ10 in daytime to avoid it affecting my sleep. I seem to only need 5 hrs of sleep most of the time

[@CK3CK3]

I have read about (and experienced myself) sleep issues related to NAC. I would not take it at night. I even used a reduced dosage. The morning seems to be a much better time for this supplement. For me, it would affect my ability to fall asleep. It still could affect sleep even if taken in the morning but maybe give that a try.

[@cinystarr4657]

@@CK3CK3 I hope it works for you. With the time change the past 2 weeks I'm only getting 3-4 hrs sleep. I fall to sleep easily & quickly, it's staying asleep I suffer from. Can I ask what NAC you take? I don't know what's good or bad.

[@ragugaranpuvaneswaran4471]

@Oahdzzt so NAC reduces the glutamate levels in the brain which is good if you have high levels of glutamate, but if you have normal level then it decreases further, which changes the glutamate/GABA ratio in the brain, which can create anxiety. Now the 2nd half of the sleep occurs 3-4 hrs after you fall sleep, and this 2nd half is where REM sleep occurs. So if NAC changes your Glutamate/GABA ratio and creates anxiety, you can easily wake up from your sleep thats why you are getting up at 2 am in morning. I took NAC during morning and experienced anxiety, so I can imagine anxiety can come when taken at night too and kick you out of sleep. I would say try Magnesium-glicinate at night to calm the brain if taking NAC, or take NAC during day time and see.

[@Jjoevme]

@@ragugaranpuvaneswaran4471 Hey thanks for the information. I didn't know that at all. I tried to look up all the components but everywhere it says to take NAC before bed and only here and there there is a bit of anecdotal evidence that it disturbs sleep for some people.

[@44hawk28]

Huge piece missing here, within the first half of this video, he should have explained what the dangers are of too much glutathione. And then about halfway through he says the bloodborne glutathione levels go down markedly after age 45.

[@paulroach0217]

Thank you for the informative video Dr Stanfield. My primary care doctor put me on The Black Box II detox system after he noticed I had multiple mercury amalgam fillings that might of caused long-term poisoning. The detox was done for 4 weeks and included Nanoemulsified DIM, Liposomal Glutathione, Micellized Pure PC, BitterX, Ultra Binder & Liposomal Methyl B-Complex. Even though there is no mention of me taking NAC, do you believe the supplements I have mentioned would be safe & effective if taken together? Would love to hear your thoughts, thank you.

[@karla_264]

Please look into the Medical Medium protocol by Anthony William. I am getting rid of all neurological symptoms with it. He’s on IG and FB.

[@paulroach0217]

@@karla_264 Thanks for sharing Karla, will look into it 🙏

[@MrBeard-ig5zc]

Eat onions. Every day.

[@Ν11-φ9ρ]

Raw cheese/youghurt, and pasture chickens/eggs much better source. 0.004 in onions per 100g, and all the antinutreints. 0.364 in (NORMAL) chicken leg. Now ...pasture chicken, very different story! A LOT more!

[@artlego1007]

I can't seem to find and order NAC on Amazon.

[@pottymouthstarseed6315]

Look elsewhere! You’ll find it.

[@leeturner1589]

I have been taking SALG for several months. And the lipofuscin on my hands has decreased...hoping the same is true for my brain (which is the point). Also, taking centrophenoxine to reduce brain lipofuscin. I'm curious what you think of SALG? Is it as bad as lyposomal glutathione? I should probably throw my bottles of reduced glutathione in the trash. I also take phosphatidylserine for sleep. Will trash that (concerned about the phosphorus and kidney health) and just stick with glycine & NAC (I bought 4 cases of it when I heard the FDA was making moronic decisions again). At 67, my work-out demands precise control, so I very much appreciate your vids. I'm also a member of FoundMyFitness, and contributor to Dr. David Sinclair...try to live my life based on clinical studies...shooting for my 100th birthday! :) Like your style and data, so will add you to the list. Thanks!

[@leeturner1589]

Just signed up as a Patreon. Hope this helps!