NAC & Glutathione Extend Mice Lifespan By 24%

A new paper shows that a combination of Glycine & NAC (the building blocks of a powerful antioxidant called glutathione) extends mice lifespan by 24%.
💊 My full supplement stack: drstanfield.co...
💊 MicroVitamin (multivitamin & mineral): drstanfield.co...
💊 Supplements I use from Amazon: amzn.to/44oEGZz
✨15% Discount Code: BRAD ✨
• ProHealth: www.prohealth....
✨10% Discount Code: BRAD ✨
• DoNotAge.org: donotage.org/p...
• Renue By Science: renuebyscience...
Donate towards my Rapamycin & Exercise clinical study: bit.ly/3QwugRx
✔️ Roadmap - Look Young & Feel Strong: drstanfield.co...
✔️ Twitter: / bradstanfieldmd
✔️ Patreon: / bradstanfieldmd
Here are the links to the research papers referenced in the video:
www.mdpi.com/2...
pubmed.ncbi.nl...
pubmed.ncbi.nl...
pubmed.ncbi.nl...
www.ncbi.nlm.n...
www.ncbi.nlm.n...
www.ncbi.nlm.n...
If you like this video please smash the thumbs up button, it really helps with the KZbin algorithm :-)
#NAC #Antioxidants #Lifespan
The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

[@robertalberts2636]

Let me tell you the story of my mom (age 83). In 2018 my dad passed away and my mom never really got over it. We saw her going backwards and about a year ago mild dementia was established. About half a year ago I read about glynac and the cognitive improvement in elderly people (among all other benefits) that was associated with it. I decided to wait no longer and put her on glynac straight away. Now 6 month later she seems so much better and the dementia seems to be stopped in it's tracks. So much even that het caregiver noticed it without knowing about the glynac. They do know by now.... Another remarkable thing is that she is now once again contacting and visiting old friends, where in the last 2 years she hardly came outside the house. 1200 mg nac and 3 grams glycine per day has done wonders. Make of this story whatever you want, but my mom asking for it when she's running out of glycine or nac says it all for me...

[@warrenweeder3569]

Very helpful, thanks!

[@derekwarren5277]

You did the right thing, well done.

[@DrBradStanfield]

That’s awesome, thanks for sharing

[@robertalberts2636]

@@everymanisyourteacher9951 Funny you say this because what I did not mention is that my mom also caught COVID (before omicron) and she only had a slight cough. She is vaccinated but still remarkable.

[@robertalberts2636]

@UCmYNJgsSNE1ocSriRSrnlGw Amazon

[@f13775]

After all this researches and studies seems mice will start to live longer than humans soon :)

[@indiankid8601]

😂😂

[@Blackfire970]

Lmao

[@michaelcarnevale5620]

lol

[@fred4687]

Hence the FDA looking at restricting access to NAC supplements again

[@christopherchardt]

I appreciate the information you've provided. I'm already taking NAC and will now include glycine. Age 71.

[@barbaras3206]

Me too!

[@DrBradStanfield]

Thanks for sharing

[@captainnerd6452]

64 here, have been taking NAC once per day, will also look at adding serine.

[@vasiliosagio3127]

What is NAC ?

[@captainnerd6452]

@@vasiliosagio3127 N-Acetyl Cysteine, it's a supplement you can buy

[@jet30d]

I can’t thank you enough Dr Brad. I try to keep up to date with a lot of nutritional and anti aging information but have a heap of trouble interpreting it. You have been a life saver in dissecting the studies and you are the voice of reason. I’m very very thankful for your public service.

[@eldel5806]

Once again fantastic job. I very much appreciate how you visually reference the studies you refer to. Also, your perspective seems to be very common sense and down to earth. Can't wait for further research to come out on this topic.

[@DrBradStanfield]

Thanks for your feedback. Glad you enjoyed the video

[@APBCTechnique]

@@DrBradStanfield I’m 53 and taking NAC 1000mg twice daily and DMG/D-glycine 1g daily

[@ricardodasilva1766]

Hi Brad, can you comment on Rhonda Patrick's findings that mouse studies using NAC caused lung cancer in healthy mice and is the reason why she stopped taking NAC

[@mercury4960]

Funny that I happened upon NAC and Glycine for other reasons. There seemed to be a boost in my energy and mood after I added glycine. Wouldn’t have know they were precursors to the body’s own production of glutathione.

[@williamgrant7963]

Great video Dr. Stanfield. I would like to briefly share my personal experience with NAC. I've been a long term sufferer of OCD and off/on depression. I've tried many things but just discovered NAC this year for the first time. NAC 600 mg twice a day with selenium & molybdenum took me out of a 2 month depression and has worked wonders on my OCD. My focus and productivity at work has improved immensely as well. Energy has also improved. I'm 33 years old and this this the only medication /supplement I'm taking right now. If NAC improves mental health, than an improvement in health span and longevity would naturally follow suit. Amazing compound, for me at least.

[@jesseali8395]

Also cured my lifetime nail biting. However studies suggest I will relapse after the two month mark which is rapidly approaching :(

[@masegomodisane249]

@Jesse Ali, how are you doing? Did you relapse? I’m a nail biter too so would be great to know

[@MegaLeoben]

Still working for you? I get blunted stimulants.

[@danielagentile8049]

Will you share the brand you use please? I hope you are doing well 🙏🏼🙏🏼

[@williamgrant7963]

@@danielagentile8049 I use NOW* brands NAC 600mg 1 every morning. It's worked wonders for me. :D

[@marshallalmeidaArt]

I have been reading a lot about the Gly/NAC study in the last week or so and there is so much information to try to digest. Thank you for such a clear and concise simplification of the data and for being so open about how you are going to use that information. Very helpful. Thank you

[@baileystruss7319]

If you already taking collagen, check the glycine amount. Its usually 600mg or more.

[@johnbielenda7336]

33% glycine in collagen......

[@ALECSF15]

I take 4g-6g of glycine daily

[@colindeer9657]

Thanks Dr. Brad. Really enjoyed your analysis and appreciate the work and the care you send us. I am 67 and a retired Registered Nurse. I’ve Just commenced taking both NAC. and Glycine 4gm each per day divided into three doses.

[@danpictish5457]

Brilliant research, Dr Brad. That's a lot of NAC and Glycine to take. I only take 1.2 grams and that may not be enough!

[@DrBradStanfield]

Thanks Dan

[@barnetthejosh]

Currently doing NAC and L Serine 2 x a day. I’m 45 and recently came out of hospital due to spine infection so I’ve been on loads analgesics.

[@backcast4220]

Based on mice studies, I have been taking rapamycin, NAC, metformin, quercetin with dasatinib, NMN, fisetin, resveratrol and eat once every 3 days. I’ve noticed a couple of side effects, my ears are getting very large, I appear to be growing a long hairless tail and I have an irresistible urge to run on a treadmill for hours. On the positive side I think I’ll live forever, so far so good🤪

[@DrBradStanfield]

😅

[@MsShadowjack]

Hah!👏👌

[@willcollins5660]

Where do you buy rapamycin? Which website do you use? Do you know Backcast, Dr. Brad or anybody?

[@ChessMasterNate]

You eat only once every three days? That is dedication. What do you eat...a whole pan of lasagna, a couple heads of lettuce, a pineapple and a large pumpkin?

[@backcast4220]

@@ChessMasterNate Cheese

[@whittlejoe]

Dr Brad, thank you for this video and all the work you do. Congratulations on your recent marriage, also. You are doing very important work. May God greatly bless you.

[@RealJoshBinder]

Been binging your videos, can't believe I'm just now discovering this

[@wesleycox5519]

My NAC and glycine arrived today. Probably would have bought serine had I paid better attention in this video. Looking forward to seeing/feeling the effects.

[@JR-ht2vy]

I’m going to wait for more data!

[@SBecktacular]

Or as dr brad would say.... “Dātā “ 🥴

[@Tereselynn]

Thank-you Dr.Stanfield! I just bought my 1st bottle of Glycine supplements today - the NAC one is next (tomorrow) so I can take them both together & see how this all plays out. Am 63 & am always trying to find ways to reverse it.

[@ReturnToHopeCove]

Good update Brad, but terrible cliffhanger at 8 minutes. Serine conversion may drive the Folate Cycle. Great! Maybe a reminder why that's good? As it happens I take both Serine and Glycine. As a vague pointer to potential future videos, L-Serine helps me sleep, but I recently found that AKG alongside it helps me sleep like a baby. Conformed by other folks on the forums, maybe worth a look?

[@joelfriedman8422]

What about agents such as curcumin that improve the ratio of gsh to gssg which is a direct measure of oxidative stress. Curcumin upregulates the enzyme that generates gsh. My guess is that curcumin with a small amount of added selenium would be very effective. NAC and Glycine would contribute if you are low on the gsh building blocks.

[@jdw5889]

I started taking Nac and glycine a few months ago; I'll be 46 in a couple days. Looks like I'm going to continue, I have noticed many interesting things since starting all of which lead me to believe I'm on to something good.

[@iamcookbook]

I take NAC in the morning with cordyceps and TMG at night to get the methyl donors to help balance niacin. Too much NAC will make your throat dry. It breaks down the mucus. It’s a side affect that can be uncomfortable in winter or dry climates. Something to think about. Small amounts are better to me, fewer side effects.

[@MegaLeoben]

Do you get blunted stimulants from Gly NAC combo?

[@redright2818]

Really appreciate the information you share. If I understand correctly, you plan on taking 3000mg of NAC and Serine daily when you reach 50? I have been proponent of NAC for many years. Took 1800mg a day when I had Covid and I barely had symptoms....shared with others with the same response.

[@TheSimArchitect]

That's nice! I was taking NAC because of COVID, but now I will also take Glycine. I'll just take 600 of NAC and 500 of Glycine, though, since I am only 43 years old and that's what comes on each capsule I bought. Thanks for sharing the study.

[@jarvisnederlof35]

Sulforaphane might also improve glutathione in the blood. Do you think you could compare NAC/Serene with sulforophane and highlight the differences?

[@JohnnnyMojo]

Reduced Glutathione works well and is probably much safer and more effective than NAC since NAC is capable of producing side effects. In one study, participants were either given 250 mg or 1,000 mg of Reduced Glutathione per day for a duration of 6 months. Glutathione levels went up significantly in erythrocytes, plasma, lymphocytes and buccal cells after 1 month of daily supplementation. After 6 months, the low dose group (250 mg/day) found an elevation in Glutathione levels of 17% in the blood and 29% in erythrocytes, whereas in the high dose group (1,000 mg/day) these changes were significantly higher at 30-35% in erythrocytes, lymphocytes and plasma.

[@rusturuss123]

Is there a danger in much elevated glutathione or should we expect health benefits, what is the data?

[@MM-wu6fl]

I'm taking reduced glutathione 250mg a day. Is this safe?

[@JohnnnyMojo]

@@rusturuss123 You probably don't want extremely elevated glutathione levels. Getting them more within a normal range or slightly higher would be ideal.

[@JohnnnyMojo]

@@MM-wu6fl yes I believe that is a safe dose and generally on the lower side. It will take a bit longer at 250mg a day to raise levels but that's perfectly fine.

[@rusturuss123]

@@JohnnnyMojo Thanks for the reply.

[@hhoneycutt19]

I've been taking 1800 mg/day of NAC and 2 gm / day of Serine and noticed increased energy levels, I'm going to increase to the dosages mentioned in the video. Of course I am a test group of 1, so there's the placebo effect, as well as the Hawthorn effect (you get better at some parameter because you're watching it) but these effects tend to trail off after time for me, and I've been on the NAC / Serine thing for some weeks now, well beyond my attention span, and they still seem to work.

[@auriellenazro2516]

Dr Brad Stansfield, what a great report to share with us. I love how you use the primary source to explain. I will be altering my ‘stack’. Many thanks

[@rosevanderreijden]

Yes, I just read this article earlier today. I have been taking both glycine and NAC daily for about 6 months and will continue to do so. (I put glycine into my green tea and take NAC with it.)

[@4444trs]

Where do you get NAC? I can't find it on amazon and I heard somewhere that they made it unavailable during Covid.

[@f13775]

Rose but he said starting from 45-50 year old

[@ScottSummerill]

Plenty still available at Vitamin Shoppe and probably at some of the other vitamin vendors.

[@derekwarren5277]

@@4444trs You can get Glynac from Youth & Earth, just thinking of trying it myself, right now.

[@DrBradStanfield]

Thanks for sharing Rose

[@MrSurferglobal]

Thank you, I just ordered 1kg of glycine to stack with my NAC.

[@5ervalkat192]

Serine seems to be only available online as 100mg capsules. That is pretty inconvenient. Maybe things will improve over time, as this research matures.

[@anoniem9518]

Sulforaphane, found in broccoli sprouts or in supplements sulforaphane glucosinolate combined with myrosinase, has also shown to increase Glutathione. So which one is the better choice to boost Glutathione? Sulforaphane or Glycine combined with NAC?

[@rosasumilepalermogofredo8333]

This is the question I wanted to ask also.

[@slappop7082]

Sulforaphane activates the genes to produce glutathione and NAC/glycine provide the building blocks of glutathione. Take both.

[@unfckyourthinking]

Take both. Sulforaphane has other incredible benefits.

[@naughtyorgneiss]

which is cheaper?

[@default2826]

@@naughtyorgneiss if you are gonna take sulforaphane make sure it is BroQ brand.

[@Constantinelatting]

Good video I currently take NAC its really helped my breathing. your the main person i watch when it comes to NAC you have the best data

[@SCOTTBULGRIN]

Great video. I will change my supplement regarding glutathione because of this information. Thank you.

[@tjocho]

I’m a 55-year-old male and I’ve been taking Glycine and NAC for a while, 2 grams of each per day for 1.5 years. After reading the papers of the human trial where they used a higher dose, I thought I would try 6g each per day. I took this for a week but had to dial it down again because of how it affected my mental state. It’s hard to pinpoint exactly how it made me feel, but I had way more anxiety and a generally super weird feeling overall. It was not a pleasant feeling and I wasn’t the most pleasant to be with at the same time. I will be more careful going forward and see if one has to build up for higher doses because I wouldn’t recommend how I felt to anybody. My normal state is very balanced and I don’t take any mind or mood-altering drugs, legal or illegal.

[@naturegirl8104]

A new study on NAC on the NIH website says that it helps stop blood clots from forming.

[@TravisBiggie]

you should link the study..

[@roycemcdougal9842]

Wow, I currently use sublingual glutathione. Now, I will switch to NAC-serine 1.5 gm bid. Thank you for your guidance.

[@markrobertdevison1227]

Well I've been taking a glutathione supplement for a little while now. I hope it isn't doing me damage. Interesting study done, thank you very much.

[@4444trs]

Me also...I also got an IV last month (I have lyme), guess I will hold off.

[@galapagospictures7677]

​@@4444trs I have friends w/ Lyme, and the inter-venous (IV) Glutathione (GSH) treatment has been a crucial part of their recovery. The GSH, in addition to being a strong anti-oxidant, provokes a detox, helping the body to flush out some of the sequestered toxins. GSH may even be a mild binder, escorting those toxins out - I need to check on that. You are probably doing the "Patricia Kane" Protocol (aka PK Protocol) which has been in use for years. Go to a Lyme Literate clinic and listen to the stories of Lyme patients who've had significant improvement on this protocol. Brad Stanfield's concern was with LIPOSOMAL GSH, which he claims the body can not regulate since the GSH is in a phospholipid bilayer (the liposome) which "hides" the GSH from the bodies regulating mechanisms. Your IV GSH is NOT HIDDEN, so the body can regulate and shuttle it around to where it is needed. Finally, a Lyme patient's body is under so much oxidative stress from the pathogens and toxins released by the pathogens, that GSH levels measured in the blood (by blood test) are abysmally low. Many Lyme patients get a Vitamin C IV (50,000 mg) followed by a GSH IV (3000 mg) and do that 3x per week for a month or two, and they have enormous improvement, proving the IV's are safe and effective, even done 3x/week (quite frequently). Lyme patients usually are affected by mold (from water-damaged buildings) and EMFs from cell phones/WiFi. To heal, one must find a mold-free lodging with no WiFi away from cell-phone towers. Hope you see this info and it aids you on your recovery from Lyme.

[@4444trs]

@@galapagospictures7677 Thank you so much....that all makes sense. Yes, I'm continuing with this doctor here in Mexico

[@jooppoojk2356]

How about the idea of taking S-Acetyl L-glutathione directly?

[@ninjashinobi2413]

I have been taking Glycine & NAC for several years, it's nice to see it may help me in my old age..

[@gennaronoviello4796]

Great info, thank you. Greetings from ROME, Italy.

[@shenchiu8883]

Hi Dr. Stanfield, did you read ref [61] mentioned in your presentation? In that paper, it says that NAC supplementation can also nullify the beneficial effects of exercise in rodents and humans, and accelerate aging. Are you saying that by combining glycine and NAC, GlyNAC will not have this problem? That is, NAC or glutathione supplementation alone may not be good, but GlyNAC is good.

[@rogerpresswood2204]

Thank you for all of your amazing knowledge, passion for health, and these extremely helpful videos along with letting us know about which supplements you take and why. We appreciate you!

[@davidottolenghi5880]

Your work is appreciated. Thank you

[@edvedder7835]

Thanks for the video Brad. I think there are human studies showing increased grip strength in elderly people that took glynac.

[@ratherrapid]

which likely is the real benefit of glycine. I began taking it and hylaronic acid for skin benefits and saw none. But later realized while taking this supplementation a lot of my weather related joint and bone sorness disappeared--believe glycine supports collagen, and that might be what really happened to these mice.

[@chrisconnor8583]

This has become my favorite health channel on youtube. Thanks for the quality content. I have a question regarding using my collagen supplement that contains 2.2 grams of glycine and 0.6 grams serine per serving and adding n-acetyl cysteine Do you think this would be a good idea?

[@ThomasNorthener]

I have suplimented with GlyNac since march this year. And I feel better. It has definitely made me stronger 💪 I'm near 50 years old and just started a bit of body weight workout and right of the bat I do more push up more often then I could even when I was 25 years old. And a I don't get sore muscles, which is insane 😮 A few years ago I did Keto and strength training, but even then I don't think I could do push-ups as easily as now. Powerful stuff 😊 thanks for all the info about this.

[@tatianaa.3694]

Thank you very much for all the information!!! ❤. I personally don't know what to do. I'm in my early forties and I really want to have a plan to reverse aging, but I'm confused with all the information out there, for instance, I'd started to take resveratrol few month ago but then I stopped when I saw one of your videos 😉. So right know I don't know what to take a suplement, maybe vitamin C? or vitamine D? As antioxidants... I really don't know 😅. Greattings from Spain! 😘

[@bobyboby372]

When you are taking NAC each day, you get serious deficiency of B6 vitamin. Because the NAC is blocking of absorbing of B6 vitamin. So you have then supplement also a Pyridoxal 5'-Phosphate (P5P), which is converted B6 vitamin.

[@SLUMP317]

What’s your source that it causes a deficiency? I can’t find any articles or videos on that in particular.

[@naughtyorgneiss]

a simple amino acid blocks b6. you better bring receipts when making outlandish claims

[@Brandoni65]

There have been updated studies showing reduced glutathione does absorb and increase glutathione levels over time recently. In part possibly I believe by simply breaking down the protein and sending it throughout body so it can synthesize its own with building blocks. There is a sublingual glutathione low dose that will absorb directly under tongue and can be adjusted as needed. Also has couple ingredients involved in the recycling of l glutathione. Astaxanthin is one of the best antioxidants and never concerts to an oxidant form. It can help maintain even other antioxidants such as glutathione.

[@WwJd2tmthy1]

Yes, Astaxanthin is marvelous lol

[@Brandoni65]

@@WwJd2tmthy1 lol? Do you not support the benefits of astaxanthin?

[@MrBeckala]

I have been taking from 1 to 2 gm NAC daily depending on local covid rates...I also take 5 to 10 gm gelatin which should give a fair amount of glycine. I will now add some glycine & use up the serine I have....I am 74 years old

[@alphamale3141]

I supplement daily with whey protein and collagen peptides - both contain glycine. Should I also take a glycine supplement? Should I also take a NAC supplement?

[@schesche69]

The right way is to boost MTHFR !! Methylcobalamim, (5-s folate, and trimethylglycine plus NAC.

[@Total_Body_Fitness_USA]

Using precursors is a great way to increase glutathione levels. However, anything you can do to reduce toxic load will increase glutathione levels. For example, using an infrared sauna, taking a supplement called R-Lipoic Acid, and for those who can't tolerate NAC, you can try SAMe. For those looking for a non-supplemental solution, 500 mL of alcohol-free beer per day raises RBC glutathione 29%! There are many other examples of foods that increase glutathione. For example, 83 g/d of almonds increases glutathione in smokers by 16% and decreases their DNA damage by 29%.

[@markveen1373]

Eat hemp seeds and pumpkin seeds. You'll be getting plenty of glycine and cystine.

[@kathleen9456]

Eating pumpkin seeds as I read this 😁

[@davin8r]

Studies are done with n-acetyl cysteine, not cysteine. NAC works much better

[@AnotherproblemOn]

@@davin8r so hemp and pumpkin etc inneficient?

[@davin8r]

@@AnotherproblemOn correct. Seeds are healthy, but they aren't going to provide the (potential) specific benefits of GlyNAC

[@uelude]

How many hemp seeds do you need for 3g glycine and 2g NAC?

[@rebeccar1036]

I took NAC & NAD when I had Covid. However, long term use has given me pause as there are conflicting studies on NAC and cancer. A lung cancer study in Sweden was halted because tumors increased dramatically in participants. Apparently it limited the expression of a tumor suppressor gene that is activated by DNA damage which NAC prevents. Then there are other studies that say it can prevent cancer by eliminating the proteins need for the cancer to survive.

[@rebeccar1036]

@@everymanisyourteacher9951 Thanks. The studies I read were on NAC though, not NAD

[@tfouto]

@@everymanisyourteacher9951 how do you know if you dont have already cancer cells in your body?

[@tfouto]

@@everymanisyourteacher9951 you can have a cancer and not know it yet.

[@alancook9102]

Thank you Brad. And thank for the warning on Glutathione lipsomal. Agree, won't touch it. But might try glycine with NAC. One thing. Have recently seen Niacinamide recommended over NR and NMN because more effective. But without advice I could trust won't risk because fear of overdosing. Any thoughts?

[@naughtyorgneiss]

his thoughts are to take apigenin like he has explained in other videos

[@juliahello6673]

I took glutathione supplements. I had standard blood tests done and they picked up some of the supplements I took and talked about how they might have affected the tests. One of these supplements was glutathione. How did they pick up on the fact that I was taking glutathione if it is broken down in the gut?

[@franciscunningham1939]

Although quite specific there are studies indicating NAC to help promote cancer growth.

[@pedecia]

For somebody with cancer I would be very careful using NAC and Glycine. They have been fund to increase cancer growth in aggressive fast growing types but not the slow ones.

[@stevenirby5576]

One thing I've realized after watching your videos, there are too many unknowns about what actually works for longevity. As you said, we need a lot more research and big studies on a lot of this stuff. For now, I'm holding off until there's more research and data into what actually works. I'm sticking to intermittent fasting, vitamin D, and eating well.

[@bobleapyear]

Dr. Brad: Is Betaine (trimethyl-glycine) a source of glycine as well as being a methyl donor? I take both glycine and TMG. Too much?

[@jdtransformation]

I’m also very interested if TMG is a good way to supplement glycine. I understand that the methyl groups are also very supportive of methylation - caused by both aging, and (potentially) as well as supplementing w/ NAD+ boosters like NMN.

[@uelude]

The issue is dosage, how much TMG are you taking per day?

[@SL-bu6qj]

@@uelude I would like to know this as well, I have just been taking it every other day

[@bobleapyear]

@@uelude I take 3g glycine and 1 g TMG daily. The question is, how much of the TMG counts as glycine?

[@naughtyorgneiss]

@@bobleapyear it doesn't matter how much glycine u take, the upper limits for toxicity haven't even been discovered yet

[@QHWelness]

Good job mate, just came across your channel, I’m passionate about biohacking and integrative/functional Med 💚

[@Metabolism_Matters]

Amazing news and as always very well documented and informative video, thank you!!!

[@anthonymccollim3769]

Dr Brad can you please clear up TMG versus Glycine? If we take TMG does it have the same affect on this pathway as just Glycine or should someone take both?

[@MegaLeoben]

Great question

[@michaelprotz4875]

Brad, thanks For the video. I was planning to take serine, But recently read concerning things about its impact on colon cancer. My genome sequencing puts me in the 100th risk percentile For this kind of cancer and I already had three Adenomas. If you search the research you will find Various studies talking about serine deprivation for treating colon cancer. At the same time, it seems glycine is important in cancer metabolism but that Glycine supplementation reduces inflammation and therefore perhaps the risk that you get cancer. I currently take glycine and collagen since the evidence seems overwhelming that unless you already have cancer this is probably good for you. But in my situation I continue to be fearful of serine. I would be very interested in your views as to who can take Serine. Can I? Thanks.

[@michaelprotz4875]

Hi Brad. Any thoughts on this?

[@leoderiviere1685]

What if the cellular autoregulation is genetically deficient tho? I am severe g6pd and apoe4/4, my NADPH pathway is severaly limited. Taking Glycine + NAC would most likely be more nutrient that cant be used properly while L-Glutathion can directly go and help repair the damaged BBB anyway no?

[@inhocsignovinces8061]

Luckily, I've been taking 1 g NAC and 2 g Glycine daily since the start of the pandemic. I guess I'll just keep going with those two supplements.

[@elizabethanderson2968]

Brilliant info!

[@faithwhite3175]

Wish I knew when I was younger! On NAc and whey protein powder due to chronic long term health issues.

[@anthonyd5643]

Thank you doctor for the excellent video. Will you be supplementing with 1.5 g of NAC and serine together or 1.5 g of each?

[@anthonymccollim3769]

I already take TMG with NMN. Would taking TMG be the same as just Glycine? I kind of confused about TMG versus regular Glycine

[@EDJOH1]

This is a good question that many including me seem to be confused about.

[@ashafir20]

Already started taking Glycin + NAC

[@andreigheorghe3135]

Amazing video!

[@rappar9673]

Looks very promising, looking forward to more studies, ideally in humans.

[@stanthompson9379]

Lol “we are not inbred” it kills me every time this is the third video of his so far where he’s said that and every time it makes me laugh the way he says it so seriously. Love this man.

[@Fearzero]

Some people are inbred. Watch an episode of cops.

[@billb5732]

Is that true even in New Zealand? ;) (just kidding)

[@amperage8032]

I caught that too. He doesn’t skip a beat, on to the research. Love it!

[@lisamariehausmann9330]

I use a vegan protein drink (pea protein) that contains 280 mg Glycin, 100 mg Cystein + a capsule with 200 mg NAC. I take this combination either after my training at noon or sometimes in the evening on training-free days. So far so good. BUT now i'm confused because Dr. Stanfield said in a previous video that we should not take antioxidants close to exercises - but these protein drinks are designed for consumption after training in order to get proteins and avoid carbs after training. Maybe it would be better to take it in the evening only?

[@Brandoni65]

Antioxidants ate best post exercise imo and well in advance to training. However I take a sublingual low dose l glutathione sometimes just before and always within time afterwards. Reminds me to take it now lol which is a couple hours post exercise

[@Brandoni65]

I want to add, towards the end of a light case of Covid this year, I felt muscle pain n legs especially right. I used sublingual laglutathione doubled dose of astaxanthin amd doubled dose of Quercetin and pain resolved. I have yet to test if increasing my antioxidant levels helps me and improves my exercise performance. I also want to test how antioxidants affect exercise BEFORE the workout by my running times and strength.

[@lisamariehausmann9330]

@@Brandoni65 Thank you. I don't anything but water before my training in the morning; first meal is at noon. And I think I'll stick with my usual behaviour and take my protein drink and the NAC right after the training.

[@uelude]

200mg is too low, you want 8 times that. Get a kg glycine for cheap and couple g a day. 3 x 600mg NAC capsules

[@lisamariehausmann9330]

@@uelude Thank you!

[@silviadavella4856]

Wow awesome!!

[@shantube75]

I have completely cessated my liposomal glutathione after your previous video and my re-evaluation of the methodology's potential harms on certain cell lines of my body. What is the thought around SHMT? The first thing that popped up is the awareness that cancer cells over-express SHMT to support their growth cycle. Do we really need to forcibly move the folate cycle? Regardless, the core point of supporting endogenous creation of glutathione so that the cells control their levels is spot on. I also like your thoughts on blocking CD38.

[@Disasterina]

Another great video Brad! Already taking Serine but now I’m going to add NAC on your recommendation!

[@belvedere92]

Dr. Stanfield, it would be helpful if you can tell us what foods naturally provide serine and or glycine. Thanks.

[@Biohacker24]

collagen supplements or bone broth have lots of glycine

[@KatGomer]

Eggs provide serine. Salmon & marine collagen provides glycine. Even peanut butter provides glycine.

[@billb5732]

Skins (like chicken and sardines), bone broth, gelatin, the liquid on the bottom of a rotisserie chicken, cartilage and connective tissue, and collagen supplements are all good sources of glycine. All except collagen supplements come from nutritious whole foods.

[@DrBradStanfield]

I think the community has come together to provide you some good answers. Love this place 😀

[@eddiepersa1752]

@@billb5732 Do you mean that Glycine from collagen suplements do not count for combining with NAC ? thanks !!!

[@ricodelta1]

Thanks for the video. Supping with nac and glycine as we speak. Currently 39.

[@browneyedgirlFL67]

Can you recommend a good brand for Glycine and NAC? Thanks

[@DivineSource444]

QUESTION: does taking a glycine supplement increase my risk for breast cancer? (re: glutamine levels).

[@michaelsnedeker5555]

Thanks Brad

[@ilianiliev6848]

Hello Dr. Stanfield, is this supplement same as SERINE you are talking about: Phosphatidylserine Thank you in advance!

[@nickjacques6087]

It seems that this is a combo supplement best taken at night on an empty stomach rather than during the morning or afternoon. Because, it may interfere with metabolic processes during the day...

[@MrZenzero2001]

Thanks for another great video. Can we use whey protein concentrate (e.g. grass fed) as an effective source of cysteine, serine / glycine for the production of glutathione? I used to suffer from CFS and I found high quality whey protein concentrate to be of great benefit to me. Many thanks

[@babyamom2004]

Yes absolutely and it’s better absorbed this way rather than taking capsules. Make sure you are not whey intolerant.

[@mailelement1100]

It's definitely worth some consideration. With more time, maybe I'll get a few more things right eventually.

[@felicisimomalinao698]

Excellent....!!!!

[@DAVE_WHITE]

Sulfur is found in two amino acids in food: methionine and cysteine. It’s primarily derived from dietary proteins, such as beef, fish and poultry. However, there are vegetarian sources of sulfur as well, such as cruciferous vegetables like broccoli, Brussels sprouts, cauliflower, kale, watercress and mustard greens. A number of human and animal studies have found that eating sulfur-rich vegetables may reduce oxidative stress by increasing glutathione levels (3Trusted Source, 4Trusted Source, 5Trusted Source). Allium vegetables, including garlic, shallots and onions, also boost glutathione levels - likely due to their sulfur-containing compounds

[@EDJOH1]

Any idea about wine? It usually says contain sulfur. It is probably added for some preservative reason and the ones that doesn't contain sulfur almost use it as a marketing point but maybe some sulfur in the wine is not so bad.

[@erikheen1291]

I'm 58 and I've just started taking 1.5 mg twice daily of both NAC and Serine and will see how it goes. I also take megadoses of Ficetin for three consecutive days every month, (2,000 mg per day) so I hope that doesn't complicate anything.

[@barkmaker]

I already supplement with both. I’m 56 and haven’t felt this good since I was 13. I’m physically more fit now than I’ve ever been. Be forewarned though, NAC supplementation could lead to your sphincter being classified as a weapon of mass destruction. Stuff stinks going in and is even worse on the tail end.

[@rebeccar1036]

😂 Took NAC when I had Covid, knew I was getting better when I could start to smell it.

[@browneyedgirlFL67]

Can you recommend a good brand for NAC?

[@barkmaker]

@@browneyedgirlFL67, Best Naturals is my favorite source for everything I can get. Second choice would be Puritan’s Pride. Coming in at a close third would be Life Extension. Go Best Naturals if you can.

[@barkmaker]

@@mikefranks4528, I think you accidentally replied to my comment.

[@mikefranks4528]

@@barkmaker thanks. My iPad does not reply properly with KZbin I can only reply properly in desktop mode. Thanks for letting me know.

[@marcush2461]

Did you see the even more recent study with more encouraging results? The dosage is quite high though so am wondering whether we need much higher doses for benefit or not.

[@marlobardo4274]

Does trimethylglycine have any advantage over glycine? And is Serine still the preferred option over Glycine in the case of MTHFR?

[@render5853]

Have you found the answer to this?

[@Casey-rr7th]

Hi Dr. Brad. Quick question: I noticed that you mentioned taking equal doses of NAC and Glycine. I currently take 1 gram of each (at night becuase the glycine helps induce sleep too). If I want to increase the dosage would you recommend taking equal amounts of each? Thank you. Great and relevant info as usual - thank you!

[@stanthompson9379]

I take 80mg NACET aka n acetyl cysteine ethyl ester which is the turbocharged version of NAC I weigh it out in a capsule then I add 500mg standard NAC to it and I take 500mg Glycine along with it. You mentioned liposomal glutathione but I wonder if you’ve heard of the newer form called “S-acetyl-Glutathione” it’s apparently a form that your body can actually use with decent bioavailability but I don’t know since I take the fancy NACET along with my NAC I don’t need it. I have a vial of injectable glutathione dosed that 200mg/ML I rarely ever use it though I give it to my parents sometimes when they’re sick or when I’m sick or something or just not feeling well or going through a stressful period only then I’ll take like a 100mg shot of glutathione but like I said that’s extremely rare. The thing is I’m so confused because apparently if you take too much antioxidants it can reduce your lifespan as well it can have like an opposite effect. I remember you talking about this once I think it was when you were referring to Alpha lipoic acid in a video you mentioned that taking it daily was actually bad for lifespan because we need some level of oxidation. Knowing that makes all of this so difficult how do I know if I’m taking enough or too much?

[@westruitt2149]

68 hrs old and taking 150mg of serine and NAC twice daily for about 6mo. and plan to continue doing so.

[@ralfandreakkd4368]

According to the sketch shown, glutamate is also needed in addition to glycine and nac to produce glutathione. That is why I also take glutamine. I wonder why it is not mentioned?

[@MegaLeoben]

Because cystein from NAC is converted to Glutamate automatically.

[@GM4ThePeople]

I "microdose" something in the order of 0.5g glycine & 0.5g NAC, about once a week (among other things in a health/life extension stack). I sleep longer after taking the stack.