Does Glycine extend Lifespan? [Study 297 Study Analysis]

[@Physionic]

No Amendments, currently.

[@szlagtrafi9115]

Why does glycine make me extremely sleepy? Same goes for magnesium, taurine, niacin, pregabaline - all these (incl. glycine) have something to do with GABA receptor so this may be the culprit but how do I counteract this sleepiness. That is the question.

[@Physionic]

Glycine is used for sleep. :)

[@szlagtrafi9115]

@@Physionic Exactly, but the extent at which it causes me sleepiness is bothersome. That makes using glycine simply impossible for me. There must be something messed up in my brain...

[@midevo_]

@@szlagtrafi9115I actually have a relatable situation whenever I drink coffee but not with caffeine supplements. I was wondering why but did not find a solution as of yet.

[@PollyAmorous]

@@szlagtrafi9115Take at bedtime.

[@pohaa]

Best bio-med videos on KZbin. Hands down. This guy could have a series on TV. It would be awesome!

[@movewithmike]

Thanks again for your approach to sharing these research studies. You arent like many KZbinrs who hype results to get likes. You are doing a great service to science snd your fans by making these clear videos! Thank you and may you live long (and prosper).

[@Physionic]

Thanks, Mike. My main priority is being realistic (but still fascinated) by the science. Plus, people lose trust in you if you just hype everything just for the sake of it.

[@yeahnahyeahnahprivateacc]

Underrated channel.

[@HisCoconutGun]

I've been taking 30g glycine per day for 5 years for a sleep condition. Havent had any side effects except occasional upset stomach. I am a healthcare provider and have extensive bloodwork frequently including ammonia levels as I've read some studies that high doses of glycine may raise ammonia levels. Liver, kidneys, cardio panel all good. Im in my late 20s so life expectancy benefit TBD. Just sharing my experience. Thanks as always, Nicholas.

[@unou12die]

Just a Google search shows no side effects up to 80-90g a day, and glycine is stomach protective it's NAC that can give stomach aches and your in your 20s so I doubt you take NAC. Although glycine can lower blood pressure (works like an antioxidant) and does have a few weird effects in high doses like odd dreams and lowering body temp(can help with sleep) slightly

[@aurapopescu1875]

Why such a high dose? Did you try a lower dose and it didn't work? I am also interested in Glycine for sleep.

[@HisCoconutGun]

@@aurapopescu1875 I have a severe sleep condition. For most people 1-3g is enough to see improvements in sleep.

[@larsnystrom6698]

I supplement with at least 10 g of glycine a day. But also with 4 g of creatine, and that takes away some of the demand for glycine. I also supplement with maybe 12 g of hydrolyzed collagen. The idea is to supply the rest of the amino acids the body needs to build its own collagen. All the 27 or so different kinds of it 🙂 Well, I supplement with more things than that, but the rest isn't glycine-related 🙂

[@aurapopescu1875]

@@larsnystrom6698 Does the glycine help with sleep?

[@davefit-areyousaturated9830]

I started taking about 9g of glycine a day divided into 3 servings of 3g, At night I take 3g with NAC before bed. I’ve noticed a significant improvement in my skin, face is smoother, firmer etc. I started taking based on age loss of glycine and for joint improvement etc, but the noticeable skin improvement was a nice bonus. I knew it was good for the skin just didn’t expect to see those results so quickly.

[@rajanganger5942]

I take all in powder form in water as follows, NAC 2 grams, Glycine 3 grams (plus in coffee so total 12+ grams, Taurine 5 grams and MSM 3 grams.

[@miracoli16]

How long did it take to see/feel improvements?

[@davefit-areyousaturated9830]

@@miracoli16 I noticed a difference in my skin in just a couple days, and it kept improving for another several days, then just maintained

[@aurapopescu1875]

9 grams is a lot! Did you see any improvement in your sleep?

[@rajanganger5942]

@@aurapopescu1875 I sleep like a baby even before taking supplements. But now I struggle to get up in the morning, I can sleep for 12 hours even before taking glycine (caffeine has no waking effect on me).

[@roqclimber]

Gly NAC is still a good bet. I've been taking NAC for asthma and osteoarthritis for over a decade. Last year I added TMG. With my other supplements, I'll live forever!

[@MochaZilla]

Nice! Do Not Age brand?

[@EhurtAfy]

Just making sure, you do have your aerobic, resistance training, and sleep on point as well right? A lot of people take supplements but don't exercise or have their diet and sleep in order

[@larsnystrom6698]

Glycine is the first limiting amino acid for our production of glutathion, L-cysteine is the next one. So GlyNAC is good for us. But the research saying so utilized 100 mg/kg bodyweight of each. A capsule of GlyNAC, what is it 600 mg? Wouldn't do much, would it? My advice is take glycine as a powder. Use it as the only healty sweetener there is. And then take NAC in capsules, because it tastes badly. Or even take L-cysteine (Thorne sells that), or both that and NAC. NAC has an anti-mucus effect. Might be good for the lungs, but is too much of it good for the intestines?

[@chriseneim1]

Mac should not be taken for long periods. It is good for short term benefits, but if you look into the studies, you can actually have downsides from NAC in the long run if taken long-term, it happened to me I felt great for a while then all of a sudden out of nowhere after about a year of taking it I woke up with morning and was wheezing and could barely get a breath And that would last for 20 minutes or so first thing in the morning it was so scary so I went to the doctors. He asked me if I’ve been taking anything. I told him yea nac he said it can cause an allergic reaction to to show show up if taking long-term and it’s an asthmatic condition. I don’t have asthma ever in my life. It was so scary for a few weeks. It was doing that. I literally was so scared so I stopped taking it and about a week later all the symptoms of the asthmatic fits disappeared. Plus, glutathione is good when your levels are in balance too much of it can be a bad thing and if you have undiagnosed cancer somewhere, it can be a really bad thing just my experience. But pure glycerin powder has been an absolute godsend, or a single side effect, only benefits I have never found a supplement or a amino acid that does the job that glycine on its own does.

[@michael-qp9xd]

Hello - i too started on glynac so taking about 3 grams gly and 3 grams nac. But then saw that nac has a side effect of cartilage and joint breakdown in some. But many other benefits as u mention. But to be safe now back way down on nac so at maybe now 0.5 grams. Don’t want to risk any joint damage as maybe not to notice till after much breakdown. This just an fyi as maybe not this bad effect for all.

[@jaytm2574]

Taking NAC and TMG daily and I've noticed my physical resiliency has gone up remarkably.

[@ilevitatecs2]

There are too many well designed studies on glycine to review for a variety of end-points-including its role as a secretagogue of GLP-1…which is entirely a separate mechanism from others including scar tissue repair/development, motor function, systemic inflammation, collagen synthesis, glutathione production…it’s such safe bet to take exogenously with low hazard ratios that one of the mechanisms will benefit longevity more than relying on endogenous production.

[@13thbiosphere]

glycine can help limit the damage caused by reactive oxygen species (ROS). Glycine is a simple amino acid that has several roles in the body, including acting as an antioxidant. Here are some ways glycine can contribute to reducing oxidative stress: Glutathione Synthesis: Glycine is a precursor for glutathione, one of the most important antioxidants in the body. Glutathione neutralizes ROS and protects cells from oxidative damage. Anti-inflammatory Properties: Glycine has anti-inflammatory effects, which can help reduce inflammation-induced oxidative stress. Membrane Stabilization: Glycine can help stabilize cell membranes, making them less susceptible to oxidative damage. Inhibition of ROS Production: Glycine can inhibit the production of ROS in certain cellular pathways, thereby reducing oxidative stress. Cytoprotective Effects: Glycine has cytoprotective effects, meaning it helps protect cells from various types of damage, including oxidative damage.

[@Mind69420]

Glycine is one of my favorite supplements for sleep quality. I've always had issues falling asleep but glycine helps me unwind enough to go to sleep if I try.

[@Beans-great]

I’ve been taking 6 grams of taurine for the past two weeks and am noticing some improvements in energy, strength, sleep, and skin health. All anecdotal but definitely noteworthy.

[@nicolatesla5786]

Who sells them ?

[@husseintammam4691]

Haven't watched the video yet, but sooo excited to see this. I'm really interested in glycine and red light therapy. I sent you a big comment on your older collagen video about glycine where I asking if the benefits of collagen supplementation could instead be to due to glycine rather than the specific collagen peptides. Do they have distinct benefits? I don't know if you address that here, I'll watch the video and edit this comment if so lol, but I think I'll definitely be joining your insider's community soon. I'm in love with your content man. its so awesome what you're doing. I'm so tired of all the youtube researchers with blatant agendas/extreme confirmation bias whether that's keto, high carb, vegan, carnivore, obsessive contrarians that are against any conventional medicine or peeps that just tryna prove that anything new or alternative is dumb. I also love that you're very careful about what conclusions we can draw from the evidence and just accepting that sometimes we just need more research, I think that's often the answer to a lot of issues.

[@AstonAcademia]

siim land joined the chat.

[@geladaizlabon3605]

😂 they should collab 😂

[@larsnystrom6698]

Slim Land and Dr diNicolantonio's book about Collagen seems to align with the research paper: A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis ENRIQUE MELÉNDEZ-HEVIA1 et al I don't remember if they referenced that paper. But their conclusions certainly does align. At least 10 g more glycine a day to fulfill every need.

[@jackbuaer3828]

LOL

[@christiancrafoord]

@@larsnystrom6698 10 g more, or 10 g baseline. so if i take collagen 10 g, then 33% would be glycine = 3g. then i supplement 6g --> = 9g, then 3 g from diet totalling 12 g? would that be sufficient?

[@chriseneim1]

I take 5 g of glycine before bed every night I have been for the last year. I work all day in the sun. I’m extremely exhausted. My body should be absolutely torn up every day, but let me tell you. I may only get four hours of sleep, but I have never felt better since I started taking glycine I sleep so good. It’s almost like it’s too good to be true because as soon as I stop taking it just to see if it is actually the glycine that’s making me feel good. I get really exhausted the next day after a long day at work and my body aches. I have taken NAC before for long periods of time, but my current regime is a gram of calm, magnesium citrate 5 g of pure glycerin from now company straight in the mouth. It’s sweet it taste good and then a gram of Ttaurine crystals powder in hot water with the magnesium I have never felt so amazing. And I do those sleep apps where it listens. If you snore, I used to snore and talk like crazy ever since I started my glycine regime I get maybe five minutes of snoring in a whole entire night when prior it was like an hour and a half to two hours. Like I said I get four hours of sleep some nights and wake up feeling like I got 10 the stuff is amazing. It’s so amazing.

[@shaunanorman4804]

What are the crystals you take ?

[@jamesalles139]

thanks for the post I am starting on Glycine + NAC

[@richardtibbetts574]

I take half of my daily dose of glycine in my bulletproof coffee. It makes the drink sweet, without the negative effects of sugar or artificial sweeteners.

[@Dan-dg9pi]

By sheer coincidence, just yesterday I was discussing Prolegomena to any Future Metaphysics with my pet mouse. He thought Kant's analysis suffered because he completely ignored the topic of cheese.

[@larsnystrom6698]

It's a myth that mice like cheese! My mouse friend told me that they eat anything, even cheese. Although they prefer to be herbivores. They just hate keto!

[@Physionic]

😂

[@christianlamb2276]

Your videos have sparked my interest in free-form amino acids 😊

[@glenntimberlake2413]

Thank you for talking on these subjects. Most appreciated.!

[@whitewolf6730]

Well, I’ll be darned. I just took it for sleep. I am a non paying member of your community. Maybe one day I’ll upgrade. I really appreciate the way you tackle things and show great easy to read charts and data to support what you are communicating. I do have a Science background however. My wife or my brothers might get lost in some of this, but I appreciate it a lot.

[@aurapopescu1875]

How much do you take for sleep?

[@bobbyventon5015]

Your mentioning of pro-inflammatory molecules and immune cells inspired me to dare to ask you a question. Have you ever run into studies analyzing how metabolic health is correlated with allergies? I know I'm just an n of 1 but I'm simply flabbergasted that this season my hay fever responded to treatment tremendously well and over the past 15 years the response was just a minor improvement. The variables that have changed the most are that I lost a lot of excess fat last summer and have been exercising quite regularly since then (i.e. I've built some muscle). Sleep quality has improved a lot as well. Another crazy side effect is that - again, after 15 years - I no longer experience hangovers (I used to get them after literally one beer). I'm obviously very happy with my improved health but I also wonder - is it mere coincidence or is there research linking metabolic health to such things, especially allergies. If this is a question you'd be happy to investigate if only I were a Physionic insider, state so bluntly! 😅

[@Physionic]

I haven't looked into it, but I know that immune cells become more or less inflammatory/activated based on their metabolism. They tend to become more active when they use glycolysis (carbohydrate metabolism) and less so when using fatty acids - there's some nuance there, but it's generally true. I suppose that might affect allergies if it applies to cells like granulocytes. I do focus my attention on what the Insiders want me to cover, mainly because I receive at least 50 requests a day and as I'm one person, it's impossible for me to meet that demand.

[@bobbyventon5015]

@@Physionic Thank you so much for the response! I'll try to digest it when I have a few spare minutes and if I'm hungry for more I'll surely join those 50+ crowd 😁.

[@RchamTV]

Donghua Jinlong industrial glycine

[@charleshartlen3914]

instant sub for this level of content. thanks a lot for this and in the future ill be considering your insider group!

[@joeblair774]

Thank you, next time please mention how to join your course please maybe at the end of your video but anyway you are the most informative KZbinr I watch and i greatly appreciate the time & effort you put into your videos much luv and respect

[@MrXharbour]

If glycine blocks methionine from triggering mTor, then should it be avoided after resistance training for a few hours (or more)?

[@charlesfuchs]

Nope, you will get ripped

[@incognitotorpedo42]

If that mechanism is a strong enough effect, and if mTor activation by Met is sufficiently important in exercise-driven hypertrophy, then yeah. Without knowing either of these, I'd say go ahead and avoid Gly after workouts (for the next 12 hours for example). That's not a big deal unless you are working out a lot more often than I do.

[@andremdm2008]

It'd be great if you made a video to clarify the link between glycine and cancer. It seems it is, like serine, used a lot by cancer cells.

[@larayilmaz8689]

I would be glad if you could answer. After using nac 1200 and glycine 10 gr, my liver enzymes are at 160. I use 15 mg mirtazapine and 1 gr clonazepam in the evening. I had a test done when I used these and there was no problem. Do you think I should stop using nac and glycine?

[@devlogicg2875]

Thanks Doctor. Is the new UTexas study relating to telomerase reverse transcriptase (TERT) valid in your opinion?

[@joen.8364]

Thank you for addressing this sir!! I just provided links below for anyone that wanted to see some data.

[@oibal60]

Thanks again.

[@christianlamb2276]

Thanks, Doc, for what you do 😊

[@fishnski9211]

Ive gone down the rabbit hole of longevity supplements but we all have to be careful in our doses..more is not better at this point imo...there will come a time maybe by AI a formula that gives proper doses that don't tip the balance one way or another...im thinking that lower doses until further notice would be the prudent approach...

[@nimblegoat]

eating well, exercise , keep moving , keep doing. Is the most simplest and is all 100% proven. My take is keep supplements to minimum and well proven , that have little or no downsides, unless you are taking bloods/tests to see doesn't affect you

[@edvedder7835]

Great content. Much appreciated! I've been combining Glycine/NAC on and off for the pass 4 years, boosting gluthiaone. Glycine helps for sleep. Kumar at BSW from Texas had a very compelling paper. Could you consider Rapamycin/Sirolimus as an upcoming content video? Thanks.

[@overandoverandover56]

I was taking glycine at about 3 grams per day. Rat studies suggest glycine increases bleeding time and this has been my experience leading to systs that had to be lanced and took weeks longer to heal than expected. Be very careful with glycine if you have any bleeding risks

[@terminator3728]

Take 4-5 g a day never experience this or heard anything about it

[@larsnystrom6698]

I was surprised by this, so I googled it Glycine reduces platelet aggregation Peter Schemmer et al Surprised that there were some truth in it. I myself haven't noticed anything like that from supplementing with at least 10 g a day for a long time. But healing wouldn't slow down by that. I would guess reduced collagen production could be the culprit. Glycine or collagen should help with that, not hinder it. Copper and vitamin C is also needed for that to work properly. By the way, less sticky blood platelets is something many actually want. Less problems with blood clots, one would think.

[@jaykraft9523]

Looks like you're analyzing a somewhat old 2019 ITP study (you seemed to disclose less about the study as usual), with unexceptional results (e.g. 4% lifespan increase), whereas the Baylor results on GLYNAC (Glycine + NAC) are way more exciting (over 20% lifespan extension). What would be REALLY nice is for another center to study GLYNAC besides Baylor since nearly all GLYNAC results have been from the same center (Baylor).

[@Physionic]

It's the only glycine ITP study I know, so the age of the study shouldn't matter. I've covered the GlyNAC Baylor studies at length, so there's no reason for me to cover them here, as well. One thing at a time, otherwise things get confusing.

[@keithbyrd7566]

Why do you choose to be condescending in your comment? What value does that tone add to the quality of the discussion?

[@werundwarum]

@@keithbyrd7566​who hurt your feelings? There’s absolutely no tone whatsoever in his comment?!

[@jaykraft9523]

@@werundwarum correct!! critical maybe, condescending no.

[@jayalanlife5926]

Ok my opinion is that Nic is one of the softest, nonconfrontational, high quality KZbinrs around, if you find his humor not to your liking find someone better and go

[@saralakushwaha1180]

Thank You

[@jdavidmorris7853]

I take Magnesium Glycinate. Any relevance? Is it a source of glycine?

[@aurapopescu1875]

Good question.

[@Discostick55]

Interesting. Gonna have to finish watching the full video but I'm reminded of a few years ago there was a 'scandal' in whey powders that they were 'spiked' with glycine or taurine. Funnily enough maybe if these appear to be beneficial, that could actually be something you want?

[@Physionic]

Interesting, I never heard of that. I remember preworkout powders being spiked with meth like molecules at one point.

[@frankenz66]

I have been "doing" 3 grm of glycine and 3 grms of NAC daily. Seems pretty nice. I can tell if I go without a few days. Which I do to not let my body get accustomed to "needing" anything. Of course I do meat and milk so glycine is supposed to be in there. Thanks!

[@jaykraft9523]

same regimen for me for about a year now, nutricost powders of both

[@miracoli16]

Meat and milk aren't high in glycine.

[@frankenz66]

@@miracoli16 Seeds are the only one category where non carnivore foods have decent amounts of glycine. Meat, fish and dairy are otherwise highest.

[@frankenz66]

@@jaykraft9523 I capsule my own powders

[@thomasmuller1850]

I wish to have studies with very healthy fed mice instead of using the standard chow, so you can see if an intervention adding any benefit above that.

[@theochris7088]

make a review of PQQ and ERGOTHIONEINE, thank you....

[@larsnystrom6698]

I didn't know that methionine activated mTOR. And if I did, I wouldn't expect glycine to reduce that effect. I belived that the negative effect of too much methionine without enough of glycine was that it increased the homocysteine level. Although, I haven't seen anyone really show that. But what I've been able to guess about it is: 1 ■ Protein restriction increases lifespan. 2 ■ It wasn't really protein restriction but methionine restriction that did it! 3 ■ it wasn't really too much methionine but too little glycine that did it! That was what I got from a sequence of research articles that didn't really combine those conclusions. Too much methionine can increase the homocysteine level, and that's not good. But is that all? I guess that's for a real scientist to find out, eventually. Meanwhile, I supplement with 10 g of glycine a day.

[@ManlioLoGiudice]

Great one. I'll reach out to have a podcast session with you! Question in the meantime: glycine interacts with methionine and, according to the study/hypothesis, does remove methionine from the cell. How do you see the action of TMG/betaine here? TMG should "convert" homocysteine into methionine. I understand the goal:TMG should give you more energy and it may be good for muscle (see mTOR) vs longevity. So, if I do take both, shall I alternate or keep separate or else?

[@laikiugarland1082]

graphs are lot easier to see !

[@Candyanthrax]

APPRECIATE YOU BRO

[@TekMoliGy]

so does methionine and mtor increase muscle growth and then glycine would inhibit mtor and muscle growth for bodybuilding?

[@photo200]

Great video! Question: It appears that if the reduction in mTOR activity is the driver of the benefits, that depends on glycine being able to accept methyl groups from methionine. If that's the case, would this benefit potentially not accrue to additional consumption of glycine which is already methylated, such as TMG?

[@Blurns]

Whenever a news article or video is a question, you know the answer is "no".

[@michael-qp9xd]

Thank you for great video. I take glycine twice a day - about 2 grams in morning and dinner time. But maybe not good all time as slows down mtor - this needed on days using heavy weight exercise for muscle development? Should avoid glycine then over full day - on days doing resistance exercises? Or avoid 2 to 4 hours before and after only? Thanks any ideas.

[@sergey9986]

If the explanation is correct, TMG (trimethylglycine) should decrease lifespan. It is quite a popular supplement though. Are there any studies on that?

[@Holy.HannaH]

14:36 well I feel called out🤷‍♀️🤣 where are these humans that understand me & Kant better than animals do? At this point Im finding it interesting that all of these molecules/supplements I utilized to keep myself alive are being looked into for longevity in general. I chose them each for their specific methods of action in accordance with what was transpiring in my body/brain at any given time. Barring any specific formula for the specific amount of amino acids our body needs(Ive not ruled this out), from my constant experience Im thinking longevity comes not from a single molecule but from providing your body with what it needs, when it needs it. Not going to the doc every so often and trying different things for weeks or momths at a time. Which requires knowledge & understanding of one's own body as well as the capacity to search, find, and interpret all the data. I highly applaud you for teaching folks how to do that.

[@littlevoice_11]

Regarding gly-NAC, would the benefits of this combination be achieved through collagen 20G (presumably high in glycine) with NAC?

[@glendaguilott3765]

Do you know of any studies for natural cures for vertebral stenosis ???

[@averylweaver]

Hi, Nick! Have you come across any studies on nicotine's effects on oral health? I'm really curious about the effect specifically of gum/pouch/lozenge on oral mucosa (vasoconstrictor is all I've heard). Thanks!

[@hafidzy9675]

I take 5 gram glycine total 15g per day after breakfast ,lunch ,diner help with digstion , blood sugar and also help with skin 👍

[@ivalani]

Here’s a fun topic for you to research (and gain thousands of new viewers): Do semaglutide and tirzepatide heal fatty liver?

[@8964-Winnie-Poo]

Just coincidental, I started taking Glycine few days ago, 1 to 3g per day, I noticed increased energy level with dry mouth. This is the only supplement I added. I was taking Taurine without much feelings which I stopped. The only other supplement I got a strong feeling is Creatine but only for the first time.

[@Alex-yo7sr]

Nick, we often see that these compounds that reduce inflammation and cell divisision/creation increase lifespan Is it possible that inflammation in general and creation of cells cause aging, meaning exercise (which causes both) could be seen as unhealthy?

[@SaxonNinja]

This is really interesting and I'm wondering if you've already done a video on the statistical benefits of creatine supplementation? According to what I've read, creatine consists of the combination of Arginine, Glycine, and Methyonine.... so it seems according to what you've said that it would be a great way to assimilate more Glycine in the body?

[@jenn1663]

He's done multiple videos on creatine along with a book you can download

[@glenntimberlake2413]

That brings up a good point. Or points. I would really like to see a talk that explains where we get Glycine in our diets and in other supplements. How much useful glycine do I actually get when I take Drs. Best Mg Glycinate? (Based on various dosing.) Which food sources have the most Glycine? Is Glycine from these various sources readily taken up and utilized as Glycine in the body? How much Glycine is really necessary for us to get desired results? Do we need to take it before food or is it well absorbed after consuming a meal? - which may be easier on gut “happiness” and keeps a person from tanking up on unsweetened tea (a way to consume sickeningly sweet Glycine) and being to full to eat food. Just honest questions that I believe a lot of people need to know the answers to. And how did my many months of miserable knee pain significantly reduce after adding in Glycine only about a week or less after adding it to the NAC and supplements I was already taking.? NAC and the other supplements combined didn’t do it. It took the addition of Glycine.. (I also take a couple scoops of Creating and a scoop or two of L-Glutamine most days.) (nd for a few weeks I have been taking 3000 mg Ashwegandha at night with hopes to help sleep and lower inflammation and pain issues.)

[@antoninmiquelis4420]

methionine won't do good it's well know that restricting meth in mice diet expand significantly their lifespan but it's not easy/impossible to do it with an omnivore diet even if you have more plant protein than animal

[@christianlamb2276]

I have been taking combinations of free-form amino acids.I have found that threonine,theanine,methionine taurine, and glutamine together along with b6 b9 b12 and betain has a very nice effect along with other combinations free form amino acids are wear it's at.do your research on each one you will discover amazing things.

[@Joe_C.]

What 'effects' are these that you describe as "very nice"??

[@chazwyman]

I wonder if the positive benefit is not about glycine per se, but the simple fact that the glycine fed mice benefit from having an extra bit of protein in their diet. and that this effect could be repeated for any amino acid and not just glcyine. Just a suggestion. Maybe having more protein in the diet causing better satiation, might improve the prospects of mice. It would depend on understanding if the mice are allowed to free browse on food, or if they are calorie and macro measured.????

[@ancesthntr]

Will TMG give similar results to pure glycine with no methyl groups?

[@Beld77]

@physionic can you do a deep dive into molecular Hydrogen and its potential benefits? Whether it be dissolved hydrogen water or hydrogen gas delivery? Lot of promising evidence, but seems too good to be true and would love your take!

[@alansnyder8448]

I'm confused by this request and hope it is a joke. H2 would be a gas and wouldn't stay around in a person very long. Could you mean something else by that?

[@yummymealsss]

One and big question, can we get enough Glycine with diet? Spend money on supplements because of mouse data show that can extend lifespan not best option. It would be cool if you in video, put some foods rich glycine or other stuff that people can think it is worth or not. I would like to watch TOP 5 Amino acid that really worth to buy which will extend your lifespan. Thanks

[@nattydred2593]

Cool. Thanks. BTW The Michigan make effect was not statistically significant, so it was a single site benefit.

[@charlesfuchs]

Glycine changed my life!

[@Nando_lifts2021]

How so? Dose?

[@charlesfuchs]

@@Nando_lifts2021 10 Grams min

[@dbzwarrior4321]

What did it do? Make you look younger?

[@unou12die]

It's can be used as a sweetener, it's 1.5 times sweeter then sugar. That's why I was interested in it at first and I used a lot more daily. Glycine is in collagen, bone marrow, glutathione. It is a life changer as a sweetener or just a supplement and a sleep aid. Easy to add to your routine

[@Nando_lifts2021]

@@charlesfuchs benefits? Changed your life how?

[@anatolydyatlov963]

Oh wow, that lens makes you look even younger!

[@Physionic]

What lens?

[@Maxim.Teleguz]

@@Physionicglasses or new camera lens.

[@Maxim.Teleguz]

@@Physioniccan you do a study on amphetamines over long term.

[@anatolydyatlov963]

@@Physionic The camera - it's different than the one you usually use. For example, your skin looks much brighter

[@unou12die]

​​@@Maxim.Teleguzif your lifespan is a candle just light both ends. That's what happens over time you age faster and die younger but look very old

[@squeakypistonproductions2228]

Can you do a video on plasmalogens and plasmalogen precursors?

[@wstockall]

So does this study indicate that glycine supplementation increases lifespan in mice, or that standard mouse chow is deficient in glycine?

[@MadLadsAnonymous]

What about TMG+NACET? And if we're going with glycine, add some collagen with Vit C, right? So.. TMG+NACET+collagen+C

[@excalibur7185]

Do a piece on allulose.

[@debmanrique6466]

I'm not too concerned about the contraindications for cancer patients- cancer thrives on almost everything we eat.

[@johnrdadrian]

Mr Physionic, I love the topic, and would love to find out what the answer is. But have you listened to yourself. I want to find out if Glycine Extends Lifespan. I'm also interested in negative and positive effects. I'm not interested if a Mouse has Blue Eyes, or where labs get their mice. You talk and talk and talk, waiting for relevant information is too painful. I'll have to search elsewhere. I humbly suggest you focus of the topic, and provide relevant information efficiently.

[@DEValentine]

What dosage of glycine is recommended for adult human males?

[@jeffg4686]

high protein only when wanting to put on muscle. Otherwise, 1 cup of lentils likely enough for the day.

[@samuraibat1916]

New Physionic video let's GOOOOO

[@jackbuaer3828]

LOL at the enthusiasm for a Nutrition video. That was not meant in a negative way in any manner. It's just not something that is typically seen. That's why it's funny to me.

[@samuraibat1916]

@@jackbuaer3828 LOL. I appreciate it. I'm so tired today my levels of excitement are all over the place so I probably seem pretty goofy.

[@wasmagpie]

GLycine completely destroys my gut for days, even in small doses

[@eelcohoogendoorn8044]

Yeah it has a bunch of mild but annoying side effects on me. 3g a day seems fine but I prefer to get most of mine from diet.

[@geladaizlabon3605]

I been using glycine for months 5-10 gm so far i only see positive. Look younger than my twin

[@larsnystrom6698]

Try it as a sweetener for natural, unsweetened whey. It's not really natural to eat single amino acids. Some people complain about a brain effect. So it's wise to test with a small dose and see if you are one of those. Most people notice nothing, though. Glycine is just food for most of us. Glycine is an inhibitory neurotransmitter in the central nervous system, especially in the spinal cord, brainstem, and retina.

[@smarzig]

​@@geladaizlabon3605dose?

[@TheKoPro11]

You probably have low stomach acid then. If the protein is not digested properly in the stomach there will be issues when the protein sits in the gut. It could be worth a try to consume the glycine with acidic beverages like coffee or juice.

[@ΝΙΚΟΣΚΑΤΣΙΡΟΥΜΠΑΣ]

A video about bromelin , please !!!!

[@tequila_baby]

The muscle preservation/growth glicine effect maybe is the reason.

[@jjperry3995]

I cannot take straight Glycine but do take TMG (Trimethylglycine) due to a genetic issue.

[@rlittlefield2691]

I seem to be allergic to glycine . I did not realize this w hen I heard it would stop the aging process, In my case if I kept using it, it would have killed me and so would have stopped the aging process.

[@betzib8021]

But if you have high cell division....wouldn't you reach Hayflick limit sooner and end up with more senescent cells? And wouldn't this accelerate the aging process for anyone....a process that even young, healthy people do not want?

[@TheSmiaf]

Need to ask this probably stupid question.... Asking with a lot of these micronutrients subjects if they help with expanding our lifespan. Could you not ask the same about water or vitamin C? Or is it not that obvious with the last two? So in this case glycine you can find in meats, fish, seeds...

[@dbzwarrior4321]

Guys im 28 years old and i want to try glycine should i also add nac? Also where can i buy theese products safely and what mlg should i take for both?

[@dbzwarrior4321]

​@_zantetsuken_ so should I just take glycine with collegan peptides? I'm trying perseve my youthful skin and body what amount should I take

[@el-artista-marginado]

much much prospèrity for you is my course on you. keep it cool

[@Physionic]

Thank you! Likewise.

[@itzikca]

Will glycine inhibit muscle growth then?

[@maestroharmony343]

I still wonder how much NAC to take. Took 3600 mg a day for almost 6 months, but blood levels of glutathione didn't change significantly before and after.

[@bradleyrm]

You must it in combination with Glycine.

[@maestroharmony343]

​@@bradleyrmI do, it doesn't move the needle.

[@ericalewis9047]

Im curious though, is there not enough glycine in rat chow? A normal person would be eating it in their food and supplementing to get extra. Maybe as long as we have it we live longer than those that dont have it but would supplements making us have extra still cause us to live longer? I used to have rats and i remember thinking their food was just enough to keep them alive, but not great. I also wondered if it wasnt their food causing tumors. I am not sure im saying this clear. I just wonder if its actually showing added glycine helps or having it at all helps, since who knows how trust worthy rat/mouse food is.

[@MrDjhealth]

When it comes to Studies is it possible to have very old obscure studies that have been forgotten about in our current time and shelved collecting dust somewhere ?

[@Physionic]

Mm.. maybe a few, but they're all scanned and collected into the medicine library PubMed - you'll find studies there from as far back as the 1920s and beyond.

[@jimdandy8996]

What about TMG?

[@diamond_s]

how about the fact in larger rats it gave 40% extension and the larger the animal the bigger the effect and need for glycine is expected to be

[@33Crazydude]

Glycine is good for skin youthfulness I hear

[@larsnystrom6698]

Good for collagen production, so yes good for the skin, tendons, ligaments, bone, joints, blood vessels, intestines, and just about everything. There's a lot of collagen in our bodies, and it ages, and has to be replaced. If that's done too slowly we become stiff and wrinkled! The best way is to eat 10 -12 g of hydrolyzed collagen for this. Then you get some glycine (3 g or so), but also the other amino acids needed to build your own 27 or so differnt kinds of collagen. In addition to that, you need glycine for other things too. You would have to eat a lot of collagen to get enough of that. So, I think supplementing also with glycine is very sensible.

[@33Crazydude]

@@larsnystrom6698 thank you 👍

[@richardcottone6620]

except for the mouse in The Green Mile

[@betzib8021]

And then you have to know Stephen King.

[@lawdogwales5921]

Mr Jingles!

[@christianlamb2276]

My comment cut out zink ,very important also in these combinations

[@anymouse6202]

Thanks

[@Soundmind68]

I need me some Donghua Jinlong Industrial Glycine

[@stoppernz229]

Glycine messes with my head...

[@minemilx2702]

Hi, without watching the video yet I just want to bring up glynac and tbe possibility of it being cancer promoting? If it is adressed in the video then don't answer if not, you would be an angel to adress it 😍. I'll become a patreon (probably will anyways).

[@darkhorseman8263]

Glycine isn't that useful when glycine cleavage becomes dysfunctional with age, so it can't be converted into serine. Even worse when the racemases that regulate the conversion of -L handed amino acids to -D handed amino acids become dysfunctional on top of that. These metabolic pathways can be repaired, though.

[@miracoli16]

Glycine can't be converted to proline. They are totally different aminoacids.

[@miracoli16]

Glycine can't be converted to proline. It's a totally different aminoacid.

[@darkhorseman8263]

You're right, I got it mixed up with another cofactor metabolic pathway they are all metabolised through. P5P dependent pathway. Technically, it can be converted to it through a distant pathway linked to AKG, but it is a bit of a stretch.