Nephrotic vs Nephritic Syndrome (Proteinuria, Hematuria, Casts)

Roger Seheult, MD of www.medcram.com/?Y... , illustrates the key differences between the nephritic and nephrotic syndromes.
This video includes proteinuria, hematuria, casts, anatomy of the kidney, glomerulus, and more. This is video 1 of 1 on nephrotic vs nephritic syndromes. See this course ad free at: www.medcram.com/courses/nephr...
This video is part of the "MedCram Remastered" series: A video we've re-edited & sped up to make learning even more efficient.
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Speaker: Roger Seheult, MD
Co-Founder of MedCram.com
Clinical and Exam Preparation Instructor
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
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[@ShimmyMD]

Nephrologist here Great job Roger! If I may add, RBC casts are classic for Nephritic syndrome. Granular casts are actually quite common with Nephrotic syndrome as ATN is commonly seen with it (particularly MCD).

[@howtomedicate]

This is a greatly misunderstood topic, but you explain it very clearly in this video! Thank you 👍

[@Medcram]

Thanks for the feedback!

[@Irene-fi6ye]

Wow. Words cannot explain how glad I watched this video! Thank you Dr. Seheult for the clarification.

[@Reliscian]

dr najeeb needs 2 weeks to explain this

[@turtguyakadanz]

Studying for the LMCC and this is genuinely SO nice and clear, thank you!

[@Xtr3me0wn4ge]

What you are here for starts at 3:09 ...

[@MaximumPotato0102]

Interesting watch. I was diagnosed with Nephrotic Syndrome a few months ago and it's good to get a bit more of an understanding of exactly how it works and what's going on. Any idea when you'll be doing the video on primary and secondary causes of Nephrotic and Nephritic syndrome?

[@mohiuddinjabbar9011]

I love how you guys make even boring topics so much interesting

[@DrUkwuama]

Best video on this so far!! 👏🏽

[@rishiranjan1898]

Was scrolling through google since past an hour.. but couldn't get such clarity. Thank ysm!

[@john.the.beloved]

So perfectly explained!

[@gamzelzem]

Thanks god finally understood underlying pathology of hematuria better. Thank you very much

[@sanist2861]

This is amazing. It is so helpful for real

[@miranmuslem]

Thanks for the video!

[@arpitpanda390]

Brilliantly explained!

[@serotonin1520]

Thanks. It's very helpful.

[@paywandd]

Great explanation Thanks ❤

[@wonderfullymade8690]

Amazing lecture!

[@beeornen]

Such a good lecture! I would like switching halves of nephrotic and nephritic or switch places of the text "endothelial" and "epithelial". Having endothelial right under nephrotic might be confusing.

[@SG333_]

How have I just come across this channel?!!! This video was SO helpful - THANK YOU!!!

[@Medcram]

Glad it was helpful!

[@sarahmassoud6578]

VERY HELPFUL Thanks.

[@john.the.beloved]

Thank you. It makes sense to me now.

[@ClingFilmsClimbing]

Just wondering where to find the videos about causes of nephrotic and nephritic syndrome?

[@alenapawlak6853]

Important topic and everything very well explained! :)

[@dx-mp6kp]

amazing explaination 😃

[@pratapkumardas8662]

Excellent. Understood the points.

[@tonyalee8703]

Very good!!!

[@muhammadaliffarhan1825]

really cool lecture sir, a huge thanks

[@monamahdi8828]

Fantastic Thank you so much

[@ghostghost1629]

Thank you 🌹💎 You are the best💎

[@Valdez9]

Very helpful

[@al-hassanhaider9327]

Thank you so much

[@manaseetelaang328]

Just came back here to say that I studied this video three times to fully grasp it and this was my exam essay question and i drew the diagram you drew to explain the concepts. Absolutely aced it! THANK YOU SO MUCH, I AM SO SO GRATEFUL!🥹❤️❤️❤️

[@mhearsayioh2010]

thank you man ❤

[@mohdirfanmohdiliyas1223]

Amazing video sir

[@DrMelanieGarrettND]

Thank you!!!

[@bengsianglee3051]

THANK YOU SO MUCHHH

[@saranordinable]

Whats the difference of this remastered version with the old version?

[@DrA902]

Thx 🙏 for impotent information

[@ezgi8684]

thank you

[@carlacutez2001]

Thank you

[@ricardotorres3709]

excellent

[@hajermazin]

Can’t be better 🤍🤍

[@HafizahHoshni]

Awesomely informative and perfectly explained! Thank you so much! 😊😊 24/8/2019

[@veemanzano7082]

Hello, thank you very much for the concise video. May I ask if acute glomerulonephritis is considered as a disease under the nephritic syndrome? Thank you!

[@SANJEEVKUMAR-ft5qi]

Dear Sir Kindly share videos with detailed symptoms of Nephrotic syndrome,यूरिन से प्रोटीन निकलता है in Child only

[@MrKago1]

we are such a complex machine, its a miracle we function at all. beyond all possible comprehension that we work well enough, consistently enough to have 7 billion of us. anyone who thinks miracles don't happen need to study medicine.

[@railguns4584]

In nephritic syndrome, since the endothelial cells are damaged, more protein should come out. So why is the proteinuria usually below the range of nephrotic syndrome? In my opinion, it should be the same or even above the nephrotic syndrome. Please kindly explain this to me.

[@teodorodevecchi4023]

Not clear to me either! I tried to find some infos online and I only found this: "Inflammatory glomerular injuries are so advanced that total glomerular filtration is reduced, thus lead to reduction in total amount of filtered proteins. That's why in these cases albuminuria and globulinuria are comparatively less in nephritic syndrome." Anyway this doesn't clarify it very much in my opinion.

[@teodorodevecchi4023]

ok, I saw the video attached to the reason I posted in the previous comment (kzbin.info/www/bejne/aJXFdKCaeMiWfc0 you can find the answer at 1:06:47) and I understood the full picture. Basically in nephritic syndrome you have a high level of inflammatory components (leukocytes, activated platelets, immunoglobulins, complement, etc.) which clog the glomerulus, thus the blood will not be able to pass through it with the same ease and the same will apply for the proteins

[@neurons6632]

I'm so glad that I don't have to memorize. Because the mechanism says a lot. Thank you :)

[@venkybly]

Tq

[@hassankhan9447]

in nephrotic the basement membrane gets damaged due to which proteinuria occur. the basement membrane has negative charge that will repel negatively charged albumin ,this the reason why albumin is not filtered through glomerolus. make this correction..

[@reynaldoseebalack9926]

I am 8 yrs old and my sister is 4 years we are diagnosed with nephrotic syndrome we have to do a biopsy to see which one we are sick with can someone please 🙏 give us some advice

[@mharjoniecanlassongco4264]

Thankyou so muchhh✨💕 but my report is about risk factors of nephritic syndrome 😭😭

[@tonmoydhar5416]

we’ll explained

[@333pinkfeather]

i woke up in the middle of the night saying " nephritis" ...never heard of it before ..what is it?

[@ellesrevisionsession]

immune complexes can also cause nephrotic syndrome, no?

[@Niloy63]

I believe Membranous Nephropathy (MN) and Membranoproliferative Glomerulonephritis (MPGN), both being nephrotic syndromes, involve immune complex deposition with secondary glomerular basement membrane thickening. MN -> subepithelial deposits (Spike & Dome), and MPGN -> subendothelial deposits (Tramtrack).

[@josipag2185]

Focal segmental also as primary GMN and as well as secondary also but then there is no immune complexes so it’s due to systemic desease that leads to accumulated PAS+ hyaline deposits and every desease including hyper filtration leads to this (diabetes, obesity, one kidney etc..) Because of destruction of the nephrons remaining are hyperfiltrating and leading to proteinuria (before called microalbuminuria).. and sometimes IgA(Berger) but it’ s impure nephrotic as is also usually seen in Membranoproliferative so this impure nephrotic concept means that there is proteinuria (nephrotic range) associated with hematuria/renal insufficiency or arterial hypertension. Actually IgA produces most commonly only isolated hematuria but can be nephritic or nephrotic (impure) also, and Membranoproliferative GMN produces hematuria + proteinuria as sediment abnormality (but also can be associated with arterial hypertension or renal insufficiency or nephritic sy also - this last usually seen in type II)