Neurology | Gustation (Taste Pathway)

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about gustation, or better known as the taste pathway. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #Gustation #Taste

[@MarioRodriguez-h3k]

Dude this presentation is awesome! Here's why: You provide a BROAD scope of a certain process. Yet, you are detailed enough to flow through the process logically and without gaps that would impede understanding. This leaves the learner with new knowledge and far more questions that answers. Thanks!

[@nikolaoskormpis3511]

Watching your videos first made studying quite easy during med school. Thank you sir!

[@godofallgodswithnoothernam920]

This guys the truth, his videos make studying the easist

[@fr3ddyfr3sh]

Thanks for sharing your profound knowledge. Your skill for explaining is outstanding

[@FarhanKhan-kx4yh]

I always like his videos before starting to watch bcoz i already know it s gonna be great

[@bublisoniyak6227]

Thank you sir! The pathway is clear now! 🙏

[@harshitac]

This is the best video I've found on the topic of Gustation so far.

[@heromovie2048]

Great lesson! However take care: ATP does not exit the taste cell by vesicles fusion, like in neurons, rather there are specific channels that open (CAHLM1/3) upon depolarisation and let the ATP to exit! Depolarization is mediated by TRPM5 channel that are regulated by Calcium!

[@granthagen3207]

That’s was the only mistake you found? There are like seven blatant inaccuracies by minute 3.

[@thehunchbackgirl]

@@granthagen3207stop being a dick

[@aaryavaze1496]

Like what? ​@@granthagen3207

[@periodcramps6757]

@@granthagen3207 At least this person seems like they’re actually trying to help. You have yet to state a single one of these “blatant inaccuracies”.

[@Reincarnation111]

Is there a way to diagnose the cause of loss of taste for someone, and get treatment? From many years before Covid, of course. I am amazed by this young ninja's level of knowledge!

[@isaakvanast]

Going back to college after 15 years and this gentleman here is the reason I passed the special senses module

[@Medicine.Course]

U deserve to be called "Sir Zach "❤️

[@Lyrics-su3kg]

Watching your videos first made studying quite easy during med school. Thank you broooooooooo

[@bacheloruz]

Assalomu alaykum dear lecturer! My english vocabulary is not enough to describe how brilliant your lessons are and i am achieving adequate knowledge about whatever you teach. THANKS GOOD LUCK!!!

[@claricecataldi7555]

You guy is amazing! I can’t say enough words about my gratitude for sharing.

[@jessicaquerin5927]

You're my favorite science teacher!!

[@ccbaxter.1384]

Thank you..and by the way, I passed my previous physiology class bcz of you.

[@learnwithareesha458]

Immensely grateful for these videos of yours. 💫

[@Emilio77able]

Clear, interesting and captivating. Thank you!

[@mrSegio100]

Nice video, but I have some issues, actually, the taste cells associated with bitter, sweet, and umami flavors do not release serotonin, they just release ATP, and ATP is not released trough vesicles, is released trough a voltage-gated channel. Also, the Ca ions do not interact with vesicles in this flavors, they bind to a channel, specificly to the TRPM5 channel wich causes it to open and the Na ions flow into the cell causing depolaration and the subsecuent aperture of the ATP channel that I mentioned before. On the other side, the taste cells asociated with salty and sour tastes do not release ATP, just serotonin. Williams, S. M., & White, L. E. (2013). Purves, D. et al. (Eds.) (2018). Neuroscience (6e). Sinauer.

[@truedrengr8625]

According to the most recent literature I could find, you are correct. (Finger, T. E., & Kinnamon, S. C. (2013). A taste for ATP: neurotransmission in taste buds. Frontiers in cellular neuroscience, 7, 264.)

[@FreeTheBro]

Where is the ATP before it leaves through the voltage gated channel?

[@khaledseggar3599]

It means that the video is wrong?''

[@susannahhannaford353]

@@FreeTheBro the ATP is produced in mitochondria that are squeezed up against the plasma membrane of the taste cell near the connection with the neuron. When those mitochondria produced ATP, it can exit the mitochondrion through pores. The close connection keeps that part of the cytoplasm pretty isolated so it can have a high ATP concentration (replenished by the mitochondria) and if the ATP release channels (CALHM1) is opened, it will exit to stimulate the neuron.

[@TALKmd]

You are wrong : Scott Herness, in Physiology of the Gastrointestinal Tract (Fifth Edition), 2012 Neurotransmitters in the Taste Bud TRCs express multiple neurotransmitters and neurotransmitter receptors across selective subsets of cells within the bud. These neurotransmitter pathways include serotonin (5-HT),187,188 ... In mouse TRCs, NE is released from type III cells in response to acid stimulation232 and a small subset of these cells coreleased both serotonin and NE. ... additionally stimulate type III cells via cell-to-cell communication by activation of P2Y receptors.201 This stimulation may then result in serotonin release from these cells.199

[@syedsaniyaahmed9995]

Excellent explaination sir

[@evgenie007]

I think you meant "Gustducin" 11:39. Transducin found inside the Rods and Cones in the eye. Correct me if I`m wrong. Thank you very much for your videos!

[@1991MissSally]

yeah, transducin is G protein inside the rod and its for activation of cGMP phosphodiesterase.

[@truedrengr8625]

Transducin seems also be active in receptors sensitive for bitter taste. Bit literature seems from 1993/1994 (McLaughlin, S. K., McKinnon, P. J., Robichon, A., Spickofsky, N., & Margolskee, R. F. (2007, September). Gustducin and transducin: a tale of two G proteins. In Ciba Foundation Symposium 179‐The Molecular Basis of Smell and Taste Transduction: The Molecular Basis of Smell and Taste Transduction: Ciba Foundation Symposium 179 (pp. 186-200). Chichester, UK: John Wiley & Sons, Ltd.. But I did not spent much time reading. And additionally Gustducin seems to have another signal pathway with Adenylate cyclase regulating cAMP (according to my pearson book).

[@NBAProductions]

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[@vikmoharir8469]

Great job! Complicated subject clearly explained.

[@April-gt9yb]

Appreciation from Tehran dear Zach🙋🏻‍♀️ cool and useful as always

[@davidarguello1994]

Dude thank you!!! You are so helpful and make it so simple to understand. I would love to buy a ninja nerd shirt, or merchandise.

[@mpreeve]

Great video - especially appreciated the clear explanation of the different signaling pathways.

[@thepurpleempress8854]

You really helped me understand this information! Thanks!

[@charlottel3709]

ninjanerds: "there's very little diseases that could actually cause some type of problem with taste" corona virus: *enters the chat*

[@patricksu9762]

A really annoying virus honestly.......

[@henrypaul1783]

when he made this video, COVID-19 had not happened

[@pacino1st]

He is correct. Once smell is affected taste follows

[@202.roomaisaqazi3]

UR LECTURES ARE AMAZING. THANKU FOR HELPING AND SAVING ME ALWAYYYYYYYSSSSSSS

[@ramyashree1339]

No words to describe such a nice explanation Thanks for ur videos 😍

[@shimaadil8220]

I don't know what I could do without your videos❤️❤️

[@abdelraheemsalahin8537]

You are the best teacher I have ever seen

[@huahuang2031]

How do you fit this much information into your brain? Please give some advice :sadge:

[@nageshsubramanya2037]

Dear Sir. Ur way of Teaching is marvelous. God bless u sir. Ur are a Real Teacher. U inspire the students so much. To learn and clearly understand the underlaying physiology . No words to praise ur way of expressing & explaining the science. Thanks

[@livelaughlove6952]

I always love your videos, you are getting me through med school! I was laughing when you mentioned that there are very little reasons to lose taste and thought to myself yup this was definitely pre-covid haha. Still suffering from parosmia and associated taste changes myself.... lol

[@Leukocyte34]

I believe COVID loss of taste, is not related to the gustation pathway but the olfactory pathway, but I could be wrong

[@nyawirawaithaka4993]

Well explained. Thank you!

[@dr.davidadeolu2166]

God bless you big! More wisdom and strength I pray for you

[@marylombardi6224]

What causes burning mouth syndrome? Your an awesome teacher!

[@Friends729]

You are great Sir

[@julesr7830]

Thank u so much for these tutorials, it helps me understand the book I’m studying “Anatomy Structure and Function “

[@yahyehassan8067]

Thank You ...Wonderful Presentation.

[@tamilian100]

This was so much help. Thank you so much!

[@NinjaNerdOfficial]

+Keshan Glad it helped, help us out by telling all of your friends about this channel 👍

[@bazejwalczykiewicz3773]

WOW!! It blows my mind .... Thanks :)

[@etiyaethiel2377]

Excellent, you are a book. God bless you and more wisdom.

[@byronstrohm9154]

Is the same cell going to consist of multiple types of receptors? If so, how would we distinguish between sweet, bitter, and umami if the same GPCR signal transduction pathway takes place leading to an action potential from the same receptor cell?

[@heromovie2048]

the receptors are mainly present on distinct cells!

[@93shreelakshmihs]

Super video. Very much informative

[@puddlemini]

Very concise summary!

[@elizabethwaters4260]

Very helpful videos. Thank you.

[@rodinaacharya4384]

amazing video. wowwww you have helped me so much thank you for your work and effort ! very easy and well expalined :)

[@abdelrahmanafifi9348]

Thank you very much. Really well structured and explained Much appreciated!!

[@harosenstein2711]

This guys is a true genius

[@josetrujillo738]

Umami! Great Lecture as usual! Thank You Ninja Nerd!

[@m.rockwellparker9162]

Great video, but the transduction has some errors. The G protein in sweet/bitter/umami cells is gustducin, not transducin. Also, the receptors do not function as monomers in sweet or umami sensation: they dimerize to initiate transduction. The latter point isn't as important as the former.

[@andrewlawendy1021]

Your Amazing man thank you so much for your videos

[@tiemma4936]

Nice video, explained in depth.

[@onyangooscar9334]

Wow!!!!,❤️❤️🔥 as always until next time.Much appreciation @ ninjanerds

[@rumeysafarhan478]

So dedicated. Bravo!

[@manalaltaf2338]

Amazingly explained.

[@Onesimo_Mahlaba]

☺ Thank you so much Zach

[@fcknluke]

Hi! I'm studying this topic from Ganong's physiology book, and here it's written that the sweet taste is connected to the G protein associated with AC (adenylate cyclase) and cAMP production, while you mentioned PLC. Are they both correct or just one of them? Thanks!

[@caiolaudano3345]

Very Good, Zac!!! 👏🏽🤩💯

[@gustavs495]

Thanks Prof God bless you

[@naradeguzman6429]

I cannot thank you enough !!! because of you, I have a shot at passing my neuroscience final

[@opeyemutaiwo5221]

Thank you so much. God bless you.

[@sanasabir1925]

Awesome lecture.

[@STUARTTOMBROS-s8i]

Just blew my mind that umami taste buds respond to glutamate. Explains why MSG adds so much flavor to foods

[@starryseokjin1871]

Great video! However, fungiform papillae are not taste buds, and instead house many taste buds within them.

[@kathykeefe7029]

Fantastic as always!

[@aneiramazaya5064]

Great Job, Ninja! 💖 God bless u!

[@jalpanchudasama4372]

Thank you VERY MUCH👍👍👍

[@aishwaryad7618]

very helpful! Thanks

[@reshmasaerah6591]

Beautiful..thank you so much

[@rahmat6405]

good video. its easy to understand

[@dagarkajal1876]

Luv u channel..❤ Plz upload more videos like this 👍

[@rahulkrishna7256]

Thanks a lot 😊

[@heidirembulat43]

Wow. You're amazing 💖 Thank you!!!

[@kanugulatejasri369]

Thankyou so much sir

[@godofallgodswithnoothernam920]

I do believe Your the best... 👍🏻

[@osterwindy]

Sorry, I had a question: where did you read about the functions of leaf-shaped papillae, please point me at this article. And perhaps you have seen articles about why papillae in the tongue are located exactly like this (for example: the letter V, etc.). Perhaps you have seen articles about age-related changes in the papillae of the tongue. Because everything I saw was about the muscles of the tongue. I will be happy to answer you.

[@kristianneaustin9530]

Hi, what fibres connect the olfactory area to the gustatory area?

[@Mission-Omega.]

Thank you so much, Sir... ♥♥♥

[@diegoabou6234]

Enjoyed!

[@misbahhussain1021]

Msc zoology 4th sem student frm kashmir Ure teaching skills are amazing sir ❤

[@heromovie2048]

Also.... the pontine taste area is present in rat, but not in human, where the neurons of the NTS project directly to the thalamus!

[@mohammadalializadeh6737]

Thanks❤

[@alansacks6347]

great informative

[@queentabengwa632]

Thank you

[@shreyaray5500]

A perfect explanation!

[@josetrujillo738]

Beautiful!

[@منارباسلمرادعبدالأمير]

Thank you 🙏

[@BacillusGlobogii]

Best one out there.

[@user-gz1xf5ny1x]

very clear thank you

[@monahrefaat1318]

Much love Ninja nerd 😂♥️♥️♥️♥️♥️

[@tatefonda9530]

YOU'RE THE GOAT!!!!

[@ammar3465]

The center of the gustatory pathway in the brain is it ipsilateral or contralateral?.?

[@ammar3465]

Orkun Akay thanks 🙏

[@anahitashahri5788]

amazing

[@drswetaruparel]

Very good videos.. very helpful !!!👍

[@danismayman-on1544]

THANK YOU 💯

[@studyharder8360]

THANK YOUUUU SOOO MUCH!!!!!!!!

[@olfater2353]

Very helpful, thanks a lot from Palestine ..

[@shahnazheidari1066]

As always you are the best, some part of this video stops, My internet is not bad but it happen with some of the renal system too. do you know what is the problem? is it me or there is other thing? again thanks a lot sir

[@yousefhamad5211]

U R THE BEST