Neurotransmitters: Norepinephrine

[@il3mendo]

Thanks

[@il3mendo]

If norepinephrine is made from dopamine (tyrosine and vitamin C) would an iron overload (% and ferritin) cause an norepinephrine toxicity ?

[@pmhnptesting]

@@il3mendo Iron overload could potentially contribute to an increased risk of norepinephrine toxicity, but it is not a direct cause. Here’s how they could be related: 1. Dopamine β-hydroxylase, the enzyme responsible for converting dopamine to norepinephrine, is iron-dependent. Excessive iron could potentially overstimulate this enzyme, leading to increased production of norepinephrine. 2. High norepinephrine levels can lead to oxidative stress, and iron overload contributes to oxidative damage through the Fenton reaction, which produces harmful free radicals. The combination of high norepinephrine and excess iron could increase oxidative stress, contributing to cellular damage. While iron overload might exacerbate norepinephrine-related toxicity or oxidative stress, it would not typically be the sole cause of norepinephrine toxicity. Other regulatory mechanisms would need to fail for true norepinephrine toxicity to occur.