Too Cool for Stool: NEW Metabolic Advantage of Ketogenic Diets

[@JamesRouzier]

More poop jokes are always appreciated

[@nicknorwitzPhD]

The title was almost "flabbergasting over feces"

[@saul450]

Dear Nick, ever since I've discovered your channel and realized that you can be healthy having a high LDL cholesterol on keto and still be healthy while also lifting weights and be active, you changed my life. Keep spreading the word and keep us curious, genius.

[@SK-ls4gb]

Layne Norton shaking his fist at the monitor right now.

[@sterlingkeful340]

he doesn't like new ideas

[@nicknorwitzPhD]

The number of comments I get on my videos akin to "Layne would be so upset" is ... interesting. TBH, I've lost respect for Layne. He can earn it back, but I feel his content is often shallow and he's resistant to feedback or challenge. I think his message of data > feelings is hypocritical and that he lacks insight. I hope he proves more wrong. But: kzbin.info/www/bejne/r5rUZ2qtpbqbf9U

[@SK-ls4gb]

@@nicknorwitzPhD I think its the strength of his convictions and inflammatory responses that make people want to go and show a paper like this and go "In your face!". He really just knows how to push people buttons in so many ways but then doesn't want to back it up. I'd love to see a discussion between you two guys moderated by Simon or another neutral party but sadly it probably won't happen. For the record I don't hate Layne and he was one of the first YT fitness/health influencers that i frequently watched and respected. It's just that there really is valid criticism to be levied at him but he's not interested in addressing it.

[@gmw3083]

​@SK-ls4gb when someone creates a mountain for themselves to ascend, and then the ascension happens, there is no backing down. The mountain crumbles. It's the same with nations. Murica is there now.

[@kirkwolak6735]

@@nicknorwitzPhD #SAME. I posted a photo after I lost 122lbs going low-carb. This was at 50yrs old, and a lifetime struggle. He replied "Congratulations, you ate less!" I've not held him in high regard ever since. FWIW, "Consistently eating less to lose 100lbs is REALLY hard". Whereas I found "Consistently eating Keto to lose 100lbs.." Not nearly so hard. Biochemistry matters. Heck.. THIS Video teaches us that a LOT of sh!t matters! (Which, BTW, would have been a great Video Title)

[@catswishes6848]

I just love Nicks curiosity ,enabling AND sharing the exploration of such a fascinating subject ……human body mechanisms …….

[@nicknorwitzPhD]

Thank you! 🙏🏻

[@acwright]

Really changes the paradigm of crap in-crap out. 😅

[@snowyperk1588]

Nice!! 😂😂😂❤

[@nicknorwitzPhD]

The New CICO!

[@Caladcholg]

Stole my line! Though I was going to equate it to epidemiological data -> public policy. 😂

[@ellie698]

Garbage in, garbage out 🗑️

[@peetos-chan2835]

👍👍👍

[@alphacause]

This gives calories in and calories out a whole new smelly meaning. 😉 In all seriousness, these ideas show just how complicated human metabolism is, and why it is almost impossible to be exact when assessing calories in and calories out. There are so many variables that can determine how many calories are absorbed, and I surmise, based on the variability of one person's gut to another person's gut, that the amount of calories one person absorbs or excretes verses another person can vary quite a bit as well.

[@nicknorwitzPhD]

YES. EXACTLY.

[@maranscandy9350]

The human machine does not perform like a calorimeter.

[@jingbi6634]

How much more calories you poop out exactly? Is it at least statistically significant?

[@alphacause]

@@jingbi6634 That is an interesting question.

[@cmozoo]

The microbiology always especially grabs my attention 🙂 (microbiology college major). I really love your content. Who can't love metabolic science. It's so interesting ❤

[@nicknorwitzPhD]

Thank you! You get it.

[@mikeob9502]

Totally agree, @cmozoo, even though I'm a rank lay person in this regard; I routinely must watch Dr.N's content 2-3 times before it really sinks in, but well worth it.

[@trentriver]

Another great presentation. Thanks!

[@nicknorwitzPhD]

You're very welcome :)

[@iconoclastic23]

Some TMI but I suppose this is the right video for it, I'm carnivore for a few months now and I eliminate once or twice a week and in very small amounts. It's not constipation either, I feel great, no bloat or difficulty in that regard, I just generate very little waste now. What I've heard from other carnivores is that this happens because the small intestine are very efficient at breaking down and absorbing meat.

[@matthewtrout1440]

Right. My bowel movements were reduced when I did carnivore, and I've heard the same from others as well. That seems counter to losing calories in stool. I wonder if it's true for all ketogenic diets, or if certain variables need to be involved (like having fiber). It's also contrary to one of the supposed benefits of carnivore, little to no malabsorption. Kind of ironic that ketogenic diets may work so well specifically because they increase malabsorption.

[@iconoclastic23]

@@matthewtrout1440 high insulin blocks the intestines from absorbing cholesterol and it ends up getting eliminated as waste. So having very little waste is probably a good sign that you are maintaining a very healthy uninflammatory vascular environment with an ideal average serum glucose level and no insulin spikes. I used to be very diabetic so any sign that I'm returning to insulin sensitivity is really encouraging in my case

[@maranscandy9350]

There's almost no waste from fat, lean meat, fatty meat, and meaty fat. Once it is reduced to a liquid slurry, the absorption is extremely efficient. Plant material not so much, though the plant advocates who want their plants to resemble some form of red/bloody meat substitute often go out of their way to say undigested meat sits rotting in the colon for weeks. I wonder how it immediately got a get out of jail card and bypassed the small intestine to go right to the colon.

[@Katlady-rs4eg]

You have so much fun and passion for what you are talking about! I believe you should have your own PBS science show for children called “Stay Curious”

[@nicknorwitzPhD]

Awe 😍

[@CatouMilou]

I second that.

[@petercbrandon]

Be careful with PBS. It's BS.

[@karenbuchert3377]

Nooooo! We adults need Dr Nick. Kids can have Blues Clues.

[@karenbuchert3377]

Thanks, Dr Nick. Very interesting info presented so well!! ❤❤❤

[@gins8781]

The classical guitar performance I am watching is fantastic! I don’t know why KZbin paired it with Nick’s feed. This has happened twice in one week on KZbin with other channels crossing “wires”. That said, you’re the bomb, Nick!

[@nicknorwitzPhD]

🎸😉🙏🏻

[@MeatHeals]

Nice job Nick. This is complicated data and I think most people would walk away from this with at least a partial understanding of how the gut microbiome may be changing in states of nutritional ketosis. Well done!

[@nicknorwitzPhD]

Glad it was helpful!

[@dacisky]

Your restraint was admirable,I could hot have held off on the jokes that well.

[@nicknorwitzPhD]

You would have given in to the urgency you mean?

[@aurapopescu1875]

Excellent content! Thank you 🙏

[@nicknorwitzPhD]

My pleasure!

[@melbbb5673]

love your videos!

[@nicknorwitzPhD]

Thanks! Means a lot!

[@joetrolo7076]

Thanks, Nick! I hope keto becomes even more poopular! 😆

[@nicknorwitzPhD]

I think it should be de-stigmatized at the very least, and that those who are not properly informed on the topic should stop spreading myths.

[@joetrolo7076]

@@nicknorwitzPhD definitely! You keep preaching it on KZbin and we'll keep preaching it in the streets!

[@nicknorwitzPhD]

@@joetrolo7076 haha... can we use a different word other than "preach?" Maybe enthusiastically inform?

[@joetrolo7076]

@@nicknorwitzPhD yes preach is just between us LOL. After over 3 years of intermittent fasting, watching KZbin videos, learning about metabolic syndrome and all the poisons in our food system, you can't help but want to save people. But I only tell them my journey if they're asking questions or interseted in help. A person convinced against their will, is of the same opinion still. I'm just glad I took the red pill. I'm 60, 6', don't wear glasses, feel great and after losing 40 lb in the first 3 months of intermittent fasting, I've maintained being between 165 and 170 for 3 years. It's very easy if you keep your eye on the ball, especially when you're at your goal weight. Thanks for all you do, my girlfriend and I love your videos.

[@robyn3349]

True “preaching “ is persuasive, not “forcing.”

[@tspicks4360]

Might want to look at studies on what happens on a high fiber diet (as with a diet of whole plant foods). I mean, talk about calories consumed leaving the body (via the fiber which is pooped out, bringing with it some other foods consumed). A very effective weight loss protocol, among other things. Miche did one or two very good videos on this.

[@AuntyJack123]

Perhaps not a good idea to eat large amounts of fibrous food that your body is not able to get nutrients from just to lose weight? Maybe eat less fibrous high nutrient food like red meat!

[@tspicks4360]

@@AuntyJack123 On the contrary - eating fiber is not just about weight loss by any means. WE don't break down fiber well, but our gut bacteria surely do, in a major way. This promotes a healthy gut biome, and hence healthy gut walls, such that every 10 grams of fiber consumed results in a 7% lower risk for colorectal cancer. Kinda the opposite of red meat. :)

[@AuntyJack123]

@@tspicks4360 ok if you choose to believe it. Our bodies don't need fibre to survive and our gut microbiome adjusts to whatever our diet is. All you're doing is adding bulk to your poop. We gain no nutrients from fibre. Your studies have been bought and paid for by big food.

[@grummelameise]

@@tspicks4360 its the short fatty acid chains from fermentaiation. you need them to do all kinds of stuff.

[@pedro.almeida]

High fiber keto diet rules 🤘

[@ParadiseInHawaii0com]

Nick’s hand 👐🏼 movements are captivating & mesmerizing.

[@nicknorwitzPhD]

I'm a hypnotist! Gotcha! Maybe it'll help with AVD.

[@TLDRHealth-y2e]

i love being surprised at new findings. at the onset I was sure this would be an uncoupling based phenomenon

[@darkhorseman8263]

Taurine will work, but it's rate limited. Taurine can be converted to homotaurine by microbiome.

[@johnstobbscpa8081]

Thanks Nick!

[@nicknorwitzPhD]

Welcome :)

[@cynthiafasulo3828]

Nick, I've suspected this for decades, honest. Science has finally broken through the calories in calories out, and that one must eat many servings of foods produced by industries that know how to lobby...

[@Pondapple]

Makes me think of Stephen King's movie "Thinner." The protagonist was losing weight due to a curse put on him, so much so that he was going to die. Here's a sci-fi scenario: a scientific discovery for weight loss that accidentally becomes irreversible and contagious.

[@nicknorwitzPhD]

Contagious... hmmmm... have you seen the new South Park on Obesity? ... I'm not usually a fan of SP, but I had to watch it and it 'resonated' ... at least to some degree.

[@Chaotic313]

...new fear unlocked, lol.

[@GenRN]

Loved that book.

[@SCW_Fitness]

@@nicknorwitzPhDHow can one not be a fan of South Park 😂

[@herbertvonsauerkrautunterh2513]

I shall look into it

[@ClovettCC]

Please “doo” more content like this! 😂

[@nicknorwitzPhD]

I promise TWO

[@Chaotic313]

I'm loving all the poop jokes, lol. Further evidence I have yet to grow up.🙂

[@nicknorwitzPhD]

Who wants to grow up? Let's Peter Pan this thing.

[@Chaotic313]

@@nicknorwitzPhD Sweeet!! Count me in. Oh, fyi, just purchased your beta hydroxybutyrate T. Can't wait for people ask what the heck it is when I wear it. 😎 Keep up the great work Nick!

[@nicknorwitzPhD]

@@Chaotic313 Thanks! Enjoy the shirt!

[@CatouMilou]

Or not.

[@SchecterMongoose]

Makes in a pita to gain weight. I lost a lot of weight from UC and cannot gain it back. Went carnivore because it's the only thing that doesn't bother my UC riddled gut. Helps to supplement with bovine gelatin in light coffee a few times a day (or add gelatin to beef stock or broth).

[@leenurG]

I don't know. I tried to reduce carbs intake only, but no avail. I didn't gain weight but didn't lose either. Only when I started additionally count in/out I started to lose weight. Probably it's my individual peculiarity.

[@paulpellico3797]

still a bit confused. i missed exactly WHAT in a ketogenic diet is causing this. is it......fiber? is it inulins that promote good bacteria?

[@YaYippieYeah]

Also how is nutritient malabsorbtion a good thing 🤨

[@onlyonecai]

I guess one of the reasons is that fat digestion is capped by your bile juice production capability by the liver. In fact, since human digestion is largely enzymatic, every nutrient absorption is capped by the stored enzyme targeting it, except for simple ones like glucose, fructose, salt, etc. Never mind about gut bacteria, they are overrated

[@dyaneharwood2023]

I'm finding that folks from MA are too cool - seriously. That means you, @NickNorwitz @MichaelBLive and Dr. Matthew Bernstein. Also, Oxford seems like such a cool place; I hope you enjoyed your studies across the pond. Ah, Oxford... if you haven't seen "Endeavor" & "Lewis" & "Inspector Morse" (Ah hell, let's throw in "The Golden Compass") then you haven't lived life!

[@samvanmeter4468]

Any tips if increased bile acid from high protein & fat meals leads to bile malabsorption + diarrhea? Maybe binders like fiber before eating my steak & eggs?

[@RebekahBavryCPHC]

Super cool!

[@chargermopar]

Well yes since I started the carnivore diet 41 years ago I have eaten up to 7 pounds of meat and a dozen eggs a day and never gained weight after age 25. The amount or poop I produce is small although daily. Interestingly decades ago there was a statement that fat people had different bacteria in poop than lean people. I know my poop has calories because along with pet waste and yard clippings it produces the gas I use for cooking!

[@onlyonecai]

7 pounds of meat a day is over 9000 kcal(literally) a day. That wouldn't be keto, perhaps it is the opposite of keto. You'd be very insulin insensitive or having a large amount of carbs together with it to suppress the satiety

[@johntravis7304]

Mr chargemopar/Rick is a big tall gentleman. And active

[@chargermopar]

@@johntravis7304 You are right, I am always on the move and work hard.

[@alliellioxenfree]

If they ever make a Castaway sequel i hope there's a rugby ball named Gilbert ❤

[@faithgky]

Reading your replies to people is better than the video. 😂👍

[@nicknorwitzPhD]

The best 🤣

[@petermadany2779]

Is the "advantage" in "metabolic advantage" a concept that has only made sense for the past 100 years of human existence? Perhaps the top 1% in previous centuries could afford to eat so much they worried about being fat, but didn't most people worry about having enough energy to get their work done? Wouldn't a "metabolic advantage" to them be to get the most amount of work done given the food they could afford?

[@TheTypeWriters-kq4pb]

You know, I always thought that the term "metabolic advantage" was a funny one. What we're doing is calling energy wastage an advantage, which is certainly not always an advantage. I think the terms "metabolic inefficiency" and "metabolic efficiency" are much better.

[@danielfaller5617]

I think its more complicated than that. Even in that case getting fat is only advatageous up to a point. You want to stay fit, even when there is plenty of food and having an extra 10-20 kilo of weight on you is not helping.

[@tommy10001]

That’s not true. Having fat helps you live longer without food, in starvation periods.

[@nicknorwitzPhD]

Advantage does require content. I think you know what context I'm operating in.

[@grummelameise]

they had a working homöostasis system. they didnt overeat. they only ate what they needed, and ramped up energy if they had to much. carbs threw a spanner in that system. people think hunger is the same as craving. they believe that sateity is when your stomach is full, regardless if you ate sawdust or potatoes. the whole concept is misleading from top to bottom. calories dont mean anything. they measue calories by burning some matter, and then maesure the ash and soot. but burning is not at all what happens in the body. its sience for toddlers.

[@andrewhowie1605]

Very nice. Would be helpful if all intake studies at population level and individual patient level(n=1) included energy out data. (Ie outcomes matter).

[@nicknorwitzPhD]

Who will serve as the population pooper scooper?

[@CatherineHurley-wk8ef]

@@nicknorwitzPhD ....some unfortunate t*rd....🤪

[@B.Rights]

My n=1 shows I can eat far in excess of my BMR calories on carnivore and lose weight while this is not possible on a 'normal' diet. It is so obvious which is better for my metabolic health. I would be interested in a study that explored the impact on BMR and metabolic health.

[@grummelameise]

try weightlifting with 2500 calories from oatmeal vs 2500 calories from meat and vegtables. yeah thats right, you cant do anything with carbs except generate fat and energy.

[@CL-im9lk]

Nick is what a scientist should be.

[@nicknorwitzPhD]

Awe… making my evening 😍

[@dbiedler]

Is anyone else confused about the use of calorie? Calorie is a measure of photons. What is the substance that’s not being absorbed or further process that is being excreted?

[@workout1520]

What about supplementing with TUDCA? I did it for a few months and I couldn't separate out any effects from a Placebo effect and I was already on a high protein restricted calorie diet.

[@capnceltblood5347]

Bile works on fat not protein.

[@nicknorwitzPhD]

What effects did you notice? And why did you start supplementing in the first place?

[@workout1520]

@@nicknorwitzPhD I've been doing a high protein, low Carb, Low fat diet and someone I follow was doing it for better "Energy" during workouts and as a digestive aid for fat burning. I did notice enhanced "Regularity" as I was still sorting out my Stomach Biome. I thought I noticed some increased energy and some better bathroom sessions but I couldn't tell the difference between that and the Placebo Effect. So after about six months, I stopped and really haven't missed it.

[@wocket42]

So, what does this mean if I want to gain weight on a ketogenic diet?

[@rrrlasse2]

If the mice study was calory restricted, then wouldn't appetite just increase according to their weight loss? And what effect would that have if they were free feeding? Also, in the human study with the 11.6 lbs weight loss, was it "free eating" or calory restricted? I mean, if you "poop out" 500 kcal, then by how much does your appetite increase to make up for that? It's also known that any diet where you suddenly restrict food groups will lead to initial weight loss, not just keto. That could be another explanation of the human weight loss.

[@AlexV-jh7ul]

Given that the body effectively never sees the unabsorbed fats (and they therefore don't participate in satiety regulation), isn't this effectively equivalent to eating less with extra steps? Oooh, my diet caused malabsorption, how great is that?

[@friedrichstein3718]

Thanks for this video! But how meaningful are mouse studies for ketogenic diets? Don't know much about mice but I would guess that when feeding on grains, seeds, fruits etc. they are never phsyiologly in ketosis and never had adaptation to it. So aren't they studying more of a arbitrary state, that has no adaptive meaning.

[@nicknorwitzPhD]

Did you note the human data I shared in the video? Ketogenic diets have similar effects on functional aspects of human intestinal microbiota with similar changes in bile acids. Suggests to me conservation of mechanism.

[@ematise]

Good 👍

[@nicknorwitzPhD]

Thanks

[@jonathanandrews6548]

How might this affect those who have had their gall bladders removed?

[@matthewdancz9152]

The reason peoole were skinnier in the past was because they ate more meat, less sugar, and more saturated fat that feeds gut bacteria that consumes and holds more energy than bacteria fed by sugars.

[@nicknorwitzPhD]

Interesting hypothesis. Care to elaborate? PMIDs appreciated. And - no - just because your profile picture is Gandalf does not mean I can automatically trust your wisdom ;)

[@tootstoyou1]

I’ve watched many videos from highly qualified doctors agreeing with Matthew and even more videos of anecdotal evidence from average people who have cured or lessened a vast assortment of ailments . I personally agree that the carnivore diet is pretty incredible for regaining health.

[@grummelameise]

@@nicknorwitzPhD its different kinds of fermentation. they have different results, yeast + sugar = alcohol and waste and gas. yeast, salt and cellulose = short fatty chain acids no gas. aka thats what fast food people lack. so they have hard times to swith from carb burning to fat burning. normal people can use these short fatty acids for energy and more.

[@jsim3787]

Might be a silly question but did the weightloss account for water retention?

[@nicknorwitzPhD]

In a word, yes

[@RC-qf3mp]

The world needs an Oreo Poop study now. Any volunteers ?

[@nicknorwitzPhD]

No. No more... please no more!

[@Technichian462]

Wait… you didn’t save any specimens? Oh my! You should have known! One can never test too much. Especially when testing something that has not previously been tested! As far as I know anyway.

[@jonathanberry9502]

Couldn't this potentially lead to LPS producing bacteria being better fed leading to a negative effect? Also maybe taking bile acid salts could help?!

[@christopherbrand5360]

I understand that industrial western culture has a diet and lifestyle problem but it really is a misuse of the term “advantage” when the effect is that a lower percentage of calories in the diet are successfully metabolized. This is, in fact less efficient 😂

[@nicknorwitzPhD]

Advantage does require content. I think you know what context I'm operating in.

[@christopherbrand5360]

@@nicknorwitzPhD I do get your context. As an ultra endurance athlete who enjoys healthy metabolism of all of the macronutrients it just struck me with horror to get less out of my fuel. The science IS FASCINATING! Thank you for putting this out, I’d probably never see it otherwise

[@dahdah6668]

Does this prevent other nutrients from absorption as well?

[@dahdah6668]

@nicknorwitzPhD..............01 Hello, don't know what this response means?

[@JohnWilliams-gy5yc]

What's your stance on keto and the pre-diabetic blood results? Can you re-act to Dr.Alo's reacts?

[@nicknorwitzPhD]

This is an inside thought but… Tbh not worth my time. Sorry. I’ll have a video specifically on “functional foes.” He doesn’t meet the criteria. He just a bit… well… 🤥… I am still chocked he can’t read a Forest plot and argues PCSK9i extends lifespan by 2 decades

[@JohnWilliams-gy5yc]

@@nicknorwitzPhD Yeah, I wouldn't be too much pessimistic but considering how much mainstream medicine praises the cumulative LDL exposure paper, eventually they might try to prescribe lipid suppressors at very young age. Well, PSK9i might become the new double mastectomy, who knows?

[@mikeward9870]

Enjoyable humor about raising the bar in avoiding (stepping into potentially offensive ;^) low humor.

[@RagdyAndy]

Cheers *Dr* bobblehead!

[@nicknorwitzPhD]

If this is a skinny neck joke, it’s on the better end of the spectrum of those I heard. I appreciate the subtly. Tactful 😉

[@wtsuser]

I remember as a kid i would eat 1-2 bags of nuts or peanuts and then see what looked like pieces of them in my poop. Now i saw that there is studies that say unprocessed nuts have like 30% less calories than what it says on the label because they are not digested fully and the fats are excreted in human poop. Is people eating less processed/absorbable calories also a reason why people are leaner on keto? Do you guys roast your nuts?

[@YaYippieYeah]

People don't chew enough these days because they are used to comfort food. Nuts are a big victim of this. I speculate this 30% would drop significantly by long chewing.

[@Kukulkan_Tours]

Thinking evolutionarily, doesn’t this suggest that meat and fat are too high calorie for us, so we excrete it. And that we are starving for glucose which is why glucose sensitivity improves.

[@onlyonecai]

Evolutionarily, there were no plates on a table to be finished. We wouldn't overeat, and would save the extra foods for later, so we wouldn't worried about hunting every day. Also, evolutionarily, glucose dense foods are extremely rare in the wild, and glucose sensitivity should be always high.

[@CatherineHurley-wk8ef]

​@@onlyonecai Very true; archaeo-medicine has established that before settled farming began (c.10,000 BCE), mTOR easily processed the relatively few carbs available to us. Once we "turned grasses into grains", insulin became dominant, to cope with the huge influx of dietary carbs. Archaeologists introduced a new word for the bulky human body shape shown in art work of c.7,000 BCE: "steatopygous". I think, today, we'd call that 'metabolic syndrome'.

[@gsts379]

Interesting that topiramate is used as an anti-epileptic treatment -- like the medical ketogenic diets.

[@Damudean]

I just don’t think we should use calories it’s that simple. Just know how much of what you eat if you measure and adjust that amount of food for your specific goals

[@CarnivoreStork]

I’m wondering if this connection plays out with when you switch to a ketogenic diet hardcore like Carnivore, that the bad gut microbe Candida that loves feeding off sugar & starches, freaks out and starts starving & dying off and you eventually start losing most of your sweet cravings.

[@grummelameise]

its a yeast. you loose your cravings because your insuline resistance falls, and the cell gets energy in a far mor effective way. so you cease to have cravings.

[@PhiIosophyGeek]

Very cool! :)

[@nicknorwitzPhD]

Thanks. Thought so.

[@MrUncleBob]

Does anyone know how people fare on ketogenic diets for seizure control after many decades?

[@grummelameise]

how do they fare after 30 years of medication?

[@realliftafromthesva]

Tudca? You mean the supplement bodybuilders use for liver problems?

[@nicknorwitzPhD]

Didn’t know they did that. Possibly

[@nicktheodorou3474]

Is there similar mechanisms to why very low carb high fat and very low fat high carb diets (assuming whole foods) share a similar outcome of weight loss?

[@YaYippieYeah]

Well the video claims differently, doesn't it? The human RCTs and metas i've read about, show the same thing you state, no advantage.

[@nicknorwitzPhD]

I'm not sure they do... I can guess what trials you may be referring to... but please drop specific references... I think there may be "quirks" worth highlighting.

[@nicktheodorou3474]

@@nicknorwitzPhD I am sorry I can provide any refences but it is just something I often come across online in travels and was curious about it. It's a constant debate between the HCLF and LCHF communities online, that their diet of choice is the best for weight loss. There is a plethora of people online and in my local communities that have also had massive success with both HCLF and LCHF. What is it that allowed them to have success with their specific diets whilst eating ad lib? My personal experience. Obese child with health issues from age 10. Now 45, have counted calories for most of my life. Have tried extended periods of both HCLF and LCHF diets and eating ad lib but still manage to eat in surplus of what is required and always end up gaining significant weight. For me, whether I do carnivore, keto, low fat vegan, starch solution, etc, eating ad lib leads to weight gain, whilst tracking my calories on any of these diets I can maintain my maintenance weight calorie and exercise kept equal. I have found whole foods regardless of the macro groups to be the most satiating and make up most of my diet, but I still have to count calories to maintain. I also eat one meal a day because that also provide me with better satiation. I would love to be able to eat ad lib, but I think there is some mechanism that causes me to have a massive appetite and I think that is the root cause of why I was an obese child even though my childhood diet was a traditional Greek whole food diet. Great video. Keep up that great work.

[@nicktheodorou3474]

@@nicknorwitzPhD I am sorry I can't provide any refences but it is just something I often come across online in travels and was curious about it. It's a constant debate between the HCLF and LCHF communities online, that their diet of choice is the best for weight loss. There is a plethora of people online and in my local communities that have also had massive success with both HCLF and LCHF. What is it that allowed them to have success with their specific diets whilst eating ad lib? My personal experience. Obese child with health issues from age 10. Now 45, have counted calories for most of my life. Have tried extended periods of both HCLF and LCHF diets and eating ad lib but still manage to eat in surplus of what is required and always end up gaining significant weight. For me, whether I do carnivore, keto, low fat vegan, starch solution, etc, eating ad lib leads to weight gain, whilst tracking my calories on any of these diets I can maintain my maintenance weight calorie and exercise kept equal. I have found whole foods regardless of the macro groups to be the most satiating and make up most of my diet, but I still have to count calories to maintain. I also eat one meal a day because that also provide me with better satiation. I would love to be able to eat ad lib, but I think there is some mechanism that causes me to have a massive appetite and I think that is the root cause of why I was an obese child even though my childhood diet was a traditional Greek whole food diet. Great video. Keep up that great work.

[@fredsmit3481]

Nick, what about peeing out ketones? Maybe that is more significant?

[@ukaszstrzelecki9157]

Any studies about keto and microbiota, immunity etc? My doc wants to sell me gut cleansing smoothy program and recommends veggies. Just had a diarrhea for 3 days and turned to only meat + bone broth and my gut felt amazing.

[@nicknorwitzPhD]

"gut cleansing smoothy program" screams all sorts of red flags. What program? Glad you feel well now.

[@ukaszstrzelecki9157]

His own program to “bring back the good gut flora”. He is “eat healthy carbs, keto is bad” kind of doctor. That’s why I am interested in this topic and how is it on keto, as everyone says you need fiber/starch to have good microbiota. Before I spend money on any “gut repair” I want to learn more about it. Your story with IBS is what I have in mind when he tries to sell it to me

[@andrewrivera4029]

However you do it driving insulin to baseline improves health.

[@rickperez8044]

I have been enjoying sh!ts and giggles now for 2 years, thanks to carnivore lifestyle. I used to experience horrific sh!ts and tears (angry hemorrhoids, anal fissures, bleeding and excruciating pain). Weight loss and T2D reversal were an added bonus.

[@CashMoneyMoore]

People always forget about that calorie out part

[@nicknorwitzPhD]

Treadmill vs porcelain throne 🚽

[@LauraB.335]

Kelly Hogan talks about how she was able to eat double the calories on carnivore than she can on the SAD (where she was gaining weight on 1200 calories). The fat fell off on double the calories. Dr. Anthony Chaffee also talks about this happening to him.

[@739jep]

I don’t see how this detracts from the concept of CICO/ energy balance. You don’t make this claim in the video (or if you did I missed it ) , but it seems to be a common take away in the comment section. At any rate I remain unconvinced of any special advantage keto may have over other diets. But this was an interesting video , I also enjoyed your interview with Simon Hill 👍

[@wtsuser]

CICO always applies, its just physics. But this shows again that its not just about how many calories you eat but which foods you eat. Because the other things in foods change the metabolism and appearently also the absorbtion of calories long-term. What most people mean by CICO is tracking dietary calories / eating less calories and expending more calories with exercise. But why even track calories if a (dietary) calorie isnt a calorie?

[@739jep]

@@wtsuser i think different groups don’t use the same definitions of CICO when they’re promoting its importance / dismissing it entirely. I think those who dismiss it most commonly simply disagree with certain conclusions drawn from it rather than the principle itself (although those people exist too). But the same can be said about looking at mechanisms such as what’s discussed in this video and the conclusions some people may draw from it. Does this mean people should all go to keto? Why? We know people have success all sorts of diets. I agree that it always applies , but there seems to be a growing amount of people who deny even this. They tend to be in the carnivore crowd mostly , but there are some in other groups - particularly low carb groups. I dont think CICO means that you MUST count calories , although some people certainly do find success that way. I think the only thing that it says is that in order to lose fat over a given time period , you must be in a caloric deficit over that time period. How people choose to do that is up to them , as long as it’s something they can adhere to long term. Learning more about the nuances of the human metabolism will probably help in most cases when people are choosing how to go about this - but perhaps there is risk of ‘paralysis via analysis’ here too. 🤷‍♂️

[@nicknorwitzPhD]

Please watch this video. Thermodynamics holds without calories needed to be causal: kzbin.info/www/bejne/b3zFqZewhbBrjZI

[@739jep]

@@nicknorwitzPhD I’ve seen the video, thanks for the reminder. I agree that it is possible for the laws of thermodynamics to hold without calories being directly causal for weight loss. However, I simply disagree with the idea that calories are not causal. Specifically, I believe that an energy deficit is indeed causal when it comes to fat loss. In other words. Sure that could be the case , I’m just not convinced it is.

[@petermadany2779]

Perhaps we can replace the CICO mantra with a CACA 💩mantra.

[@nicknorwitzPhD]

HA!!!

[@AlvaroCesar-pb3wu]

Doctor Nick, could you do a video about constipation and keto diet? All the times I quitted goin' keto was because of this. Thanks, doc. Cheers from Brazil!

[@capnceltblood5347]

Simple... Not enough fat constipation... too much fat diarrhea.

[@GBOAC]

Too much protein constipates, also calcium from dairy, so cheese is by far the worst food in that regard.

[@paulhailey2537]

I'll bet you were eating Chicken and Turkey without any FAT

[@Angel283]

@@paulhailey2537 Happens to me as well and I eat ribeyes, bacon, pork belly, butter by the stick!!!!!

[@paulhailey2537]

@@Angel283 I suggest more Fat , such as 73/27 Hamburger

[@jeffschollmeyer5247]

Great content, Nick Steaks > Cakes

[@nicknorwitzPhD]

What cut? What flavor?

[@떡볶이나리]

What about steaks shaped like cakes 🤔

[@markiangooley]

I always hear “chow diet” as “ciao diet” as in “a diet that’s fatal.”

[@nicknorwitzPhD]

Haha! Can’t unsee/hear this

[@dilettanter]

Very interesting though

[@nicknorwitzPhD]

Thanks!

[@jeffrey4577]

😂 I'm straining not to laugh too hard

[@nicknorwitzPhD]

lol straining

[@MichaelCarroll-pv1mk]

You're not just messing around.

[@nicknorwitzPhD]

What, you mean with the data? Def not!

[@sammavitae114]

The key word is might. OTW's unproven.

[@drscott1]

👍🏼

[@chrisavetrano]

On your KZbin name I think you should list MD and Phd after your name. There are so many KZbin folks who are chiropractors and people think they have actual training in medicine when they clearly do not.

[@nicknorwitzPhD]

I can see arguments either way. There is an argument for “flexing” PhD, MD, Oxford, Harvard etc. to differentiate myself; however, I prefer to let my arguments speak for themselves where possible and raise credentials primarily when someone else raises them in “attack mode” … a sort of prefer to have and not need than to need and not have. Plus, in 2024, I’m not sure how much the “Dr” flex helps. I think it can come across as arrogant, even if that’s not the intent. Really, I could go either way… may change my mind but for right now… Nick is good. You can call me Dr Cookie Monster if you prefer, or the dude who looks like if “Harry Potter went to Harvard” - you’d be surprised how much I get that exact statement thrown at me 😂

[@chrisavetrano]

@@nicknorwitzPhD I can see your point but some of your videos are way out there, which I love, but I guess the credentials are more important to some than others. I do notice that KZbin puts some sort of “real doctor” emblem on certain channels. See Dr Mikes as an example. Regardless, I will watch your stuff and throw random cash at you occasionally..

[@FutureLaugh]

although i think keto diet is more forgiving than standard diets, you can certainly get fat with any diet if you over consume calories. ive been on a keto diet for 8 years, always maintained very lean healthy weight and still do; but where i moved has terrible air quality and i dont ride my bike every day and only weight lift 4 days a week because of my work schedule; so yeah ive been most certainly getting softer in the last year. Not overweight by any means but noticeably different

[@onlyonecai]

Air pollution could definitely be a factor which is seen to affect insulin sensitivity. Exercises don't really have an effect on insulin sensitivity, and your body will compensate the appetite accordingly which means you will just get a bit hungrier after exercises. I only do about 20 mins of weight lifting per week, no other exercise besides walking to my work. I easily maintain 10% body fat all time.

[@DanielFernandez-h3l]

It’s surprising how a so intelligent guy like you and with so experience in Keto diets can believe on Calories hypothesis. Non sense.

[@pauls3075]

You've got to respect the opinion of someone who shaves using a set square.

[@nicknorwitzPhD]

I have no idea what this means... but I think you like my beard.

[@HarryLlewellyn27]

Maybe this explains floating stool😏

[@kinanireland8122]

Wrong concept. eat more with hope to inefficient absorption.... Instead of fasting or eating less and avoid stress on organs

[@nicknorwitzPhD]

You jump over curiosity straight to value judgement. Where do I advocative for stinging more in the hopes of inefficient absorption

[@kinanireland8122]

@@nicknorwitzPhD you didn't. But I wanted to draw people's attention

[@ellek6505]

Fecal transplant...on a...MOUSE. Let that sink in and picture it.

[@nicknorwitzPhD]

I mean I don’t know many germ free humans

[@markmacdonald1849]

not sure I want to poop hard-earned meat calories...

[@nicknorwitzPhD]

Hard earned? By that do you mean you hunt? Or is walking to the butcher section at Whole Foods “hard earned?”

[@markmacdonald1849]

@@nicknorwitzPhD Well, until relatively recently in human history I would have had to hunt, also people generally didn't need or want to lose weight (like me now). I was maybe exaggerating "hard-earned" for effect, but there are certainly some qualities and cuts of meat that I can't justify paying for too often at the supermarket...Point being, I don't see the benefit to our species of pooping out food unless I am missing something

[@divadyrdnal]

Great job on discussing such a shitty subject… When my doctor prescribed me Metformin I’m sure my weight loss was by almost the same process, finally had to add it to my list of things tried and failed.

[@notrandom2]

don't tell outdated science bro's They hate the concept of calories not playing fair.

[@nicknorwitzPhD]

But bro. Calories bro. It's all the calories bro. BROOOO

[@dilettanter]

Were these fat mice? Was it good they lost 18% or whatever of their weight?

[@nicknorwitzPhD]

Are you body shaming the mice. Shame on you (I'm joking btw)

[@dilettanter]

@@nicknorwitzPhD lol 😂- but if mice aren’t overweight it kind of changes the value of teh weight loss (?)

[@dilettanter]

Maybe I didn’t follow the study carefully - I was a little distracted so should listen again

[@jameschesterton]

2 things. 1 As usual, I'm going to have to feed the entire video into ChatGPT and ask it to simplify it. 2 It amazes me how every time you bring your fingers together into the 'interlocked' position, you never miss or bang fingertips.

[@nicknorwitzPhD]

So… Me use bigs words and very coordinated

[@sebastianhoracioforondagon8813]

Layne is going to kill himself with this one.

[@nicknorwitzPhD]

As he knows, I’m very ready to have a discussion or debate with him. He has thus far chosen instead to do a poor job covering data of interest to both of us, and avoids responding to (earned) critical feedback.

[@sebastianhoracioforondagon8813]

@@nicknorwitzPhD Is true. I met him on an event with Donald Layman and he was such egocentric when I was trying to tell him the nuances of ketogenic diet and the fuel partitioning importance in terms of obesity. He just said " I am not interested in n =1"

[@YeshuaKingMessiah]

I did wonder what all the fuss was about Tudca but never looked into it I’m sure there’s a huge market for it “Poo out my meals? I’ll take as much 🤪” humanz iz lazy

[@nicknorwitzPhD]

I struggled with whether or not to mention you can buy it OTC…

[@macoediv]

The shter is not full.

[@LyingEyes-t3m]

I’m a big fan, ButI can’t understand how a very smart scientists will keep talking about calories. I it because of your Colleagues, can’t break out of false teachings, trying to avoid arguments? Scientist should be accurate and honest. We know the body has no means of knowing how much energy you ate and how much your expended. There is no value comparison, no calorie receptors etc. To think a person can eat within a 35 calorie window every day for decades to not out on weight is ridiculous. No one has ever since there has been man in this planet monitored energy consumption nor expenditures. If cant recognize the bodies ills come from the body o Being poisoned and interferes with, we Can’t Make any progress to help the population.

[@GenRN]

Anyone on keto that wants to be a poop donor ?

[@nicknorwitzPhD]

I volunteer as tribute

[@natto84]

TUDCA always causes me lots of health benefits.

[@nicknorwitzPhD]

Have you been taking it? If so, for what use case?

[@AProperBurial]

@@nicknorwitzPhD steroid using bodybuilders have been using TUDCA to repair liver damage and get their liver enzymes back in check for decades.

[@jodyjackson5475]

Yes please elaborate I have some since Pottengers Human has talked about it on his channel and liver help but I’d love to know what benefits you got