Immunology | Inflammation: Vascular Events: Part 1

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
Join Professor Zach Murphy in this four part lecture series where we talk about the physiology of inflammation. In part 1 of this lecture we discuss the vascular events that involve the local chemical mediators, as well as leukocytosis, margination, diapedesis, and positive chemotaxis. We hope you enjoy this lecture and be sure to support us below!
Inflammatory Response Video Series:
Part 1: • Immunology | Inflammat...
Part 2: • Immunology | Inflammat...
Part 3: • Immunology | Inflammat...
Part 4: • Immunology | Inflammat...
References:
● Le T, Bhushan V, Sochat M, Chavda Y, Zureick A. First Aid for the USMLE Step 1 2018. New York, NY: McGraw-Hill Medical; 2017
● Marieb EN, Hoehn K. Anatomy & Physiology. Hoboken, NJ: Pearson; 2020.
● Boron WF, Boulpaep EL. Medical Physiology.; 2017.
● Urry LA, Cain ML, Wasserman SA, Minorsky PV, Orr RB, Campbell NA. Campbell Biology. New York, NY: Pearson; 2020.
● Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison's Principles of Internal Medicine. New York etc.: McGraw-Hill Education; 2018.
● Iberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P . Molecular Biology of the Cell. New York, NY: Garland Science; 2002
● Murphy K, Weaver C. Janeway's Immunobiology. Garland Science; 2016
● Doan T, Melvold R, Viselli S, Waltenbaugh C. Immunology. Lippincott Williams & Wilkins; 2012
● Levinson W. Review of Medical Microbiology and Immunology. Lange; 2012
● Soman N Abraham. ResearchGate [digital image] Retrieved from: www.researchga... 2011
● The University of Western Australia. [digital image] from: www.meddent.uwa.edu.au/__data/assets/pdf_file/0018/3036123/PATH2220-2017-Lecture-4-Inflammation-1.pdf
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#ninjanerd #Inflammation #Immunology

[@madrid22j]

god has blessed us with your existence

[@Bilbus7]

madrid22j Has God also blessed us with horrible diseases too?

[@raanoooshh9296]

@@Bilbus7 Don't be that person ...

[@Bilbus7]

@@raanoooshh9296 A logical and not fond of bullshit type of person?

[@raanoooshh9296]

@@Bilbus7 pfftt why are you being so negative did you step on a lego? You're not logical anywhere bruh.

[@Bilbus7]

@@raanoooshh9296 How am I not logical anywhere? Clearly you believe in fairytales too.

[@lawrencelockhart7739]

Murphy is a rare and fabulous lecturer. Don't pressure him to go faster to fit the production time or you'll wreck the delivery to the listener.

[@HibaJasim-y1e]

What pressure ... i thought the video lasted just 5 minutes and when it ended i said what the hell the video seemed 5 minutes long

[@mohammedahmedjalloh531]

NOT TO OVER-COMMENT "I JUST WANNA SAY THANK YOU FOR MAKING MY STAYHOME LEARNING EFFECTIVE.

[@dranthonyasturi9790]

I absolutely adore these lectures. I am both an MD and a PhD but limit my activities to electrophysiology here in Italy. Whoever does not appreciate your lectures with the thumb down, either should not be in the field of medicine or simply do not have what it takes to follow any discipline within the scientific spectrum. You are more knowledgeable and much more clear than many professors I have met in the U.S, and Europe. I refer to you as the "SOLISTA VENETO" di Padova where I had training in electrophysiology and hemodynamics

[@NinjaNerdOfficial]

You should join the Discord! We have some electro-cardio folks and perfusionists who just love to talk ECG case studies! discord.com/invite/Jzd3fYbAa4 or link in the Channel Description

[@MohammedKhan-j2d]

Where are you based in the USA I would like to meet you Just say thank you for being such a great blessing to humanity

[@maxillarycanine4443]

instead of netflix, i open youtube for THIS, YOU ARE GREAT GUYS!!

[@meganletavish3333]

me too such a relief right?

[@Morning_Owl_O_O]

@@meganletavish3333 yup

[@prameeth]

Ninja nerd is going to reach a million student subscribers in a few days. HOW COOL IS THAT! 🤜🤛

[@Choogaleh]

Nurse practitioner student here. This is helping understand inflammation for my advanced pathophysiology course. :) Thank you so much!!

[@HollywoodWestern]

Jennifer N where are you a student at?

[@Tself02]

Just received my grade for my last test on the immune system and Urinary system. I got a B! Ever since I started using your videos as part of my study program, I have been able to make above average grades! Thank you so much for all of your help! ..Reproduction is next!

[@NinjaNerdOfficial]

+Tiffany Selrick So glad we could help Tiffany! Make sure to tell your friends! Keep studying!

[@haematologistparvaizwar6803]

@@NinjaNerdOfficial sir plz I can't understand.. If we are giving BCG vaccination to newborn, but instid of that why people are infected by mycobacterium TB, and sir why can't we apply BCG again after some age two or three times, so that long term immunity can be developed against it.

[@cibisaravanan929]

@@haematologistparvaizwar6803 BCG can only be protective against the meningitis and disseminated TB in children. It does not prevent neither the primary infection nor the reactivation of latent pulmonary infection. - WHO

[@st.jamesivey9052]

q

[@st.jamesivey9052]

q

[@franciscogutierrez6920]

Passed my Hematology exam with your other Videos thank you sooo much man. I'm a visual learner and these videos really help me see the info come to life out the book.

[@wolfie5470]

You saved me many times, Zach! And now I am so happy that I can learn the basics of Immunology with you. Our teacher told us we don't have much time during the lessons so she goes through everything very quickly and told us that we have to learn it at home on our owns. Well, it's kind of a waste of time because I was just sitting there and didn't understand anything - it was so quick and she acted like we should get all the stuff that was in her presentation - the activation of complement almost killed me. We were just staring at her and thought she was crazy, haha. I am sure she is intelligent so much but she probably can't imagine how hard and complicated it is for us to learn and understand because almost everything is completely new stuff. You, Zach, have a gift and you really know how to explain everything so easily. So many doctors/professors/teachers with 4 degrees should learn from YOU how to teach students. THANK YOU SO MUCH xoxo

[@zerolingping7047]

You deserve 10M subs

[@angelat3238]

I could barely make it through reading the pages in the pathophysiology book I have, and I would start nodding off. You take pages and pages of confusion and turn it into a visual everyone can interpret. Thank you...

[@fallond3013]

I am currently enrolled in a Chinese medicine program, and your videos help me out so much with anatomy. Also couldn't help but notice your cupping marks on the back of your neck! So great, thanks for all the important info.

[@mangographieellen]

I just had to cry because my exam is tomorrow and I hadn't gotten around to this topic until last minute and I'm just so grateful that I can always count on you to explain a topic

[@chrisatronx]

This is the best description of this process I have ever seen. This is channel is GOLD. G O L D!

[@rewakaur7375]

Hello Ninja Nerd, I have no words for how grateful I feel to have access to this knowledge! Thank you so much for your work! Due to my ADHD I always struggled with my textbooks and notes reading material and these videos are a big blessing for my visual learner brain! thank you for your efforts!!! I'm getting way more than passing marks in my anatomy classes! Thank you AGAIN! Got bless :)

[@wahabdilawar]

You don't have ADHD. You were just "too quick" to misdiagnose yourself.

[@dinaghulyan]

Thank you so much for ALL your efforts. I cannot imagine anybody can ever explain this topic in a better way. The BEST explanation EVER!!!!

[@rwaidaalkhoury5885]

honestly you should get a nobelprize for being able to explain this so easily and clearly

[@戴源成-e3e]

Bro I got all the respect for you, but I would like to remind you that at 22:14 P-CAM should be modified as PECAM, which stands for Platelet Endothelial Cell Adhesion Moleclue. As a MD student and immunology researcher from Taiwan, I would like to thank you for producing these high quality videos that provide me and my classmates with plenty of food for thought. Wish you all the best.

[@andrewlaird2407]

How on earth do you remember all this! Absolute legend

[@pranoydas140]

You deserve 10M subs

[@iqra4397]

So true❤

[@mrsamandabernier]

How are they not at 1 million yet?!?!

[@mohsinfareed1797]

LONG TIME I STOPPED USING KZbin FOR ANYTHING EXCEPT WATCHING YOUR WONDERFUL VIDEOS. THANKS VERY MUCH FOR MAKING OUR LIFE SO EASY.

[@mboe94]

I always go to your page, when there's something I dont entirely understand at med school. Thank you for making these videos!

[@leonardopeixoto5162]

You're such a freaking good teacher!

[@linaletsgo9466]

try taking B vitamins (B9 and B12 - this will relieve vascular inflammation. B12 is methylcobalamin) and essential phospholipids (lecithin). Coenzyme Q10 also helps. In one of my videos I talked about the fact that when I was given intravenous cytoflavin (and these are just B vitamins), I felt very good. Then I did not understand why. B12 should be more than 500 according to the test results - then homocysteine will decrease

[@chestnutsev7]

Yes be careful and read the label because I learnt and I’m nobody in this field that there’s two kinds of b12 methylcobalamin and cyanacobalamin the latter not good I believe.

[@shilpakelkar4269]

i am just in awe of your lectures . They are just very well explained . very methodical

[@katiele1989]

this is the very first time in my school journey I do understand what I learned from school, You are an amazing teacher, thank you so much

[@gultekinunal]

Just passed my doctroral qualification exam with great help with your immunology videos! You are awesome man! I did my master's in Microbiology, I tought I learned a lot but I was wrong. I learnt a lot from your videos. Just for the info, if you make a video about hipersentivity types that is going to be awesome, too! Greetings from Turkey!

[@ranookukoo9632]

Hi my microbiology mate ..... From Pakistan 🇵🇰

[@ishaqureshi402]

I wish I could give you more than just one view because you are saving my life while my professor's earning six digits by just reading through the slides. Gosh! Thank You.

[@Tinyteacher1111]

I’m not even in med school; I’m just trying to heal from toxins. This is fascinating, and I’ve found out a lot about why this happened to me!

[@louisprusa9833]

toxins...LMFAO

[@Tinyteacher1111]

@@louisprusa9833 That’s funny? Why? I almost died.

[@nathanbarnett5492]

My PhD thesis diverged into the immune aspects of epilepsy and this is a beautiful way to make sure I'm familiar with everything. Thank you Prof

[@tariqhassan7306]

An amazing and unparalleled teacher ever existing on earth. Love you sir.

[@EduardoEulalio-d3n]

You are the best medical content creator I have seen so far, thank you so much for helping in my medical formation Zach, you are a phenomenon. All the best from Brazil.

[@atilacrm]

Zach and the Ninja Nerd gang. I am an EMT instructor and your presentations are amazing deliveries of information. You're helping me better organize and prioritize info. and understand processes that I would be lost in understanding without Ninja Nerds. Thanks from Rio de Janeiro

[@NinjaNerdOfficial]

Thanks so much!

[@bethanyweston91]

I got 83% on my last test because of your lecture videos! :)

[@nyirantunganesolotiinah9277]

you are the best lecturer i have come across, you share your knowledge for free. never selfish. Many blessings

[@grishaasher7653]

That's what a real hero looks like.very grateful for this channel .

[@mziwonkexola3707]

Vet- student here... Your videos are truly the best...thank you

[@LoraShima-ESC]

You have a unique gift to make the complicated not so complicated! Thank you for being amazing!!!

[@SiekerMusic]

THIS IS SO HELPFULL!!!!!!!! I am so glad there´s a video of this subject since our lecturer wasn't teaching us this clearly as you are doing!! THAAAAANKS!

[@anmolyadav1855]

Showing gratitude to the best teacher I've learnt from. You are AMAZING!

[@kotencwto0o]

You're so good at explaining so complicated mechanisms! I passed one exam thanks to another video of yours last week and I think I'm gonna need this video for my next exam this week! 😁 You're awesome! 😊😊

[@Masmaskias]

Oh my god, I am in nursing school and currently taking patho and pharm. This totally helped me! Thank you so much, you are the BEST!! Subscribed and gave you a thumbs up! Thank you! Thank you! Thank you! ❤

[@deandreeccles854]

You made margination/rolling along the endothelial surface so much easier to understand! I can't thank you enough!!!

[@yachiapatel]

Mr. Murphy's creativity is strictly next level. Like I not only learn such boring concepts but I enjoy learning it even in my free time. The drawings and explanations of this guy is so cool that I just watch and enjoy it like a movie 🎥 ❤. Thank-you so much to you and your off screen team to work so hard for students like us. ❤🎖🏆

[@مصطفى-ش3ه2ص]

Zach, You are the best lecturer I have ever seen, wish you the best

[@amexoyideg4570]

Their is nothing that replaces the favor that you do on us.thanks so much prof.Zach.

[@thelifeofnioh7986]

I'm a first year Medical student from India, and this channel is gold for me.

[@fay5805]

This was so helpful. I have been watching a lot of videos on inflammation but this made a perfect picture in my head. thanks a lot.

[@rickfearn3663]

Exceptional clarity while still detailing the underlying mechanism of action. Inspiring.

[@bethanytowne2970]

Our immune systems are so cool!! Your illustrations and talk really help to bring the content to life more so than just reading the textbook or listening to a lecture. Thank you so much!

[@carolinemakwanyamoyo515]

Cf jtguyyf Fghyh

[@ramshamahmood6413]

Best and easy to understand explanation, thank you !!!!!! Love your work, it's really helping me get through med school.

[@stevenweickjr9949]

As always, great videos and info...FYI - Gram (-) bacteria only releases endotoxins when the bacteria dies and the cell wall breaks up because the endotoxins are part of the cell wall. Gram (+) & Gram (-) both can release exotoxins while still alive.

[@minisman9596]

Your videos are amazing, saving me in so many subjects. And it makes just fun to study with your videos. Thanks a lot from a 3rd year medical student!

[@DrShahid-Shafi]

hats off man, the way he reaches the conclusions, just wow... Thank you very much Sir..

[@margaretmcduck5381]

Ok, I can't believe he explained this so well 😮 I was trying to study with the help of every textbook I could find, but it seemed damn near impossible and i was feeling like a giant loser, but then I found you. Thank you so much

[@sharonborman6513]

Thank you 🙏........I can sit for hours...watching & listening. If only this kind of lectures was made this easy in my Nursing Career. You're a excellent Lecturer 👏

[@SuneZa91]

You have helped me so much in understanding topics I never actually understood properly in Med School! Best teacher. Thank you for making these. Have been using these videos to study for primary surgical exams.

[@mrsamandabernier]

I seriously sit and watch your videos and SEVERAL times throughout EVERY SINGLE VIDEO I am saying OUT LOUD, "Wow! That is SO COOL!" etc. The more I learn, the more I want to know.

[@calamity4551]

My professors could never... Despite reading materials time and time again I couldn't grasp what was going on before watching this 🙏🙏 thankyou

[@shandani7215]

Gosh, the medical vocabulary of this guy is mind blowing.

[@youreworthyourweightinavoc7189]

This was so helpful. I really find the level of detail you give helps me better understand the processes. Thanks heaps!

[@JoTKirk]

When you called TNF-alpha a MOFO I just about died. Librarians givin me the stink eye. Thanks!! (No, really, thank you! Great info)

[@CosimoSecundus]

I swear your lectures are just mindblowing good, you make me start loving immunology

[@nadakudititab405]

This is just speechless... very well explained... you are really talented

[@saadmaath1189]

I feel so hyped after watching you explaining the lecture but I do not know what to do next how to keep those info from being lost

[@vanwhosits5539]

You either need to apply it directly (like in a testing or physical assessment) and I would highly recommend rewatching the video. I've used this process to get through my A&P classes. Just watching this series over and over until I can quote it while I'm watching it (or almost) The key to retention is ALWAYS repetition. Emotional attachment helps, but repetition should always be the default. Repetition to the point of "muscle memory" (being able to recall without effort) is the BEST way to hold on to a concept. The secondary (but also very important, path to memory) is understanding. If you can talk your way through it using something like "if/then" statements, you'll be able to remind yourself of what you've learned. If I see swelling, I know that's because of a fluid build up, what causes fluid build up? cytokines that communicate to the inflammatory hormones...etc. I hope this helps. This is the process that got me through A&P and EMT school.

[@vanwhosits5539]

Hence why I'm watching this vid again, even though I've been done with this particular A&P class from about 4 years. Continuing education always requires repetition.

[@vihaansinghdhami908]

Best teacher ever !!! An expert in Medical Sciences

[@sirinesaleh5398]

Hello ninja nerd, first thank you so much for your videos they saved my life. Can you make more immunology videos, because a vast subject, and i think many people, other than me need them ( cytokines and chemokines, Dendritic cells, MHC, B-cells development, immunological synapse). Thank you deserve so much more recognition.

[@irinaserpi9437]

I love you so much! couldn’t pass my exams without you!

[@taneshaplummer8712]

All I know is you can teach. You come with drawing, you don't take the pic from the book and just to explain you out in the work. I wish I could pay you but for now I send your youtube link in my batch main group so others can watch and learn. Thank you nuff love from Jamaica 🇯🇲

[@rlh716]

Hi Ninja! Just a quick note: I noticed that in the video, CRP was mentioned as 'C-reactive peptide,' it should be 'C-reactive protein.' Thanks for all the amazing videos!

[@nwheelhouse6768]

Thank you NN, this was so useful! Any chance of a chronic inflammation video being released?

[@mduplooy6763]

Zac, you are simply the best. Thank you for all the hours you spend on studying and producing these videos for us. a TRUE legend...

[@lanecarpenter5871]

You explain everything so easily to understand. Struggling nursing school student LOVES ninja nerd!!

[@jennifermeadows6901]

I can’t tell you how happy I am that I stumbled upon your page! I have a nutrition degree and have been watching your videos as refreshers, but really I’m learning things I never learned in school as well! Thank you so much for making these videos. I’m your newest fan

[@kasozimarvin8972]

nutritionist too,

[@Vividsify]

Excellent video - you just effortlessly brought four pages of my textbook to life. Thank you!

[@ReginaFarfalla]

YOU LEGEND!!!!!! i passed my compleeete physiology exam including neuro thank you!

[@enkhtuvshinkhorolgarav]

I will be a teacher like you, one day. Thanks for being such a role model for me.

[@linaletsgo9466]

try taking B vitamins (B9 and B12 - this will relieve vascular inflammation. B12 is methylcobalamin) and essential phospholipids (lecithin). Coenzyme Q10 also helps. In one of my videos I talked about the fact that when I was given intravenous cytoflavin (and these are just B vitamins), I felt very good. Then I did not understand why. B12 should be more than 500 according to the test results - then homocysteine will decrease

[@j-em5762]

Hello! I think you mistook kallikreins as kalikiren in the video, and I suggest you include that in the closed captions or annotations (so you won't need to upload a corrected video). But otherwise, great explanation!

[@parmida6744]

omg your videos are amazing... i attend all my university classes and all those 2 hour lectures are not even comparable to yours in details and being understandable. i think i never understood these processes this well before and please please for the sake of science and helping med community please continue making videos thank you so much. loves from overseas

[@suje8032]

This guy is phenomenal. I’m complete layperson and I’m enjoying this sooooo much,

[@tycoonerr]

Thanks for all your videos. You make something difficult to understand much easier, FUN and EXCITING!!!

[@robgomez76]

I absolutely loved this video!! The way you break things down helps me both auditorily and visually learn. I especially loved when you called TNF a “mofo”

[@enochbrown8178]

You are the best thing since sliced bread. Your lectures are complete and detailed and answers a lot of the why's in medicine? Thank you, sir!!!

[@Korporaal1]

I really like how you teach. All the way from common basics like in this video to 'three decimals-deep' complexer material.

[@melinabaltogianni]

I passed my Physiology exam thanks to this video alone. Thank you!

[@ferrislkpokpa7867]

You are really a hero-figure for your generation.

[@siwodgeta5443]

The way you explain makes your lecture sticky to mind

[@kamilrajput7454]

Thank you Ninja for Always Available for helping us in our tough time.

[@suiteritch]

how come i dont feel sleepy and i never yawn watching and listening your vids! 😍

[@annabellealberton5470]

I literally end each video wondering how you do it...incredible

[@jiixuyr]

الله يهديه ويدخل الاسلام , انسان نظيف وصالح 💞💞

[@johnfrancis_kennedy]

Fantastic content. You're helping me and so many others out with your videos!

[@amalayoub5478]

If I pass my NBDE1 it will be mainly because of you! ❤ thank you so much for all these videos!

[@saminmotaleb7431]

I couldn't imagine that immunology become my favorite subject & watch your immunology playlist with enthusiasm😍😍😍

[@ferrislkpokpa7867]

Zacko! You are incredibly different from all other Teachers on KZbin, and you are so young.

[@corentinbellet583]

tu es le professeur que tu penses être, t'es le GOAT champion

[@nived8476]

The process where leukocytes are "rolling, rolling, rolling" is called-- rolling. Margination occurs just before rolling when the blood vessels dilate. There is stasis of RBC (think back to Bernoulli's Law and the change in velocity that occurs with a change in the crossectional area of a cylinder). The slower moving neutrophils get pushed to the periphery, or margins, of the blood vessels, making them more likely to interact with the selectins. Then before transmigration (diapedesis), the leukocytes need to undergo firm adhesion to integrins. TNF-alpha and IL-1 are already being released by sentinel macrophages and dendritic cells that live in the tissue and encounter the microbe when it breaches the protective barrier. ICAM and VCAM are the integrins needed for firm adhesion, which stops the neutrophils from rolling. PECAM (platelet endothelial cell adhesion molecules) expressed on both neutrophil and endothelial surfaces are what allow for transmigration to occur.

[@ronelgallon6949]

BLESS YOUR HEART THANK YOU FOR DOING SUCH A GREAT JOB! CAN YOU ALSO DISCUSS WOUND HEALING PLEASE!

[@drdineshpahlajani6199]

Wow....u are a great teacher.... Explanation to immunology basics at its best...!!! Thanks buddy...

[@soulsmith-bg9ub]

You are great and wonderful ❤, I wish you continued Immunology Lack of information in this era, really suffer us😢

[@knasttrast7168]

The thing you called margination is in fact rolling. Margination is the process in which the blood cells moves from the center to the sides of the blood vessel (due to vasodilatation slowing the blood flow) and that happens before rolling.