Insulin Resistance: Top Causes & Contributing Factors

[@nourishedbyscience]

This video has chapter markers, which you can see in the video description below the video, and if you hover over the video with the cursor. If you have seen the last two videos about the Personal Fat Threshold and Hyperinsulinemia already, you can start the video at #3 (Inflammation). Cheers Mario

[@mybabygirl666]

My glucose always starts to rise starting 10:30pm and throughout the whole night til next morning until I eat (100-120). I know that morning spike is due to dawn phenomenon, but I don’t understand why it starts rise before midnight and throughout the whole night (the highest number). I eat low carb diet. During the day, my blood sugar is in the 90’s. What other factors could it be? Hormone?

[@Mr-hn2bp]

​@@mybabygirl666Low carb diet means high fat and protein which are slow in digestion and absorption. Unneeded amino acids are converted into glucose. A large dinner would sustain digestion and absorption longer. It also depends on your dinner time.

[@mybabygirl666]

@@Mr-hn2bp Thank you for taking the time to reply. Do you mean that I over consume protein (amino acid) which turns into glucose? I normally eat between 7-8pm.

[@Mr-hn2bp]

@@mybabygirl666 So your blood glucose starts to rise about 3 hours after dinner. Carb digestion starts in the mouth as the saliva contains amylase which releases glucose (not absorbed in the mouth but you can taste the sweetness) whereas protein digestion starts in the stomach into peptides and continues in the duodenum (first section of small intestine 12 fingers long, your own) by pancreatic proteases. Peptides are not absorbable and can cause passing of rotten egg gases (hydrogen sulphide). Incomplete digestion of carbs feeds your gut bacteria so they don't have to feed on your mucin layer causing leaky gut syndrome. Fats don't get processed until they reach the duodenum where they can be emulsified or digested into free fatty acids and glycerin (aka glycerol, a carb). Emulsification depends on bile salts and cholesterol all secreted by the liver and stored in the gallbladder. Fats in the stomach coats other food fragments interfering with their digestion and formation of chyme, thus causing satiety and delayed gastric emptying. If you have a large fat intake and/or low bile output, you can end up with steatorrhea (fatty diarrhea). May be try a more balanced dinner with a smaller portion size.

[@itsm3th3b33]

4. Low muscle mass Thank you for this info. Such an important factor but it's not discussed by the tons of KZbin videos promoting time restricted diet as a way to reduce insulin resistance. If you have low muscle mass TRD will make you lose weight (for sure) but not only it will not improve IR it may make it worse. Do the studies that reported this factor discuss why that is the case? What is the relationship between muscle mass and IR?

[@andreac5152]

I don't know exactly your background but it's clear that you are a top expert about metabolic health. The amount of knowledge in this video is incredible.

[@nourishedbyscience]

Thank you. You can find all of my background, including a link to my Google Scholar page and my full academic CV, here: nourishedbyscience.com/about/ Best, Mario

[@TheTylerjoy04]

W😮W!! I Am Only Now Finding This Out..! I'm SUPER Glad I Came Across This Video..!👍🏼😊👍🏼I've Been Insulin Resistance Over 12 Yrs, Probably Even Close To 15yrs Now & Its No Wonder I've Had A Hard Time Gaining Muscles.. I've Been Lifting Heavy Weights, I'd Say Over 8yrs Straight Now From Low Reps To High Reps.. @ One Point I Had A Personal Trainer Train Me.. He Even Wonder Why I Had A Hard Time Gaining Muscels.. He Told Me To Increase My Calorie Intake & More Protein But It Only Increase My Wasteline & Not So Much My Muscel Mass..He Said I Was The Only Is Client That He Had So Far That I Had A Wired Metabolism.. I Guess He Doesn't Know About Insulin Resistance People.. So My Question Is, Why Is That Us People Who Are Pre-Diabetic Or Insulin Resistance Have A Hard Time Gaining Muscle Mass?? Is There Anything I Can Do, Besides Taking Enhancement Drugs Lol! To Gain Lean Muscle Mass?

[@nourishedbyscience]

Insulin has numerous anabolic actions, including increasing protein synthesis in muscle and decreasing the breakdown of muscle protein. If we are insulin resistant, the cell may not receive the full insulin signal, and therefore the muscle-building process can be impaired. Follow along on the channel over the next few weeks and months to learn how to improve your insulin sensitivity. Sorry for always referring to future videos, but there is so much to say about that, it wouldn't make sense to type it up here (it would be a book!). Cheers Mario

[@alexmanea-9751]

​@@nourishedbysciencelooking forward to solutions on high visceral fat, low muscle, low fat everywhere else but the belly. How to fix e debalanced gut microbiota, could candida overgrowth affect insulin resistance? God bless you

[@Sarah-with-an-H]

@@alexmanea-9751 Belly fat is the outward expression of chronic fatty liver disease. Fatty liver is a result of a carnivore consuming more carbohydrates then we can adequately burn off. A protruding belly is an indication that the individual has fatty liver and ran out of storage in the liver and so the next option is around the midsection. Kinda like a beer belly. We should really call it carbohydrate belly is that more truthful these days.

[@barbarabutler4701]

Just foundv you tonight. RN here. While I knew a lot of what you said it is your professional informative presentation that is 5star. No selling stuff or hype. Sharing this with my colleagues. Thank you

[@rajg7037]

We just found your channel and we are so grateful and impressed by the quality of the content. I've spent the last 6 years digging into IR and glucose control, trying to dig through the nonsense on the internet and find well balanced, scientific, non-agenda driven information. We are literally watching every video systematically. Please keep making content!

[@nourishedbyscience]

Thank you for taking the time to provide such kind feedback, Best, Mario

[@Whistlewalk]

Me too. It's been a slog, but this information makes sense to to.

[@HeinzRuetschi]

Mario’s presentations are one of the best I have seen so far on the internet concerning insulin resistance and diabetes. What I find very disturbing, with all the new science available, how much or better, how little the medical world is applying the new information. As long as the financial interest of the medical world and the influence of the big pharmaceutical companies prevail, backed also by some questionable politicians, a lot of people still will be maltreated for years to come. Pushing the pill by treating the symptoms and not the root cause! This will break our health system in not too further distance throughout the world. Mario thank you very much for your fantastic informative work and efforts!

[@nourishedbyscience]

Thank you for the kind feedback. The current medical system is truly broken in most countries. It's such a shame that we have armies of passionate, smart, and dedicated professionals such as physician and nutritionists, and we are not using them to their fullest capacity to help people prevent chronic diseases. I actually think these professionals are suffering as much from this medical system as the patients. Change is long overdue, but until that happens, I do think arming people with the knowledge to help themselves is the best we can do. I honestly think that prevention is where it's at. Best, Mario

[@susanfreeman6350]

Your videos are so clear and deliver important information that is easily understandable. Sigh. Instead of resting on my good fortune in being a 73 year old, very healthy woman, I’m going to go do some weight bearing exercise. Thanks for another great video.

[@nourishedbyscience]

Thank you, Susan. It does seem like you have done a lot of things right in your life, so maybe you don't need any of my suggestions ...;-) At the same time, I do think it is fair to say that regular resistance training is something that most people could benefit from, so I am hoping you'll find a way to enjoy your exercise! Warm wishes, Mario

[@TooBuffed]

Not only a “like” but I would like to express great gratitude for your efforts. Very clear and needed explanation!

[@franrushie.510]

This video helps me understand why my insulin can rise even after I eat healthy and exercise…. I tend to go out and exercise early… then the rest of my day is inactive… my insulin can still become resistant… I thought as long as I exercise that’s all my body needs… I need to change my activity levels throughout the day.. thank you so much..

[@sssoup]

Easily one of the best lectures connecting underlying cell biology to common diseases. Brilliant work

[@nourishedbyscience]

Thank you for the kind feedback. Cheers Mario

[@tubetop123]

This is literally the best info video ever. Every doctor or nurse says we will look for the root cause. But no one really knows what root cause means. They just keep telling us to change our diet. That's not resolving the issue. That's just reacting. Thank you for this video

[@afonsodealbuquerque4115]

Dr Mario, this last 3 videos are your best ones so far. Very informative, I really learned a lot. Thank you

[@kaycheng1588]

Newly diagnosed with pre-diabetes and I’m hanging on to every word like as if you’re sending out a lifeline. Thank you so much for explaining in such detail as I am wanting to understand science and facts and not fads. I’m someone who has been underweight most of my life, eating relatively healthy, exercise regularly. Now I’m realizing I wasn’t as healthy as I thought. My diet could have gone without the glass of wine every night for the last 10+ years. I would do a hard workout, but would have a sedentary rest of the day at work or after dinner. I would have a sweet treat 2-3 times a week but ate healthy otherwise. And here I am, with pre-diabetes. 56 years old, post-menopausal, staying up too late watching Netflix and not getting enough sleep…..on and on. Now I know there are so many factors leading up to the state I’m in now. I’m at 5.7…if I work on these strategies, how soon could I expect to see improvements in insulin sensitivity?

[@jax9349]

Thank you so much. I thought I knew about insulin resistance and have followed a ketogenic diet for 5 years. I had an initial weight loss but have stalled dreadfully. I worked much of my nursing career as a night sister, but for the past few years have worked reduced hours on day shifts, I am 65, so it's a semi retirement post. I have felt very stressed lately, both with life problems and too much "news"! I have recently given up coffee (6 weeks) and the difference is incredible. My stress levels have dropped and my sleep very much improved. My weight is starting to drop again. Thank you for helping me to understand the missing links. I walk plenty, but I think it's time to dig out my old weights!

[@catherinewilson1079]

I just stopped coffee too! The difference is amazing. I am so much more relaxed! And all I used to drink was 2 cups when I woke up😳

[@acac5003]

Wow!!!! I have been studying the physiology of human body for 35 years!! No one-NO ONE-thousands of hours of seminars and classes has explained insulin resistance and inflammation so elegantly, clearly and beautifully!! You have inspired me beyond words! Thank you Keep up the great work you are doing!! I would love to meet you in person one day May God bless you and your family, your children and their children’s children Sincerely Dr Aaron Chadwick

[@nourishedbyscience]

Thank you, Dr. Aaron!

[@praguecr-Premium]

After watching many health and nutrition podcasts, I would say one of the best and most professional are those of Dr. Mario. Very informative, direct to the point commentary without silly jokes and constantly selling some other product or service. Other presenters should take a queue from this doctor.

[@ebluz]

Due to advancing age and some minor health scares, I'm new to the self-health interest crowd. Of the myriad of health related KZbin influencers that exist, this channel has become one of only two that I have come to trust. I haven't seen a lot evidence produced here (in the form of reference to specific studies, particularly meta-studies). However, Mario's discussions seem to me to be very high level and consistently reliable when I research his ideas elsewhere, and with every Nourished by Science video I watch, I become more trusting that this dude knows what he's talking about.

[@nourishedbyscience]

Thank you for your kind feedback. However, you don't need to trust my judegement here. I have made it my mission to raise the standard of scientific rigor with which nutrition information is shared here on KZbin, and you can find a blog post with more detailed discussion and all of the relevant references on my website for each video. The link to that is always in the description box below each video. For this particular video here, I have cited 65 scientific papers, for example: nourishedbyscience.com/insulin-resistance-top-causes/ Best wishes, Mario

[@ebluz]

@@nourishedbyscience Oh wow, you cited 65 studies to support this video? That's beyond impressive. I stand corrected. Sorry, I hadn't noticed the links to your blog. I don't always click "More" in the Video Description... perhaps I should be more diligent of doing that. I'm particularly interested in this current topic of Insulin Resistance, as my recent Glucose numbers indicate I'm pre-diabetic (110-115 morning fast and 5.9 A1C - although my Doc seems rather cavalier about those numbers). I appreciate your reply, and I'll be looking forward to the upcoming discussions on Insulin resistance you mention.

[@nourishedbyscience]

@@ebluzYou caught this at a good time. I realize many doctors don't take prediabetes seriously, but I do think of gluocse intolerance as more of a continuous measure than a categorical one. In clinical medicine, all we consider is diabetes (yes/no), where in reality there is not just black and white, but many shades of grey in between. That said, it's a great opportunity for you to find some shifts in your diet and lifestyle that you can happily live with in the long run and that can help you normalize that glucose tolerance. All the best, Mario

[@marzenarongione4968]

I am in the same situation as for lab values. No big deal to my doctor, however HUGE deal to me as I become aware how quickly this can get out of control. I am investing in CGM and trying to implement many changes I learned from experts on you tube Thank you for this presentation

[@cathyellington7599]

Hi Mario, I wish I had know about all of this before my problems hit. You are so right about the hidden chronic diseases that are caused by insulin resistance. After finding out about my NAFLD I started reading and found out that over 30% of the world’s population are probably walking around with fatty liver. Studies show it to be epidemic. It is one of those things that pops up accidentally when having a test done for something else. People often ask me well how come you didn’t know. Didn’t it show up in your labs. I had normal liver enzymes and lab work. It was found when I had a bladder scan for another reason. Then sent to hepatology Dr. He did a fibroscan and there it was. I was very lucky because now I am working to reverse it because it had not reached the fibrosis stage. It would not have been long because everything was going up. B/P up, cholesterol up, weight up and I had a border hgb A1c which never was high. I now watch all your videos and will continue to watch them all. I struggle but at least headed in the right direction. Thank you

[@nourishedbyscience]

Thank you, Cathy, for sharing. I am glad to hear you found your NAFLD early. Dietary and lifestyle change are quite powerful in reversing the condition at this stage. Your story is not the first one of this kind that I have heard. So often in the clinical trials I have led have participants shared that once they hit a certain age, they felt like their health was slipping away from them, and every 2-3 years they needed a new drug for elevated blood lipids, high blood pressure, diabetes, painful joints etc etc. I have absolutely come to believe that we ourselves need to take matters into our own hands by educating ourselves, asking for lab tests, and changing our diet and lifestyle preventatively. The slow accumulation of visceral and ectopic fat as well as insulin resistance in particular are linked to so many other risk factors such as blood pressure, high blood sugar, high blood apo B/LDL-cholesterol, high triglycerides, high inflammation markers etc., it doesn't make much sense to me that we don't pay more attention to these markers in primary clinical care so that we can fight the causal factors early. Best, Mario

[@margareteversley7850]

​@@nourishedbyscience😅

[@franrushie.510]

A carnivore diet helps reverse fatty liver..

[@marcoantoniosundfelddagama7690]

Hi Mario, this is a fabulous video. Thanks once again for sharing such a high quality evidence-based information. Unfortunately many well-paid doctors and public health authorities are not even aware of it. Watching your videos should be mandatory for any health professional truly devoted to improve the metabolic health of their patients.

[@nourishedbyscience]

Thank you, Marco! Hope all is well!

[@animo-y-adelante]

The best channel about diabetes and I insulin resistance!

[@lucvandermeeren]

I get so excited when I see a new Nourished by Science video. Mario, you are a true treasure. Thank you, thank you, thank you! Your videos are backed by science, clearly presented, and well researched. I can't wait for the rest of the series.

[@nourishedbyscience]

Thank you for your very kind feedback. Best, Mario

[@tobiasruland4553]

Clear language, great structure, right on the spot. Danke Mario!!!

[@redhen689]

I just found your channel. I’m 65 years old have a BMI of 23. When I was eating 2-4 eggs each day, my total cholesterol was up to 290. Over the past year I have transitioned to a mostly plant based, high fiber diet, avoiding most added sugar. My cholesterol was 201 last week. My triglycerides are good. My fasting blood sugar has been around 100 the past few years. I am currently doing the Zoe program and have a CGM for 2 weeks. My glucose on the CGM is below 100 most of the night, but when I eat I get spikes up to 150-170. I just had my HbA1c checked it was 5.9. I’m experimenting with meals and am trying to add more exercise to my routine. Hopefully I can find something to eat that keeps my cholesterol and glucose under control. Thanks for your channel. I need to watch more of your content.

[@choyvong6843]

You may want to try intermittent fasting. My A1C was 5.8 now is 5.4 due to intermittent fasting and of course exercise along with healthy foods.

[@AndyLambg]

This doctor is God sent to save us all. Making a complicated issue easily understood. God bless him as well. ❤

[@Nic-of3dy]

I ate low calorie ( 800 or less) every day for years and filled up mostly on protein and simple (crappy) carbs… I’m 38 ,141 lbs, and type 2 diabetic and have severe issues with my muscles now … I struggle so much with losing weight . I’m completely changing how I eat now and hoping to incorporate exercise again soon. Thank you so much for your videos they are extremely educational.

[@goongalay]

Top class delivery. The best I have seen on diabetes- related problems.

[@markb6407]

I spent most of my day researching insulin resistance and trying to find GOOD information. And I finally found you! Thank you so very much for your concise yet meticulous presentation. I just become a new subscriber. I really appreciate your science/study based approach. There are too many influencers on YT. You are a rare and refreshing presence. I look forward to learning more from you.

[@annmc6353]

Good information but truly I have to listen several time for it to sink in my head. Thank you for the information.

[@lotembenatar7163]

This was an amazing and very informative video, Mario! The best I have ever seen on KZbin about insulin resistance

[@StarLover85]

Thank you for another great informative video 🙏🏻😊. I stumbled upon your channel a few months ago as somebody with PCOS that I believe is caused by insulin resistance. Using a CGM tracker and following (amongst others) your advice, has helped me tremendously in regulating my cycle. I’m looking forward to your next videos!

[@BluegrassCatDrummer]

Thank you! Insightful and thought-provoking.

[@AminPishehvar]

You are absolutely amazing! Very useful information. I got the answers to many of my questions that my primary care doctor and endocrinologist were unable to answer.

[@nourishedbyscience]

Thank you for your kind feedback. Warmly, Mario

[@rolitiwari0909]

I completely agree with the circadian rhythm factor.. happens with me.. I am more insulin sensitive in morning and afternoon and least in the night.. after dinner if I eat/drink any carbs eg. Coffee with sugar etc. my blood sugar stays high

[@chenskitchen]

Could you give some lessons on gestational diabetes? How to increase insulin sensitivity in pregnancy? Or increase the insulin production?

[@MrVegimi]

German calmness, attention to very detailed information, and great knowledge. Such a pleasure to have found your channel. Please keep up your amazing videos on educating people on metabolic health. Danke Dr. Kratz!

[@nourishedbyscience]

Thank you for your kind comment! Cheers Mario

[@OrlandoKissimmeeHomes]

Your videos are great. Extremely informative and well paced for learning. These helped me alot. Thank you Mario

[@alexm7310]

Excellent. Comprehensive, but succinct! Looking forward to future presentations. Thank you 😊❤

[@nadiaboulanger9323]

I love you❤ ❤❤Dr Mario! Your videos are so helpful for me and I am grateful for your walking the planet at the same time as me.

[@drbachimanchi]

Wonderfully presented

[@jerzybaczyk2769]

That's why I listen to such interesting lectures while exercising on the elliptical...

[@KoiRun50]

Hi Mario I love your animation and explanation of how insulin holds the insulin receptor ‘hostage’ for a long time. It needs time for it’s release. The way you explained is a golden take away for me. Is there a reason why that binding needs to be strong and prolonged?

[@nourishedbyscience]

Good question. I am actually not an expert on the binding dynamics here, and how they compare to other ligand-receptor relationships. Will look into this and report back if I find something noteworthy. Cheers Mario

[@paulantoine1696]

Thank you again Mario. It's been very clear to me that insulin resistance is simply **not** taken seriously enough as an urgent problem to address, at least here in Australia. Only once people fall off the insulin resistance cliff into full type 2 diabetes does anyone do anything, and that usually consists of "oh here's some Metformin, and try to eat healthier/exercise". This level of public health intervention is far too weak to have anything like enough impact.

[@nourishedbyscience]

Love your comment, as I will talk about exactly this in the very next video. Cheers Mario

[@susanfreeman6350]

@nourishedbyscience, I cannot wait to see this next video. I’m often shocked at the intelligent, educated people I know who believe their Type II Diabetes is “hereditary.” As the oldest of 5 kids, I grew up in a household where there was no money for junk food and soda. For sure, we had some things like hydrogenated peanut butter and store bought mayonnaise, but our big treat was popcorn. Fast forward into adulthood and all five of us are over 65 now. One sister has scleroderma, another has really bad arthritis. One brother has numerous joint, BP, and lipid problems. Another brother is OK for now. Three of my siblings have had cataract surgery in their 60’s! It’s just heartbreaking to me.

[@Sarah-with-an-H]

Insulin resistance is the result of over consumption of carbohydrates. Our bodies are not designed to eat as much carbohydrates that we do in maternity. Unless you’re extremely active and Carbo load for a marathon we don’t need to eat as much carbohydrates as we currently do. Overconsumption of carbohydrates creates a fatty liver think forced delicacy it’s now band nearly everywhere because it’s an abusive practice but in humans and by choice because addiction to carbs being always hungry and can’t stop eating or drinking is beer good equals fatty liver disease fire alcohol and fatty liver and fat people is known as non-alcoholic fatty liver it’s caused by insulin resistance Andover consumption of foods that raise blood sugar. Other than fruits plants don’t want us to eat them and fruits are there to get animals to spread the seed for them by enticing them to eat something sweet and delicious and originally not available in the quantities that we have available to us today and anytime of year all the time.

[@nourishedbyscience]

@@Sarah-with-an-H Sorry, Sarah, but I'll have to disagree here. I realize that what you are sharing is a wide-spread belief in the low-carb community, but I don't think the cumulative data support it at all. If you are open to considering the data, I invite you to review the data from 21 randomized controlled trials with me in this video: kzbin.info/www/bejne/kJS5lqGLl9amj7ssi=i-zjpkEJ_EbaEYAA Many of these are well-controlled feeding trials where all of the food was provided to participants (i.e., we know excatly whay they ate) and in which insulin sensitivity was assessed by the gold-standard method, the hyperinsulinemic-euglycemic clamp! There is very clearly no consistent evidence that high-carb diets per se, i.e. when controlling for changes in body weight, trigger insulin resistance. Just like there is no consistent evidence that high-fat diets trigger insulin resistance, as is often claimed by low-fat vegans. You mention addiction to carbs. I understand what you mean here, but is anyone really addicted to legumes, whole grains, and starchy vegetables? Is it really the carbs themselves? Or are people addicted to carbs in the form of ultra-processed foods, refined grains, and added sugars? If the later, is it not a bit superficial to claim that all carbs are similarly bad? Also your argument that plants don't want us to eat them is not all that convincing. Do animals want us to eat them? Of course not. And if what you mean are antinutrients, yes, I am also very interested in that topic and will cover it in time, but do we really have data that suggest that eating plants leads to poor health? Come on! Lastly, carbs cause fatty liver is as much incorrect as saturated fats cause fatty liver. And the latter point I could even support with a well-controlled dietary intervention trial. The biggest point here is that both carbs and fats can promote a fatty liver if we overeat calories chronically. And maybe if we consume a lot of fructose in liquid form (even though that almost always leads to caloric excess as well). I don't take sides here in the tribal diet wars. My side is that of evidence. I am willing to consider the very interesting anecdotal evidence of health sucess stories people in the lwo-carb, keto- and carnivore communities are having. Really interesting stuff. But I am also interested in the very good long-term health in people who eat whole-foods plant-based diets, and the excellent health of many populations such as Italians or Japanese who to this day eat diets rich in carbs but low in ultra-processed foods and who have much, much fewer problems with obesity and diabetes than the US or much of Western/Northern Europe. We should try to reconcile these data, and not pour the baby out with the bathwater. Looking forward to your response. I get a lot of comments from both the low-carb and low-fat crowd, but no one ever seems seriously interested in learning something or being open to an argument and engaging with it. Best wishes, Mario

[@TomiRantanen]

​@@nourishedbyscience Your channel and videos are already fantastic, but this reply really shows how wonderfully dedicated you are to spreading the right information. Very few people would've taken the time to provide such a detailed answer to a KZbin comment. Absolutely exemplary. I wish you all the best in this endeavour and will be watching every single video.

[@susanmayner998]

Thank you for this comprehensive information. I am currently taking part in a lifestyle program designed to reverse insulin resistance and diabetes. The program incorporates many of the same concepts that you discuss; however I gain much greater understanding by watching your videos. They help me to more deeply understand my condition, how it developed and why the lifestyle changes I'm making are working. Many thanks for doing this good work and sharing it with all of us who are watching.

[@Ambrose-jw9hz]

Excellent I have learnt a lot in a very short time. Thanks

[@nourishedbyscience]

Thank you! Your KZbin user name suggests we know each other in real life? (If not: sorry ...;-). Cheers Mario

[@SaSPonchICo]

I do support an entire PCOS video, it'd be great! I'm someone with PCOS who has managed to lower my blood sugar, started leading a healthier life and also keep my hormones in check with medication but my insulin level is still high. This is very confusing for me and I'm not quite sure what else there is to do.

[@foodforfertility]

I totally agree!

[@Daniele__D9]

Thank You Sincerely ! Really appreciate the trouble taken to separate the wheat from the chaff !! So much of mis-information & half baked information out there it is a real advantage & pleasure to have such comprehensive & educative information delivered right to our door step free of charge !!!

[@nourishedbyscience]

Thank you for your kind feedback. Cheers Mario

[@FurEliseTX]

Thank you for the marvelous content. I am diabetic and I hope by watching your videos I can reduce blood sugar and reverse the diabetes somewhat.

[@tenmihlratchett]

I started looking into this subject about 4 months ago by watching relevant videos on YT and reading research papers and as a result embarked on a restricted time eating regime (18 hours fasting and a 6 hour eating window) plus eating only whole foods and drastically limiting carbs and increasing high saturated fat. I had blood tests for cholesterol, triglycerides and HbA1c at the start and again after 3 months of time restricted eating. The first lot of blood tests were not at all what I wanted to hear as my cholesterol and triglycerides were very high (LDL way out of whack) and my HbA1c was 68 (I had been diagnosed as diabetic in 2014). After 3 months my cholesterol and triglycerides are now normal and my HbA1c said I was no longer in the diabetic range. I am continuing the regime until at least the end of January to see what other improvements I can achieve.

[@Tammy-zr9zw]

FANTASTIC discussion of the causes of IR and what we can do to combat it. Thank you so much!

[@danieldana6884]

Excellent video! The part about chronic inflammation was so elucidating! Thank you!

[@bobwhiteman1045]

Mario, thankyou for your wonderful, easy- to - understand videos. I have become much better informed about two issues that I am interested in ( and are interelated)- gut biome health and insulin factors). Both of these issues are now recieving much coverage in general medicine, with a greater focus on proactive lifestyle behaviours rather than reactive behaviour ( that is, prescription of drugs. Your comments on drug prescription and effects on insulin point to the need for greater education of doctors about not only possible side-effects and drug interactions but their impact on the insulin issues you rightly focus on.) While we are seeing a greatly enhanced level of medicine knowledge and availability, there needs to be a greater acknowledgement of the importance of lifestyle and holistic factors, with a focus on proactive medicine. We should never forget about the old but invaluable dictum - a healthy body and a healthy mind- and your knowledge and videos are greatly contributing to that.

[@marron1975]

We got great information from all your videos! Thank you very much from Spain.

[@tinkerbell1270]

As usual, great information presented in an easy to understand way. Thank you!

[@operskapevacica1]

Finally talk about menopause. I was fine until I got into perimenopause/menopause.

[@sheila7814]

Or menopause caused by taking anastrazole due to breast cancer. Anastrazole steals estrogen and estrogen is a glucose moderator. MY body is in a crazy fluctuation state due to no estrogen. I am headed toward being diabetic even though I eat healthy and exercise a ton.

[@adamokoriscant8500]

great information as always, keep up the great work! you were instrumental in helping me get my A1C outside of diabetic range

[@nourishedbyscience]

Love hearing this. There is much more to come that I hope you will find helpful. Best wishes, Mario

[@yukeli7525]

this video is very informative and the info presented is easy to understand/digest. I went down a rabbit hole to find this channel, will keep watching other related videos doctor recommended. thank you, Doc!

[@JimmaworkWaktole]

I am very amaixed about the smartness of my body.I have no idea how it works very hard to keep me healthy. But i was abusing it by giving it harmful things due to lack of knowledge.I am health professional but i don't know that much. Because, i studied sickness and treatment of symptoms.That is the reason why i left over without having any knoweladge.I am so lucky now to start learning from scrach. Thank you again for your eye opening health information.

[@lindabuckner9006]

Mario, you explain this better than anyone else I have followed!

[@nourishedbyscience]

Thank you, Linda, for your kind comment. Cheers Mario

[@abdulwahid-xg6xo]

Excellent summary. Thank you.

[@BCSTS]

WOW.....BEST I HAVE SEEN...BY FAR ! 😍

[@marrieannamerced4202]

Thanks for this very informative video. So lucky i found this channel.

[@nastiacooksplants]

Such an amazing channel! Thank you for putting all these videos together

[@nourishedbyscience]

Hey, Fellow KZbinr! Thank you for your kind feedback! Will check out your videos on occasion as well! Cheers Mario

[@nastiacooksplants]

@@nourishedbyscience thank you🙏🏼it has been a long while since I’ve been here as a creator :) Getting my education in nutrition now, and your content helps a lot!

[@susanfreeman6350]

SunnyV, in regards to your comment, yes my siblings and I all grew up eating the same diet of no processed foods. But, and this is a big one, once we became adults, our eating habits changed radically. I shudder when I see the foods they and their families eat. I do believe their serious health issues are attributable to their diets. There for the grace of God go I though. I became seriously interested in nutrition when I married at age 23. I was determined that my family would eat the healthiest food I could make. I became even more fervent when our first baby arrived. I guess what I’m saying is that this healthy way of eating is for the long haul and will help you regardless of your genetic makeup.

[@deepdabbler]

Thank you so much for this clear explanation in simple to understand language. I really appreciate your delivery style. Please keep making these videos.

[@blumingwellness]

Your last few videos have really grown my knowledge about insulin resistance--thanks! Insulin resistance is such an important topic since so many people are suffering from this condition and don't know it. So glad you pointed out the cumulative effects of the causal factors and the "chicken and egg problem"--salient nuances! You often show that glucose spikes result from "high glycemic foods" (pictured are highly refined and ultra-processed foods). You are certainly identifying the culprits in many peoples' diets. But I work with relatively health-conscious people who might be insulin resistant and eating a breakfast of 1 cup oatmeal with 3 cups of fruit and they don't understand why their HbA1c is in prediabetic range. I teach them about insulin resistance and balancing macronutrients which helps. Do you agree that even healthy carbs may best be consumed as part of balanced meals, especially for those who are already insulin resistant? At the end you touched on: Insulin resistance makes building muscle more difficult. I look forward to learning more about that in future videos.

[@nourishedbyscience]

Excellent question. Yes, I agree that all highly glycemic carb foods should either be avoided, or consumed with the strategies I mention in the video entitled How to Avoid Blood Sugar Spikes (link below) IF someone is already insulin resistant and particularly of they are glucose intolerant. These include a lot of foods that otherwise offer quite a few nutritional benefits, such as whole-grain bread or oatmeal. kzbin.info/www/bejne/r5iTimabg7h0hMksi=Al_F4rH62V3Nt744 I would actually suggest that even people who are fully insulin sensitive and glucose tolerant pair such highly glycemic foods with some fiber-rich vegetables, an appetizer salad with some vinaigrette or lemon, and some protein. It's just not as critically important for totally healthy people. Best, Mario

[@iyabodeadeyefa1010]

Ketogenic diet has been used for centuries. I have used it for 5 years to keep healthy post stage 4 breast cancer. Though n=1 it is enough evidence for me. I try to manage other factors as well- exercise, sleep etc. But the most important factor is drastically reducing my carb intake- I wear a cgm and track my ketones. I am open to other strategies in addition to low carb but low carb is the single most important factor if ideology- religion or environment is not a barrier. I’m not a novice- I hold a PhD in Nutrition and understand the biochemical basis of most food lifestyles. I have been able to keep my mother alive on ketovore post diabetes diagnosis since 2010-she is 85yrs. So I am not coming from the point of ignorance of knowledge or practice. Please be assured that I am not impressionable- I am 64yrs old. Thank you.

[@marti6335]

Thank you very very much for another incredibly informative video, Dr. Mario. 8:38 “Minimise the consumption of foods with a high glycemic index to give the body a few hours between meals to get back into a fasting state” I’m insulin resistant (HOMA index of 4.5) and I struggle with going more than 3-4 hours without eating. After that time, I start feeling weak and the typical symptoms of hypoglycaemia and I get afraid I will faint. As long as I eat a snack (typically a banana and some kefir or some nuts) I’m fine and can wait another 3 hours before having the next meal. I was wondering if this has anything to do with my body’s inability to tolerate when the cells get back into a fasting state. I was wondering if you can give me some insight into this process and maybe make a video about it, as I think a lot of people struggle with that (but some people with IR seem to be able to fast just fine?)

[@jackgoldman1]

Excellent as always. Like my doctor said, "Exercise, lose weight, eat whole food", NOT ultra processed foods." Love the scientific view. What we agree on is science. What we disagree on is politics. Thank you for promoting good health for all.

[@John-the-Bass]

Thanks a lot. I am looking forward to the future episodes . Very good information

[@galaxywanderer5945]

Hi Dr K, Your presentation makes PERFECT sense! However there are always the exception!

[@techeteri]

The most complete explanation about the topic. FW-ed to family as this so important for health and overall well being! Valuable channel, asset to the whole humanity!

[@nourishedbyscience]

Thank you for helping spread the word!

[@deflo56]

IR is a metabolic compensatory mechanism of many of the enumerated ailments. Understanding the specific metabolic disorders is paramount.

[@dianastoevelaar9548]

❤Thank you so much for this fantastic presentation that even a lay person can understand and benefit from. 😊I’m subscribing and will look at what else I can learn from you.😊

[@catherinewilson1079]

Thank you so much for making this video. The amount I have just learned will help me tremendously! I am borderline diabetic type 2, but not particularly heavy. However I have had problems with my circadian rythme for a few years and I have almost never been athletically inclined. Now I understand better what I have to do to avoid ending up on drugs. My sincere appreciation for what you do❣️

[@dianaecheverry1208]

AMAZING 👏🏻👏🏻👏🏻 thank you so much! Have paid so much on private doctors, endocrinologists with PhD blah blah everyone just wants to put me on medication without explaining in detail what it is I had… your videos have resonated deeply with me, have taught me and helped me understand my health in these valuable minutes than years of tests and consultations. I’m so grateful to you Mario. Thank you for your time and dedication 🙏🏻❤️

[@nourishedbyscience]

Thank you for your kind words. I agree that paying attention to the root causes of our glucose intolerance is one of the things that could be improved upon in many cases in clinical care. Because while lowering blood glucose levels is certainly a good idea, most of the factors causing glucose intolerance and insulin resistance (such as chronic inflammation, excess visceral and ectopic fat, or low muscle mass) are chronic disease risk factors in their own right. Very often, these are never addressed, or even identified. Best, Mario

[@jessicayim6896]

I think my turn to fellow your advise thanks

[@icttesoltutor3449]

Doctor, thank you for your excellent medical information.

[@redneckinthebardo]

This video was extremely helpful, thank you. I recently found out I have a pre-diabetic A1C level for the first time, but I don't have several of the more commonly known precipitating conditions. What I do have is several of the less commonly known precursors.

[@deborahrainey4810]

Thank you for your calmness clarity of explanation.

[@doccritica9456]

Einer der besten Vorträge, die ich bisher zum Thema Insulinresistenz gehört habe. Und ja, es stimmt, dass die Rolle der Insulinresistenz und des Lebensstils in der klinischen Medizin zu wenig Beachtung findet. Reparaturmedizin eben! Vielen Dank für dieses Video. Ich wünsche mir, dass Ihre Videos weite Verbreitung finden.

[@nourishedbyscience]

Danke für die nette Rückmeldung! LG Mario

[@hjuliechen]

@nourishedbyscience - Thanks much for this great video! I learned so much from it. I’m skinny (slightly under weight) and yet prediabetic. Losing weight to manage prediabetes just doesn’t apply to me. And I’m already eating very healthy, with minimal carbs. Your video stresses for me the importance of gaining muscle mass for my glucose management. Big thanks!!

[@santarosa6676]

Very informative! Thank you.

[@TheSignseeker]

Outstanding video. Thank you for providing clear info without hyperbole and gimmicks. The chapter links are really helpful for review. Based on this, I am creating a series of experiments to try to sort out what is going on with my blood glucose. My A1c is 5.0, so my doctors aren't concerned, but my swings are crazy. Going for a walk after a meal can cause a crash that makes me weak and breathless, and sometimes triggers an 'urgent low' warning on my CGM. I'm chronically sleep deprived (just can't stay asleep), so I'm going to tackle that first. This video is empowering. 💪

[@ludiabooth7718]

Thank you! Love the info and the presentation, calm, no hype, informative. Grateful.

[@DeeKru]

Getting to the underlying cause is what doctors don't care to do today. Just prescribe meds for it. Period.

[@MegaMia007]

This was very helpful. I can see now I have had a cascade of circumstances that have caused my insulin restance

[@michaelmatey8193]

Mario, thanks for the education. You really know what you talk about. What I appreciate the most is the fact that you teach with clarity. If only these priceless and in-depth knowledge shared with passion will reach out to all, especially the clinicians and put into practice, lots of lives will be saved and needless pain avoided.

[@galaxywanderer5945]

Your point 15 is 100% correct as I noticed the older I got the more BGL Imbalance!

[@Whistlewalk]

Thank you - this has been both interesting and useful to me. Much appreciated.

[@suwanneec-sirisuk7065]

Thanks

[@nourishedbyscience]

Thanks so much for your support!

[@tknow9298]

Outstanding presentation. I had no idea of the conditions that trigger insulin resistance.

[@Lisdodde]

Looking forward to your next videos, feeling very lucky I have been able to make progress on the body fat cause (mostly by lower glycemic index eating and intermittent fasting) and the low muscle mass cause before getting serious about weathering the menopause in the coming years 😅

[@theresaotoole9141]

Another great Video - very helpful..

[@richardbartos7191]

Thanks!

[@nourishedbyscience]

Thank you for your generous support! Best, Mario

[@jonthomas9708]

This answered something that has puzzled me and I have seen nothing anywhere else to address it; how does insulin un-dock from the insulin receptor and how is insulin itself removed or degraded. Excellent piece, thank you!

[@nourishedbyscience]

Thanks for the feedback. I often wonder whether or not, and to which degree, to go deeper on such mechanistic/physiological/pathophysiological aspects. I personally like to understand how stuff works, but I am often worried I lose my audience with too much detail. It's good to hear of instances where someone appreciates it. Cheers Mario

[@peterg.masseysr.]

Thank you for your splendid lecture....

[@bedi3yamida870]

hugeee amount of information which i never heard before thx a lot mario

[@azdhan]

Great video! Many thanks for sharing

[@justsaying7065]

Great video! Keep more coming please. Thank you.

[@jeanneschwabacher4066]

Wow, it helps to see the connections!

[@msshiraroth]

Thank you for this treasure of knowledge!

[@shauna996]

Thanks!

[@nourishedbyscience]

Thank you so much!

[@pelawren]

Thank You Mario for yet another informative video. Is there any information on any of the literature you have studied on the ideal range for muscle mass? Thank You

[@nourishedbyscience]

I actually wondered about that myself, i.e., is there a minimum threshold at which we gain the most, or an upper threshold at which further muscle gains don't improve insulin sensitivity further? I did not come across any paper that has looked into that specifically, but truth be told, I read a lot of papers for this video across all 16 factors, and didn't go particularly deep on any one cause. I will keep this question in mind for future episodes dedicated to exercise and insulin sensitivity. Cheers Mario

[@pelawren]

@@nourishedbyscience Thank You