Nucleotides, Chromosomes, and Haplotypes... Oh My!

[@pembapemba4330]

basic but useful. Haplotype explanatiion was great

[@aravindvenkateswaran5294]

cleared!

[@martynasvenckus423]

At 5:14, why is TT a SNP if both letters are the same? Why GG and AA, which are next to TT, ar not highlighted as SNPs then?

[@marinasantin_]

I still not understanding what Haplotype is :(

[@Poraqui]

Imagine a single strand of DNA that in it exist regions that are known to mutate. These smaller informative segments are called Markers. Their specific sequence can vary, so there are different versions of this sequence. These versions are called Alleles. Alleles can be different among themselves just in one position. Ex Allele A is: CTTTA Allele B is: CTTTC Allele A is: CTTTT A given Marker can have Allele A or B or C. This is true for all markers that we analyse on a given strand. It follows that a Haplotype is a set of Markers with a specific allele makeup in each one of them. As an example a Haplotype composed by three markers: Haplotype 1: Allele A in Marker 1; Allele Z in Marker 2; Allele H in Marker 3. Haplotype 2: Allele A in Marker 1; Allele Z in Marker 2; Allele I in Marker 3. Haplotype 3: Allele A in Marker 1; Allele X in Marker 2; Allele J in Marker 3. Simplifying: Haplotype 1 is composed by the set of Alleles A,Z,H Haplotype 2 maintains Allele A in the first region (marker) and Allele Z in the second region, but it differs in the third region of the strand; theres an I allele instead of the H of the first Haplotype. Haplotype 3, following the same approach, is composed instead by the alleles A, X and J in the same strand regions (markers) as the previous two haplotypes. An Haplogroup is when a group of people whose haplotypes have all or most of the same marker alleles in common.

[@yashneetmaan7273]

Good

[@talaalkhaledi1981]

4:24 الأنماط الفردانية

[@donaldaham6656]

Hi Wii party

[@tomvice]

Valley accent is insufferable